JP2019534695A5 - - Google Patents
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- JP2019534695A5 JP2019534695A5 JP2019517246A JP2019517246A JP2019534695A5 JP 2019534695 A5 JP2019534695 A5 JP 2019534695A5 JP 2019517246 A JP2019517246 A JP 2019517246A JP 2019517246 A JP2019517246 A JP 2019517246A JP 2019534695 A5 JP2019534695 A5 JP 2019534695A5
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- 108090000765 processed proteins & peptides Proteins 0.000 claims 58
- 229920001184 polypeptide Polymers 0.000 claims 56
- 102000004196 processed proteins & peptides Human genes 0.000 claims 56
- 230000000694 effects Effects 0.000 claims 38
- 210000004027 cell Anatomy 0.000 claims 34
- 108020004707 nucleic acids Proteins 0.000 claims 31
- 102000039446 nucleic acids Human genes 0.000 claims 31
- 150000007523 nucleic acids Chemical class 0.000 claims 31
- 125000003275 alpha amino acid group Chemical group 0.000 claims 26
- 108020005004 Guide RNA Proteins 0.000 claims 21
- 230000004927 fusion Effects 0.000 claims 14
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 12
- 239000002773 nucleotide Substances 0.000 claims 12
- 125000003729 nucleotide group Chemical group 0.000 claims 12
- 108020004414 DNA Proteins 0.000 claims 10
- 210000003527 eukaryotic cell Anatomy 0.000 claims 5
- 238000000034 method Methods 0.000 claims 4
- 108060004795 Methyltransferase Proteins 0.000 claims 3
- 230000002255 enzymatic effect Effects 0.000 claims 3
- 230000004048 modification Effects 0.000 claims 3
- 238000012986 modification Methods 0.000 claims 3
- 230000035772 mutation Effects 0.000 claims 3
- 239000004209 oxidized polyethylene wax Substances 0.000 claims 3
- 241000271566 Aves Species 0.000 claims 2
- 102000007260 Deoxyribonuclease I Human genes 0.000 claims 2
- 108010008532 Deoxyribonuclease I Proteins 0.000 claims 2
- 241000238631 Hexapoda Species 0.000 claims 2
- 101000615488 Homo sapiens Methyl-CpG-binding domain protein 2 Proteins 0.000 claims 2
- 241000270322 Lepidosauria Species 0.000 claims 2
- 102100021299 Methyl-CpG-binding domain protein 2 Human genes 0.000 claims 2
- 102000016397 Methyltransferase Human genes 0.000 claims 2
- 241000288906 Primates Species 0.000 claims 2
- 238000006243 chemical reaction Methods 0.000 claims 2
- 210000003763 chloroplast Anatomy 0.000 claims 2
- 210000002308 embryonic cell Anatomy 0.000 claims 2
- 210000001163 endosome Anatomy 0.000 claims 2
- 230000002538 fungal effect Effects 0.000 claims 2
- 210000004602 germ cell Anatomy 0.000 claims 2
- 210000005260 human cell Anatomy 0.000 claims 2
- 238000000338 in vitro Methods 0.000 claims 2
- 210000004962 mammalian cell Anatomy 0.000 claims 2
- 102000004169 proteins and genes Human genes 0.000 claims 2
- 108090000623 proteins and genes Proteins 0.000 claims 2
- 238000013518 transcription Methods 0.000 claims 2
- 230000035897 transcription Effects 0.000 claims 2
- 241000251468 Actinopterygii Species 0.000 claims 1
- 241000239290 Araneae Species 0.000 claims 1
- 239000004475 Arginine Substances 0.000 claims 1
- 241000238421 Arthropoda Species 0.000 claims 1
- 230000005778 DNA damage Effects 0.000 claims 1
- 231100000277 DNA damage Toxicity 0.000 claims 1
- 230000033616 DNA repair Effects 0.000 claims 1
- 108010046331 Deoxyribodipyrimidine photo-lyase Proteins 0.000 claims 1
- 102000004190 Enzymes Human genes 0.000 claims 1
- 108090000790 Enzymes Proteins 0.000 claims 1
- 108091006027 G proteins Proteins 0.000 claims 1
- 102000030782 GTP binding Human genes 0.000 claims 1
- 108091000058 GTP-Binding Proteins 0.000 claims 1
- 108010033040 Histones Proteins 0.000 claims 1
- 102100034343 Integrase Human genes 0.000 claims 1
- 108010061833 Integrases Proteins 0.000 claims 1
- ODKSFYDXXFIFQN-BYPYZUCNSA-P L-argininium(2+) Chemical compound NC(=[NH2+])NCCC[C@H]([NH3+])C(O)=O ODKSFYDXXFIFQN-BYPYZUCNSA-P 0.000 claims 1
- HNDVDQJCIGZPNO-YFKPBYRVSA-N L-histidine Chemical compound OC(=O)[C@@H](N)CC1=CN=CN1 HNDVDQJCIGZPNO-YFKPBYRVSA-N 0.000 claims 1
