JP2019532275A5 - - Google Patents
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- Publication number
- JP2019532275A5 JP2019532275A5 JP2019511411A JP2019511411A JP2019532275A5 JP 2019532275 A5 JP2019532275 A5 JP 2019532275A5 JP 2019511411 A JP2019511411 A JP 2019511411A JP 2019511411 A JP2019511411 A JP 2019511411A JP 2019532275 A5 JP2019532275 A5 JP 2019532275A5
- Authority
- JP
- Japan
- Prior art keywords
- group
- hapten
- target
- carbon atoms
- enzyme
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562211590P | 2015-08-28 | 2015-08-28 | |
| US201662301489P | 2016-02-29 | 2016-02-29 | |
| USPCT/US2016/049153 | 2016-08-26 | ||
| PCT/US2016/049153 WO2017040349A1 (en) | 2015-08-28 | 2016-08-26 | Protein proximity assay in formalin fixed paffafin embedded tissue using caged haptens |
| PCT/US2017/048687 WO2018039605A1 (en) | 2015-08-28 | 2017-08-25 | Protein proximity assay in formalin fixed paraffin embedded tissue using caged haptens |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2019532275A JP2019532275A (ja) | 2019-11-07 |
| JP2019532275A5 true JP2019532275A5 (enExample) | 2020-09-24 |
| JP7033122B2 JP7033122B2 (ja) | 2022-03-09 |
Family
ID=58188142
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018510803A Active JP6880001B2 (ja) | 2015-08-28 | 2016-08-26 | ケージドハプテンを使用するホルマリン固定パラフィン包埋組織におけるタンパク質近接アッセイ |
| JP2019511411A Active JP7033122B2 (ja) | 2015-08-28 | 2017-08-25 | ケージドハプテンを使用するホルマリン固定パラフィン包埋組織におけるタンパク質近接アッセイ |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018510803A Active JP6880001B2 (ja) | 2015-08-28 | 2016-08-26 | ケージドハプテンを使用するホルマリン固定パラフィン包埋組織におけるタンパク質近接アッセイ |
Country Status (7)
| Country | Link |
|---|---|
| US (6) | US11053266B2 (enExample) |
| EP (1) | EP3341734B1 (enExample) |
| JP (2) | JP6880001B2 (enExample) |
| CN (3) | CN107923915B (enExample) |
| AU (3) | AU2016316846B2 (enExample) |
| CA (1) | CA2996798A1 (enExample) |
| WO (2) | WO2017040349A1 (enExample) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107923915B (zh) | 2015-08-28 | 2021-05-04 | 文塔纳医疗系统公司 | 使用经掩蔽的半抗原在福尔马林固定石蜡包埋的组织中的蛋白质邻近测定 |
| WO2020121304A1 (en) * | 2018-12-10 | 2020-06-18 | Ariel Scientific Innovations Ltd. | Therapeutic conjugates |
| CN110632040B (zh) * | 2019-05-10 | 2022-03-29 | 长沙理工大学 | 一种血清中前列腺特异性抗原的分析方法 |
| WO2021037869A1 (en) * | 2019-08-28 | 2021-03-04 | Ventana Medical Systems, Inc. | Assessing antigen retrieval and target retrieval progression quantitation with vibrational spectroscopy |
| CN115552248A (zh) * | 2020-05-07 | 2022-12-30 | 文塔纳医疗系统公司 | 用于评价肿瘤样品中egfr和egfr配体表达的组织化学系统和方法 |
| EP4278181A1 (en) * | 2021-01-15 | 2023-11-22 | Ventana Medical Systems, Inc. | Storage stable caged haptens |
| CN114994329A (zh) * | 2022-04-28 | 2022-09-02 | 杭州广科安德生物科技有限公司 | 一种检测肿瘤组织中p185蛋白与p95蛋白表达水平的方法 |
Family Cites Families (36)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2730523A (en) * | 1952-08-16 | 1956-01-10 | Eastman Kodak Co | 5-nitrothiazoleazo-n-fluoroalkyl-aniline compounds |
| WO1990000618A1 (en) | 1988-07-08 | 1990-01-25 | Jbl Scientific, Inc. | Preparation and use of fluorescent benzothiazole derivatives |
