JP2019527200A5 - - Google Patents
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- Publication number
- JP2019527200A5 JP2019527200A5 JP2018566552A JP2018566552A JP2019527200A5 JP 2019527200 A5 JP2019527200 A5 JP 2019527200A5 JP 2018566552 A JP2018566552 A JP 2018566552A JP 2018566552 A JP2018566552 A JP 2018566552A JP 2019527200 A5 JP2019527200 A5 JP 2019527200A5
- Authority
- JP
- Japan
- Prior art keywords
- amino acid
- polypeptide
- scil
- monomer subunit
- seq
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 150000001413 amino acids Chemical group 0.000 claims 16
- 108090000765 processed proteins & peptides Proteins 0.000 claims 13
- 235000001014 amino acid Nutrition 0.000 claims 12
- 229920001184 polypeptide Polymers 0.000 claims 12
- 102000004196 processed proteins & peptides Human genes 0.000 claims 12
- 239000000178 monomer Substances 0.000 claims 9
- 238000006467 substitution reaction Methods 0.000 claims 8
- CKLJMWTZIZZHCS-REOHCLBHSA-N L-aspartic acid Chemical compound OC(=O)[C@@H](N)CC(O)=O CKLJMWTZIZZHCS-REOHCLBHSA-N 0.000 claims 6
- 229940024606 amino acid Drugs 0.000 claims 6
- 235000003704 aspartic acid Nutrition 0.000 claims 6
- OQFSQFPPLPISGP-UHFFFAOYSA-N beta-carboxyaspartic acid Natural products OC(=O)C(N)C(C(O)=O)C(O)=O OQFSQFPPLPISGP-UHFFFAOYSA-N 0.000 claims 6
- 230000004927 fusion Effects 0.000 claims 4
- 229930182817 methionine Natural products 0.000 claims 3
- 102220512227 Endosomal/lysosomal potassium channel TMEM175_D41N_mutation Human genes 0.000 claims 2
- 102100030236 Interleukin-10 receptor subunit alpha Human genes 0.000 claims 2
- 101710146672 Interleukin-10 receptor subunit alpha Proteins 0.000 claims 2
- 102100020788 Interleukin-10 receptor subunit beta Human genes 0.000 claims 2
- 101710199214 Interleukin-10 receptor subunit beta Proteins 0.000 claims 2
- QNAYBMKLOCPYGJ-REOHCLBHSA-N L-alanine Chemical compound C[C@H](N)C(O)=O QNAYBMKLOCPYGJ-REOHCLBHSA-N 0.000 claims 2
- FFEARJCKVFRZRR-BYPYZUCNSA-N L-methionine Chemical compound CSCC[C@H](N)C(O)=O FFEARJCKVFRZRR-BYPYZUCNSA-N 0.000 claims 2
- 108010063954 Mucins Proteins 0.000 claims 2
- 235000004279 alanine Nutrition 0.000 claims 2
- DCXYFEDJOCDNAF-UHFFFAOYSA-N Asparagine Natural products OC(=O)C(N)CC(N)=O DCXYFEDJOCDNAF-UHFFFAOYSA-N 0.000 claims 1
- 101001133091 Homo sapiens Mucin-20 Proteins 0.000 claims 1
- DCXYFEDJOCDNAF-REOHCLBHSA-N L-asparagine Chemical compound OC(=O)[C@@H](N)CC(N)=O DCXYFEDJOCDNAF-REOHCLBHSA-N 0.000 claims 1
- COLNVLDHVKWLRT-QMMMGPOBSA-N L-phenylalanine Chemical compound OC(=O)[C@@H](N)CC1=CC=CC=C1 COLNVLDHVKWLRT-QMMMGPOBSA-N 0.000 claims 1
- 102100034242 Mucin-20 Human genes 0.000 claims 1
- 229960001230 asparagine Drugs 0.000 claims 1
- 235000009582 asparagine Nutrition 0.000 claims 1
- 238000012217 deletion Methods 0.000 claims 1
- 230000037430 deletion Effects 0.000 claims 1
- 229960000310 isoleucine Drugs 0.000 claims 1
- AGPKZVBTJJNPAG-UHFFFAOYSA-N isoleucine Natural products CCC(C)C(N)C(O)=O AGPKZVBTJJNPAG-UHFFFAOYSA-N 0.000 claims 1
