JP2019528267A5 - - Google Patents

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Publication number
JP2019528267A5
JP2019528267A5 JP2019508255A JP2019508255A JP2019528267A5 JP 2019528267 A5 JP2019528267 A5 JP 2019528267A5 JP 2019508255 A JP2019508255 A JP 2019508255A JP 2019508255 A JP2019508255 A JP 2019508255A JP 2019528267 A5 JP2019528267 A5 JP 2019528267A5
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JP
Japan
Prior art keywords
pharmaceutical composition
reducing
pneumonia
disease
onset
Prior art date
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Application number
JP2019508255A
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English (en)
Japanese (ja)
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JP2019528267A (ja
JP7013446B2 (ja
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Priority claimed from PCT/US2017/047185 external-priority patent/WO2018035246A1/en
Publication of JP2019528267A publication Critical patent/JP2019528267A/ja
Publication of JP2019528267A5 publication Critical patent/JP2019528267A5/ja
Application granted granted Critical
Publication of JP7013446B2 publication Critical patent/JP7013446B2/ja
Active legal-status Critical Current
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JP2019508255A 2016-08-16 2017-08-16 Ｇａｂａ（ａ）受容体モジュレーター、及び、喘息における気道過敏及び炎症を抑制するための方法 Active JP7013446B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201662375694P 2016-08-16 2016-08-16
US62/375,694 2016-08-16
US201662427771P 2016-11-29 2016-11-29
US62/427,771 2016-11-29
PCT/US2017/047185 WO2018035246A1 (en) 2016-08-16 2017-08-16 Gaba(a) receptor modulators and methods to control airway hyperresponsiveness and inflammation in asthma

Publications (3)

Publication Number Publication Date
JP2019528267A JP2019528267A (ja) 2019-10-10
JP2019528267A5 true JP2019528267A5 (https=) 2020-09-24
JP7013446B2 JP7013446B2 (ja) 2022-02-15

Family

ID=59714151

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2019508255A Active JP7013446B2 (ja) 2016-08-16 2017-08-16 Ｇａｂａ（ａ）受容体モジュレーター、及び、喘息における気道過敏及び炎症を抑制するための方法

Country Status (8)

Country Link
US (2) US11447495B2 (https=)
EP (1) EP3500573B1 (https=)
JP (1) JP7013446B2 (https=)
CN (1) CN109790170B (https=)
AU (1) AU2017313753B2 (https=)
CA (1) CA3033964A1 (https=)
ES (1) ES2895965T3 (https=)
WO (1) WO2018035246A1 (https=)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PE20230440A1 (es) * 2020-03-31 2023-03-08 Hoffmann La Roche Derivados de benzodiazepinas como pam de gaba a gamma1
EP3901155A1 (en) * 2020-04-20 2021-10-27 F. Hoffmann-La Roche AG New benzodiazepine derivatives as gaba a gamma1 pam
CN118019742A (zh) 2021-09-29 2024-05-10 豪夫迈·罗氏有限公司 作为GABA A γ1 PAM的新颖苯并二氮杂䓬衍生物
CA3232152A1 (en) 2021-10-06 2023-04-13 F. Hoffman-La Roche Ag Benzodiazepine derivatives as positive allosteric modulators of the gaba a gamma1 receptor

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ZA755418B (en) 1974-09-11 1977-06-29 Hoffmann La Roche Diazepine derivatives
US4125726A (en) 1977-03-11 1978-11-14 Hoffmann-La Roche Inc. Imidazo[1,5-a][1,4]benzodiazepines
US4401597A (en) 1978-05-15 1983-08-30 Hoffmann-La Roche Inc. Imidazodiazepines and processes therefor
US4226768A (en) * 1979-05-29 1980-10-07 Hoffmann-La Roche Inc. Process for the preparation of imidazobenzodiazepines
US4238610A (en) 1979-12-20 1980-12-09 Hoffmann-La Roche Inc. Intermediates for the production of imidazobenzodiazepines
ZA845757B (en) 1983-08-25 1985-04-24 Hoffmann La Roche Benzodiazepine derivatives
US5317018A (en) 1992-06-09 1994-05-31 Armin Walser Benzodiazepines and compositions for treating anxiety and panic disorders, and idiopathic and psychomotor epilepsy
TW349100B (en) * 1994-11-11 1999-01-01 Hoffmann La Roche Oxazolyl- and thiazolylimidazo-benzo- and thienodiazepines
CA2184802C (en) 1995-10-10 2007-07-31 Karl-Heinz Bender Process for manufacture of imidazo benzodiazepine derivatives
GB9911152D0 (en) 1999-05-14 1999-07-14 Glaxo Group Ltd Short-acting benzodiazepines
US6512114B1 (en) 1999-06-30 2003-01-28 Abbott Laboratories Process for the preparation of Midazolam
US20010014738A1 (en) 1999-06-30 2001-08-16 Madhup K. Dhaon Process for the preparation of imidazodiazepine intermediates
US6262260B1 (en) 2000-03-23 2001-07-17 Abbott Laboratories Process for the preparation of midazolam
DE60319812T2 (de) 2002-03-28 2009-04-23 Wisys Technology Foundation, Inc., Madison Angstlösende wirkstoffe mit verminderten beruhigenden und ataktischen nebenwirkungen
US8835424B2 (en) 2002-03-28 2014-09-16 Wisconsin Alumni Research Foundation Selective agents for pain suppression
MXJL06000069A (es) * 2004-06-09 2007-04-10 Avanir Pharmaceuticals Derivados heterociclicos para el tratamiento de hiperlipidemia y enfermedades relacionadas.
CA2570185A1 (en) 2004-06-30 2006-01-12 Wisys Technology Foundation Inc. Stereospecific anxiolytic and anticonvulsant agents with reduced muscle-relaxant, sedative-hypnotic and ataxic effects
EP1888594A2 (en) 2005-05-16 2008-02-20 Wisys Technology Foundation, Inc. Gabaergic agents to treat memory deficits
US8119629B2 (en) 2007-10-03 2012-02-21 Bristol-Meyers Squibb Company Carboxamide GABAA α2 modulators
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US9006233B2 (en) * 2011-04-28 2015-04-14 Uwm Research Foundation, Inc. Gabaergic receptor subtype selective ligands and their uses
AU2012258977A1 (en) * 2011-05-23 2014-01-16 Imago Pharmaceuticals, Inc. Inhibitors of LRRK2 kinase activity
EP2592077A1 (en) 2011-11-11 2013-05-15 Almirall, S.A. New cyclohexylamine derivatives having beta2 adrenergic agonist and M3 muscarinic antagonist activities
CN103204838B (zh) 2012-01-13 2017-06-09 北京盛诺基医药科技有限公司 多羟基苯并吡喃酮类化合物的合成及其抗肿瘤作用
CN103319486B (zh) 2012-03-22 2017-10-10 徐州市心血管病研究所 合成4H‑咪唑并[1,5‑a][1,4]苯二氮卓,特别是咪达唑仑的方法
CA2885148A1 (en) * 2012-09-21 2014-03-27 Uwm Research Foundation, Inc. Novel gabaa agonists and methods of using to control airway hyperresponsiveness and inflammation in asthma
DK3439665T3 (da) 2016-03-18 2022-09-26 Uwm Res Foundation Inc Behandling af kognitive og sindsstemningssymptomer ved neurodegenerative og neuropsykiatriske lidelser med alpha5-holdige gabaa-receptoragonister

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