| US5196306A (en) * | 1989-03-29 | 1993-03-23 | E. I. Du Pont De Nemours And Company | Method for the detection or quantitation of an analyte using an analyte dependent enzyme activation system |
| US5182203A (en) * | 1989-03-29 | 1993-01-26 | E. I. Du Pont De Nemours And Company | Bifunctional compounds useful in catalyzed reporter deposition |
| US5180828A (en) * | 1990-02-09 | 1993-01-19 | Molecular Devices Corporation | Chromophoric reagents for incorporation of biotin or other haptens into macromolecules |
| US5595707A (en) | 1990-03-02 | 1997-01-21 | Ventana Medical Systems, Inc. | Automated biological reaction apparatus |
| US5371241A (en) * | 1991-07-19 | 1994-12-06 | Pharmacia P-L Biochemicals Inc. | Fluorescein labelled phosphoramidites |
| GB9517060D0 (en) * | 1995-08-17 | 1995-10-25 | Ciba Geigy Ag | Acylated oligopeptide derivatives |
| US20030235877A1 (en) * | 1996-04-30 | 2003-12-25 | La Region Wallone | Conjugates of haptens to beta-lactam derivatives and their use for detecting and/or quantifying haptens in solution and device for implementation thereof |
| US20030211630A1 (en) | 1998-02-27 | 2003-11-13 | Ventana Medical Systems, Inc. | Automated molecular pathology apparatus having independent slide heaters |
| US6582962B1 (en) | 1998-02-27 | 2003-06-24 | Ventana Medical Systems, Inc. | Automated molecular pathology apparatus having independent slide heaters |
| EP2284543A3 (en) | 1998-02-27 | 2015-05-27 | Ventana Medical Systems, Inc. | System and method of aspirating and dispensing reagent |
| US20060040319A1 (en) * | 2000-01-14 | 2006-02-23 | Tom Muir | Multiple sensor-containing active modified polypeptides, preparation and uses thereof |
| EP1442296A4 (en) * | 2001-08-07 | 2007-09-12 | Merck & Co Inc | BIOLOGICAL ASSAY DETECTION PROCEDURE |
| JP4950022B2 (ja) * | 2004-03-23 | 2012-06-13 | コンプレックス バイオシステムズ ゲーエムベーハー | 自壊性リンカーを有する高分子プロドラッグ |
| WO2006116628A2 (en) | 2005-04-28 | 2006-11-02 | Ventana Medical Systems, Inc. | Enzymes conjugated to antiobodies via a peg heterobifuctional linker |
| ES2548518T3 (es) | 2005-11-23 | 2015-10-19 | Ventana Medical Systems, Inc. | Conjugado molecular |
| ES2905054T3 (es) | 2006-11-01 | 2022-04-06 | Ventana Med Syst Inc | Haptenos, conjugados de haptenos, composiciones de los mismos y método para su preparación y uso |
| WO2008098100A2 (en) * | 2007-02-07 | 2008-08-14 | Perscitus Biosciences, Llc | Detection of molecule proximity |
| JP2010528285A (ja) | 2007-05-23 | 2010-08-19 | ベンタナ・メデイカル・システムズ・インコーポレーテツド | 免疫組織化学およびｉｎｓｉｔｕハイブリダーゼーションのためのポリマー担体 |
| WO2009018003A2 (en) * | 2007-07-27 | 2009-02-05 | Ensemble Discovery Corporation | Detection assays and use thereof |
| AU2009282760B2 (en) | 2008-08-22 | 2013-08-15 | Ventana Medical Systems, Inc. | Method for chromogenic detection of two or more target molecules in a single sample |
| JP5627698B2 (ja) | 2009-10-19 | 2014-11-19 | ベンタナ メディカル システムズ， インコーポレイテッド | 撮像システムおよび技法 |
| CA2782009C (en) * | 2009-11-27 | 2017-10-03 | Ecole Polytechnique Federale De Lausanne (Epfl) | Nanofluidic biosensor and its use for rapid measurement of biomolecular interactions in solution and methods |
