JP2019533652A5 - - Google Patents
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- Publication number
- JP2019533652A5 JP2019533652A5 JP2019517257A JP2019517257A JP2019533652A5 JP 2019533652 A5 JP2019533652 A5 JP 2019533652A5 JP 2019517257 A JP2019517257 A JP 2019517257A JP 2019517257 A JP2019517257 A JP 2019517257A JP 2019533652 A5 JP2019533652 A5 JP 2019533652A5
- Authority
- JP
- Japan
- Prior art keywords
- subject
- cdk1
- clk2
- cell
- disorder
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 0 CC(C)[n]1c2nc(N[C@@]3C*CC3)nc(Nc3cccc(Cl)c3)c2nc1 Chemical compound CC(C)[n]1c2nc(N[C@@]3C*CC3)nc(Nc3cccc(Cl)c3)c2nc1 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662402876P | 2016-09-30 | 2016-09-30 | |
| US62/402,876 | 2016-09-30 | ||
| PCT/US2017/054442 WO2018064545A1 (en) | 2016-09-30 | 2017-09-29 | Dual clk/cdk1 inhibitors for cancer treatment |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2019533652A JP2019533652A (ja) | 2019-11-21 |
| JP2019533652A5 true JP2019533652A5 (https=) | 2020-11-12 |
Family
ID=61760971
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019517257A Pending JP2019533652A (ja) | 2016-09-30 | 2017-09-29 | がんを処置するための二重ｃｌｋ／ｃｄｋ１阻害剤 |
Country Status (5)
| Country | Link |
|---|---|
| US (2) | US10722515B2 (https=) |
| EP (2) | EP4086257A1 (https=) |
| JP (1) | JP2019533652A (https=) |
| CN (2) | CN114149432B (https=) |
| WO (1) | WO2018064545A1 (https=) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AR108325A1 (es) | 2016-04-27 | 2018-08-08 | Samumed Llc | Isoquinolin-3-il carboxamidas y preparación y uso de las mismas |
| CN114149432B (zh) | 2016-09-30 | 2024-07-05 | 斯坦福国际研究院 | 用于癌症治疗的双重clk/cdk1抑制剂 |
| WO2020006115A1 (en) * | 2018-06-26 | 2020-01-02 | Betty Tam | Methods of treating cancer using a clk inhibitor |
| TW202202498A (zh) * | 2020-07-01 | 2022-01-16 | 大陸商四川海思科製藥有限公司 | 一種並環雜環衍生物及其在醫藥上的應用 |
| CN113384703B (zh) * | 2021-06-21 | 2023-03-10 | 深圳市第二人民医院(深圳市转化医学研究院) | Dhx34基因的表达抑制剂在制备抑制肝癌细胞转移和侵袭的药物中的应用 |
| CN120289460A (zh) * | 2024-01-09 | 2025-07-11 | 中国科学院合肥物质科学研究院 | 含有嘌呤环的化合物及其用途 |
| WO2025243082A2 (en) * | 2024-05-24 | 2025-11-27 | The Chinese University Of Hong Kong | Covalent protein-protein interaction inhibitor against srpks |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR901464A (fr) | 1943-01-23 | 1945-07-27 | Boehringer & Soehne Gmbh | Procédé d'obtention de vanilline |
| BR9611157A (pt) * | 1995-11-01 | 1999-03-30 | Novartis Ag | Derivados de purina e processos para sua preparação |
| GB9903762D0 (en) * | 1999-02-18 | 1999-04-14 | Novartis Ag | Organic compounds |
| FR2793794B1 (fr) * | 1999-05-21 | 2001-07-27 | Hoechst Marion Roussel Inc | Nouveaux derives de la purine, leur procede de preparation, leur application a titre de medicaments, compositions pharmaceutiques et nouvelle utilisation |
| CA2394654A1 (en) * | 1999-12-17 | 2001-06-21 | Manfred Weigele | Proton pump inhibitors |
| US20020103161A1 (en) * | 1999-12-17 | 2002-08-01 | Manfred Weigele | Novel heterocycles |
| ATE345349T1 (de) * | 1999-12-17 | 2006-12-15 | Ariad Pharma Inc | Purinderivate |
| US7723340B2 (en) * | 2005-01-13 | 2010-05-25 | Signal Pharmaceuticals, Llc | Haloaryl substituted aminopurines, compositions thereof, and methods of treatment therewith |
| WO2009085226A2 (en) * | 2007-12-21 | 2009-07-09 | Sirtris Pharmaceuticals, Inc. | Inhibitors of cdc2-like kinases (clks) and methods of use thereof |
| KR101705158B1 (ko) * | 2009-05-05 | 2017-02-09 | 다나-파버 캔서 인스티튜트 인크. | Ｅｇｆｒ 억제제 및 질환 치료방법 |
| WO2013144532A1 (en) | 2012-03-30 | 2013-10-03 | Astrazeneca Ab | 3 -cyano- 5 -arylamino-7 -cycloalkylaminopyrrolo [1, 5 -a] pyrimidine derivatives and their use as antitumor agents |
| WO2013171473A1 (en) | 2012-05-15 | 2013-11-21 | Cyclacel Limited | Dosage regimen for sapacitabine and seliciclib |
| WO2014160183A1 (en) * | 2013-03-13 | 2014-10-02 | The United States Of America,As Represented By The Secretary,Department Of Health And Human Services | Methods for modulating chemotherapeutic cytotoxicity |
| UA115388C2 (uk) * | 2013-11-21 | 2017-10-25 | Пфайзер Інк. | 2,6-заміщені пуринові похідні та їх застосування в лікуванні проліферативних захворювань |
| WO2017210138A1 (en) | 2016-05-31 | 2017-12-07 | The J. David Gladstone Institutes | In vitro methods of differentiating stem cells into neurons and neurons generated using the same |
| CN114149432B (zh) * | 2016-09-30 | 2024-07-05 | 斯坦福国际研究院 | 用于癌症治疗的双重clk/cdk1抑制剂 |
-
2017
- 2017-09-29 CN CN202111328981.9A patent/CN114149432B/zh active Active
- 2017-09-29 US US16/334,229 patent/US10722515B2/en active Active
- 2017-09-29 CN CN201780067717.XA patent/CN109937039A/zh active Pending
- 2017-09-29 EP EP22165211.8A patent/EP4086257A1/en not_active Withdrawn
- 2017-09-29 WO PCT/US2017/054442 patent/WO2018064545A1/en not_active Ceased
- 2017-09-29 JP JP2019517257A patent/JP2019533652A/ja active Pending
- 2017-09-29 EP EP17857539.5A patent/EP3518925A4/en not_active Withdrawn
-
2020
- 2020-05-28 US US16/886,290 patent/US11337981B2/en active Active
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