- KDXKERNSBIXSRK-YFKPBYRVSA-N L-lysine Chemical compound NCCCC[C@H](N)C(O)=O KDXKERNSBIXSRK-YFKPBYRVSA-N 0.000 claims 1
- 102000003960 Ligases Human genes 0.000 claims 1
- 108090000364 Ligases Proteins 0.000 claims 1
- KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 claims 1
- 239000004472 Lysine Substances 0.000 claims 1
- 102100025169 Max-binding protein MNT Human genes 0.000 claims 1
- 108010077850 Nuclear Localization Signals Proteins 0.000 claims 1
- 101710163270 Nuclease Proteins 0.000 claims 1
- 102000004160 Phosphoric Monoester Hydrolases Human genes 0.000 claims 1
- 108090000608 Phosphoric Monoester Hydrolases Proteins 0.000 claims 1
- 108091000080 Phosphotransferase Proteins 0.000 claims 1
- CZPWVGJYEJSRLH-UHFFFAOYSA-N Pyrimidine Chemical compound C1=CN=CN=C1 CZPWVGJYEJSRLH-UHFFFAOYSA-N 0.000 claims 1
- 108091093078 Pyrimidine dimer Proteins 0.000 claims 1
- 102000018120 Recombinases Human genes 0.000 claims 1
- 108010091086 Recombinases Proteins 0.000 claims 1
- 241000283984 Rodentia Species 0.000 claims 1
- 108700019146 Transgenes Proteins 0.000 claims 1
- 102000008579 Transposases Human genes 0.000 claims 1
- 108010020764 Transposases Proteins 0.000 claims 1
- 102000006275 Ubiquitin-Protein Ligases Human genes 0.000 claims 1
- 108010083111 Ubiquitin-Protein Ligases Proteins 0.000 claims 1
- 241000251539 Vertebrata <Metazoa> Species 0.000 claims 1
- 102000005421 acetyltransferase Human genes 0.000 claims 1
- 108020002494 acetyltransferase Proteins 0.000 claims 1
- 230000006154 adenylylation Effects 0.000 claims 1
- 230000029936 alkylation Effects 0.000 claims 1
- 238000005804 alkylation reaction Methods 0.000 claims 1
- ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 claims 1
- 230000015572 biosynthetic process Effects 0.000 claims 1
- 230000000295 complement effect Effects 0.000 claims 1
- 230000007423 decrease Effects 0.000 claims 1
- 230000022811 deglycosylation Effects 0.000 claims 1
- 230000006114 demyristoylation Effects 0.000 claims 1
- 230000027832 depurination Effects 0.000 claims 1
- 230000009504 deubiquitination Effects 0.000 claims 1
- 230000013595 glycosylation Effects 0.000 claims 1
- 238000006206 glycosylation reaction Methods 0.000 claims 1
- HNDVDQJCIGZPNO-UHFFFAOYSA-N histidine Natural products OC(=O)C(N)CC1=CN=CN1 HNDVDQJCIGZPNO-UHFFFAOYSA-N 0.000 claims 1
- 230000010354 integration Effects 0.000 claims 1
- 230000007498 myristoylation Effects 0.000 claims 1
- 230000001590 oxidative effect Effects 0.000 claims 1
- 244000045947 parasite Species 0.000 claims 1
- 102000020233 phosphotransferase Human genes 0.000 claims 1
- 230000029279 positive regulation of transcription, DNA-dependent Effects 0.000 claims 1
- 239000013635 pyrimidine dimer Substances 0.000 claims 1
- 230000001105 regulatory effect Effects 0.000 claims 1
- 230000008685 targeting Effects 0.000 claims 1
- 108091006107 transcriptional repressors Proteins 0.000 claims 1
- 230000009261 transgenic effect Effects 0.000 claims 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2022202406A JP2023030067A (ja) | 2016-09-30 | 2022-12-19 | Ｒｎａ誘導型核酸修飾酵素及びその使用方法 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662402849P | 2016-09-30 | 2016-09-30 | |
| US62/402,849 | 2016-09-30 | ||
| PCT/US2017/054047 WO2018064352A1 (en) | 2016-09-30 | 2017-09-28 | Rna-guided nucleic acid modifying enzymes and methods of use thereof |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022202406A Division JP2023030067A (ja) | 2016-09-30 | 2022-12-19 | Ｒｎａ誘導型核酸修飾酵素及びその使用方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2019534695A JP2019534695A (ja) | 2019-12-05 |
| JP2019534695A5 true JP2019534695A5 (https=) | 2020-11-12 |
| JP7306696B2 JP7306696B2 (ja) | 2023-07-11 |
Family
ID=61760117
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019517246A Active JP7306696B2 (ja) | 2016-09-30 | 2017-09-28 | Ｒｎａ誘導型核酸修飾酵素及びその使用方法 |
