JP2019527229A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2019527229A5 JP2019527229A5 JP2019504021A JP2019504021A JP2019527229A5 JP 2019527229 A5 JP2019527229 A5 JP 2019527229A5 JP 2019504021 A JP2019504021 A JP 2019504021A JP 2019504021 A JP2019504021 A JP 2019504021A JP 2019527229 A5 JP2019527229 A5 JP 2019527229A5
- Authority
- JP
- Japan
- Prior art keywords
- nucleic acid
- seq
- acid sequence
- protein
- cdna
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 150000007523 nucleic acids Chemical class 0.000 claims 29
- CKLJMWTZIZZHCS-REOHCLBHSA-N L-aspartic acid Chemical compound OC(=O)[C@@H](N)CC(O)=O CKLJMWTZIZZHCS-REOHCLBHSA-N 0.000 claims 18
- 235000003704 aspartic acid Nutrition 0.000 claims 18
- OQFSQFPPLPISGP-UHFFFAOYSA-N beta-carboxyaspartic acid Natural products OC(=O)C(N)C(C(O)=O)C(O)=O OQFSQFPPLPISGP-UHFFFAOYSA-N 0.000 claims 18
- 108090000765 processed proteins & peptides Proteins 0.000 claims 18
- 108091028043 Nucleic acid sequence Proteins 0.000 claims 17
- 239000002299 complementary DNA Substances 0.000 claims 16
- 229920001184 polypeptide Polymers 0.000 claims 16
- 102000004196 processed proteins & peptides Human genes 0.000 claims 16
- 239000000523 sample Substances 0.000 claims 14
- 101001039301 Homo sapiens Probable G-protein coupled receptor 156 Proteins 0.000 claims 13
- 102100041015 Probable G-protein coupled receptor 156 Human genes 0.000 claims 13
- 108020004705 Codon Proteins 0.000 claims 12
- 210000004027 cell Anatomy 0.000 claims 12
- 108020004707 nucleic acids Proteins 0.000 claims 12
- 102000039446 nucleic acids Human genes 0.000 claims 12
- 239000000935 antidepressant agent Substances 0.000 claims 8
- 230000035772 mutation Effects 0.000 claims 8
- 230000001430 anti-depressive effect Effects 0.000 claims 7
- 229940005513 antidepressants Drugs 0.000 claims 7
- 230000000295 complement effect Effects 0.000 claims 5
- 235000018102 proteins Nutrition 0.000 claims 5
- 102000004169 proteins and genes Human genes 0.000 claims 5
- 108090000623 proteins and genes Proteins 0.000 claims 5
- 101100505306 Homo sapiens GPR156 gene Proteins 0.000 claims 4
- 150000001413 amino acids Chemical group 0.000 claims 4
- 108091032973 (ribonucleotides)n+m Proteins 0.000 claims 3
- 108020004414 DNA Proteins 0.000 claims 3
- 208000020401 Depressive disease Diseases 0.000 claims 3
- 101000887490 Homo sapiens Guanine nucleotide-binding protein G(z) subunit alpha Proteins 0.000 claims 3
- 201000003104 endogenous depression Diseases 0.000 claims 3
- 102000052301 human GNAZ Human genes 0.000 claims 3
- 208000024714 major depressive disease Diseases 0.000 claims 3
- 102000005962 receptors Human genes 0.000 claims 3
- 108020003175 receptors Proteins 0.000 claims 3
- YBJHBAHKTGYVGT-ZKWXMUAHSA-N (+)-Biotin Chemical compound N1C(=O)N[C@@H]2[C@H](CCCCC(=O)O)SC[C@@H]21 YBJHBAHKTGYVGT-ZKWXMUAHSA-N 0.000 claims 2
- 108700028369 Alleles Proteins 0.000 claims 2
- 241000700605 Viruses Species 0.000 claims 2
- 239000013543 active substance Substances 0.000 claims 2
- 239000013566 allergen Substances 0.000 claims 2
- 239000007850 fluorescent dye Substances 0.000 claims 2
- 102000034287 fluorescent proteins Human genes 0.000 claims 2
- 108091006047 fluorescent proteins Proteins 0.000 claims 2
- 230000001939 inductive effect Effects 0.000 claims 2
