AU2016316846B2 - Protein proximity assay in formalin fixed paffafin embedded tissue using caged haptens - Google Patents

Protein proximity assay in formalin fixed paffafin embedded tissue using caged haptens Download PDF

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Publication number
AU2016316846B2
AU2016316846B2 AU2016316846A AU2016316846A AU2016316846B2 AU 2016316846 B2 AU2016316846 B2 AU 2016316846B2 AU 2016316846 A AU2016316846 A AU 2016316846A AU 2016316846 A AU2016316846 A AU 2016316846A AU 2016316846 B2 AU2016316846 B2 AU 2016316846B2
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group
hapten
antibody
caged
conjugate
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AU2016316846A1 (en
Inventor
Yuri Belosludtsev
Traci D. Degeer
Wendy J. French
Junshan HAO
Brian Daniel Kelly
Adrian MURILLO
Nathan Walter Polaske
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Ventana Medical Systems Inc
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Ventana Medical Systems Inc
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Priority to AU2021218128A priority Critical patent/AU2021218128B2/en
Priority to AU2023201682A priority patent/AU2023201682B2/en
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6558—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system
    • C07F9/65583—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system each of the hetero rings containing nitrogen as ring hetero atom
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/536—Immunoassay; Biospecific binding assay; Materials therefor with immune complex formed in liquid phase
    • G01N33/542—Immunoassay; Biospecific binding assay; Materials therefor with immune complex formed in liquid phase with steric inhibition or signal modification, e.g. fluorescent quenching
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/573—Immunoassay; Biospecific binding assay; Materials therefor for enzymes or isoenzymes

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Food Science & Technology (AREA)
  • Microbiology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Cell Biology (AREA)
  • Biotechnology (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Organic Chemistry (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Enzymes And Modification Thereof (AREA)
AU2016316846A 2015-08-28 2016-08-26 Protein proximity assay in formalin fixed paffafin embedded tissue using caged haptens Active AU2016316846B2 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
AU2021218128A AU2021218128B2 (en) 2015-08-28 2021-08-19 Protein proximity assay in formalin fixed paffafin embedded tissue using caged haptens
AU2023201682A AU2023201682B2 (en) 2015-08-28 2023-03-17 Protein proximity assay in formalin fixed paffafin embedded tissue using caged haptens

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201562211590P 2015-08-28 2015-08-28
US62/211,590 2015-08-28
US201662301489P 2016-02-29 2016-02-29
US62/301,489 2016-02-29
PCT/US2016/049153 WO2017040349A1 (en) 2015-08-28 2016-08-26 Protein proximity assay in formalin fixed paffafin embedded tissue using caged haptens

Related Child Applications (1)

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AU2021218128A Division AU2021218128B2 (en) 2015-08-28 2021-08-19 Protein proximity assay in formalin fixed paffafin embedded tissue using caged haptens

Publications (2)

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AU2016316846A1 AU2016316846A1 (en) 2018-02-22
AU2016316846B2 true AU2016316846B2 (en) 2021-07-08

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AU2016316846A Active AU2016316846B2 (en) 2015-08-28 2016-08-26 Protein proximity assay in formalin fixed paffafin embedded tissue using caged haptens
AU2021218128A Active AU2021218128B2 (en) 2015-08-28 2021-08-19 Protein proximity assay in formalin fixed paffafin embedded tissue using caged haptens
AU2023201682A Active AU2023201682B2 (en) 2015-08-28 2023-03-17 Protein proximity assay in formalin fixed paffafin embedded tissue using caged haptens

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AU2021218128A Active AU2021218128B2 (en) 2015-08-28 2021-08-19 Protein proximity assay in formalin fixed paffafin embedded tissue using caged haptens
AU2023201682A Active AU2023201682B2 (en) 2015-08-28 2023-03-17 Protein proximity assay in formalin fixed paffafin embedded tissue using caged haptens

Country Status (7)

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US (6) US11053266B2 (enExample)
EP (1) EP3341734B1 (enExample)
JP (2) JP6880001B2 (enExample)
CN (3) CN107923915B (enExample)
AU (3) AU2016316846B2 (enExample)
CA (1) CA2996798A1 (enExample)
WO (2) WO2017040349A1 (enExample)

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CN107923915B (zh) 2015-08-28 2021-05-04 文塔纳医疗系统公司 使用经掩蔽的半抗原在福尔马林固定石蜡包埋的组织中的蛋白质邻近测定
WO2020121304A1 (en) * 2018-12-10 2020-06-18 Ariel Scientific Innovations Ltd. Therapeutic conjugates
CN110632040B (zh) * 2019-05-10 2022-03-29 长沙理工大学 一种血清中前列腺特异性抗原的分析方法
WO2021037869A1 (en) * 2019-08-28 2021-03-04 Ventana Medical Systems, Inc. Assessing antigen retrieval and target retrieval progression quantitation with vibrational spectroscopy
CN115552248A (zh) * 2020-05-07 2022-12-30 文塔纳医疗系统公司 用于评价肿瘤样品中egfr和egfr配体表达的组织化学系统和方法
EP4278181A1 (en) * 2021-01-15 2023-11-22 Ventana Medical Systems, Inc. Storage stable caged haptens
CN114994329A (zh) * 2022-04-28 2022-09-02 杭州广科安德生物科技有限公司 一种检测肿瘤组织中p185蛋白与p95蛋白表达水平的方法

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CN107923915B (zh) 2021-05-04
JP7033122B2 (ja) 2022-03-09
CN107923915A (zh) 2018-04-17
US20180186821A1 (en) 2018-07-05
US12559511B2 (en) 2026-02-24
US12577266B2 (en) 2026-03-17
US20210221833A1 (en) 2021-07-22
JP6880001B2 (ja) 2021-06-02
AU2023201682A1 (en) 2023-04-13
AU2021218128A1 (en) 2021-09-09
US20250066397A1 (en) 2025-02-27
US11053266B2 (en) 2021-07-06
US20210309680A1 (en) 2021-10-07
EP3341734B1 (en) 2024-08-07
AU2016316846A1 (en) 2018-02-22
US11345719B2 (en) 2022-05-31
EP3341734A1 (en) 2018-07-04
US20190233447A1 (en) 2019-08-01
JP2018528425A (ja) 2018-09-27
US12173019B2 (en) 2024-12-24
WO2017040349A1 (en) 2017-03-09
AU2021218128B2 (en) 2022-12-22
CN109791144A (zh) 2019-05-21
AU2023201682B2 (en) 2023-12-07
EP3341734A4 (en) 2019-02-06
US20220089622A1 (en) 2022-03-24
JP2019532275A (ja) 2019-11-07
CN109791144B (zh) 2023-04-18
CN116338167A (zh) 2023-06-27
WO2018039605A1 (en) 2018-03-01
CA2996798A1 (en) 2017-03-09

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