JP2019526269A - 灌流バイオリアクタバッグアセンブリ - Google Patents

灌流バイオリアクタバッグアセンブリ Download PDF

Info

Publication number
JP2019526269A
JP2019526269A JP2019513829A JP2019513829A JP2019526269A JP 2019526269 A JP2019526269 A JP 2019526269A JP 2019513829 A JP2019513829 A JP 2019513829A JP 2019513829 A JP2019513829 A JP 2019513829A JP 2019526269 A JP2019526269 A JP 2019526269A
Authority
JP
Japan
Prior art keywords
port
bioreactor
cells
bag
bioreactor bag
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2019513829A
Other languages
English (en)
Japanese (ja)
Other versions
JP2019526269A5 (enExample
Inventor
パスカル ボーシュネ
パスカル ボーシュネ
クリス ダンカン バルバーグ
クリス ダンカン バルバーグ
Original Assignee
ジュノー セラピューティクス インコーポレイテッド
ジュノー セラピューティクス インコーポレイテッド
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by ジュノー セラピューティクス インコーポレイテッド, ジュノー セラピューティクス インコーポレイテッド filed Critical ジュノー セラピューティクス インコーポレイテッド
Publication of JP2019526269A publication Critical patent/JP2019526269A/ja
Publication of JP2019526269A5 publication Critical patent/JP2019526269A5/ja
Pending legal-status Critical Current

Links

Images

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M23/00—Constructional details, e.g. recesses, hinges
    • C12M23/02—Form or structure of the vessel
    • C12M23/14—Bags
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M1/00—Apparatus for enzymology or microbiology
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M23/00—Constructional details, e.g. recesses, hinges
    • C12M23/40—Manifolds; Distribution pieces
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M27/00—Means for mixing, agitating or circulating fluids in the vessel
    • C12M27/16—Vibrating; Shaking; Tilting
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M29/00—Means for introduction, extraction or recirculation of materials, e.g. pumps
    • C12M29/04—Filters; Permeable or porous membranes or plates, e.g. dialysis
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M29/00—Means for introduction, extraction or recirculation of materials, e.g. pumps
    • C12M29/10—Perfusion
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M29/00—Means for introduction, extraction or recirculation of materials, e.g. pumps
    • C12M29/24—Recirculation of gas
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M3/00—Tissue, human, animal or plant cell, or virus culture apparatus
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M3/00—Tissue, human, animal or plant cell, or virus culture apparatus
    • C12M3/06—Tissue, human, animal or plant cell, or virus culture apparatus with filtration, ultrafiltration, inverse osmosis or dialysis means

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Sustainable Development (AREA)
  • Clinical Laboratory Science (AREA)
  • Cell Biology (AREA)
  • Virology (AREA)
  • Water Supply & Treatment (AREA)
  • Medicinal Chemistry (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
JP2019513829A 2016-09-12 2017-09-12 灌流バイオリアクタバッグアセンブリ Pending JP2019526269A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201662393583P 2016-09-12 2016-09-12
US62/393,583 2016-09-12
PCT/US2017/051228 WO2018049420A1 (en) 2016-09-12 2017-09-12 Perfusion bioreactor bag assemblies

Publications (2)

Publication Number Publication Date
JP2019526269A true JP2019526269A (ja) 2019-09-19
JP2019526269A5 JP2019526269A5 (enExample) 2020-10-22

Family

ID=59955681

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2019513829A Pending JP2019526269A (ja) 2016-09-12 2017-09-12 灌流バイオリアクタバッグアセンブリ

Country Status (12)

Country Link
US (1) US20190211292A1 (enExample)
EP (1) EP3510136A1 (enExample)
JP (1) JP2019526269A (enExample)
KR (1) KR20190045321A (enExample)
CN (1) CN109890952A (enExample)
AU (1) AU2017322752A1 (enExample)
BR (1) BR112019004662A2 (enExample)
CA (1) CA3035829A1 (enExample)
MA (1) MA46194A (enExample)
MX (1) MX2019002765A (enExample)
RU (2) RU2755725C2 (enExample)
WO (1) WO2018049420A1 (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2023521726A (ja) * 2020-04-10 2023-05-25 サウスウエスト リサーチ インスティテュート ウイルスベクター産生のための３次元バイオリアクター

