JP2019534269A5 - - Google Patents
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- JP2019534269A5 JP2019534269A5 JP2019519762A JP2019519762A JP2019534269A5 JP 2019534269 A5 JP2019534269 A5 JP 2019534269A5 JP 2019519762 A JP2019519762 A JP 2019519762A JP 2019519762 A JP2019519762 A JP 2019519762A JP 2019534269 A5 JP2019534269 A5 JP 2019534269A5
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- JP
- Japan
- Prior art keywords
- composition
- compound
- pharmaceutically acceptable
- acceptable salt
- pharmaceutical composition
- Prior art date
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- 150000001875 compounds Chemical class 0.000 claims description 43
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- 239000008194 pharmaceutical composition Substances 0.000 claims description 21
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 14
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- 206010064930 age-related macular degeneration Diseases 0.000 claims description 11
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- 208000035475 disorder Diseases 0.000 claims description 9
- 208000002780 macular degeneration Diseases 0.000 claims description 9
- -1 Konbaseputo Chemical compound 0.000 claims description 8
- 208000005590 Choroidal Neovascularization Diseases 0.000 claims description 6
- 206010060823 Choroidal neovascularisation Diseases 0.000 claims description 6
- 206010012688 Diabetic retinal oedema Diseases 0.000 claims description 5
- 201000011190 diabetic macular edema Diseases 0.000 claims description 5
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- 102100028198 Macrophage colony-stimulating factor 1 receptor Human genes 0.000 claims description 4
- 101710150918 Macrophage colony-stimulating factor 1 receptor Proteins 0.000 claims description 4
- 206010029113 Neovascularisation Diseases 0.000 claims description 4
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- 230000001404 mediated effect Effects 0.000 claims description 3
- HXHAJRMTJXHJJZ-UHFFFAOYSA-N 3-[(4-bromo-2,6-difluorophenyl)methoxy]-5-(4-pyrrolidin-1-ylbutylcarbamoylamino)-1,2-thiazole-4-carboxamide Chemical compound S1N=C(OCC=2C(=CC(Br)=CC=2F)F)C(C(=O)N)=C1NC(=O)NCCCCN1CCCC1 HXHAJRMTJXHJJZ-UHFFFAOYSA-N 0.000 claims description 2
- YRJWHQPZBNQJCR-UHFFFAOYSA-N 5-(1-methylcyclopropyl)-1h-pyrazol-3-amine Chemical compound C1=C(N)NN=C1C1(C)CC1 YRJWHQPZBNQJCR-UHFFFAOYSA-N 0.000 claims description 2
- WLCZTRVUXYALDD-IBGZPJMESA-N 7-[[(2s)-2,6-bis(2-methoxyethoxycarbonylamino)hexanoyl]amino]heptoxy-methylphosphinic acid Chemical compound COCCOC(=O)NCCCC[C@H](NC(=O)OCCOC)C(=O)NCCCCCCCOP(C)(O)=O WLCZTRVUXYALDD-IBGZPJMESA-N 0.000 claims description 2
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- UIRKNQLZZXALBI-MSVGPLKSSA-N Squalamine Chemical compound C([C@@H]1C[C@H]2O)[C@@H](NCCCNCCCCN)CC[C@]1(C)[C@@H]1[C@@H]2[C@@H]2CC[C@H]([C@H](C)CC[C@H](C(C)C)OS(O)(=O)=O)[C@@]2(C)CC1 UIRKNQLZZXALBI-MSVGPLKSSA-N 0.000 claims description 2
- UIRKNQLZZXALBI-UHFFFAOYSA-N Squalamine Natural products OC1CC2CC(NCCCNCCCCN)CCC2(C)C2C1C1CCC(C(C)CCC(C(C)C)OS(O)(=O)=O)C1(C)CC2 UIRKNQLZZXALBI-UHFFFAOYSA-N 0.000 claims description 2
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- FXUVERVIEVUNPC-UHFFFAOYSA-N 5-(6,7-dihydro-5h-pyrrolo[3,4-d]pyrimidin-4-yloxy)indole-1-carboxylic acid Chemical compound C=1C=C2N(C(=O)O)C=CC2=CC=1OC1=NC=NC2=C1CNC2 FXUVERVIEVUNPC-UHFFFAOYSA-N 0.000 claims 1