- 125000000741 isoleucyl group Chemical group [H]N([H])C(C(C([H])([H])[H])C([H])([H])C([H])([H])[H])C(=O)O* 0.000 claims 1
- 125000001360 methionine group Chemical group N[C@@H](CCSC)C(=O)* 0.000 claims 1
- 238000012986 modification Methods 0.000 claims 1
- 230000004048 modification Effects 0.000 claims 1
- COLNVLDHVKWLRT-UHFFFAOYSA-N phenylalanine Natural products OC(=O)C(N)CC1=CC=CC=C1 COLNVLDHVKWLRT-UHFFFAOYSA-N 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662353478P | 2016-06-22 | 2016-06-22 | |
| US62/353,478 | 2016-06-22 | ||
| PCT/US2017/038747 WO2018005226A2 (en) | 2016-06-22 | 2017-06-22 | Compositions and methods for modulating il-10 immunostimulatory and anti-inflammatory properties |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2019527200A JP2019527200A (ja) | 2019-09-26 |
| JP2019527200A5 true JP2019527200A5 (cg-RX-API-DMAC7.html) | 2020-07-30 |
| JP7084881B2 JP7084881B2 (ja) | 2022-06-15 |
Family
ID=60674961
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018566552A Active JP7084881B2 (ja) | 2016-06-22 | 2017-06-22 | Ｉｌ－１０の免疫刺激特性および抗炎症特性を調節するための組成物および方法 |
Country Status (6)
| Country | Link |
|---|---|
| US (2) | US10335459B2 (cg-RX-API-DMAC7.html) |
| EP (1) | EP3474884A4 (cg-RX-API-DMAC7.html) |
| JP (1) | JP7084881B2 (cg-RX-API-DMAC7.html) |
| AU (2) | AU2017291321B2 (cg-RX-API-DMAC7.html) |
| CA (1) | CA3026393C (cg-RX-API-DMAC7.html) |
| WO (1) | WO2018005226A2 (cg-RX-API-DMAC7.html) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US11246915B2 (en) | 2010-09-15 | 2022-02-15 | Applied Molecular Transport Inc. | Cholix toxin-derived fusion molecules for oral delivery of biologically active cargo |
| MX354016B (es) | 2010-09-15 | 2018-02-07 | J Mrsny Randall | Sistemas y metodos de suministro de agentes bioactivos mediante el uso de secuencias transportadoras derivadas de toxinas. |
| DK3139965T3 (da) | 2014-05-07 | 2021-11-22 | Applied Molecular Transport Inc | Fusionsmolekyler afledt af cholix-toksin til oral indgivelse af biologisk aktive stoffer |
| US20160175458A1 (en) * | 2014-12-19 | 2016-06-23 | Alkermes, Inc. | Single chain fc fusion proteins |
| CA3026393C (en) | 2016-06-22 | 2023-03-14 | Alkermes, Inc. | Compositions and methods for modulating il-10 immunostimulatory and anti-inflammatory properties |
| CA3094927A1 (en) * | 2018-03-23 | 2019-09-26 | Gavish-Galilee Bio Applications Ltd. | Genetically reprogrammed tregs expressing membrane-bound il-10 |
| AU2019377117B2 (en) | 2018-11-07 | 2025-05-29 | Applied Molecular Transport Inc. | Delivery constructs for transcytosis and related methods |
| CN113811549A (zh) * | 2019-02-21 | 2021-12-17 | Xencor股份有限公司 | 非靶向和靶向性il-10 fc融合蛋白 |
| JP2022544624A (ja) | 2019-08-16 | 2022-10-19 | アプライド モレキュラー トランスポート インコーポレイテッド | 組成物、製剤およびインターロイキンの生成および精製 |
| EP3795583A1 (en) * | 2019-09-19 | 2021-03-24 | Ecole Polytechnique Federale de Lausanne (EPFL) | Il10/fc fusion proteins useful as enhancers of immunotherapies |
