JP2019532672A5 - - Google Patents
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- JP2019532672A5 JP2019532672A5 JP2019538110A JP2019538110A JP2019532672A5 JP 2019532672 A5 JP2019532672 A5 JP 2019532672A5 JP 2019538110 A JP2019538110 A JP 2019538110A JP 2019538110 A JP2019538110 A JP 2019538110A JP 2019532672 A5 JP2019532672 A5 JP 2019532672A5
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- JP
- Japan
- Prior art keywords
- cells
- optionally
- pores
- drug
- microns
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 238000000034 method Methods 0.000 claims 56
- 210000004027 cell Anatomy 0.000 claims 49
- 239000011148 porous material Substances 0.000 claims 25
- 229940079593 drug Drugs 0.000 claims 14
- 239000003814 drug Substances 0.000 claims 14
- 239000012528 membrane Substances 0.000 claims 13
- 210000003958 hematopoietic stem cell Anatomy 0.000 claims 10
- 238000010362 genome editing Methods 0.000 claims 9
- 239000003795 chemical substances by application Substances 0.000 claims 7
- 239000007788 liquid Substances 0.000 claims 7
- 229920002477 rna polymer Polymers 0.000 claims 6
- 230000003833 cell viability Effects 0.000 claims 5
- 238000010354 CRISPR gene editing Methods 0.000 claims 4
- 229920000089 Cyclic olefin copolymer Polymers 0.000 claims 4
- 108020004414 DNA Proteins 0.000 claims 4
- 102000053602 DNA Human genes 0.000 claims 4
- -1 polytetrafluoroethylene Polymers 0.000 claims 4
- 102000004169 proteins and genes Human genes 0.000 claims 4
- 108090000623 proteins and genes Proteins 0.000 claims 4
- 108010019670 Chimeric Antigen Receptors Proteins 0.000 claims 3
- 102100031573 Hematopoietic progenitor cell antigen CD34 Human genes 0.000 claims 3
- 101000777663 Homo sapiens Hematopoietic progenitor cell antigen CD34 Proteins 0.000 claims 3
- 210000003040 circulating cell Anatomy 0.000 claims 3
- 108091023037 Aptamer Proteins 0.000 claims 2
- 239000004713 Cyclic olefin copolymer Substances 0.000 claims 2
- 102000004127 Cytokines Human genes 0.000 claims 2
- 108090000695 Cytokines Proteins 0.000 claims 2
- 102100020715 Fms-related tyrosine kinase 3 ligand protein Human genes 0.000 claims 2
- 101710162577 Fms-related tyrosine kinase 3 ligand protein Proteins 0.000 claims 2
- 102000004889 Interleukin-6 Human genes 0.000 claims 2
- 108090001005 Interleukin-6 Proteins 0.000 claims 2
- 108091034117 Oligonucleotide Proteins 0.000 claims 2
- 239000002033 PVDF binder Substances 0.000 claims 2
- 239000002202 Polyethylene glycol Substances 0.000 claims 2
- 239000004642 Polyimide Substances 0.000 claims 2
- 239000004743 Polypropylene Substances 0.000 claims 2
- 210000001744 T-lymphocyte Anatomy 0.000 claims 2
- 102000036693 Thrombopoietin Human genes 0.000 claims 2
- 108010041111 Thrombopoietin Proteins 0.000 claims 2
- 239000000074 antisense oligonucleotide Substances 0.000 claims 2
- 238000012230 antisense oligonucleotides Methods 0.000 claims 2
- 150000001875 compounds Chemical class 0.000 claims 2
- 235000013870 dimethyl polysiloxane Nutrition 0.000 claims 2
- 150000004676 glycans Chemical class 0.000 claims 2
- 239000012642 immune effector Substances 0.000 claims 2
- 229940121354 immunomodulator Drugs 0.000 claims 2
- 210000004263 induced pluripotent stem cell Anatomy 0.000 claims 2
- 229940100601 interleukin-6 Drugs 0.000 claims 2
- 150000002632 lipids Chemical class 0.000 claims 2
- 239000002105 nanoparticle Substances 0.000 claims 2
- 210000000822 natural killer cell Anatomy 0.000 claims 2
- 229920001542 oligosaccharide Polymers 0.000 claims 2