| JP2022202406A Pending JP2023030067A (ja) | 2016-09-30 | 2022-12-19 | Ｒｎａ誘導型核酸修飾酵素及びその使用方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022202406A Pending JP2023030067A (ja) | 2016-09-30 | 2022-12-19 | Ｒｎａ誘導型核酸修飾酵素及びその使用方法 |
Country Status (14)
| Country | Link |
|---|---|
| US (2) | US11371062B2 (https=) |
| EP (1) | EP3532089A4 (https=) |
| JP (2) | JP7306696B2 (https=) |
| KR (2) | KR102812752B1 (https=) |
| CN (1) | CN110418647B (https=) |
| AU (1) | AU2017335883B2 (https=) |
| BR (1) | BR112019006388A2 (https=) |
| CA (1) | CA3038982A1 (https=) |
| EA (1) | EA201990860A1 (https=) |
| GB (1) | GB2569734B (https=) |
| IL (1) | IL265599A (https=) |
| MX (1) | MX2019003678A (https=) |
| SA (1) | SA519401442B1 (https=) |
| WO (1) | WO2018064352A1 (https=) |
Families Citing this family (83)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10323236B2 (en) | 2011-07-22 | 2019-06-18 | President And Fellows Of Harvard College | Evaluation and improvement of nuclease cleavage specificity |
| US9163284B2 (en) | 2013-08-09 | 2015-10-20 | President And Fellows Of Harvard College | Methods for identifying a target site of a Cas9 nuclease |
| US9359599B2 (en) | 2013-08-22 | 2016-06-07 | President And Fellows Of Harvard College | Engineered transcription activator-like effector (TALE) domains and uses thereof |
| US9322037B2 (en) | 2013-09-06 | 2016-04-26 | President And Fellows Of Harvard College | Cas9-FokI fusion proteins and uses thereof |
| US9526784B2 (en) | 2013-09-06 | 2016-12-27 | President And Fellows Of Harvard College | Delivery system for functional nucleases |
| US9228207B2 (en) | 2013-09-06 | 2016-01-05 | President And Fellows Of Harvard College | Switchable gRNAs comprising aptamers |
| US20150165054A1 (en) | 2013-12-12 | 2015-06-18 | President And Fellows Of Harvard College | Methods for correcting caspase-9 point mutations |
| US10077453B2 (en) | 2014-07-30 | 2018-09-18 | President And Fellows Of Harvard College | CAS9 proteins including ligand-dependent inteins |
| AU2015330699B2 (en) | 2014-10-10 | 2021-12-02 | Editas Medicine, Inc. | Compositions and methods for promoting homology directed repair |
| EP4464338A3 (en) | 2014-11-07 | 2025-02-12 | Editas Medicine, Inc. | Systems for improving crispr/cas-mediated genome-editing |
| CA2986310A1 (en) | 2015-05-11 | 2016-11-17 | Editas Medicine, Inc. | Optimized crispr/cas9 systems and methods for gene editing in stem cells |
| CN108026526B (zh) | 2015-06-09 | 2023-05-12 | 爱迪塔斯医药公司 | 用于改善移植的crispr/cas相关方法和组合物 |
| EP3353296B1 (en) | 2015-09-24 | 2020-11-04 | Editas Medicine, Inc. | Use of exonucleases to improve crispr/cas-mediated genome editing |
| IL310721B2 (en) | 2015-10-23 | 2025-11-01 | Harvard College | Nucleobase editors and uses thereof |
| US11597924B2 (en) | 2016-03-25 | 2023-03-07 | Editas Medicine, Inc. | Genome editing systems comprising repair-modulating enzyme molecules and methods of their use |
| US11236313B2 (en) | 2016-04-13 | 2022-02-01 | Editas Medicine, Inc. | Cas9 fusion molecules, gene editing systems, and methods of use thereof |
| US10337051B2 (en) | 2016-06-16 | 2019-07-02 | The Regents Of The University Of California | Methods and compositions for detecting a target RNA |
| CN110214183A (zh) | 2016-08-03 | 2019-09-06 | 哈佛大学的校长及成员们 | 腺苷核碱基编辑器及其用途 |
| WO2018031683A1 (en) | 2016-08-09 | 2018-02-15 | President And Fellows Of Harvard College | Programmable cas9-recombinase fusion proteins and uses thereof |
| US11542509B2 (en) | 2016-08-24 | 2023-01-03 | President And Fellows Of Harvard College | Incorporation of unnatural amino acids into proteins using base editing |
| MX2019003674A (es) | 2016-09-30 | 2021-01-08 | Univ California | Enzimas modificadoras de ácido nucleico guiadas por arn y métodos de uso de estas. |
| BR112019006388A2 (pt) | 2016-09-30 | 2019-06-25 | Univ California | enzimas modificadoras de ácido nucleico guiadas por rna e métodos de uso das mesmas |