- 210000004962 mammalian cell Anatomy 0.000 claims 2
- 239000013612 plasmid Substances 0.000 claims 2
- 238000000746 purification Methods 0.000 claims 2
- 230000002285 radioactive effect Effects 0.000 claims 2
- WHXSMMKQMYFTQS-UHFFFAOYSA-N Lithium Chemical compound [Li] WHXSMMKQMYFTQS-UHFFFAOYSA-N 0.000 claims 1
- 229940121991 Serotonin and norepinephrine reuptake inhibitor Drugs 0.000 claims 1
- 239000002253 acid Substances 0.000 claims 1
- 229960002685 biotin Drugs 0.000 claims 1
- 235000020958 biotin Nutrition 0.000 claims 1
- 239000011616 biotin Substances 0.000 claims 1
- 230000000994 depressogenic effect Effects 0.000 claims 1
- 229910052744 lithium Inorganic materials 0.000 claims 1
- 238000002493 microarray Methods 0.000 claims 1
- 239000002767 noradrenalin uptake inhibitor Substances 0.000 claims 1
- 229940127221 norepinephrine reuptake inhibitor Drugs 0.000 claims 1
- 239000002773 nucleotide Substances 0.000 claims 1
- 125000003729 nucleotide group Chemical group 0.000 claims 1
- 229940124834 selective serotonin reuptake inhibitor Drugs 0.000 claims 1
- 239000012896 selective serotonin reuptake inhibitor Substances 0.000 claims 1
- 239000003775 serotonin noradrenalin reuptake inhibitor Substances 0.000 claims 1
- 239000000758 substrate Substances 0.000 claims 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2023019464A JP2023071704A (ja) | 2016-07-28 | 2023-02-10 | Ｇｐｒ１５６変異体及びその使用 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662367973P | 2016-07-28 | 2016-07-28 | |
| US62/367,973 | 2016-07-28 | ||
| PCT/US2017/044321 WO2018022967A1 (en) | 2016-07-28 | 2017-07-28 | Gpr156 variants and uses thereof |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023019464A Division JP2023071704A (ja) | 2016-07-28 | 2023-02-10 | Ｇｐｒ１５６変異体及びその使用 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2019527229A JP2019527229A (ja) | 2019-09-26 |
| JP2019527229A5 true JP2019527229A5 (https=) | 2020-09-03 |
| JP7556688B2 JP7556688B2 (ja) | 2024-09-26 |
Family
ID=59649989
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019504021A Active JP7556688B2 (ja) | 2016-07-28 | 2017-07-28 | Ｇｐｒ１５６変異体及びその使用 |
| JP2023019464A Pending JP2023071704A (ja) | 2016-07-28 | 2023-02-10 | Ｇｐｒ１５６変異体及びその使用 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023019464A Pending JP2023071704A (ja) | 2016-07-28 | 2023-02-10 | Ｇｐｒ１５６変異体及びその使用 |
Country Status (13)
| Country | Link |
|---|---|
| US (4) | US10266582B2 (https=) |
| EP (2) | EP4230648A3 (https=) |
| JP (2) | JP7556688B2 (https=) |
| KR (2) | KR20240027874A (https=) |
| CN (1) | CN109563516B (https=) |
| AU (1) | AU2017302611B2 (https=) |
| CA (1) | CA3032124A1 (https=) |
| DK (1) | DK3491014T5 (https=) |
| IL (1) | IL264473A (https=) |
| MX (2) | MX2019001084A (https=) |
| NZ (1) | NZ751010A (https=) |
| SG (1) | SG11201900738YA (https=) |
| WO (1) | WO2018022967A1 (https=) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP7556688B2 (ja) * | 2016-07-28 | 2024-09-26 | リジェネロン・ファーマシューティカルズ・インコーポレイテッド | Ｇｐｒ１５６変異体及びその使用 |
| CA3074652A1 (en) | 2017-09-06 | 2019-03-14 | Regeneron Pharmaceuticals, Inc. | Single immunoglobulin interleukin-1 receptor related (sigirr) variants and uses thereof |