- 150000002482 oligosaccharides Chemical class 0.000 claims 2
- 239000013612 plasmid Substances 0.000 claims 2
- 229920000435 poly(dimethylsiloxane) Polymers 0.000 claims 2
- 229920003229 poly(methyl methacrylate) Polymers 0.000 claims 2
- 229920001223 polyethylene glycol Polymers 0.000 claims 2
- 229920000139 polyethylene terephthalate Polymers 0.000 claims 2
- 239000005020 polyethylene terephthalate Substances 0.000 claims 2
- 229920001721 polyimide Polymers 0.000 claims 2
- 239000004926 polymethyl methacrylate Substances 0.000 claims 2
- 229920001155 polypropylene Polymers 0.000 claims 2
- 229920001282 polysaccharide Polymers 0.000 claims 2
- 239000005017 polysaccharide Substances 0.000 claims 2
- 239000004810 polytetrafluoroethylene Substances 0.000 claims 2
- 229920001343 polytetrafluoroethylene Polymers 0.000 claims 2
- 229920002981 polyvinylidene fluoride Polymers 0.000 claims 2
- 108090000765 processed proteins & peptides Proteins 0.000 claims 2
- 210000000130 stem cell Anatomy 0.000 claims 2
- 108010051219 Cre recombinase Proteins 0.000 claims 1
- 239000004793 Polystyrene Substances 0.000 claims 1
- 238000010459 TALEN Methods 0.000 claims 1
- 108010043645 Transcription Activator-Like Effector Nucleases Proteins 0.000 claims 1
- 210000000270 basal cell Anatomy 0.000 claims 1
- 239000006143 cell culture medium Substances 0.000 claims 1
- 239000000919 ceramic Substances 0.000 claims 1
- 239000003599 detergent Substances 0.000 claims 1
- 239000003623 enhancer Substances 0.000 claims 1
- 125000000031 ethylamino group Chemical group [H]C([H])([H])C([H])([H])N([H])[*] 0.000 claims 1
- 238000012239 gene modification Methods 0.000 claims 1
- 238000001415 gene therapy Methods 0.000 claims 1
- 230000005017 genetic modification Effects 0.000 claims 1
- 235000013617 genetically modified food Nutrition 0.000 claims 1
- 239000003102 growth factor Substances 0.000 claims 1
- 230000001788 irregular Effects 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 239000000463 material Substances 0.000 claims 1
- 239000002184 metal Substances 0.000 claims 1
- 229920000515 polycarbonate Polymers 0.000 claims 1
- 239000004417 polycarbonate Substances 0.000 claims 1
- 229920000728 polyester Polymers 0.000 claims 1
- 239000002861 polymer material Substances 0.000 claims 1
- 229920002223 polystyrene Polymers 0.000 claims 1
- 229920000036 polyvinylpyrrolidone Polymers 0.000 claims 1
- 239000001267 polyvinylpyrrolidone Substances 0.000 claims 1
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 claims 1
- BDERNNFJNOPAEC-UHFFFAOYSA-N propan-1-ol Chemical compound CCCO BDERNNFJNOPAEC-UHFFFAOYSA-N 0.000 claims 1
- 239000004065 semiconductor Substances 0.000 claims 1
- 239000012679 serum free medium Substances 0.000 claims 1
- 150000003384 small molecules Chemical class 0.000 claims 1
- 239000003381 stabilizer Substances 0.000 claims 1
- 230000004083 survival effect Effects 0.000 claims 1
- 230000035899 viability Effects 0.000 claims 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662401053P | 2016-09-28 | 2016-09-28 | |
| US62/401,053 | 2016-09-28 | ||
| PCT/US2017/054110 WO2018064387A1 (en) | 2016-09-28 | 2017-09-28 | Porous membrane-based macromolecule delivery system |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2019532672A JP2019532672A (ja) | 2019-11-14 |
| JP2019532672A5 true JP2019532672A5 (enExample) | 2020-11-12 |
Family
ID=60183103
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019538110A Pending JP2019532672A (ja) | 2016-09-28 | 2017-09-28 | 多孔質膜系巨大分子送達システム |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US20190203230A1 (enExample) |
