JP2019527068A5 - - Google Patents
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- JP2019527068A5 JP2019527068A5 JP2019518148A JP2019518148A JP2019527068A5 JP 2019527068 A5 JP2019527068 A5 JP 2019527068A5 JP 2019518148 A JP2019518148 A JP 2019518148A JP 2019518148 A JP2019518148 A JP 2019518148A JP 2019527068 A5 JP2019527068 A5 JP 2019527068A5
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- JP
- Japan
- Prior art keywords
- cells
- inhibitor
- organoid
- inhibitors
- cell
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2022024460A JP2022068302A (ja) | 2016-06-20 | 2022-02-21 | 改善された分化方法 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB1610748.4 | 2016-06-20 | ||
| GBGB1610748.4A GB201610748D0 (en) | 2016-06-20 | 2016-06-20 | Improved diffrentation method |
| PCT/EP2017/065101 WO2017220586A1 (en) | 2016-06-20 | 2017-06-20 | Improved differentiation method |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022024460A Division JP2022068302A (ja) | 2016-06-20 | 2022-02-21 | 改善された分化方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2019527068A JP2019527068A (ja) | 2019-09-26 |
| JP2019527068A5 true JP2019527068A5 (https=) | 2020-07-16 |
| JP7525263B2 JP7525263B2 (ja) | 2024-07-30 |
Family
ID=56895200
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019518148A Active JP7525263B2 (ja) | 2016-06-20 | 2017-06-20 | 改善された分化方法 |
| JP2022024460A Pending JP2022068302A (ja) | 2016-06-20 | 2022-02-21 | 改善された分化方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022024460A Pending JP2022068302A (ja) | 2016-06-20 | 2022-02-21 | 改善された分化方法 |
Country Status (12)
| Country | Link |
|---|---|
| US (2) | US20210047618A1 (https=) |
| EP (1) | EP3472302A1 (https=) |
| JP (2) | JP7525263B2 (https=) |
| KR (2) | KR102478617B1 (https=) |
| CN (1) | CN109844098A (https=) |
| AU (1) | AU2017281406B2 (https=) |
| CA (1) | CA3030098A1 (https=) |
| GB (1) | GB201610748D0 (https=) |
| IL (1) | IL263854A (https=) |
| MX (2) | MX2018016258A (https=) |
| SG (1) | SG11201811405QA (https=) |
| WO (1) | WO2017220586A1 (https=) |
Families Citing this family (58)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9719068B2 (en) | 2010-05-06 | 2017-08-01 | Children's Hospital Medical Center | Methods and systems for converting precursor cells into intestinal tissues through directed differentiation |
| US10006904B2 (en) | 2011-12-19 | 2018-06-26 | Umc Utrecht Holding B.V. | Rapid quantitative assay to measure CFTR function in a primary intestinal culture model |
| CA2949171A1 (en) | 2014-05-16 | 2015-11-19 | Koninklijke Nederlandse Akademie Van Wetenschappen | Improved culture method for organoids |
| SG10201801654RA (en) | 2014-05-28 | 2018-04-27 | Childrens Hospital Med Ct | Methods and systems for converting precursor cells into gastric tissues through directed differentiation |
| AU2015331848B2 (en) | 2014-10-17 | 2022-03-03 | Children's Hospital Medical Center, D/B/A Cincinnati Children's Hospital Medical Center | In vivo model of human small intestine using pluripotent stem cells and methods of making and using same |