| PL3505157T3 (pl) | 2017-12-29 | 2022-04-11 | Celon Pharma S.A. | Kompozycja ketaminy w postaci suchego proszku do podawania dopłucnego w leczeniu depresji opornej na leczenie |
| US20210393621A1 (en) | 2018-10-26 | 2021-12-23 | The Research Foundation For The State University Of New York | Combination serotonin specific reuptake inhibitor and serotonin 1a receptor partial agonist for reducing l-dopa-induced dyskinesia |
| CN113423266A (zh) * | 2019-01-17 | 2021-09-21 | 雷杰纳荣制药公司 | 情绪障碍的啮齿动物模型 |
Family Cites Families (40)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4399216A (en) | 1980-02-25 | 1983-08-16 | The Trustees Of Columbia University | Processes for inserting DNA into eucaryotic cells and for producing proteinaceous materials |
| US4634665A (en) | 1980-02-25 | 1987-01-06 | The Trustees Of Columbia University In The City Of New York | Processes for inserting DNA into eucaryotic cells and for producing proteinaceous materials |
| US5179017A (en) | 1980-02-25 | 1993-01-12 | The Trustees Of Columbia University In The City Of New York | Processes for inserting DNA into eucaryotic cells and for producing proteinaceous materials |
| US4751180A (en) | 1985-03-28 | 1988-06-14 | Chiron Corporation | Expression using fused genes providing for protein product |
| US4935233A (en) | 1985-12-02 | 1990-06-19 | G. D. Searle And Company | Covalently linked polypeptide cell modulators |
| US5294533A (en) | 1988-07-05 | 1994-03-15 | Baylor College Of Medicine | Antisense oligonucleotide antibiotics complementary to the macromolecular synthesis operon, methods of treating bacterial infections and methods for identification of bacteria |
| US5135917A (en) | 1990-07-12 | 1992-08-04 | Nova Pharmaceutical Corporation | Interleukin receptor expression inhibiting antisense oligonucleotides |
| US5271941A (en) | 1990-11-02 | 1993-12-21 | Cho Chung Yoon S | Antisense oligonucleotides of human regulatory subunit RI.sub.α of cAMP-dependent protein kinases |
| US5786138A (en) | 1993-01-29 | 1998-07-28 | Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College | Hyperstabilizing antisense nucleic acid binding agents |
| JPH10510700A (ja) | 1993-06-04 | 1998-10-20 | アメリカ合衆国 | アンチセンスオリゴヌクレオチドを用いてカポジ肉腫を治療する方法 |
| US5578716A (en) | 1993-12-01 | 1996-11-26 | Mcgill University | DNA methyltransferase antisense oligonucleotides |
| US5641754A (en) | 1994-01-10 | 1997-06-24 | The Board Of Regents Of The University Of Nebraska | Antisense oligonucleotide compositions for selectively killing cancer cells |
| EP0775204A1 (en) | 1994-08-09 | 1997-05-28 | Novartis AG | Antitumor antisense oligonucleotides |
| US5856103A (en) | 1994-10-07 | 1999-01-05 | Board Of Regents The University Of Texas | Method for selectively ranking sequences for antisense targeting |
| US5994320A (en) | 1995-02-06 | 1999-11-30 | Regents Of The University Of Minnesota | Antisense oligonucleotides and methods for treating central nervous system tumors |
| IT1275862B1 (it) | 1995-03-03 | 1997-10-24 | Consiglio Nazionale Ricerche | Trascritto antisenso associato ad alcuni tipi di cellule tumorali ed oligodeossinucleotidi sintetici utili nella diagnosi e nel trattamento |
| US6040296A (en) | 1995-06-07 | 2000-03-21 | East Carolina University | Specific antisense oligonucleotide composition & method for treatment of disorders associated with bronchoconstriction and lung inflammation |