| KR102622411B1 (ko) | 2016-10-14 | 2024-01-10 | 프레지던트 앤드 펠로우즈 오브 하바드 칼리지 | 핵염기 에디터의 aav 전달 |
| EP3555297A1 (en) | 2016-12-19 | 2019-10-23 | Editas Medicine, Inc. | Assessing nuclease cleavage |
| WO2018119359A1 (en) | 2016-12-23 | 2018-06-28 | President And Fellows Of Harvard College | Editing of ccr5 receptor gene to protect against hiv infection |
| JP7229923B2 (ja) | 2017-01-06 | 2023-02-28 | エディタス・メディシン、インコーポレイテッド | ヌクレアーゼ切断を評価する方法 |
| WO2018136396A2 (en) * | 2017-01-18 | 2018-07-26 | Excision Biotherapeutics, Inc. | Crisprs |
| US10995333B2 (en) | 2017-02-06 | 2021-05-04 | 10X Genomics, Inc. | Systems and methods for nucleic acid preparation |
| US12390514B2 (en) | 2017-03-09 | 2025-08-19 | President And Fellows Of Harvard College | Cancer vaccine |
| EP3592853A1 (en) | 2017-03-09 | 2020-01-15 | President and Fellows of Harvard College | Suppression of pain by gene editing |
| US11542496B2 (en) | 2017-03-10 | 2023-01-03 | President And Fellows Of Harvard College | Cytosine to guanine base editor |
| KR20240116572A (ko) | 2017-03-23 | 2024-07-29 | 프레지던트 앤드 펠로우즈 오브 하바드 칼리지 | 핵산 프로그램가능한 dna 결합 단백질을 포함하는 핵염기 편집제 |
| US11499151B2 (en) | 2017-04-28 | 2022-11-15 | Editas Medicine, Inc. | Methods and systems for analyzing guide RNA molecules |
| US11560566B2 (en) | 2017-05-12 | 2023-01-24 | President And Fellows Of Harvard College | Aptazyme-embedded guide RNAs for use with CRISPR-Cas9 in genome editing and transcriptional activation |
| MX2019014640A (es) | 2017-06-09 | 2020-10-05 | Editas Medicine Inc | Nucleasas de repeticiones palíndromicas agrupadas y regularmente interespaciadas de proteina asociada 9 (cas9) genomanipuladas. |
| US11866726B2 (en) | 2017-07-14 | 2024-01-09 | Editas Medicine, Inc. | Systems and methods for targeted integration and genome editing and detection thereof using integrated priming sites |
| CN111801345A (zh) | 2017-07-28 | 2020-10-20 | 哈佛大学的校长及成员们 | 使用噬菌体辅助连续进化(pace)的进化碱基编辑器的方法和组合物 |
| EP3676376B1 (en) | 2017-08-30 | 2025-01-15 | President and Fellows of Harvard College | High efficiency base editors comprising gam |
| KR20250107288A (ko) | 2017-10-16 | 2025-07-11 | 더 브로드 인스티튜트, 인코퍼레이티드 | 아데노신 염기 편집제의 용도 |
| AU2018358051B2 (en) | 2017-11-01 | 2025-01-09 | The Regents Of The University Of California | CasZ compositions and methods of use |
| US11970719B2 (en) * | 2017-11-01 | 2024-04-30 | The Regents Of The University Of California | Class 2 CRISPR/Cas compositions and methods of use |
| WO2019089804A1 (en) | 2017-11-01 | 2019-05-09 | The Regents Of The University Of California | Casy compositions and methods of use |
| US12406749B2 (en) | 2017-12-15 | 2025-09-02 | The Broad Institute, Inc. | Systems and methods for predicting repair outcomes in genetic engineering |
| US11807877B1 (en) | 2018-03-22 | 2023-11-07 | National Technology & Engineering Solutions Of Sandia, Llc | CRISPR/Cas activity assays and compositions thereof |
| KR20210039983A (ko) * | 2018-04-24 | 2021-04-12 | 리간달 인코포레이티드 | 게놈 편집을 위한 방법 및 조성물 |
| WO2019214604A1 (zh) * | 2018-05-07 | 2019-11-14 | 中国农业大学 | CRISPR/Cas效应蛋白及系统 |
| US12157760B2 (en) | 2018-05-23 | 2024-12-03 | The Broad Institute, Inc. | Base editors and uses thereof |
| AU2019282812B2 (en) | 2018-06-07 | 2025-08-14 | Arc Bio, Llc | Compositions and methods for making guide nucleic acids |
| EP3823633A4 (en) | 2018-06-29 | 2023-05-03 | Editas Medicine, Inc. | SYNTHETIC LEAD MOLECULES, COMPOSITIONS AND METHODS RELATED THERETO |
| US12522807B2 (en) | 2018-07-09 | 2026-01-13 | The Broad Institute, Inc. | RNA programmable epigenetic RNA modifiers and uses thereof |
| US20210284981A1 (en) * | 2018-07-24 | 2021-09-16 | The Regents Of The University Of California | Rna-guided nucleic acid modifying enzymes and methods of use thereof |
| EP3830301B1 (en) | 2018-08-01 | 2024-05-22 | Mammoth Biosciences, Inc. | Programmable nuclease compositions and methods of use thereof |