| GB201421094D0 (en) | 2014-11-27 | 2015-01-14 | Koninklijke Nederlandse Akademie Van Wetenschappen | Culture medium |
| GB201421092D0 (en) | 2014-11-27 | 2015-01-14 | Koninklijke Nederlandse Akademie Van Wetenschappen | Culture medium |
| GB201603569D0 (en) | 2016-03-01 | 2016-04-13 | Koninklijke Nederlandse Akademie Van Wetenschappen | Improved differentiation method |
| CN109415685B (zh) | 2016-05-05 | 2023-07-04 | 儿童医院医疗中心 | 用于体外制造胃底组织的方法和与其相关的组合物 |
| EP4553082A3 (en) | 2016-11-04 | 2025-08-20 | Children's Hospital Medical Center | Liver organoid compositions and methods of making and using same |
| EP3548507A4 (en) | 2016-12-05 | 2020-07-15 | Children's Hospital Medical Center | COLON ORGANOIDS AND PROCESSES FOR THE PREPARATION AND USE THEREOF |
| JP7248586B2 (ja) | 2017-04-14 | 2023-03-29 | チルドレンズ ホスピタル メディカル センター | 複数ドナー幹細胞組成物およびそれを作製する方法 |
| EP3694603B1 (en) | 2017-10-10 | 2026-04-08 | Children's Hospital Medical Center | Esophageal tissue and/or organoid compositions and methods of making same |
| EP3727394A4 (en) | 2017-12-21 | 2021-09-08 | Children's Hospital Medical Center | DIGITALIZED HUMAN ORGANOIDS AND METHOD OF USING THEREOF |
| GB201721615D0 (en) | 2017-12-21 | 2018-02-07 | Koninklijke Nederlandse Akademie Van Wetenschappen | Immune cell organoid co-cultures |
| WO2019148067A1 (en) * | 2018-01-26 | 2019-08-01 | Massachusetts Eye And Ear Infirmary | Treatment of hearing loss |
| CN110317775B (zh) * | 2018-03-30 | 2022-06-10 | 中国科学院分子细胞科学卓越创新中心 | 用于肝细胞培养及肝脏类器官制备的培养基 |
| JP2021522819A (ja) * | 2018-05-07 | 2021-09-02 | プレジデント アンド フェローズ オブ ハーバード カレッジ | インビトロベータ細胞分化に関連する細胞集団および遺伝子発現 |
| EP4678727A3 (en) | 2018-07-26 | 2026-03-11 | Children's Hospital Medical Center | Hepato-biliary-pancreatic tissues and methods of making same |
| JP7377486B2 (ja) * | 2018-09-10 | 2023-11-10 | 国立大学法人東京工業大学 | 多能性幹細胞から腸細胞の作製方法 |
| CA3112026A1 (en) | 2018-09-12 | 2020-03-19 | Children's Hospital Medical Center | Organoid compositions for the production of hematopoietic stem cells and derivatives thereof |
| GB201819224D0 (en) | 2018-11-26 | 2019-01-09 | Koninklijke Nederlandse Akademie Van Wetenschappen | Hepatocyte expansion methods |
| KR20200065892A (ko) | 2018-11-30 | 2020-06-09 | 오가노이드사이언스 주식회사 | 오가노이드의 생체 이식용 조성물 |
| KR102133693B1 (ko) * | 2018-12-28 | 2020-07-13 | 서울대학교병원 | 타액선 유래 줄기세포를 타액선 조직으로 분화시키는 방법 및 구강 건조증 치료 또는 예방용 조성물 |
| CN111500525B (zh) * | 2019-01-30 | 2023-05-02 | 中国科学院广州生物医药与健康研究院 | 一种组合物及其应用 |
| US12600943B2 (en) | 2019-02-01 | 2026-04-14 | The University Of Hong Kong | Innervated organoid compositions and methods of making same |
| US12221630B2 (en) | 2019-02-19 | 2025-02-11 | Miltenyi Biotec B.V. & Co. KG | Cell culture medium and method for generation of epithelial organoids from epithelial stem cells |
| CN113423818A (zh) * | 2019-02-26 | 2021-09-21 | 北京大学 | 长期培养肝细胞的组合物和方法 |
| GB201906978D0 (en) | 2019-05-17 | 2019-07-03 | Koninklijke Nederlandse Akademie Van Wetenschappen | Improved culture method using integrin agonist |