- XPIHPLVWOUDMPF-UHFFFAOYSA-N 5-[6-(methylaminomethyl)pyrimidin-4-yl]oxy-n-[1-methyl-5-(trifluoromethyl)pyrazol-3-yl]indole-1-carboxamide Chemical compound C1=NC(CNC)=CC(OC=2C=C3C=CN(C3=CC=2)C(=O)NC2=NN(C)C(=C2)C(F)(F)F)=N1 XPIHPLVWOUDMPF-UHFFFAOYSA-N 0.000 claims 1
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- CXHHBESKHSJGOL-UHFFFAOYSA-N n-[5-(1-methylcyclopropyl)-1h-pyrazol-3-yl]-5-(5,6,7,8-tetrahydropyrido[3,4-d]pyrimidin-4-yloxy)indole-1-carboxamide Chemical compound C1=C(NC(=O)N2C3=CC=C(OC=4C=5CCNCC=5N=CN=4)C=C3C=C2)NN=C1C1(C)CC1 CXHHBESKHSJGOL-UHFFFAOYSA-N 0.000 claims 1
- WFJQCQNBWDAYSK-AWEZNQCLSA-N n-[5-(1-methylcyclopropyl)-1h-pyrazol-3-yl]-5-[[(6s)-6-methyl-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidin-4-yl]oxy]indole-1-carboxamide Chemical compound C([C@@H](NC1)C)C2=C1N=CN=C2OC(C=C1C=C2)=CC=C1N2C(=O)NC(NN=1)=CC=1C1(C)CC1 WFJQCQNBWDAYSK-AWEZNQCLSA-N 0.000 claims 1
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- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 4
- 229940054534 ophthalmic solution Drugs 0.000 description 4
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- 230000000649 photocoagulation Effects 0.000 description 2
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- 239000011780 sodium chloride Substances 0.000 description 2
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- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 2
- 125000006432 1-methyl cyclopropyl group Chemical group [H]C([H])([H])C1(*)C([H])([H])C1([H])[H] 0.000 description 1
- PWFUHQNZBFJHNX-UHFFFAOYSA-N 5-(5,6,7,8-tetrahydropyrido[3,4-d]pyrimidin-4-yloxy)indole-1-carboxylic acid Chemical compound C1NCCC2=C1N=CN=C2OC1=CC=C2N(C(=O)O)C=CC2=C1 PWFUHQNZBFJHNX-UHFFFAOYSA-N 0.000 description 1
- ADZBMFGQQWPHMJ-UHFFFAOYSA-N CNC(c1nccc(Oc2ccc3nc(NC(CCCC4)C4O)[s]c3c2)c1)=O Chemical compound CNC(c1nccc(Oc2ccc3nc(NC(CCCC4)C4O)[s]c3c2)c1)=O ADZBMFGQQWPHMJ-UHFFFAOYSA-N 0.000 description 1
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- YQEZLKZALYSWHR-UHFFFAOYSA-N Ketamine Chemical compound C=1C=CC=C(Cl)C=1C1(NC)CCCCC1=O YQEZLKZALYSWHR-UHFFFAOYSA-N 0.000 description 1
- 239000004166 Lanolin Substances 0.000 description 1
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- 241000699670 Mus sp. Species 0.000 description 1
- HSHXDCVZWHOWCS-UHFFFAOYSA-N N'-hexadecylthiophene-2-carbohydrazide Chemical compound CCCCCCCCCCCCCCCCNNC(=O)c1cccs1 HSHXDCVZWHOWCS-UHFFFAOYSA-N 0.000 description 1
- 229940124639 Selective inhibitor Drugs 0.000 description 1
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- 229940069531 neomycin ophthalmic ointment Drugs 0.000 description 1
- 229940100655 ophthalmic gel Drugs 0.000 description 1
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- SONNWYBIRXJNDC-VIFPVBQESA-N phenylephrine Chemical compound CNC[C@H](O)C1=CC=CC(O)=C1 SONNWYBIRXJNDC-VIFPVBQESA-N 0.000 description 1
- 229960001802 phenylephrine Drugs 0.000 description 1
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- NLVFBUXFDBBNBW-PBSUHMDJSA-N tobramycin Chemical compound N[C@@H]1C[C@H](O)[C@@H](CN)O[C@@H]1O[C@H]1[C@H](O)[C@@H](O[C@@H]2[C@@H]([C@@H](N)[C@H](O)[C@@H](CO)O2)O)[C@H](N)C[C@@H]1N NLVFBUXFDBBNBW-PBSUHMDJSA-N 0.000 description 1
- 229940026156 tobramycin ophthalmic ointment Drugs 0.000 description 1
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- 229940082509 xanthan gum Drugs 0.000 description 1