| WO2020092453A1 (en) | 2018-10-29 | 2020-05-07 | The Broad Institute, Inc. | Nucleobase editors comprising geocas9 and uses thereof |
| EP3931313A2 (en) * | 2019-01-04 | 2022-01-05 | Mammoth Biosciences, Inc. | Programmable nuclease improvements and compositions and methods for nucleic acid amplification and detection |
| AU2020208346B2 (en) * | 2019-01-14 | 2026-01-29 | University Of Rochester | Targeted nuclear RNA cleavage and polyadenylation with CRISPR-cas |
| US12351837B2 (en) | 2019-01-23 | 2025-07-08 | The Broad Institute, Inc. | Supernegatively charged proteins and uses thereof |
| MX2021010559A (es) | 2019-03-07 | 2021-12-15 | Univ California | Polipéptidos efectores de crispr-cas y métodos de uso de estos. |
| WO2020191233A1 (en) | 2019-03-19 | 2020-09-24 | The Broad Institute, Inc. | Methods and compositions for editing nucleotide sequences |
| CA3136228A1 (en) | 2019-04-09 | 2020-10-15 | Arc Bio, Llc | Compositions and methods for nucleotide modification-based depletion |
| US12473543B2 (en) | 2019-04-17 | 2025-11-18 | The Broad Institute, Inc. | Adenine base editors with reduced off-target effects |
| JP2022546701A (ja) * | 2019-08-27 | 2022-11-07 | アーバー バイオテクノロジーズ， インコーポレイテッド | 新規ｃｒｉｓｐｒ ｄｎａターゲティング酵素及びシステム |
| US12435330B2 (en) | 2019-10-10 | 2025-10-07 | The Broad Institute, Inc. | Methods and compositions for prime editing RNA |
| EP4081533A4 (en) * | 2019-12-23 | 2024-03-20 | The Regents of The University of California | CRISPR-CAS EFFECTOR POLYPEPTIDES AND METHODS OF USE |
| JP2023508731A (ja) * | 2019-12-30 | 2023-03-03 | ライフエディット セラピューティクス，インコーポレイティド | Ｒｎａ誘導ヌクレアーゼ、その活性断片および多様体、ならびに使用方法 |
| KR102651824B1 (ko) * | 2020-01-31 | 2024-03-27 | 현대모비스 주식회사 | 루프 에어백 장치 |
| WO2021202568A1 (en) * | 2020-03-31 | 2021-10-07 | Metagenomi Ip Technologies, Llc | Class ii, type ii crispr systems |
| WO2021216772A1 (en) * | 2020-04-21 | 2021-10-28 | Mammoth Biosciences, Inc. | Casy programmable nucleases and rna component systems |
| IL297761A (en) | 2020-05-08 | 2022-12-01 | Broad Inst Inc | Methods and compositions for simultaneously editing two helices of a designated double-helix nucleotide sequence |
| KR20240011120A (ko) | 2020-12-22 | 2024-01-25 | 크로마 메디슨, 인크. | 후성유전학적 편집을 위한 조성물 및 방법 |
| CN113151387B (zh) * | 2021-04-16 | 2022-08-16 | 安徽国肽生物科技有限公司 | 一种具有抗氧化和增强免疫功能的鳕鱼皮胶原蛋白肽及其制备方法 |
| EP4347818A2 (en) | 2021-06-01 | 2024-04-10 | Arbor Biotechnologies, Inc. | Gene editing systems comprising a crispr nuclease and uses thereof |
| WO2023283622A1 (en) | 2021-07-08 | 2023-01-12 | Montana State University | Crispr-based programmable rna editing |
| WO2023004391A2 (en) | 2021-07-21 | 2023-01-26 | Montana State University | Nucleic acid detection using type iii crispr complex |
| AU2022335499A1 (en) | 2021-08-27 | 2024-02-22 | Metagenomi Therapeutics, Inc. | Enzymes with ruvc domains |
| AU2022396533A1 (en) | 2021-11-24 | 2024-05-02 | Metagenomi Therapeutics, Inc. | Endonuclease systems |
| CN114921439B (zh) * | 2022-06-16 | 2024-04-26 | 尧唐(上海)生物科技有限公司 | CRISPR-Cas效应子蛋白、其基因编辑系统及应用 |
| US12435357B2 (en) | 2022-12-22 | 2025-10-07 | Kanso Diagnostics Ltd. | Diagnostic device for detecting a target nucleic acid molecule in a biological sample |
| KR20250151430A (ko) | 2023-02-15 | 2025-10-21 | 아버 바이오테크놀로지스, 인크. | 스타스민 2(stmn2) 전사체에서 비정상적인 스플라이싱을 억제하는 유전자 편집 방법 |
| AU2024270764A1 (en) | 2023-05-15 | 2025-12-04 | Nchroma Bio, Inc. | Compositions and methods for epigenetic regulation of hbv gene expression |
| WO2025049527A1 (en) * | 2023-08-29 | 2025-03-06 | The Medical College Of Wisconsin, Inc. | Y-rna compositions and methods of using the same |
| WO2025171210A1 (en) | 2024-02-09 | 2025-08-14 | Arbor Biotechnologies, Inc. | Compositions and methods for gene editing via homology-mediated end joining |
| WO2026015832A2 (en) | 2024-07-12 | 2026-01-15 | Arbor Biotechnologies, Inc. | Reverse transcriptases and gene editing systems comprising such |