| US12497597B2 (en) | 2019-05-31 | 2025-12-16 | Children's Hospital Medical Center | Methods of generating and expanding hematopoietic stem cells |
| AU2020283048A1 (en) | 2019-05-31 | 2021-12-23 | Children's Hospital Medical Center | Shaped organoid compositions and methods of making same |
| US20220404339A1 (en) * | 2019-09-17 | 2022-12-22 | The Trustees Of Indiana University | Prolonged function of liver organoids by 3d coculturing of hepatic linage cells as an in vitro model for the study of liver disease |
| WO2021081253A1 (en) | 2019-10-22 | 2021-04-29 | Tempus Labs, Inc. | Systems and methods for predicting therapeutic sensitivity |
| US11629385B2 (en) | 2019-11-22 | 2023-04-18 | Tempus Labs, Inc. | Tumor organoid culture compositions, systems, and methods |
| KR102232244B1 (ko) * | 2019-11-29 | 2021-03-24 | 고려대학교 산학협력단 | Mhy1485 또는 이의 유도체를 포함하는 체세포로부터 유도만능줄기세포로의 역분화 효율 증진용 조성물 및 이를 이용한 역분화 효율 증진 방법 |
| EP4070232A4 (en) | 2019-12-05 | 2024-01-31 | Tempus Labs, Inc. | SYSTEMS AND METHODS FOR HIGH-THROUGHPUT ACTIVE SCREENING |
| WO2021113924A1 (en) * | 2019-12-12 | 2021-06-17 | The Walter And Eliza Hall Institute Of Medical Research | Organoid cultures |
| GB202004706D0 (en) | 2020-03-31 | 2020-05-13 | Koninklijke Nederlandse Akademie Van Wetenschappen | Methods and tools for studying enteroendocrine cells |
| US11561178B2 (en) | 2020-04-20 | 2023-01-24 | Tempus Labs, Inc. | Artificial fluorescent image systems and methods |
| WO2021254296A1 (zh) * | 2020-06-14 | 2021-12-23 | 浙江大学 | 一种生物活性物质组合物、包含所述组合物的无血清培养基及其用途 |
| US20220135950A1 (en) * | 2020-11-03 | 2022-05-05 | Korea Research Institute Of Bioscience And Biotechnology | Human intestinal epithelium model and method for preparing same |
| WO2022152672A1 (en) * | 2021-01-12 | 2022-07-21 | Astrazeneca Ab | Graph construction and visualization of multiplex immunofluorescence images |
| AU2022247250A1 (en) | 2021-03-30 | 2023-11-09 | Trailhead Biosystems Inc. | Methods and compositions for generating oligodendrocyte progenitor cells |
| JP2024515805A (ja) * | 2021-04-27 | 2024-04-10 | アヴィータ・メディカル・インコーポレイテッド | 新たに脱凝集された組織に由来する再生生物活性懸濁液および臨床治療における使用方法 |
| CN113151152A (zh) * | 2021-05-11 | 2021-07-23 | 中国人民解放军军事科学院军事医学研究院 | 一种小鼠肺类器官的培养方法及其专用培养液 |
| WO2022241303A1 (en) * | 2021-05-14 | 2022-11-17 | University Of South Florida | Composition and method for treating covid-19 |
| CN113073080B (zh) * | 2021-06-03 | 2021-08-13 | 北京科途医学科技有限公司 | 一种多形性横纹肌肉瘤类器官及其培养方法、培养基和用途 |
| CN113403277B (zh) * | 2021-06-28 | 2023-05-16 | 山东省第二人民医院(山东省耳鼻喉医院、山东省耳鼻喉研究所) | 一种分离内耳fzd10阳性胶质细胞的方法 |
| GB202109913D0 (en) | 2021-07-09 | 2021-08-25 | Stichting Hubrecht Organoid Tech | Organoid-derived monolayers and uses thereof |
| WO2023074648A1 (ja) * | 2021-10-25 | 2023-05-04 | 富士フイルム株式会社 | 腸内分泌細胞を製造する方法、多能性幹細胞由来の腸内分泌細胞、培地又は培地キット、およびそれらの利用 |
| WO2023075913A1 (en) * | 2021-10-29 | 2023-05-04 | Trailhead Biosystems Inc. | Methods and compositions for generating human forebrain neural progenitor cells and for maturation thereof to parvalbumin+ interneurons |