| AU7286696A (en) | 1995-10-13 | 1997-05-07 | F. Hoffmann-La Roche Ag | Antisense oligomers |
| CA2236825A1 (en) | 1995-11-21 | 1997-05-29 | Icn Pharmaceuticals, Inc. | Inhibition of tumor growth by antisense oligonucleotides for il-8 and il-8 receptor |
| WO1997029757A1 (en) | 1996-02-15 | 1997-08-21 | National Institutes Of Health | Rnase l activators and antisense oligonucleotides effective to treat rsv infections |
| US5955590A (en) | 1996-07-15 | 1999-09-21 | Worcester Foundation For Biomedical Research | Conjugates of minor groove DNA binders with antisense oligonucleotides |
| US6046004A (en) | 1997-02-27 | 2000-04-04 | Lorne Park Research, Inc. | Solution hybridization of nucleic acids with antisense probes having modified backbones |
| JPH1142091A (ja) | 1997-07-25 | 1999-02-16 | Toagosei Co Ltd | アンチセンス核酸化合物 |
| US6046319A (en) | 1997-10-22 | 2000-04-04 | University Technologies International, Inc. | Antisense oligodeoxynucleotides regulating expression of TNF-α |
| US6551795B1 (en) | 1998-02-18 | 2003-04-22 | Genome Therapeutics Corporation | Nucleic acid and amino acid sequences relating to pseudomonas aeruginosa for diagnostics and therapeutics |
| US6007995A (en) | 1998-06-26 | 1999-12-28 | Isis Pharmaceuticals Inc. | Antisense inhibition of TNFR1 expression |
| US6013522A (en) | 1999-02-23 | 2000-01-11 | Isis Pharmaceuticals Inc. | Antisense inhibition of human Smad1 expression |
| US6025198A (en) | 1999-06-25 | 2000-02-15 | Isis Pharmaceuticals Inc. | Antisense modulation of Ship-2 expression |
| AU6343400A (en) * | 1999-07-09 | 2001-01-30 | Genaissance Pharmaceuticals, Inc. | Drug target isogenes: polymorphisms in the osteoclastogenesis inhibitory factor gene |
| US6033910A (en) | 1999-07-19 | 2000-03-07 | Isis Pharmaceuticals Inc. | Antisense inhibition of MAP kinase kinase 6 expression |
| WO2001079230A2 (en) * | 2000-04-18 | 2001-10-25 | Genaissance Pharmaceuticals, Inc. | Haplotypes of the ugt1a1 gene |
| EP1581648A2 (en) * | 2002-09-09 | 2005-10-05 | Nura, Inc. | G protein coupled receptors and uses thereof |
| DE10334188B4 (de) * | 2003-07-26 | 2007-07-05 | Schwarz Pharma Ag | Verwendung von Rotigotin zur Behandlung von Depressionen |
| JP2007535538A (ja) * | 2004-04-29 | 2007-12-06 | メルク エンド カムパニー インコーポレーテッド | アゼチジングリシン輸送体インヒビター |
| EP2091556B1 (en) | 2006-11-15 | 2018-07-25 | Omeros Corporation | Non-human animal comprising a mutation in the sreb2/gpr85 gene as animal model of metabolic disease |
| AU2013262709A1 (en) * | 2012-05-16 | 2015-01-22 | Rana Therapeutics, Inc. | Compositions and methods for modulating MECP2 expression |
| EP3241902B1 (en) | 2012-05-25 | 2018-02-28 | The Regents of The University of California | Methods and compositions for rna-directed target dna modification and for rna-directed modulation of transcription |
| EP3363902B1 (en) | 2012-12-06 | 2019-11-27 | Sigma Aldrich Co. LLC | Crispr-based genome modification and regulation |
| MX2018007674A (es) * | 2015-12-21 | 2018-09-12 | Bayer Oy | Un metodo para la fabricacion de un anillo vaginal. |
| JP7556688B2 (ja) * | 2016-07-28 | 2024-09-26 | リジェネロン・ファーマシューティカルズ・インコーポレイテッド | Ｇｐｒ１５６変異体及びその使用 |
-
2017
- 2017-07-28 JP JP2019504021A patent/JP7556688B2/ja active Active
- 2017-07-28 NZ NZ751010A patent/NZ751010A/en unknown
