JP2019526261A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2019526261A5 JP2019526261A5 JP2019511993A JP2019511993A JP2019526261A5 JP 2019526261 A5 JP2019526261 A5 JP 2019526261A5 JP 2019511993 A JP2019511993 A JP 2019511993A JP 2019511993 A JP2019511993 A JP 2019511993A JP 2019526261 A5 JP2019526261 A5 JP 2019526261A5
- Authority
- JP
- Japan
- Prior art keywords
- modified
- fhbp
- factor binding
- foreign peptide
- binding protein
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 101710186862 Factor H binding protein Proteins 0.000 claims 16
- 108090000765 processed proteins & peptides Proteins 0.000 claims 15
- 102100030386 Granzyme A Human genes 0.000 claims 11
- 101001009599 Homo sapiens Granzyme A Proteins 0.000 claims 11
- 102000039446 nucleic acids Human genes 0.000 claims 7
- 108020004707 nucleic acids Proteins 0.000 claims 7
- 150000007523 nucleic acids Chemical class 0.000 claims 7
- 102000004169 proteins and genes Human genes 0.000 claims 5
- 108090000623 proteins and genes Proteins 0.000 claims 5
- 230000000069 prophylactic effect Effects 0.000 claims 3
- 108010060123 Conjugate Vaccines Proteins 0.000 claims 2
- 230000006229 amino acid addition Effects 0.000 claims 2
- 229940031670 conjugate vaccine Drugs 0.000 claims 2
- 238000012217 deletion Methods 0.000 claims 2
- 230000037430 deletion Effects 0.000 claims 2
- 229920001184 polypeptide Polymers 0.000 claims 2
- 229940031937 polysaccharide vaccine Drugs 0.000 claims 2
- 102000004196 processed proteins & peptides Human genes 0.000 claims 2
- 238000006467 substitution reaction Methods 0.000 claims 2
- 238000011282 treatment Methods 0.000 claims 2
- 101710116435 Outer membrane protein Proteins 0.000 claims 1
- 238000007792 addition Methods 0.000 claims 1
- 239000002671 adjuvant Substances 0.000 claims 1
- 125000003275 alpha amino acid group Chemical group 0.000 claims 1
- 125000000539 amino acid group Chemical group 0.000 claims 1
- 150000001413 amino acids Chemical class 0.000 claims 1
- 239000000427 antigen Substances 0.000 claims 1
- 102000036639 antigens Human genes 0.000 claims 1
- 108091007433 antigens Proteins 0.000 claims 1
- 230000027455 binding Effects 0.000 claims 1
- 102000023732 binding proteins Human genes 0.000 claims 1
- 108091008324 binding proteins Proteins 0.000 claims 1
- 229940079593 drug Drugs 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 239000012634 fragment Substances 0.000 claims 1
- 208000015181 infectious disease Diseases 0.000 claims 1
- 230000004048 modification Effects 0.000 claims 1
- 238000012986 modification Methods 0.000 claims 1
- 230000001717 pathogenic effect Effects 0.000 claims 1
- 230000002265 prevention Effects 0.000 claims 1
- 238000011321 prophylaxis Methods 0.000 claims 1
- 230000001225 therapeutic effect Effects 0.000 claims 1
- 229960005486 vaccine Drugs 0.000 claims 1
- 239000013598 vector Substances 0.000 claims 1