- BPICBUSOMSTKRF-UHFFFAOYSA-N xylazine Chemical compound CC1=CC=CC(C)=C1NC1=NCCCS1 BPICBUSOMSTKRF-UHFFFAOYSA-N 0.000 description 1
- 229960001600 xylazine Drugs 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662408345P | 2016-10-14 | 2016-10-14 | |
| US62/408,345 | 2016-10-14 | ||
| PCT/IB2017/056380 WO2018069893A1 (en) | 2016-10-14 | 2017-10-13 | Methods for treating ocular disease using inhibitors of csf-1r |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2019534269A JP2019534269A (ja) | 2019-11-28 |
| JP2019534269A5 true JP2019534269A5 (https=) | 2020-11-26 |
Family
ID=60569957
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019519762A Pending JP2019534269A (ja) | 2016-10-14 | 2017-10-13 | Ｃｓｆ−１ｒの阻害剤を使用して眼疾患を治療するための方法 |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US10537563B2 (https=) |
| EP (1) | EP3525819A1 (https=) |
| JP (1) | JP2019534269A (https=) |
| KR (1) | KR20190069459A (https=) |
| CN (1) | CN109789209A (https=) |
| AU (1) | AU2017342240A1 (https=) |
| CA (1) | CA3037116A1 (https=) |
| IL (1) | IL265596A (https=) |
| RU (1) | RU2019114205A (https=) |
| WO (1) | WO2018069893A1 (https=) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2019230001A1 (en) * | 2018-03-05 | 2020-09-24 | Massachusetts Eye And Ear Infirmary | Amelioration of autoimmune uveitis through blockade of CSF1R |
| CN118718181A (zh) | 2019-06-05 | 2024-10-01 | 里珍纳龙药品有限公司 | 用于精确剂量递送的装置及方法 |
| USD1120314S1 (en) | 2022-11-30 | 2026-03-24 | Regeneron Pharmaceuticals, Inc. | Dose delivery device |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1179541B1 (en) * | 1999-04-28 | 2004-06-16 | Board Of Regents, The University Of Texas System | Compositions and methods for cancer treatment by selectively inhibiting VEGF |
| US7531553B2 (en) * | 2003-03-21 | 2009-05-12 | Amgen Inc. | Heterocyclic compounds and methods of use |
| TW200640443A (en) * | 2005-02-23 | 2006-12-01 | Alcon Inc | Methods for treating ocular angiogenesis, retinal edema, retinal ischemia, and diabetic retinopathy using selective RTK inhibitors |
| PE20080359A1 (es) | 2006-04-19 | 2008-06-06 | Novartis Ag | Compuestos de benzoxazol y benzotiazol 6-0-sustituidos y metodos de inhibicion de la senalizacion de csf-1r |
| AR062239A1 (es) * | 2007-08-07 | 2008-10-22 | Civil De Estudios Superiores A | Composicion farmaceutica sinergica util para inhibir la neovascularizacion (angiogenesis) corneal y retinal, y de otros organos, en un humano o animal |
| JO3265B1 (ar) | 2008-12-09 | 2018-09-16 | Novartis Ag | مثبطات بيريديلوكسى اندولات vegf-r2 واستخدامها لعلاج المرض |
| HUE032754T2 (en) * | 2011-05-05 | 2017-10-30 | Novartis Ag | CSF-1R inhibitors for the treatment of brain tumors |
-
2017
- 2017-10-13 EP EP17808577.5A patent/EP3525819A1/en not_active Withdrawn
- 2017-10-13 CA CA3037116A patent/CA3037116A1/en not_active Abandoned
- 2017-10-13 WO PCT/IB2017/056380 patent/WO2018069893A1/en not_active Ceased
- 2017-10-13 CN CN201780060945.4A patent/CN109789209A/zh not_active Withdrawn
- 2017-10-13 JP JP2019519762A patent/JP2019534269A/ja active Pending
- 2017-10-13 AU AU2017342240A patent/AU2017342240A1/en not_active Abandoned
- 2017-10-13 KR KR1020197012853A patent/KR20190069459A/ko not_active Withdrawn
- 2017-10-13 US US16/341,075 patent/US10537563B2/en not_active Expired - Fee Related
- 2017-10-13 RU RU2019114205A patent/RU2019114205A/ru not_active Application Discontinuation
-
2019
- 2019-03-25 IL IL265596A patent/IL265596A/en unknown
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