| KR20240088578A (ko) * | 2022-11-24 | 2024-06-20 | 한국생명공학연구원 | 박막 코팅된 표면 위에서 장 줄기세포를 무이종 배양하는 법 |
| CN116478912A (zh) | 2023-06-07 | 2023-07-25 | 合肥工业大学 | 一种诱导小鼠肠道类器官定向分化为肠内分泌细胞的培养基及其应用 |
| EP4495227A1 (en) | 2023-07-18 | 2025-01-22 | HUB Organoids IP B.V. | Co-cultures of organoids and stromal cells |
| WO2025111693A1 (en) * | 2023-11-30 | 2025-06-05 | University Health Network | Generation of enterochromaffin and pancreatic cells |
| KR20250087176A (ko) * | 2023-12-07 | 2025-06-16 | 한국화학연구원 | 역분화 줄기세포 유래 염증성 장 질환 모델, 이의 제조 방법 및 이를 이용한 약물 효능 평가 방법 |
| WO2026006723A1 (en) * | 2024-06-27 | 2026-01-02 | Anand Rene | Reagents and methods for treating headache and migraine pain and co-morbidities thereof |
| CN119931962B (zh) * | 2025-04-07 | 2025-08-05 | 北京华诺泰生物医药科技有限公司 | 一种人偏肺病毒的培养方法 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2393917B1 (en) * | 2009-02-03 | 2016-04-06 | Koninklijke Nederlandse Akademie van Wetenschappen | Culture medium for epithelial stem cells and organoids comprising said stem cells. |
| EP2772534B1 (en) * | 2011-10-27 | 2019-09-18 | National University Corporation Tokyo Medical and Dental University | Culturing colorectal epithelial stem cells and transplanting colorectal epithelium |
| KR20210018540A (ko) * | 2013-02-18 | 2021-02-17 | 유니버시티 헬스 네트워크 | 다능성 줄기세포로부터 간세포 및 담관세포의 생성 방법 |
| PL2970890T3 (pl) * | 2013-03-14 | 2020-11-16 | The Brigham And Women's Hospital, Inc. | Kompozycje i sposoby ekspansji i hodowli nabłonkowych komórek macierzystych |
| US10487314B2 (en) | 2014-06-26 | 2019-11-26 | The Trustees Of Columbia University In The City Of New York | Inhibition of serotonin expression in gut enteroendocrine cells results in conversion to insulin-positive cells |
| US11021687B2 (en) * | 2016-01-08 | 2021-06-01 | The Brigham And Women's Hospital, Inc. | Production of differentiated enteroendocrine cells and insulin producing cells |
-
2016
- 2016-06-20 GB GBGB1610748.4A patent/GB201610748D0/en not_active Ceased
-
2017
- 2017-06-20 JP JP2019518148A patent/JP7525263B2/ja active Active
- 2017-06-20 WO PCT/EP2017/065101 patent/WO2017220586A1/en not_active Ceased
- 2017-06-20 SG SG11201811405QA patent/SG11201811405QA/en unknown
- 2017-06-20 CA CA3030098A patent/CA3030098A1/en active Pending
- 2017-06-20 KR KR1020197001809A patent/KR102478617B1/ko active Active
- 2017-06-20 CN CN201780047555.3A patent/CN109844098A/zh active Pending
- 2017-06-20 AU AU2017281406A patent/AU2017281406B2/en active Active
- 2017-06-20 EP EP17732860.6A patent/EP3472302A1/en active Pending
- 2017-06-20 KR KR1020227043758A patent/KR20230004913A/ko not_active Ceased
- 2017-06-20 MX MX2018016258A patent/MX2018016258A/es unknown
- 2017-06-20 US US16/310,933 patent/US20210047618A1/en not_active Abandoned
-
2018
- 2018-12-19 MX MX2025004237A patent/MX2025004237A/es unknown
- 2018-12-20 IL IL263854A patent/IL263854A/en unknown
-
2022
- 2022-02-21 JP JP2022024460A patent/JP2022068302A/ja active Pending
-
2024
- 2024-10-17 US US18/918,172 patent/US20250145963A1/en active Pending
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