| CN112625137B (zh) * | 2019-10-08 | 2021-10-08 | 北京东方百泰生物科技股份有限公司 | 一种人白细胞介素10-Fc融合蛋白及其医药用途 |
| IL320038A (en) | 2019-11-25 | 2025-06-01 | Alkermes Inc | Substituted macrocyclic compounds compositions comprising same and uses thereof |
| US20230103554A1 (en) * | 2020-04-03 | 2023-04-06 | Baylor College Of Medicine | TNFa SIGNALING TRIGGERS TUMOR-PROMOTING INFLAMMATION THAT CAN BE TARGETED TO THERAPY |
| US11673930B2 (en) * | 2020-05-12 | 2023-06-13 | Regeneran Pharmaceuticals, Inc. | IL10 agonists and methods of use thereof |
| IL298471A (en) * | 2020-05-28 | 2023-01-01 | Univ Leland Stanford Junior | Engineered interleukin-10 polypeptides and uses thereof |
| US11760747B2 (en) | 2020-12-21 | 2023-09-19 | Alkermes, Inc. | Substituted piperidino compounds and related methods of treatment |
| WO2024094755A1 (en) * | 2022-11-02 | 2024-05-10 | Synerkine Pharma B.V. | Engineered immunocytokines, fusion polypeptides, and il10 polypeptides |
| WO2024131864A1 (zh) * | 2022-12-21 | 2024-06-27 | 广东菲鹏制药股份有限公司 | 一种il-10单体融合蛋白 |
| WO2024144336A1 (ko) * | 2022-12-30 | 2024-07-04 | 주식회사 프로젠 | 신규 이중 특이성 융합단백질 및 그의 용도 |
| TW202502807A (zh) * | 2023-06-02 | 2025-01-16 | 美商新舍凱公司 | 融合il10多肽 |
Family Cites Families (33)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE10399023I2 (de) | 1989-09-12 | 2006-11-23 | Ahp Mfg B V | TFN-bindende Proteine |
| JP2002530066A (ja) | 1998-11-19 | 2002-09-17 | スミスクライン・ビーチャム・コーポレイション | Ｒｈａｍｍアンタゴニスト抗体 |
| US6428985B1 (en) | 1998-12-02 | 2002-08-06 | The Regents Of The University Of Michigan | Immunosuppressive structural definition of IL-10 |
| ATE407697T1 (de) | 1999-07-13 | 2008-09-15 | Bolder Biotechnology Inc | Erythropoietin immunglobulin fusionsproteine |
| AU2001231532A1 (en) * | 2000-02-11 | 2001-08-20 | Maxygen Aps | Improved interleukin 10 |
| WO2004044006A1 (en) * | 2002-11-14 | 2004-05-27 | Maxygen, Inc. | Conjugates of interleukin-10 and polymers |
| ES2558102T3 (es) | 2003-05-06 | 2016-02-02 | Biogen Hemophilia Inc. | Proteínas quiméricas del factor de coagulación para el tratamiento de un trastorno hemostático |
| US7696322B2 (en) | 2003-07-28 | 2010-04-13 | Catalent Pharma Solutions, Inc. | Fusion antibodies |
| US20150071948A1 (en) | 2003-09-26 | 2015-03-12 | Gregory Alan Lazar | Novel immunoglobulin variants |
| WO2008140595A2 (en) | 2006-12-01 | 2008-11-20 | President And Fellows Of Harvard College | Synthetic trivalent haptens, complexes thereof, and uses therefor |
| TW201130511A (en) | 2009-12-22 | 2011-09-16 | Novartis Ag | Soluble proteins for use as therapeutics |
| WO2011090762A1 (en) | 2009-12-29 | 2011-07-28 | Emergent Product Development Seattle, Llc | Heterodimer binding proteins and uses thereof |
| AR080993A1 (es) | 2010-04-02 | 2012-05-30 | Hanmi Holdings Co Ltd | Formulacion de accion prolongada de interferon beta donde se usa un fragmento de inmunoglobulina |