- 239000013603 viral vector Substances 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB1614687.0 | 2016-08-31 | ||
| GBGB1614687.0A GB201614687D0 (en) | 2016-08-31 | 2016-08-31 | fHbp scaffold |
| PCT/GB2017/052535 WO2018042178A1 (en) | 2016-08-31 | 2017-08-31 | Modified factor h binding protein |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2019526261A JP2019526261A (ja) | 2019-09-19 |
| JP2019526261A5 true JP2019526261A5 (cg-RX-API-DMAC7.html) | 2020-10-08 |
| JP7525093B2 JP7525093B2 (ja) | 2024-07-30 |
Family
ID=57119942
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019511993A Active JP7525093B2 (ja) | 2016-08-31 | 2017-08-31 | 改変ｈ因子結合タンパク質 |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US12497432B2 (cg-RX-API-DMAC7.html) |
| EP (1) | EP3506934A1 (cg-RX-API-DMAC7.html) |
| JP (1) | JP7525093B2 (cg-RX-API-DMAC7.html) |
| KR (1) | KR102643280B1 (cg-RX-API-DMAC7.html) |
| CN (1) | CN109890412B (cg-RX-API-DMAC7.html) |
| AU (1) | AU2017319218B2 (cg-RX-API-DMAC7.html) |
| BR (1) | BR112019003957A2 (cg-RX-API-DMAC7.html) |
| CA (1) | CA3035159A1 (cg-RX-API-DMAC7.html) |
| GB (2) | GB201614687D0 (cg-RX-API-DMAC7.html) |
| IL (1) | IL265078B2 (cg-RX-API-DMAC7.html) |
| MX (1) | MX420767B (cg-RX-API-DMAC7.html) |
| WO (1) | WO2018042178A1 (cg-RX-API-DMAC7.html) |
| ZA (1) | ZA201901862B (cg-RX-API-DMAC7.html) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB201614687D0 (en) * | 2016-08-31 | 2016-10-12 | Univ Oxford Innovation Ltd | fHbp scaffold |
| CN110903400A (zh) * | 2019-11-08 | 2020-03-24 | 苏州微超生物科技有限公司 | B群脑膜炎球菌fHBP多变体融合蛋白及其制备方法与应用 |
| CN111533792B (zh) * | 2020-07-07 | 2020-10-16 | 康希诺生物股份公司 | 一种定点突变的载体蛋白及其在制备疫苗中的用途 |
| WO2022071291A1 (ja) * | 2020-09-29 | 2022-04-07 | 出光興産株式会社 | ペプチドタグおよびそれを含むタグ付加タンパク質 |
| IN202321021121A (cg-RX-API-DMAC7.html) * | 2023-03-24 | 2024-04-19 |
Family Cites Families (47)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MX339524B (es) * | 2001-10-11 | 2016-05-30 | Wyeth Corp | Composiciones inmunogenicas novedosas para la prevencion y tratamiento de enfermedad meningococica. |
| US7351413B2 (en) * | 2002-02-21 | 2008-04-01 | Lorantis, Limited | Stabilized HBc chimer particles as immunogens for chronic hepatitis |
| US7785608B2 (en) * | 2002-08-30 | 2010-08-31 | Wyeth Holdings Corporation | Immunogenic compositions for the prevention and treatment of meningococcal disease |
| ATE492288T1 (de) * | 2002-10-11 | 2011-01-15 | Novartis Vaccines & Diagnostic | Polypeptidimpstoffe zum breiten schutz gegen hypervirulente meningokokken-linien |
| GB0227346D0 (en) * | 2002-11-22 | 2002-12-31 | Chiron Spa | 741 |
| KR100991679B1 (ko) * | 2002-12-10 | 2010-11-04 | 셀덱스 테라퓨틱스 리미티드 | 안정화 면역원성 ＨＢｃ 키메라 입자 |
| CN102302776B (zh) * | 2003-01-30 | 2014-06-18 | 诺华疫苗和诊断有限公司 | 抗多种脑膜炎球菌血清组的可注射性疫苗 |
| CN103405761A (zh) * | 2003-10-02 | 2013-11-27 | 诺华疫苗和诊断有限公司 | 多种脑膜炎球菌血清群的液体疫苗 |
| GB0408977D0 (en) * | 2004-04-22 | 2004-05-26 | Chiron Srl | Immunising against meningococcal serogroup Y using proteins |