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11149244B2 (en) 2018-04-04 2021-10-19 Southwest Research Institute Three-dimensional bioreactor for T-cell activation and expansion for immunotherapy
US11118149B2 (en) * 2018-04-25 2021-09-14 Global Life Sciences Solutions Usa Llc Bioreactor bags
WO2020068840A1 (en) 2018-09-24 2020-04-02 Southwest Research Institute Three-dimensional bioreactors
WO2020109377A1 (en) * 2018-11-28 2020-06-04 Global Life Sciences Solutions Usa Llc Bioreactor with filter
EP3990610A4 (en) * 2019-06-30 2023-11-01 Saint-Gobain Performance Plastics Corporation CELL CULTURE SYSTEM
WO2024122708A1 (ko) * 2022-12-07 2024-06-13 주식회사 팡세 생물반응기 시스템 및 이를 이용한 세포 배양방법
WO2024122714A1 (ko) * 2022-12-07 2024-06-13 주식회사 팡세 투석장치 및 이를 포함하는 생물반응기 시스템

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2007527853A (ja) * 2003-05-01 2007-10-04 メドジニックス・インコーポレイテッド 真皮小器官及びそれを作成及び使用するための方法及び器具
JP2014507959A (ja) * 2011-03-18 2014-04-03 ジーイー・ヘルスケア・バイオサイエンス・アクチボラグ 細胞培養用可撓性バッグ
WO2016012249A1 (en) * 2014-07-25 2016-01-28 Ge Healthcare Bio-Sciences Ab Method and system for suspension culture

