JP2019530659A - 高温での固相ペプチド合成のためのインサイツ溶媒リサイクル法 - Google Patents

高温での固相ペプチド合成のためのインサイツ溶媒リサイクル法 Download PDF

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Publication number
JP2019530659A
JP2019530659A JP2019511957A JP2019511957A JP2019530659A JP 2019530659 A JP2019530659 A JP 2019530659A JP 2019511957 A JP2019511957 A JP 2019511957A JP 2019511957 A JP2019511957 A JP 2019511957A JP 2019530659 A JP2019530659 A JP 2019530659A
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Japan
Prior art keywords
deprotection
coupling
cycle
solid phase
solution
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JP2019511957A
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English (en)
Japanese (ja)
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JP2019530659A5 (enExample
Inventor
コリンズ，ジョナサン・エム
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シーイーエム・コーポレーション
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Priority claimed from PCT/US2016/058181 external-priority patent/WO2017070512A1/en
Priority claimed from US15/490,090 external-priority patent/US10239914B2/en
Application filed by シーイーエム・コーポレーション filed Critical シーイーエム・コーポレーション
Publication of JP2019530659A publication Critical patent/JP2019530659A/ja
Publication of JP2019530659A5 publication Critical patent/JP2019530659A5/ja
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/04—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length on carriers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/04—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length on carriers
    • C07K1/045—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length on carriers using devices to improve synthesis, e.g. reactors, special vessels
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/04—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length on carriers
    • C07K1/047—Simultaneous synthesis of different peptide species; Peptide libraries
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Analytical Chemistry (AREA)
  • Peptides Or Proteins (AREA)
JP2019511957A 2016-09-03 2017-04-19 高温での固相ペプチド合成のためのインサイツ溶媒リサイクル法 Pending JP2019530659A (ja)

Applications Claiming Priority (9)

Application Number Priority Date Filing Date Title
US201662383397P 2016-09-03 2016-09-03
US62/383,397 2016-09-03
USPCT/US2016/058181 2016-10-21
PCT/US2016/058181 WO2017070512A1 (en) 2015-10-23 2016-10-21 Improvements in solid phase peptide synthesis
US15/299,931 2016-10-21
US15/299,931 US10125163B2 (en) 2015-10-23 2016-10-21 Solid phase peptide synthesis
US15/490,090 US10239914B2 (en) 2015-10-23 2017-04-18 In-situ solvent recycling process for solid phase peptide synthesis at elevated temperatures
US15/490,090 2017-04-18
PCT/US2017/028254 WO2018044356A1 (en) 2016-09-03 2017-04-19 In-situ solvent recycling process for solid phase peptide synthesis at elevated temperatures

Publications (2)

Publication Number Publication Date
JP2019530659A true JP2019530659A (ja) 2019-10-24
JP2019530659A5 JP2019530659A5 (enExample) 2019-12-19

Family

ID=61301481

Family Applications (1)

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JP2019511957A Pending JP2019530659A (ja) 2016-09-03 2017-04-19 高温での固相ペプチド合成のためのインサイツ溶媒リサイクル法

Country Status (6)

Country Link
EP (1) EP3507299B1 (enExample)
JP (1) JP2019530659A (enExample)
CN (1) CN109715647A (enExample)
CA (1) CA3034810C (enExample)
DK (1) DK3507299T3 (enExample)
WO (1) WO2018044356A1 (enExample)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
USRE49961E1 (en) 2016-10-21 2024-05-07 Cem Corporation Solid phase peptide syntheses
EP4551587A1 (en) * 2022-09-16 2025-05-14 CEM Corporation Peptide synthesis processes

Citations (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040238794A1 (en) * 2003-05-30 2004-12-02 Karandikar Prashant G. Microwave processing of composite bodies made by an infiltration route
JP2005015483A (ja) * 2003-06-23 2005-01-20 Cem Corp マイクロ波利用のペプチド合成
JP2007211013A (ja) * 2006-02-10 2007-08-23 Cem Corp ペプチド合成におけるマイクロ波により向上されたｎ−ｆｍｏｃ脱保護
JP2008110977A (ja) * 2006-10-24 2008-05-15 Cem Corp マイクロ波の利用によるペプチド合成
US7803351B2 (en) * 2004-08-20 2010-09-28 Washington University Blood brain barrier permeation peptides
US20130034547A1 (en) * 2011-08-02 2013-02-07 Kelly Jeffery W Reliable stabilization of n-linked polypeptide native states with enhanced aromatic sequons located in polypeptide tight turns
JP2013534247A (ja) * 2010-08-16 2013-09-02 シーイーエム・コーポレーション 水溶性固相ペプチド合成
WO2014033297A1 (en) * 2012-08-31 2014-03-06 Biotage Ab Apparatus and method for solid phase synthesis
US20140275481A1 (en) * 2013-03-15 2014-09-18 Massachusetts Institute Of Technology Solid phase peptide synthesis processes and associated systems

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3365352A4 (en) * 2015-10-23 2019-06-05 CEM Corporation IMPROVEMENTS OF SOLID PHASE PEPTIDE SYNTHESIS

Patent Citations (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040238794A1 (en) * 2003-05-30 2004-12-02 Karandikar Prashant G. Microwave processing of composite bodies made by an infiltration route
JP2005015483A (ja) * 2003-06-23 2005-01-20 Cem Corp マイクロ波利用のペプチド合成
US7803351B2 (en) * 2004-08-20 2010-09-28 Washington University Blood brain barrier permeation peptides
JP2007211013A (ja) * 2006-02-10 2007-08-23 Cem Corp ペプチド合成におけるマイクロ波により向上されたｎ−ｆｍｏｃ脱保護
JP2008110977A (ja) * 2006-10-24 2008-05-15 Cem Corp マイクロ波の利用によるペプチド合成
JP2013534247A (ja) * 2010-08-16 2013-09-02 シーイーエム・コーポレーション 水溶性固相ペプチド合成
US20130034547A1 (en) * 2011-08-02 2013-02-07 Kelly Jeffery W Reliable stabilization of n-linked polypeptide native states with enhanced aromatic sequons located in polypeptide tight turns
WO2014033297A1 (en) * 2012-08-31 2014-03-06 Biotage Ab Apparatus and method for solid phase synthesis
US20140275481A1 (en) * 2013-03-15 2014-09-18 Massachusetts Institute Of Technology Solid phase peptide synthesis processes and associated systems

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
JOURNAL OF PEPTIDE SCIENCE, vol. 12, JPN6019015884, 2006, pages 633 - 638, ISSN: 0004089669 *
MOLECULAR BIOTECHNOLOGY, vol. 33, JPN6019015888, 2006, pages 239 - 254, ISSN: 0004089671 *
NATURE PROTOCOLS, vol. 2, JPN6019015885, 2007, pages 3247 - 3256, ISSN: 0004089670 *
ORGANIC LETTERS, vol. 16, JPN6019015881, 2014, pages 940 - 943, ISSN: 0004089668 *

Also Published As

Publication number Publication date
CN109715647A (zh) 2019-05-03
EP3507299A4 (en) 2020-04-29
DK3507299T3 (da) 2022-09-05
CA3034810A1 (en) 2018-03-08
WO2018044356A1 (en) 2018-03-08
EP3507299A1 (en) 2019-07-10
CA3034810C (en) 2023-09-05
EP3507299B1 (en) 2022-07-27

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