- 2017-07-28 AU AU2017302611A patent/AU2017302611B2/en not_active Ceased
- 2017-07-28 DK DK17754224.8T patent/DK3491014T5/da active
- 2017-07-28 CN CN201780048589.4A patent/CN109563516B/zh active Active
- 2017-07-28 US US15/662,689 patent/US10266582B2/en active Active
- 2017-07-28 CA CA3032124A patent/CA3032124A1/en active Pending
- 2017-07-28 WO PCT/US2017/044321 patent/WO2018022967A1/en not_active Ceased
- 2017-07-28 EP EP23162215.0A patent/EP4230648A3/en not_active Withdrawn
- 2017-07-28 KR KR1020247005755A patent/KR20240027874A/ko not_active Ceased
- 2017-07-28 SG SG11201900738YA patent/SG11201900738YA/en unknown
- 2017-07-28 KR KR1020197001965A patent/KR102661616B1/ko active Active
- 2017-07-28 MX MX2019001084A patent/MX2019001084A/es unknown
- 2017-07-28 EP EP17754224.8A patent/EP3491014B1/en active Active
-
2019
- 2019-01-25 MX MX2024013403A patent/MX2024013403A/es unknown
- 2019-01-27 IL IL264473A patent/IL264473A/en unknown
- 2019-03-15 US US16/354,563 patent/US10562953B2/en active Active
-
2020
- 2020-01-03 US US16/733,663 patent/US11155598B2/en not_active Expired - Fee Related
-
2021
- 2021-09-23 US US17/483,047 patent/US20220073589A1/en not_active Abandoned
-
2023
- 2023-02-10 JP JP2023019464A patent/JP2023071704A/ja active Pending
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2019527229A5 (https=) | ||
| Kammerer et al. | Heterodimerization of a functional GABAB receptor is mediated by parallel coiled-coil α-helices | |
| JP6559227B2 (ja) | 細胞透過性の改善のための進化型巨大分子伝達ドメイン（ａｄｖａｎｃｅｄ ｍａｃｒｏｍｏｌｅｃｕｌｅ ｔｒａｎｓｄｕｃｔｉｏｎ ｄｏｍａｉｎ）（ＡＭＴＤ）配列、それをコードするポリヌクレオチド、それを含むＡＭＴＤの固有の特性を同定する方法、それを含むＡＭＴＤ配列を開発する方法 | |
| Generous et al. | Identification of putative interactions between swine and human influenza A virus nucleoprotein and human host proteins | |
| JP2005507648A5 (https=) | ||
| JP2013502217A5 (https=) | ||
| CN103954601A (zh) | 一种mdm2拮抗剂的检验试剂盒及其制备方法 | |
| JP2004500055A5 (https=) | ||
| Krishnan et al. | A molecular dynamics study on RAGE-Aβ42 interaction and the influence of G82S RAGE polymorphism on Aβ interaction | |
| JP2008509659A5 (https=) | ||
| To | Interaction Study of Influenza RNA Polymerase Subunit PB2 and Nucleoprotein | |
| US20100291120A1 (en) | Peptides regulating the surface expression of the t cell receptor | |
| CN102329377B (zh) | 狂犬病病毒优势表位肽抗原及其用途 | |
| JP2013545440A (ja) | マカカ・ファシキュラリス（Ｍａｃａｃａｆａｓｃｉｃｕｌａｒｉｓ）ＣＣＬ１７ | |
| JP7709383B2 (ja) | 抗体の精製を促進するための機能化ｕｂｘタンパク質物質 | |
| RU2020112313A (ru) | Варианты члена 1 семейства 14 переносчиков растворенных веществ (slc14a1)и их применение | |
| IL272940B1 (en) | Variants linked to the interleukin-1 immunoglobulin-single receptor and their uses | |
| WO2001048221A1 (fr) | Nouveau polypeptide, colipase 12, et polynucleotide codant pour ce polypeptide | |
| Tam | Characterization of a small heat shock protein B 3(HSPB 3) | |
| WO2001085752A1 (fr) | Polynucleotide codant un peptide de myosine | |
| WO2001055197A1 (fr) | Nouveau polypeptide, facteur humain de liberation de la corticotropine 23(hcrf-23), et polynucleotide codant pour ce polypeptide | |
| JP2005500820A5 (https=) | ||
| JP2005500011A5 (https=) | ||
| WO2002000823A2 (en) | A novel polypeptide, a enzymatic activation protein ras gtp 9.57 and the polynucleotide encoding the polypeptide | |
| JP2006296429A5 (https=) |