JP2019531275A - 脱水素アビエチン酸及びコンパウンドkを含む皮膚抗老化用組成物 - Google Patents
脱水素アビエチン酸及びコンパウンドkを含む皮膚抗老化用組成物 Download PDFInfo
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- JP2019531275A JP2019531275A JP2019511981A JP2019511981A JP2019531275A JP 2019531275 A JP2019531275 A JP 2019531275A JP 2019511981 A JP2019511981 A JP 2019511981A JP 2019511981 A JP2019511981 A JP 2019511981A JP 2019531275 A JP2019531275 A JP 2019531275A
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Abstract
Description
Ramidus AB社から購買した前記化学式1で表される脱水素アビエチン酸(比較例1)、Ambo Institute社から購買した前記化学式2で表されるコンパウンドK(比較例2)、及び前記脱水素アビエチン酸と前記コンパウンドKとを1:7の質量比で混合した混合物を実施例1とし、前記比較例1〜2及び実施例1を試料とする実験例1〜3を進行した。
シワ改善及び皮膚弾力増進効果としての皮膚細胞(Skin cell)増殖効果を調べるために、ヒト正常線維芽細胞(fibroblast)を96ウェルマイクロプレート(96−wellmicroplate)の各ウェル(well)に1×104細胞になるように接種し、DMEM(Dulbecco’s Modified Eagle’s Medium)培地で24時間培養した。培養後、脱水素アビエチン酸(比較例1)、コンパウンドK(比較例2)、脱水素アビエチン酸とコンパウンドKとの混合物(1:7での混合物、実施例1)をそれぞれ最終濃度10ppmになるように調整した血清のないDMEM培地に交替してから24時間さらに培養した。3−(4,5−ジメチルチアゾール−2−イル)−2,5−ジフェニルテトラゾリウム(MTT:(3−(4,5−dimdimeth−thiazol−2−yl)2,5−diphenyl tetrazolium:5mg/ml)10μlずつ添加し4時間放置の後、培地部分を捨てた。各ウェル当たり100μlのジメチルスルホキシド溶液を加え、マイクロプレートリーダーで570nmにおける吸光度を測定した。
シワ改善及び皮膚弾力増進効果としてのコラーゲン生合成促進効果を調べるために、ヒト正常線維芽細胞(fibroblast)を96ウェルマイクロプレート(96−wellmicroplate)の各ウェル(well)に1×104細胞になるように接種し、DMEM(Dulbecco’s Modified Eagle’s Medium)培地で 24時間培養した。
老化抑制効果としてのリポフスチン蓄積抑制効果を調べるために、ヒト正常線維芽細胞(fibroblast)を96ウェルマイクロプレート(96−wellmicroplate)の各ウェル(well)に1×104細胞になるように接種し、DMEM(Dulbecco’s Modified Eagle’s Medium)培地で24時間培養した。
下表4に記載された組成にて通常の方法に従い化粧水を製造する。
下表5に記載された組成にて通常の方法に従い栄養クリームを製造する。
下表6に記載された組成にて通常の方法に従いマッサージクリームを製造する。
下表7に記載された組成にて通常の方法に従いパックを製造する。
Claims (12)
- 前記脱水素アビエチン酸、その立体異性体、その塩、その水和物又はその溶媒和物;及び前記コンパウンドK、その立体異性体、その塩、その水和物又はその溶媒和物;は、1:1〜15の質量比の範囲で含まれる、請求項1に記載の皮膚抗老化用組成物。
- 前記質量比は、1:5〜10の質量比の範囲である、請求項2に記載の皮膚抗老化用組成物。
- 前記有効成分は、組成物の総質量に対し、0.0001〜10質量%の範囲で含まれる、請求項1に記載の皮膚抗老化用組成物。
- 当該組成物は皮膚シワ改善用組成物である、請求項1に記載の皮膚抗老化用組成物。
- 当該組成物は皮膚弾力増進用組成物である、請求項1に記載の皮膚抗老化用組成物。
- 当該組成物は、線維芽細胞の増殖によって皮膚老化を防止する、請求項1に記載の皮膚抗老化用組成物。
- 当該組成物は、コラーゲン生合成の促進によって皮膚老化を防止する、請求項1に記載の皮膚抗老化用組成物。
- 当該組成物は、皮膚内リポフスチン(lipofuscin)蓄積の抑制によって皮膚老化を防止する、請求項1に記載の皮膚抗老化用組成物。
- 当該組成物は化粧料組成物である、請求項1〜請求項9のいずれか一項に記載の皮膚抗老化用組成物。
- 当該組成物は食品組成物である、請求項1〜請求項9のいずれか一項に記載の皮膚抗老化用組成物。
- 当該組成物は薬学組成物である、請求項1〜請求項9のいずれか一項に記載の皮膚抗老化用組成物。
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PCT/KR2017/009767 WO2018048196A1 (ko) | 2016-09-08 | 2017-09-06 | 탈수소 아비에틱산 및 컴파운드 k를 포함하는 피부 항노화용 조성물 |
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KR20180028181A (ko) | 2018-03-16 |
CN109689020B (zh) | 2022-06-21 |
TWI741024B (zh) | 2021-10-01 |
EP3510991A1 (en) | 2019-07-17 |
JP7035022B2 (ja) | 2022-03-14 |
KR102081204B1 (ko) | 2020-02-25 |
CN109689020A (zh) | 2019-04-26 |
EP3510991A4 (en) | 2020-04-01 |
US20190192413A1 (en) | 2019-06-27 |
TW201811304A (zh) | 2018-04-01 |
WO2018048196A1 (ko) | 2018-03-15 |
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