| RU2578420C2 (ru) | 2010-05-10 | 2016-03-27 | Эсенд Байофармасьютикалз Пти Лтд | Иммуностимулирующие и вакцинные композиции |
| CN101962413B (zh) * | 2010-09-21 | 2013-03-13 | 中国科学技术大学 | 具有透皮能力和白细胞介素-10活性的融合蛋白及其编码基因与应用 |
| US8883134B2 (en) | 2010-10-20 | 2014-11-11 | Handok Pharmaceuticals, Inc. | Human interleukin-1 receptor antagonist—hybrid Fc fusion protein |
| EP2457579A1 (en) * | 2010-11-26 | 2012-05-30 | Technische Universität Dresden | Covalently linked interleukin -10 |
| TWI838039B (zh) | 2011-03-28 | 2024-04-01 | 法商賽諾菲公司 | 具有交叉結合區定向之雙重可變區類抗體結合蛋白 |
| EA201892619A1 (ru) * | 2011-04-29 | 2019-04-30 | Роше Гликарт Аг | Иммуноконъюгаты, содержащие мутантные полипептиды интерлейкина-2 |
| WO2012178137A1 (en) | 2011-06-24 | 2012-12-27 | Gillies Stephen D | Light chain immunoglobulin fusion proteins and methods of use thereof |
| EA030147B1 (ru) | 2011-08-23 | 2018-06-29 | Роше Гликарт Аг | Биспецифические антигенсвязывающие молекулы, активирующие т-клетки |
| US9062120B2 (en) | 2012-05-02 | 2015-06-23 | Janssen Biotech, Inc. | Binding proteins having tethered light chains |
| HUE037849T2 (hu) * | 2012-06-08 | 2018-09-28 | Alkermes Pharma Ireland Ltd | Cirkuláris permutációval módosított ligandumok agonistaként és antagonistaként |
| CN104640561A (zh) | 2012-07-23 | 2015-05-20 | 酵活有限公司 | 包含轻链和重链的选择性配对的免疫球蛋白构建体 |
| CN104540848B (zh) * | 2012-08-08 | 2019-05-31 | 罗切格利卡特公司 | 白介素-10融合蛋白及其用途 |
| EP3424952A1 (en) | 2013-03-15 | 2019-01-09 | Amgen, Inc | Heterodimeric bispecific antibodies |
| HK1215595A1 (zh) * | 2013-04-24 | 2016-09-02 | Armo Biosciences, Inc. | 白細胞介素-10藥物組合物和使用方法 |
| KR20160034404A (ko) * | 2013-07-31 | 2016-03-29 | 암젠 인크 | Ｆc-함유 폴리펩타이드의 안정화 |
| CA2935665A1 (en) | 2014-02-06 | 2015-08-13 | F. Hoffmann-La Roche Ag | Interleukine 10 immunoconjugates |
| CN104403004B (zh) | 2014-11-24 | 2017-10-13 | 苏州丁孚靶点生物技术有限公司 | 抗体‑干扰素异二聚体的制备和用途 |
| US20160175458A1 (en) | 2014-12-19 | 2016-06-23 | Alkermes, Inc. | Single chain fc fusion proteins |
| WO2017165464A1 (en) | 2016-03-21 | 2017-09-28 | Elstar Therapeutics, Inc. | Multispecific and multifunctional molecules and uses thereof |
| CA3026393C (en) | 2016-06-22 | 2023-03-14 | Alkermes, Inc. | Compositions and methods for modulating il-10 immunostimulatory and anti-inflammatory properties |
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2017
- 2017-06-22 CA CA3026393A patent/CA3026393C/en active Active
- 2017-06-22 EP EP17820960.7A patent/EP3474884A4/en not_active Withdrawn
- 2017-06-22 AU AU2017291321A patent/AU2017291321B2/en not_active Ceased
- 2017-06-22 JP JP2018566552A patent/JP7084881B2/ja active Active
- 2017-06-22 US US15/630,341 patent/US10335459B2/en active Active
- 2017-06-22 WO PCT/US2017/038747 patent/WO2018005226A2/en not_active Ceased
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2019
- 2019-05-16 US US16/414,223 patent/US11534480B2/en active Active
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2020
- 2020-07-03 AU AU2020204457A patent/AU2020204457A1/en not_active Abandoned