Family Cites Families (48)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4452773A (en) 1982-04-05 1984-06-05 Canadian Patents And Development Limited Magnetic iron-dextran microspheres
US4795698A (en) 1985-10-04 1989-01-03 Immunicon Corporation Magnetic-polymer particles
US5219740A (en) 1987-02-13 1993-06-15 Fred Hutchinson Cancer Research Center Retroviral gene transfer into diploid fibroblasts for gene therapy
ATE114507T1 (de) 1988-12-28 1994-12-15 Stefan Miltenyi Verfahren sowie materialien zur hochgraduierten magnetischen abspaltung biologischer materialien.
CA2066645A1 (en) * 1989-09-14 1991-03-15 Richard A. Knazek Method for the production of in vitro expanded lymphoid cells for use in adoptive immunotherapy
US5200084A (en) 1990-09-26 1993-04-06 Immunicon Corporation Apparatus and methods for magnetic separation
US5827642A (en) 1994-08-31 1998-10-27 Fred Hutchinson Cancer Research Center Rapid expansion method ("REM") for in vitro propagation of T lymphocytes
DE19608753C1 (de) 1996-03-06 1997-06-26 Medigene Gmbh Transduktionssystem und seine Verwendung
WO1997034634A1 (en) 1996-03-20 1997-09-25 Sloan-Kettering Institute For Cancer Research Single chain fv constructs of anti-ganglioside gd2 antibodies
DE69605062T2 (de) 1996-04-24 2000-07-13 Claude Fell Zelltrennungsvorrichtung für biologische flüssigkeiten wie blut
WO2000014257A1 (en) 1998-09-04 2000-03-16 Sloan-Kettering Institute For Cancer Research Fusion receptors specific for prostate-specific membrane antigen and uses thereof
AU2472400A (en) 1998-10-20 2000-05-08 City Of Hope CD20-specific redirected T cells and their use in cellular immunotherapy of CD20+ malignancies
ATE271890T1 (de) 1998-12-24 2004-08-15 Biosafe Sa Vorrichtung zur bluttrennung, insbesondere zur konzentrierung von hematopoietischen stammzellen
WO2001094944A2 (en) 2000-06-02 2001-12-13 Memorial Sloan-Kettering Cancer Center Artificial antigen presenting cells and methods of use thereof
EP1334188B1 (en) 2000-11-07 2006-08-30 City of Hope Cd19-specific redirected immune cells
US6544788B2 (en) * 2001-02-15 2003-04-08 Vijay Singh Disposable perfusion bioreactor for cell culture
US7070995B2 (en) 2001-04-11 2006-07-04 City Of Hope CE7-specific redirected immune cells
US20090257994A1 (en) 2001-04-30 2009-10-15 City Of Hope Chimeric immunoreceptor useful in treating human cancers
US7446190B2 (en) 2002-05-28 2008-11-04 Sloan-Kettering Institute For Cancer Research Nucleic acids encoding chimeric T cell receptors
US20050129671A1 (en) 2003-03-11 2005-06-16 City Of Hope Mammalian antigen-presenting T cells and bi-specific T cells
RU45733U1 (ru) * 2004-11-23 2005-05-27 Давыдов Владимир Николаевич Установка для осуществления микробиологических процессов
EP1893253B1 (en) 2005-03-23 2010-05-19 Biosafe S.A. Integrated system for collecting, processing and transplanting cell subsets, including adult stem cells, for regenerative medicine
PT2856876T (pt) 2007-03-30 2018-03-28 Memorial Sloan Kettering Cancer Center Expressão constitutiva de ligantes co-estimulatórios em linfócitos t adotivamente transferidos
EP3338895B1 (en) 2007-12-07 2022-08-10 Miltenyi Biotec B.V. & Co. KG Sample processing systems and methods
US8479118B2 (en) 2007-12-10 2013-07-02 Microsoft Corporation Switching search providers within a browser search box
JP5173594B2 (ja) 2008-05-27 2013-04-03 キヤノン株式会社 管理装置、画像形成装置及びそれらの処理方法
PL2451936T3 (pl) * 2009-07-06 2020-02-28 F. Hoffmann-La Roche Ag Sposób hodowli komórek eukariotycznych
WO2011142670A1 (en) * 2010-05-12 2011-11-17 Xpand Biotechnology B.V. Cell-culture-bag
PH12013501201A1 (en) 2010-12-09 2013-07-29 Univ Pennsylvania Use of chimeric antigen receptor-modified t cells to treat cancer
KR101976882B1 (ko) 2011-03-23 2019-05-09 프레드 헛친슨 켄서 리서치 센터 세포 면역요법용 방법 및 조성물
US8398282B2 (en) 2011-05-12 2013-03-19 Delphi Technologies, Inc. Vehicle front lighting assembly and systems having a variable tint electrowetting element
JP6368243B2 (ja) 2011-11-11 2018-08-08 フレッド ハッチンソン キャンサー リサーチ センター がんのためのサイクリンａ１に標的化されたｔ細胞免疫療法
TWM434774U (en) * 2012-01-19 2012-08-01 Taiwan Advance Bio Pharmaceutical Inc Suspension type closed cell culturing system allowing supply of culture additive
KR101909000B1 (ko) * 2012-02-01 2018-10-17 도요세이칸 그룹 홀딩스 가부시키가이샤 세포 배양용 키트 및 세포 배양용 키트의 사용 방법
JP6850528B2 (ja) 2012-02-13 2021-03-31 シアトル チルドレンズ ホスピタル ドゥーイング ビジネス アズ シアトル チルドレンズ リサーチ インスティテュート 二重特異性キメラ抗原受容体およびその治療的使用
WO2013126726A1 (en) 2012-02-22 2013-08-29 The Trustees Of The University Of Pennsylvania Double transgenic t cells comprising a car and a tcr and their methods of use
EP2639294A1 (fr) * 2012-03-15 2013-09-18 CellProthera Automate et procédé automatisé de culture cellulaire
RU2665548C2 (ru) 2012-05-03 2018-08-30 Фред Хатчинсон Кансэр Рисёч Сентер Способ получения клеток, экспрессирующих т-клеточный рецептор
PL2884999T3 (pl) 2012-08-20 2021-07-05 Fred Hutchinson Cancer Research Center Sposób i kompozycje do immunoterapii komórkowej
RU2729401C2 (ru) 2012-10-02 2020-08-06 Мемориал Слоан-Кеттеринг Кэнсер Сентер Композиции и способы для иммунотерапии
US9405601B2 (en) 2012-12-20 2016-08-02 Mitsubishi Electric Corporation In-vehicle apparatus and program
CN203048949U (zh) * 2012-12-29 2013-07-10 上海乐纯生物技术有限公司 细胞培养袋
US9108442B2 (en) 2013-08-20 2015-08-18 Ricoh Company, Ltd. Image forming apparatus
US11400115B2 (en) 2014-04-23 2022-08-02 Juno Therapeutics, Inc. Methods for isolating, culturing, and genetically engineering immune cell populations for adoptive therapy
CN204138670U (zh) * 2014-10-09 2015-02-04 沈阳澔源生物科技有限公司 一种细胞培养袋及其支架
CN204198747U (zh) * 2014-10-22 2015-03-11 天津灏洋华科生物科技有限公司 一种便于操作的细胞培养袋
MA40318A (fr) 2014-11-05 2017-09-13 Juno Therapeutics Inc Procédés de transduction et de traitement de cellules
CN105385597B (zh) * 2015-12-23 2018-10-12 上海吉倍生物技术有限公司 一种细胞培养袋及其应用

