JP2019528267A5 - - Google Patents
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- JP2019528267A5 JP2019528267A5 JP2019508255A JP2019508255A JP2019528267A5 JP 2019528267 A5 JP2019528267 A5 JP 2019528267A5 JP 2019508255 A JP2019508255 A JP 2019508255A JP 2019508255 A JP2019508255 A JP 2019508255A JP 2019528267 A5 JP2019528267 A5 JP 2019528267A5
- Authority
- JP
- Japan
- Prior art keywords
- pharmaceutical composition
- reducing
- pneumonia
- disease
- onset
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662375694P | 2016-08-16 | 2016-08-16 | |
| US62/375,694 | 2016-08-16 | ||
| US201662427771P | 2016-11-29 | 2016-11-29 | |
| US62/427,771 | 2016-11-29 | ||
| PCT/US2017/047185 WO2018035246A1 (en) | 2016-08-16 | 2017-08-16 | Gaba(a) receptor modulators and methods to control airway hyperresponsiveness and inflammation in asthma |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2019528267A JP2019528267A (ja) | 2019-10-10 |
| JP2019528267A5 true JP2019528267A5 (enExample) | 2020-09-24 |
| JP7013446B2 JP7013446B2 (ja) | 2022-02-15 |
Family
ID=59714151
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019508255A Active JP7013446B2 (ja) | 2016-08-16 | 2017-08-16 | Ｇａｂａ（ａ）受容体モジュレーター、及び、喘息における気道過敏及び炎症を抑制するための方法 |
Country Status (8)
| Country | Link |
|---|---|
| US (2) | US11447495B2 (enExample) |
| EP (1) | EP3500573B1 (enExample) |
| JP (1) | JP7013446B2 (enExample) |
| CN (1) | CN109790170B (enExample) |
| AU (1) | AU2017313753B2 (enExample) |
| CA (1) | CA3033964A1 (enExample) |
| ES (1) | ES2895965T3 (enExample) |
| WO (1) | WO2018035246A1 (enExample) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PE20230440A1 (es) | 2020-03-31 | 2023-03-08 | Hoffmann La Roche | Derivados de benzodiazepinas como pam de gaba a gamma1 |
| EP3901155A1 (en) * | 2020-04-20 | 2021-10-27 | F. Hoffmann-La Roche AG | New benzodiazepine derivatives as gaba a gamma1 pam |
| WO2023052312A1 (en) | 2021-09-29 | 2023-04-06 | F. Hoffmann-La Roche Ag | New benzodiazepine derivatives as gaba a gamma1 pam |
| EP4426683A1 (en) | 2021-10-06 | 2024-09-11 | F. Hoffmann-La Roche AG | Benzodiazepine derivatives as positive allosteric modulators of the gaba a gamma1 receptor |
Family Cites Families (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ZA755418B (en) | 1974-09-11 | 1977-06-29 | Hoffmann La Roche | Diazepine derivatives |
| US4125726A (en) | 1977-03-11 | 1978-11-14 | Hoffmann-La Roche Inc. | Imidazo[1,5-a][1,4]benzodiazepines |
| US4401597A (en) | 1978-05-15 | 1983-08-30 | Hoffmann-La Roche Inc. | Imidazodiazepines and processes therefor |
| US4226768A (en) * | 1979-05-29 | 1980-10-07 | Hoffmann-La Roche Inc. | Process for the preparation of imidazobenzodiazepines |
| US4238610A (en) | 1979-12-20 | 1980-12-09 | Hoffmann-La Roche Inc. | Intermediates for the production of imidazobenzodiazepines |
| ZA845757B (en) | 1983-08-25 | 1985-04-24 | Hoffmann La Roche | Benzodiazepine derivatives |
| US5317018A (en) | 1992-06-09 | 1994-05-31 | Armin Walser | Benzodiazepines and compositions for treating anxiety and panic disorders, and idiopathic and psychomotor epilepsy |
| TW349100B (en) * | 1994-11-11 | 1999-01-01 | Hoffmann La Roche | Oxazolyl- and thiazolylimidazo-benzo- and thienodiazepines |
| CA2184802C (en) | 1995-10-10 | 2007-07-31 | Karl-Heinz Bender | Process for manufacture of imidazo benzodiazepine derivatives |
