JP2019529472A5 - - Google Patents
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- JP2019529472A5 JP2019529472A5 JP2019516442A JP2019516442A JP2019529472A5 JP 2019529472 A5 JP2019529472 A5 JP 2019529472A5 JP 2019516442 A JP2019516442 A JP 2019516442A JP 2019516442 A JP2019516442 A JP 2019516442A JP 2019529472 A5 JP2019529472 A5 JP 2019529472A5
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- 239000008194 pharmaceutical composition Substances 0.000 claims description 97
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- 125000006574 non-aromatic ring group Chemical group 0.000 claims description 16
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- 230000013629 beta-amyloid clearance Effects 0.000 claims description 12
- 229910052736 halogen Inorganic materials 0.000 claims description 12
- 150000002367 halogens Chemical class 0.000 claims description 12
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- 150000003839 salts Chemical class 0.000 claims description 12
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- MZOFCQQQCNRIBI-VMXHOPILSA-N (3s)-4-[[(2s)-1-[[(2s)-1-[[(1s)-1-carboxy-2-hydroxyethyl]amino]-4-methyl-1-oxopentan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-3-[[2-[[(2s)-2,6-diaminohexanoyl]amino]acetyl]amino]-4-oxobutanoic acid Chemical compound OC[C@@H](C(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(O)=O)NC(=O)CNC(=O)[C@@H](N)CCCCN MZOFCQQQCNRIBI-VMXHOPILSA-N 0.000 claims description 6
- 201000001320 Atherosclerosis Diseases 0.000 claims description 6
- WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical compound [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 claims description 6
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- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims description 6
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- AVKIFKMDHWOPPA-WYNBGMTASA-N Cc1cc(-c2ccccc2)cc(CN(C(C=CN2[C@@H](C3O)O[C@H](CO)C3O)=O)C2=O)n1 Chemical compound Cc1cc(-c2ccccc2)cc(CN(C(C=CN2[C@@H](C3O)O[C@H](CO)C3O)=O)C2=O)n1 AVKIFKMDHWOPPA-WYNBGMTASA-N 0.000 description 1
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- QSVXHHJYMKZCAL-HOHBBMLPSA-N OC[C@H](C1O)OCC1(CN(C=CC(N1Cc2ncc(C(F)(F)F)c(-c3ccccc3)c2)=O)C1=O)O Chemical compound OC[C@H](C1O)OCC1(CN(C=CC(N1Cc2ncc(C(F)(F)F)c(-c3ccccc3)c2)=O)C1=O)O QSVXHHJYMKZCAL-HOHBBMLPSA-N 0.000 description 1
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662399691P | 2016-09-26 | 2016-09-26 | |
| US62/399,691 | 2016-09-26 | ||
| PCT/US2017/053565 WO2018058148A1 (en) | 2016-09-26 | 2017-09-26 | Uridine nucleoside derivatives, compositions and methods of use |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2019529472A JP2019529472A (ja) | 2019-10-17 |
| JP2019529472A5 true JP2019529472A5 (enExample) | 2020-11-12 |
| JP7121731B2 JP7121731B2 (ja) | 2022-08-18 |
Family
ID=61690038
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019516442A Active JP7121731B2 (ja) | 2016-09-26 | 2017-09-26 | ウリジンヌクレオシド誘導体、組成物及び使用方法 |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US20200040025A1 (enExample) |
| EP (1) | EP3515447A4 (enExample) |
| JP (1) | JP7121731B2 (enExample) |
| CA (1) | CA3038519A1 (enExample) |
| WO (1) | WO2018058148A1 (enExample) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP7506473B2 (ja) * | 2019-12-20 | 2024-06-26 | ポッカサッポロフード＆ビバレッジ株式会社 | アミロイドβ蓄積抑制剤 |
| WO2021194959A1 (en) * | 2020-03-24 | 2021-09-30 | Gliaguard, Inc. | Treatment of eye disorders with uridine phosphate derivatives |
| AU2022328136A1 (en) | 2021-08-10 | 2023-11-30 | Abbvie Inc. | Nicotinamide ripk1 inhibitors |
| US12116382B2 (en) | 2022-11-28 | 2024-10-15 | Hongene Biotech Corporation | Functionalized N-acetylgalactosamine analogs |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4724232A (en) * | 1985-03-16 | 1988-02-09 | Burroughs Wellcome Co. | Treatment of human viral infections |
| JPH0344379A (ja) * | 1989-07-13 | 1991-02-26 | Yamasa Shoyu Co Ltd | Ｎ↑３―ピペラジノウラシル誘導体 |
| US5859014A (en) * | 1995-06-09 | 1999-01-12 | Syntex (U.S.A.) Inc. | Pyrimidinedione, pyrimidinetrione, triazinedione and tetrahydroquinazolinedione derivatives as α1 -adrenergic receptor antagonists |
| EP2291187B1 (en) * | 2008-04-24 | 2018-08-15 | Newlink Genetics Corporation | Ido inhibitors |
| KR20110079197A (ko) * | 2009-12-31 | 2011-07-07 | 제일모직주식회사 | 유기광전소자용 화합물 및 이를 포함하는 유기광전소자 |
| JP6162125B2 (ja) | 2011-09-30 | 2017-07-12 | タフツ・ユニバーシティ | 神経変性障害を処置するためのウリジン二リン酸誘導体、組成物および方法 |
| AU2013323188B2 (en) | 2012-09-28 | 2018-04-19 | Tufts University | Uridine diphosphate derivatives, prodrugs, compositions and uses thereof |
| CN103232509B (zh) * | 2013-05-14 | 2015-07-08 | 郑州大学 | 氟尿嘧啶类化合物、其制备方法及其应用 |
-
2017
- 2017-09-26 JP JP2019516442A patent/JP7121731B2/ja active Active
- 2017-09-26 EP EP17854152.0A patent/EP3515447A4/en not_active Withdrawn
- 2017-09-26 WO PCT/US2017/053565 patent/WO2018058148A1/en not_active Ceased
- 2017-09-26 CA CA3038519A patent/CA3038519A1/en not_active Abandoned
- 2017-09-26 US US16/336,898 patent/US20200040025A1/en not_active Abandoned
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