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2007527853A (ja) * 2003-05-01 2007-10-04 メドジニックス・インコーポレイテッド 真皮小器官及びそれを作成及び使用するための方法及び器具
JP2014507959A (ja) * 2011-03-18 2014-04-03 ジーイー・ヘルスケア・バイオサイエンス・アクチボラグ 細胞培養用可撓性バッグ
WO2016012249A1 (en) * 2014-07-25 2016-01-28 Ge Healthcare Bio-Sciences Ab Method and system for suspension culture

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2023521726A (ja) * 2020-04-10 2023-05-25 サウスウエスト リサーチ インスティテュート ウイルスベクター産生のための３次元バイオリアクター

Also Published As

Publication number Publication date
EP3510136A1 (en) 2019-07-17
BR112019004662A2 (pt) 2019-05-28
US20190211292A1 (en) 2019-07-11
KR20190045321A (ko) 2019-05-02
RU2021123536A (ru) 2022-01-14
CA3035829A1 (en) 2018-03-15
MX2019002765A (es) 2019-05-09
CN109890952A (zh) 2019-06-14
RU2019110824A (ru) 2020-10-12
MA46194A (fr) 2019-07-17
RU2019110824A3 (enExample) 2021-01-22
AU2017322752A1 (en) 2019-03-21
NZ752132A (en) 2022-03-25
RU2755725C2 (ru) 2021-09-20
WO2018049420A1 (en) 2018-03-15

Similar Documents

Publication Publication Date Title
US20240011051A1 (en) Methods for transduction and cell processing
CN111542596B (zh) 产生工程化细胞的治疗性组合物的方法
RU2755725C2 (ru) Сборочные узлы перфузионных биореакторных мешков
US20200330983A1 (en) Closed-system cryogenic vessels
NZ752132B2 (en) Perfusion bioreactor bag assemblies
HK40044236A (en) Methods for transduction and cell processing
Zah Engineering bispecific chimeric antigen receptors to improve the efficacy of adoptive T-cell therapy
NZ732130B2 (en) Methods for transduction and cell processing
HK1243120A1 (en) Methods for transduction and cell processing
HK1243120B (en) Methods for transduction and cell processing

Legal Events

Date Code Title Description
A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20190410

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20200910

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20200910

RD04 Notification of resignation of power of attorney

Free format text: JAPANESE INTERMEDIATE CODE: A7424

Effective date: 20210204

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20210624

A977 Report on retrieval

Free format text: JAPANESE INTERMEDIATE CODE: A971007

Effective date: 20210623

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20210921

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20211125

A02 Decision of refusal

Free format text: JAPANESE INTERMEDIATE CODE: A02

Effective date: 20220331