| EP2659000B1 (en) | 2010-12-30 | 2016-08-10 | Ventana Medical Systems, Inc. | Enhanced deposition of chromogens utilizing pyrimidine analogs |
| US8852599B2 (en) * | 2011-05-26 | 2014-10-07 | Bristol-Myers Squibb Company | Immunoconjugates, compositions for making them, and methods of making and use |
| CA2928374C (en) | 2011-09-09 | 2018-09-25 | Ventana Medical Systems, Inc. | Imaging systems, cassettes, and methods of using the same |
| CA2867144C (en) | 2012-03-27 | 2019-07-02 | Ventana Medical Systems, Inc. | Signaling conjugates and methods of use |
| EP2971064B1 (en) * | 2013-03-12 | 2019-10-16 | Ventana Medical Systems, Inc. | Proximity assay for in situ detection of targets |
| CN103513039B (zh) * | 2013-07-10 | 2015-12-23 | 广州美格生物科技有限公司 | 一种利用定向肽库检测蛋白质与其他分子相互作用的方法 |
| US10241115B2 (en) * | 2013-12-10 | 2019-03-26 | Merck Sharp & Dohme Corp. | Immunohistochemical proximity assay for PD-1 positive cells and PD-ligand positive cells in tumor tissue |
| WO2015124703A1 (en) * | 2014-02-24 | 2015-08-27 | Ventana Medical Systems, Inc. | Quinone methide analog signal amplification |
| WO2015153401A1 (en) * | 2014-04-04 | 2015-10-08 | Merck Sharp & Dohme Corp | Phosphate based linkers for intracellular delivery of drug conjugates |
| EP3224621B1 (en) * | 2014-11-25 | 2019-06-12 | Ventana Medical Systems, Inc. | Proximity assays using chemical ligation and hapten transfer |
| EP3037820A1 (en) * | 2014-12-27 | 2016-06-29 | Miltenyi Biotec GmbH | Cell detection methods and reagents having a releasable labelling moiety |
| CN107923915B (zh) * | 2015-08-28 | 2021-05-04 | 文塔纳医疗系统公司 | 使用经掩蔽的半抗原在福尔马林固定石蜡包埋的组织中的蛋白质邻近测定 |
-
2016
- 2016-08-26 CN CN201680049897.4A patent/CN107923915B/zh active Active
- 2016-08-26 AU AU2016316846A patent/AU2016316846B2/en active Active
- 2016-08-26 WO PCT/US2016/049153 patent/WO2017040349A1/en not_active Ceased
- 2016-08-26 JP JP2018510803A patent/JP6880001B2/ja active Active
- 2016-08-26 EP EP16842723.5A patent/EP3341734B1/en active Active
- 2016-08-26 CA CA2996798A patent/CA2996798A1/en active Pending
-
2017
- 2017-08-25 CN CN202310341013.4A patent/CN116338167A/zh active Pending
- 2017-08-25 WO PCT/US2017/048687 patent/WO2018039605A1/en not_active Ceased
- 2017-08-25 CN CN201780060757.1A patent/CN109791144B/zh active Active
- 2017-08-25 JP JP2019511411A patent/JP7033122B2/ja active Active
-
2018
- 2018-02-28 US US15/907,479 patent/US11053266B2/en active Active
-
2019
- 2019-02-25 US US16/284,098 patent/US11345719B2/en active Active
-
2021
- 2021-01-15 US US17/149,911 patent/US12559511B2/en active Active
- 2021-06-11 US US17/345,072 patent/US12173019B2/en active Active
- 2021-08-19 AU AU2021218128A patent/AU2021218128B2/en active Active
- 2021-10-16 US US17/503,303 patent/US12577266B2/en active Active
-
2023
- 2023-03-17 AU AU2023201682A patent/AU2023201682B2/en active Active
-
2024
- 2024-11-13 US US18/945,898 patent/US20250066397A1/en active Pending
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