| WO2026015829A2 (en) | 2024-07-12 | 2026-01-15 | Arbor Biotechnologies, Inc. | Small reverse transcriptases and gene editing systems comprising such |
Family Cites Families (76)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2004521606A (ja) | 2000-05-24 | 2004-07-22 | サード・ウェーブ・テクノロジーズ・インク | Ｒｎａの検出法 |
| US6773885B1 (en) | 2000-09-29 | 2004-08-10 | Integrated Dna Technologies, Inc. | Compositions and methods for visual ribonuclease detection assays |
| CN1886512A (zh) | 2002-04-23 | 2006-12-27 | 斯克里普斯研究所 | 多肽在叶绿体中的表达以及用于表达多肽的组合物和方法 |
| EP1580273A1 (en) | 2004-03-26 | 2005-09-28 | Friedrich-Alexander-Universität Erlangen-Nürnberg | Peptide-based method for monitoring gene expression in a host cell |
| CN101283089A (zh) | 2005-10-07 | 2008-10-08 | 加利福尼亚大学董事会 | 修饰细胞色素p450酶的编码核酸和其应用方法 |
| US9689031B2 (en) | 2007-07-14 | 2017-06-27 | Ionian Technologies, Inc. | Nicking and extension amplification reaction for the exponential amplification of nucleic acids |
| EP2432794B1 (en) | 2009-05-22 | 2017-08-30 | The Research Foundation of State University of New York | Trans-acting rna switches |
| US8597886B2 (en) | 2010-02-15 | 2013-12-03 | Cascade Biosystems, Inc. | Methods and materials for detecting viral or microbial infections |
| US20130261196A1 (en) | 2010-06-11 | 2013-10-03 | Lisa Diamond | Nucleic Acids For Multiplex Organism Detection and Methods Of Use And Making The Same |
| US9730967B2 (en) | 2011-02-04 | 2017-08-15 | Katherine Rose Kovarik | Method and system for treating cancer cachexia |
| US8815782B2 (en) | 2011-11-11 | 2014-08-26 | Agilent Technologies, Inc. | Use of DNAzymes for analysis of an RNA sample |
| AU2013266968B2 (en) | 2012-05-25 | 2017-06-29 | Emmanuelle CHARPENTIER | Methods and compositions for RNA-directed target DNA modification and for RNA-directed modulation of transcription |
| US20140024024A1 (en) | 2012-07-17 | 2014-01-23 | General Electric Company | Methods of detecting dna, rna and protein in biological samples |
| AU2013335451C1 (en) | 2012-10-23 | 2024-07-04 | Toolgen Incorporated | Composition for cleaving a target DNA comprising a guide RNA specific for the target DNA and Cas protein-encoding nucleic acid or Cas protein, and use thereof |
| PL3360964T3 (pl) | 2012-12-06 | 2020-03-31 | Sigma-Aldrich Co. Llc | Modyfikacja i regulacja genomu oparta na crispr |
| EP3031921B1 (en) | 2012-12-12 | 2025-03-12 | The Broad Institute, Inc. | Delivery, engineering and optimization of systems, methods and compositions for sequence manipulation and therapeutic applications |
| EP2840140B2 (en) | 2012-12-12 | 2023-02-22 | The Broad Institute, Inc. | Crispr-Cas based method for mutation of prokaryotic cells |
| CN103088128B (zh) | 2013-01-09 | 2015-11-18 | 华中科技大学 | 一种microRNA的二次循环扩增检测方法及试剂盒 |
| RU2662932C2 (ru) | 2013-03-14 | 2018-07-31 | Карибо Биосайенсиз, Инк. | Композиции и способы с участием нуклеиновых кислот, нацеленных на нуклеиновые кислоты |
| US9234213B2 (en) | 2013-03-15 | 2016-01-12 | System Biosciences, Llc | Compositions and methods directed to CRISPR/Cas genomic engineering systems |
| CA2930877A1 (en) | 2013-11-18 | 2015-05-21 | Crispr Therapeutics Ag | Crispr-cas system materials and methods |
| JP6793547B2 (ja) | 2013-12-12 | 2020-12-02 | ザ・ブロード・インスティテュート・インコーポレイテッド | 最適化機能ＣＲＩＳＰＲ−Ｃａｓ系による配列操作のための系、方法および組成物 |
| EP3835419A1 (en) * | 2013-12-12 | 2021-06-16 | The Regents of The University of California | Methods and compositions for modifying a single stranded target nucleic acid |
| US9850525B2 (en) | 2014-01-29 | 2017-12-26 | Agilent Technologies, Inc. | CAS9-based isothermal method of detection of specific DNA sequence |
| AU2015234204A1 (en) | 2014-03-20 | 2016-10-06 | Universite Laval | CRISPR-based methods and products for increasing frataxin levels and uses thereof |
| US10253311B2 (en) | 2014-04-10 | 2019-04-09 | The Regents Of The University Of California | Methods and compositions for using argonaute to modify a single stranded target nucleic acid |