| GB2414667A (en) * | 2004-06-03 | 2005-12-07 | Isis Innovation | Vaccine compositions of N. meningitidis PorA and FetA antigens |
| ATE493437T1 (de) * | 2004-07-23 | 2011-01-15 | Novartis Vaccines & Diagnostic | Polypeptide für die oligomerisierung von antigenen |
| GB0419408D0 (en) * | 2004-09-01 | 2004-10-06 | Chiron Srl | 741 chimeric polypeptides |
| MX2007008785A (es) * | 2005-01-27 | 2008-02-15 | Childrens Hosp & Res Ct Oak | Vacunas de vesicula basadas en gna1870 para proteccion de amplio espectro contra padecimientos causados por neisseria meningitidis. |
| GB0524066D0 (en) * | 2005-11-25 | 2006-01-04 | Chiron Srl | 741 ii |
| EP1925318A1 (en) * | 2006-11-20 | 2008-05-28 | Paul-Ehrlich-Institut | Recombinant modified vaccinia virus Ankara (MVA)-based vaccine for the avian flu |
| US9579372B2 (en) * | 2008-02-21 | 2017-02-28 | Glaxosmithkline Biologicals Sa | Meningococcal fHBP polypeptides |
| EP2631245A1 (en) | 2008-03-10 | 2013-08-28 | Children's Hospital & Research Center at Oakland | Chimeric factor H binding proteins (fHBP) containing a heterologous B domain and methods of use |
| KR20110053314A (ko) * | 2008-05-30 | 2011-05-20 | 더 유에스에이, 애즈 리프리젠티드 바이 더 세크리터리 오브 더 아미, 온 비하프 오브 월터 리드 아미 | 수막구균성 다가 천연 외막 소포체 백신, 이의 제조 방법 및 사용 방법 |
| WO2009150531A1 (en) * | 2008-06-09 | 2009-12-17 | Novartis Ag | Antibodies against neisserial factor h binding protein |
| US8470340B2 (en) * | 2008-09-03 | 2013-06-25 | Children's Hospital & Research Center Oakland | Peptides presenting an epitope of a domain of factor H binding protein and methods of use |
| GB0819633D0 (en) * | 2008-10-25 | 2008-12-03 | Isis Innovation | Composition |
| HRP20201076T1 (hr) * | 2009-03-24 | 2020-10-30 | Glaxosmithkline Biologicals Sa | Adjuvantni vezujući protein meningokokalnog faktora h |
| WO2010127172A2 (en) * | 2009-04-30 | 2010-11-04 | Children's Hospital & Research Center At Oakland | Chimeric factor h binding proteins (fhbp) and methods of use |
| NZ622048A (en) * | 2009-08-27 | 2015-10-30 | Novartis Ag | Hybrid polypeptides including meningococcal fhbp sequences |
| AU2010310985B2 (en) * | 2009-10-27 | 2014-11-06 | Glaxosmithkline Biologicals S.A. | Modified meningococcal fHBP polypeptides |
| US9567377B2 (en) * | 2010-03-10 | 2017-02-14 | Glaxosmithkline Biologicals Sa | Immunogenic composition |
| ES2661569T3 (es) * | 2010-03-30 | 2018-04-02 | Children's Hospital & Research Center At Oakland | Proteínas de unión al factor H (fHbp) con propiedades alteradas y métodos de uso de las mismas |
| WO2011125015A2 (en) * | 2010-04-05 | 2011-10-13 | Bar-Ilan University | Protease-activatable pore-forming polypeptides |
| US10478483B2 (en) * | 2010-06-25 | 2019-11-19 | Glaxosmithkline Biologicals Sa | Combinations of meningococcal factor H binding proteins |
| CA2809758C (en) * | 2010-09-10 | 2021-07-13 | Wyeth Llc | Non-lipidated variants of neisseria meningitidis orf2086 antigens |