| GB9911152D0 (en) | 1999-05-14 | 1999-07-14 | Glaxo Group Ltd | Short-acting benzodiazepines |
| US20010014738A1 (en) | 1999-06-30 | 2001-08-16 | Madhup K. Dhaon | Process for the preparation of imidazodiazepine intermediates |
| US6512114B1 (en) | 1999-06-30 | 2003-01-28 | Abbott Laboratories | Process for the preparation of Midazolam |
| US6262260B1 (en) | 2000-03-23 | 2001-07-17 | Abbott Laboratories | Process for the preparation of midazolam |
| KR20080060286A (ko) | 2002-03-28 | 2008-07-01 | 위시스 테크놀로지 파운데이션, 인크. | 진정 및 운동실조 효과가 감소된 항불안제 |
| US8835424B2 (en) | 2002-03-28 | 2014-09-16 | Wisconsin Alumni Research Foundation | Selective agents for pain suppression |
| CN1968928A (zh) * | 2004-06-09 | 2007-05-23 | 阿文尼尔药品公司 | 用于治疗高脂血症及相关疾病的杂环衍生物 |
| CA2570185A1 (en) | 2004-06-30 | 2006-01-12 | Wisys Technology Foundation Inc. | Stereospecific anxiolytic and anticonvulsant agents with reduced muscle-relaxant, sedative-hypnotic and ataxic effects |
| EP1888594A2 (en) | 2005-05-16 | 2008-02-20 | Wisys Technology Foundation, Inc. | Gabaergic agents to treat memory deficits |
| US8119629B2 (en) | 2007-10-03 | 2012-02-21 | Bristol-Meyers Squibb Company | Carboxamide GABAA α2 modulators |
| US20100261711A1 (en) | 2009-03-20 | 2010-10-14 | Wisys Technology Foundation | Selective anticonvulsant agents and their uses |
| IT1399764B1 (it) | 2010-05-04 | 2013-05-03 | F S I Fabbrica Italiana Sint | Procedimento per la sintesi di 4h-imidazo [1,5-a][1,4]benzodiazepine, in particolare di midazolam. |
| US9006233B2 (en) | 2011-04-28 | 2015-04-14 | Uwm Research Foundation, Inc. | Gabaergic receptor subtype selective ligands and their uses |
| US9884828B2 (en) | 2011-05-23 | 2018-02-06 | Imago Pharmaceuticals, Inc. | Substituted cinnolines as inhibitors of LRRK2 kinase activity |
| EP2592077A1 (en) * | 2011-11-11 | 2013-05-15 | Almirall, S.A. | New cyclohexylamine derivatives having beta2 adrenergic agonist and M3 muscarinic antagonist activities |
| CN103204838B (zh) | 2012-01-13 | 2017-06-09 | 北京盛诺基医药科技有限公司 | 多羟基苯并吡喃酮类化合物的合成及其抗肿瘤作用 |
| CN103319486B (zh) | 2012-03-22 | 2017-10-10 | 徐州市心血管病研究所 | 合成4H‑咪唑并[1,5‑a][1,4]苯二氮卓,特别是咪达唑仑的方法 |
| CA2885148A1 (en) * | 2012-09-21 | 2014-03-27 | Uwm Research Foundation, Inc. | Novel gabaa agonists and methods of using to control airway hyperresponsiveness and inflammation in asthma |
| PT3439665T (pt) | 2016-03-18 | 2022-09-27 | Uwm Res Foundation Inc | Tratamento de sintomas cognitivos e de humor em distúrbios neurodegenerativos e neuropsiquiátricos com gaba contendo agonistas de recetores de gabaa contendo alfa5 |
-
2017
- 2017-08-16 WO PCT/US2017/047185 patent/WO2018035246A1/en not_active Ceased
- 2017-08-16 US US16/325,080 patent/US11447495B2/en active Active
- 2017-08-16 CA CA3033964A patent/CA3033964A1/en active Pending
- 2017-08-16 JP JP2019508255A patent/JP7013446B2/ja active Active
- 2017-08-16 EP EP17758373.9A patent/EP3500573B1/en active Active
- 2017-08-16 AU AU2017313753A patent/AU2017313753B2/en active Active
- 2017-08-16 ES ES17758373T patent/ES2895965T3/es active Active
- 2017-08-16 CN CN201780063337.9A patent/CN109790170B/zh active Active
-
2022
- 2022-08-11 US US17/886,403 patent/US12054491B2/en active Active
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