| EP3155116A4 (en) | 2014-06-10 | 2017-12-27 | Massachusetts Institute Of Technology | Method for gene editing |
| EP3183358B1 (en) | 2014-08-19 | 2020-10-07 | President and Fellows of Harvard College | Rna-guided systems for probing and mapping of nucleic acids |
| WO2016094872A1 (en) | 2014-12-12 | 2016-06-16 | The Broad Institute Inc. | Dead guides for crispr transcription factors |
| EP3889260A1 (en) | 2014-12-12 | 2021-10-06 | The Broad Institute, Inc. | Protected guide rnas (pgrnas) |
| WO2016106236A1 (en) | 2014-12-23 | 2016-06-30 | The Broad Institute Inc. | Rna-targeting system |
| EP3250689B1 (en) | 2015-01-28 | 2020-11-04 | The Regents of The University of California | Methods and compositions for labeling a single-stranded target nucleic acid |
| GB201506509D0 (en) | 2015-04-16 | 2015-06-03 | Univ Wageningen | Nuclease-mediated genome editing |
| TWI906646B (zh) | 2015-06-18 | 2025-12-01 | 美商博得學院股份有限公司 | 降低脫靶效應的ｃｒｉｓｐｒ酶突變 |
| AU2016279077A1 (en) | 2015-06-18 | 2019-03-28 | Omar O. Abudayyeh | Novel CRISPR enzymes and systems |
| US9790490B2 (en) * | 2015-06-18 | 2017-10-17 | The Broad Institute Inc. | CRISPR enzymes and systems |
| WO2016205749A1 (en) | 2015-06-18 | 2016-12-22 | The Broad Institute Inc. | Novel crispr enzymes and systems |
| US9580727B1 (en) | 2015-08-07 | 2017-02-28 | Caribou Biosciences, Inc. | Compositions and methods of engineered CRISPR-Cas9 systems using split-nexus Cas9-associated polynucleotides |
| CN116814590A (zh) | 2015-10-22 | 2023-09-29 | 布罗德研究所有限公司 | Vi-b型crispr酶和系统 |
| US11193127B2 (en) | 2016-01-08 | 2021-12-07 | University Of Georgia Research Foundation, Inc. | Methods for cleaving DNA and RNA molecules |
| US11441146B2 (en) | 2016-01-11 | 2022-09-13 | Christiana Care Health Services, Inc. | Compositions and methods for improving homogeneity of DNA generated using a CRISPR/Cas9 cleavage system |
| US9896696B2 (en) | 2016-02-15 | 2018-02-20 | Benson Hill Biosystems, Inc. | Compositions and methods for modifying genomes |
| AU2017223821B2 (en) | 2016-02-23 | 2023-07-27 | Arc Bio, Llc | Methods and compositions for target detection |
| US20190093091A1 (en) | 2016-04-06 | 2019-03-28 | Temple University - Of The Commonwealth System Of Higher Education | Compositions for eradicating flavivirus infections in subjects |
| WO2017205668A1 (en) | 2016-05-25 | 2017-11-30 | Arizona Board Of Regents On Behalf Of Arizona State University | Portable, low-cost pathogen detection and strain identification platform |
| EP3464594A1 (en) | 2016-06-01 | 2019-04-10 | Kws Saat Se | Hybrid nucleic acid sequences for genome engineering |
| US10337051B2 (en) | 2016-06-16 | 2019-07-02 | The Regents Of The University Of California | Methods and compositions for detecting a target RNA |
| CN109642231A (zh) | 2016-06-17 | 2019-04-16 | 博德研究所 | Vi型crispr直向同源物和系统 |
| AU2017280353B2 (en) | 2016-06-24 | 2021-11-11 | Inscripta, Inc. | Methods for generating barcoded combinatorial libraries |
| CN110214183A (zh) | 2016-08-03 | 2019-09-06 | 哈佛大学的校长及成员们 | 腺苷核碱基编辑器及其用途 |
| EP3500967A1 (en) | 2016-08-17 | 2019-06-26 | The Broad Institute, Inc. | Methods for identifying class 2 crispr-cas systems |
| MX2019003674A (es) | 2016-09-30 | 2021-01-08 | Univ California | Enzimas modificadoras de ácido nucleico guiadas por arn y métodos de uso de estas. |
| BR112019006388A2 (pt) | 2016-09-30 | 2019-06-25 | Univ California | enzimas modificadoras de ácido nucleico guiadas por rna e métodos de uso das mesmas |
| CN106701830B (zh) | 2016-12-07 | 2020-01-03 | 湖南人文科技学院 | 一种敲除猪胚胎p66shc基因的方法 |
| CN110506128A (zh) | 2016-12-09 | 2019-11-26 | 博德研究所 | 基于crispr效应系统的诊断 |
| WO2018136396A2 (en) | 2017-01-18 | 2018-07-26 | Excision Biotherapeutics, Inc. | Crisprs |
| CN106548744B (zh) | 2017-01-20 | 2019-11-01 | 京东方科技集团股份有限公司 | 栅极驱动单元及其驱动方法、栅极驱动电路和显示装置 |