| EP (1) | EP3519577A1 (enExample) |
| JP (1) | JP2019532672A (enExample) |
| CN (1) | CN109844126A (enExample) |
| WO (1) | WO2018064387A1 (enExample) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9017991B2 (en) | 2009-03-13 | 2015-04-28 | Tufts University | Methods tip assemblies and kits for introducing material into cells |
| CA2986310A1 (en) | 2015-05-11 | 2016-11-17 | Editas Medicine, Inc. | Optimized crispr/cas9 systems and methods for gene editing in stem cells |
| US11911415B2 (en) | 2015-06-09 | 2024-02-27 | Editas Medicine, Inc. | CRISPR/Cas-related methods and compositions for improving transplantation |
| TW201839136A (zh) | 2017-02-06 | 2018-11-01 | 瑞士商諾華公司 | 治療血色素異常症之組合物及方法 |
| EP3652312A1 (en) | 2017-07-14 | 2020-05-20 | Editas Medicine, Inc. | Systems and methods for targeted integration and genome editing and detection thereof using integrated priming sites |
| CN110272810A (zh) * | 2019-07-01 | 2019-09-24 | 广州世赛生物科技有限公司 | 外源物质递送至真核细胞内的装置和方法及其应用 |
| EP4337769A1 (en) * | 2021-05-10 | 2024-03-20 | SQZ Biotechnologies Company | Methods for delivering genome editing molecules to the nucleus or cytosol of a cell and uses thereof |
| WO2024072514A1 (en) * | 2022-09-30 | 2024-04-04 | Xellar, Inc. | Edge effect systems and methods for functionalized microfluidic devices |
| CN116297429B (zh) * | 2023-03-14 | 2026-03-06 | 青岛农业大学 | 一种检测农药的比色传感器、其制备方法及应用 |
| CN121399269A (zh) * | 2023-05-15 | 2026-01-23 | 波特尔生物技术有限公司 | 基因编辑复合物及其组合的细胞递送 |
Family Cites Families (37)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7687267B2 (en) * | 2006-09-30 | 2010-03-30 | Rational Biotechnology Inc. | High-throughput cell transfection device and methods of using thereof |
| US20110213288A1 (en) * | 2007-04-23 | 2011-09-01 | The Board Of Regents, The University Of Texas System | Device And Method For Transfecting Cells For Therapeutic Uses |
| PE20100362A1 (es) | 2008-10-30 | 2010-05-27 | Irm Llc | Derivados de purina que expanden las celulas madre hematopoyeticas |
| US20110239315A1 (en) | 2009-01-12 | 2011-09-29 | Ulla Bonas | Modular dna-binding domains and methods of use |
| EP2206723A1 (en) | 2009-01-12 | 2010-07-14 | Bonas, Ulla | Modular DNA-binding domains |
| US20120244593A1 (en) * | 2009-10-19 | 2012-09-27 | Yong Huang | Method, device and apparatus for inducing self-adjusting cell electroporation |
| US8956828B2 (en) | 2009-11-10 | 2015-02-17 | Sangamo Biosciences, Inc. | Targeted disruption of T cell receptor genes using engineered zinc finger protein nucleases |
| GB2481983A (en) | 2010-07-12 | 2012-01-18 | Hart Fenton & Co Ltd | A ship including a gas tank room |
| CA2805442C (en) | 2010-07-21 | 2020-05-12 | Sangamo Biosciences, Inc. | Methods and compositions for modification of an hla locus |
| SI2807165T1 (sl) | 2012-01-27 | 2019-08-30 | Universite De Montreal | Pirimido(4,5-B)indol derivati in njihova uporaba pri ekspanziji hematopoetskih matičnih celic |
| ES2728782T3 (es) | 2012-05-25 | 2019-10-28 | Univ California | Métodos y composiciones para la modificación de ADN objetivo dirigida por ARN y para la modulación de la transcripción dirigida por ARN |
| US8697359B1 (en) | 2012-12-12 | 2014-04-15 | The Broad Institute, Inc. | CRISPR-Cas systems and methods for altering expression of gene products |
| KR102955556B1 (ko) | 2012-12-12 | 2026-04-22 | 더 브로드 인스티튜트, 인코퍼레이티드 | 서열 조작을 위한 crispr-cas 성분 시스템, 방법 및 조성물 |
| CN105209621B (zh) | 2012-12-12 | 2021-05-25 | 布罗德研究所有限公司 | 对用于序列操纵的改进的系统、方法和酶组合物进行的工程化和优化 |