| GB201015132D0 (en) | 2010-09-10 | 2010-10-27 | Univ Bristol | Vaccine composition |
| WO2013078223A1 (en) * | 2011-11-23 | 2013-05-30 | Children's Hospital & Research Center Oakland | Anti-factor h binding protein antibodies and methods of use thereof |
| AU2011384634A1 (en) * | 2011-12-29 | 2014-06-19 | Novartis Ag | Adjuvanted combinations of meningococcal factor H binding proteins |
| WO2013132040A2 (en) * | 2012-03-08 | 2013-09-12 | Novartis Ag | In vitro potency assay for protein-based meningococcal vaccines |
| SA115360586B1 (ar) * | 2012-03-09 | 2017-04-12 | فايزر انك | تركيبات لعلاج الالتهاب السحائي البكتيري وطرق لتحضيرها |
| MX351993B (es) * | 2012-03-09 | 2017-11-03 | Pfizer | Composiciones de neisseria meningitidis y metodos de las mismas. |
| CN104602704B (zh) * | 2012-06-14 | 2019-08-06 | 诺华股份有限公司 | 针对血清组x脑膜炎球菌的疫苗 |
| GB201215005D0 (en) * | 2012-08-23 | 2012-10-10 | Isis Innovation | Stabilised meningitis vaccine |
| ES2685894T3 (es) * | 2013-03-08 | 2018-10-15 | Pfizer Inc. | Polipéptidos de fusión inmunogénicos |
| US20160030544A1 (en) * | 2013-03-14 | 2016-02-04 | Isis Innovation Limited | Immunogenic composition to neisseria |
| MX380129B (es) * | 2013-09-08 | 2025-03-11 | Pfizer | Composiciones de neisseria meningitidis y sus metodos |
| SG10201907875TA (en) * | 2014-02-28 | 2019-09-27 | Glaxosmithkline Biologicals Sa | Modified meningococcal fhbp polypeptides |
| ES2922554T3 (es) * | 2014-07-23 | 2022-09-16 | Childrens Hospital & Res Center At Oakland | Variantes de proteínas de unión al factor H y métodos de uso de las mismas |
| US20170326220A1 (en) * | 2014-11-28 | 2017-11-16 | Janssen Vaccines & Prevention B.V. | Meningitis b vaccine |
| CN107249626A (zh) * | 2015-02-19 | 2017-10-13 | 辉瑞大药厂 | 脑膜炎奈瑟球菌组合物及其方法 |
| GB201614687D0 (en) * | 2016-08-31 | 2016-10-12 | Univ Oxford Innovation Ltd | fHbp scaffold |
| IL267733B2 (en) * | 2017-01-31 | 2023-10-01 | Pfizer | Neisseria meningitidis compositions and methods thereof |
-
2016
- 2016-08-31 GB GBGB1614687.0A patent/GB201614687D0/en not_active Ceased
-
2017
- 2017-08-31 WO PCT/GB2017/052535 patent/WO2018042178A1/en not_active Ceased
- 2017-08-31 KR KR1020197008694A patent/KR102643280B1/ko active Active
- 2017-08-31 JP JP2019511993A patent/JP7525093B2/ja active Active
- 2017-08-31 EP EP17762178.6A patent/EP3506934A1/en active Pending
- 2017-08-31 BR BR112019003957A patent/BR112019003957A2/pt unknown
- 2017-08-31 AU AU2017319218A patent/AU2017319218B2/en active Active
- 2017-08-31 GB GB1903866.0A patent/GB2568440B/en active Active
- 2017-08-31 CN CN201780060701.6A patent/CN109890412B/zh active Active
- 2017-08-31 MX MX2019002248A patent/MX420767B/es unknown
- 2017-08-31 CA CA3035159A patent/CA3035159A1/en active Pending
- 2017-08-31 US US16/328,340 patent/US12497432B2/en active Active
-
2019
- 2019-02-27 IL IL265078A patent/IL265078B2/en unknown
- 2019-03-26 ZA ZA2019/01862A patent/ZA201901862B/en unknown