| US20190367924A1 (en) | 2017-02-17 | 2019-12-05 | Temple University - Of The Commonwealth System Of Higher Education | Gene editing therapy for hiv infection via dual targeting of hiv genome and ccr5 |
| SG11201906297QA (en) | 2017-03-24 | 2019-10-30 | Curevac Ag | Nucleic acids encoding crispr-associated proteins and uses thereof |
| US11591589B2 (en) | 2017-04-21 | 2023-02-28 | The General Hospital Corporation | Variants of Cpf1 (Cas12a) with altered PAM specificity |
| US20200407737A1 (en) | 2017-05-03 | 2020-12-31 | KWS SAAT SE & Co. KGaA | Use of crispr-cas endonucleases for plant genome engineering |
| EP3665279B1 (en) | 2017-08-09 | 2023-07-19 | Benson Hill, Inc. | Compositions and methods for modifying genomes |
| WO2019036185A1 (en) | 2017-08-15 | 2019-02-21 | The Regents Of The University Of California | COMPOSITIONS AND METHODS FOR IMPROVING GENOMIC SEQUENCE CORRECTION |
| AU2018358051B2 (en) | 2017-11-01 | 2025-01-09 | The Regents Of The University Of California | CasZ compositions and methods of use |
| US11970719B2 (en) | 2017-11-01 | 2024-04-30 | The Regents Of The University Of California | Class 2 CRISPR/Cas compositions and methods of use |
| WO2019089796A1 (en) | 2017-11-01 | 2019-05-09 | The Regents Of The University Of California | Cas12c compositions and methods of use |
| WO2019089804A1 (en) | 2017-11-01 | 2019-05-09 | The Regents Of The University Of California | Casy compositions and methods of use |
| US10253365B1 (en) | 2017-11-22 | 2019-04-09 | The Regents Of The University Of California | Type V CRISPR/Cas effector proteins for cleaving ssDNAs and detecting target DNAs |
| CN110295231A (zh) | 2017-12-20 | 2019-10-01 | 威廉马歇莱思大学 | 通过选择性等位基因富集或消耗用低深度测序检测和定量稀有变体 |
| CA3086550A1 (en) | 2017-12-22 | 2019-06-27 | The Broad Institute, Inc. | Crispr effector system based multiplex diagnostics |
| WO2019222555A1 (en) | 2018-05-16 | 2019-11-21 | Arbor Biotechnologies, Inc. | Novel crispr-associated systems and components |
| US20210284981A1 (en) | 2018-07-24 | 2021-09-16 | The Regents Of The University Of California | Rna-guided nucleic acid modifying enzymes and methods of use thereof |
| US12275964B2 (en) | 2018-08-22 | 2025-04-15 | The Regents Of The University Of California | Variant type V CRISPR/Cas effector polypeptides and methods of use thereof |
| CA3120432A1 (en) | 2018-11-15 | 2020-05-22 | China Agricultural University | Crispr-cas12j enzyme and system |
| CN110713940B (zh) | 2019-10-15 | 2021-02-19 | 天津科技大学 | 一种高产重油出芽短梗霉菌株及其构建方法与用途 |
| WO2022055998A1 (en) | 2020-09-09 | 2022-03-17 | The Regents Of The University Of California | Crispr-cas effector polypeptides and methods of use thereof |
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2017
- 2017-09-28 BR BR112019006388A patent/BR112019006388A2/pt unknown
- 2017-09-28 EP EP17857432.3A patent/EP3532089A4/en active Pending
- 2017-09-28 JP JP2019517246A patent/JP7306696B2/ja active Active
- 2017-09-28 KR KR1020237041560A patent/KR102812752B1/ko active Active
- 2017-09-28 CA CA3038982A patent/CA3038982A1/en active Pending
- 2017-09-28 GB GB1905581.3A patent/GB2569734B/en active Active
- 2017-09-28 US US16/335,630 patent/US11371062B2/en active Active
- 2017-09-28 EA EA201990860A patent/EA201990860A1/ru unknown
- 2017-09-28 WO PCT/US2017/054047 patent/WO2018064352A1/en not_active Ceased
- 2017-09-28 CN CN201780074122.7A patent/CN110418647B/zh active Active
- 2017-09-28 KR KR1020197012246A patent/KR20190072548A/ko not_active Ceased
- 2017-09-28 AU AU2017335883A patent/AU2017335883B2/en not_active Ceased
- 2017-09-28 MX MX2019003678A patent/MX2019003678A/es unknown
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- 2019-03-25 IL IL265599A patent/IL265599A/en unknown
- 2019-03-28 SA SA519401442A patent/SA519401442B1/ar unknown
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- 2022-12-19 JP JP2022202406A patent/JP2023030067A/ja active Pending
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