| SG11201505896YA (en) | 2013-02-20 | 2015-09-29 | Novartis Ag | Treatment of cancer using humanized anti-egfrviii chimeric antigen receptor |
| WO2014130635A1 (en) | 2013-02-20 | 2014-08-28 | Novartis Ag | Effective targeting of primary human leukemia using anti-cd123 chimeric antigen receptor engineered t cells |
| UY35468A (es) | 2013-03-16 | 2014-10-31 | Novartis Ag | Tratamiento de cáncer utilizando un receptor quimérico de antígeno anti-cd19 |
| EP3004339B1 (en) | 2013-05-29 | 2021-07-07 | Cellectis | New compact scaffold of cas9 in the type ii crispr system |
| WO2015048577A2 (en) | 2013-09-27 | 2015-04-02 | Editas Medicine, Inc. | Crispr-related methods and compositions |
| ES2918501T3 (es) | 2013-12-19 | 2022-07-18 | Novartis Ag | Receptores de antígenos quiméricos de mesotelina humana y usos de los mismos |
| US20170015994A1 (en) * | 2014-02-24 | 2017-01-19 | Massachusetts Institute Of Technology | Methods for in vivo genome editing |
| CN122399016A (zh) | 2014-03-15 | 2026-07-17 | 诺华股份有限公司 | 使用嵌合抗原受体治疗癌症 |
| US10472651B2 (en) * | 2014-03-28 | 2019-11-12 | The Regents Of The University Of California | Efficient delivery of large cargos into cells on a porous substrate |
| WO2015191693A2 (en) * | 2014-06-10 | 2015-12-17 | Massachusetts Institute Of Technology | Method for gene editing |
| JP6831777B2 (ja) | 2014-07-21 | 2021-02-17 | ノバルティス アーゲー | Ｃｄ３３キメラ抗原受容体を使用する癌の処置 |
| BR112017000939A2 (pt) | 2014-07-21 | 2017-11-14 | Novartis Ag | tratamento de câncer usando um receptor antigênico quimérico de cll-1 |
| AU2015292744C1 (en) | 2014-07-21 | 2021-01-21 | Novartis Ag | Treatment of cancer using humanized anti-BCMA chimeric antigen receptor |
| FR3024778B1 (fr) * | 2014-08-05 | 2021-01-22 | Screencell | Procede pour le depistage de la drepanocytose et kit pour sa mise en oeuvre |
| EP3712171A1 (en) | 2014-08-19 | 2020-09-23 | Novartis AG | Treatment of cancer using a cd123 chimeric antigen receptor |
| CN122564053A (zh) * | 2014-10-31 | 2026-08-14 | 麻省理工学院 | 递送生物分子至免疫细胞 |
| WO2016094880A1 (en) * | 2014-12-12 | 2016-06-16 | The Broad Institute Inc. | Delivery, use and therapeutic applications of crispr systems and compositions for genome editing as to hematopoietic stem cells (hscs) |
| AU2016206870B2 (en) * | 2015-01-12 | 2022-02-17 | Massachusetts Institute Of Technology | Gene editing through microfluidic delivery |
| US20190024065A1 (en) * | 2015-02-06 | 2019-01-24 | Cellectis | Primary hematopoietic cells genetically engineered by slow release of nucleic acids using nanoparticles |
| PL3280729T3 (pl) | 2015-04-08 | 2022-08-22 | Novartis Ag | Terapie cd20, terapie cd22 i terapie skojarzone komórką eksprymującą chimeryczny receptor antygenowy (car) cd19 |
| US20190382796A1 (en) * | 2015-09-04 | 2019-12-19 | Sqz Biotechnologies Company | Intracellular delivery of biomolecules mediated by a surface with pores |
| WO2017093969A1 (en) | 2015-12-04 | 2017-06-08 | Novartis Ag | Compositions and methods for immunooncology |
| MX2018007987A (es) | 2015-12-28 | 2019-01-10 | Novartis Ag | Composiciones y metodos para el tratamiento de hemoglobinopatias. |
-
2017
- 2017-09-28 WO PCT/US2017/054110 patent/WO2018064387A1/en not_active Ceased
- 2017-09-28 US US16/331,967 patent/US20190203230A1/en not_active Abandoned
- 2017-09-28 JP JP2019538110A patent/JP2019532672A/ja active Pending
- 2017-09-28 CN CN201780060638.6A patent/CN109844126A/zh active Pending
- 2017-09-28 EP EP17790886.0A patent/EP3519577A1/en not_active Withdrawn
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