JP2019524821A5 - - Google Patents
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- Publication number
- JP2019524821A5 JP2019524821A5 JP2019507811A JP2019507811A JP2019524821A5 JP 2019524821 A5 JP2019524821 A5 JP 2019524821A5 JP 2019507811 A JP2019507811 A JP 2019507811A JP 2019507811 A JP2019507811 A JP 2019507811A JP 2019524821 A5 JP2019524821 A5 JP 2019524821A5
- Authority
- JP
- Japan
- Prior art keywords
- leucine
- acetyl
- pharmaceutically acceptable
- acceptable salt
- subject
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Priority Applications (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2022001694A JP2022050564A (ja) | 2016-08-11 | 2022-01-07 | リソソーム蓄積障害に関する医薬組成物及び使用 |
| JP2024027864A JP7757446B2 (ja) | 2016-08-11 | 2024-02-27 | リソソーム蓄積障害に関する医薬組成物及び使用 |
| JP2025170034A JP2025188157A (ja) | 2016-08-11 | 2025-10-08 | リソソーム蓄積障害に関する医薬組成物及び使用 |
Applications Claiming Priority (9)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB1613828.1 | 2016-08-11 | ||
| GBGB1613828.1A GB201613828D0 (en) | 2016-08-11 | 2016-08-11 | Therapeutic agents for lysosomal storage disorders |
| GB1702552.9 | 2017-02-16 | ||
| GBGB1702552.9A GB201702552D0 (en) | 2017-02-16 | 2017-02-16 | Therapeutic agents for lysosomal storage disorders |
| GB1705762.1 | 2017-04-10 | ||
| GBGB1705762.1A GB201705762D0 (en) | 2017-04-10 | 2017-04-10 | Therapeutic agents for lysosomal storage disorders |
| GB1706854.5 | 2017-04-28 | ||
| GBGB1706854.5A GB201706854D0 (en) | 2017-04-28 | 2017-04-28 | Therapeutic agents for lysosomal storage disorders |
| PCT/IB2017/054928 WO2018029657A1 (en) | 2016-08-11 | 2017-08-11 | Pharmaceutical compositions and uses directed to lysosomal storage disorders |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022001694A Division JP2022050564A (ja) | 2016-08-11 | 2022-01-07 | リソソーム蓄積障害に関する医薬組成物及び使用 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2019524821A JP2019524821A (ja) | 2019-09-05 |
| JP2019524821A5 true JP2019524821A5 (https=) | 2020-09-17 |
| JP7393943B2 JP7393943B2 (ja) | 2023-12-07 |
Family
ID=59859423
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019507811A Active JP7393943B2 (ja) | 2016-08-11 | 2017-08-11 | リソソーム蓄積障害に関する医薬組成物及び使用 |
| JP2022001694A Pending JP2022050564A (ja) | 2016-08-11 | 2022-01-07 | リソソーム蓄積障害に関する医薬組成物及び使用 |
| JP2024027864A Active JP7757446B2 (ja) | 2016-08-11 | 2024-02-27 | リソソーム蓄積障害に関する医薬組成物及び使用 |
| JP2025170034A Pending JP2025188157A (ja) | 2016-08-11 | 2025-10-08 | リソソーム蓄積障害に関する医薬組成物及び使用 |
Family Applications After (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022001694A Pending JP2022050564A (ja) | 2016-08-11 | 2022-01-07 | リソソーム蓄積障害に関する医薬組成物及び使用 |
| JP2024027864A Active JP7757446B2 (ja) | 2016-08-11 | 2024-02-27 | リソソーム蓄積障害に関する医薬組成物及び使用 |
| JP2025170034A Pending JP2025188157A (ja) | 2016-08-11 | 2025-10-08 | リソソーム蓄積障害に関する医薬組成物及び使用 |
Country Status (30)
| Country | Link |
|---|---|
| US (4) | US11400067B2 (https=) |
| EP (4) | EP3482754B1 (https=) |
| JP (4) | JP7393943B2 (https=) |
| KR (4) | KR20220154849A (https=) |
| CN (3) | CN109843275B (https=) |
| AU (3) | AU2017308864B2 (https=) |
| CA (1) | CA3033557A1 (https=) |
| CY (2) | CY1121345T1 (https=) |
| DK (2) | DK3359146T3 (https=) |
| ES (2) | ES2849566T3 (https=) |
| FI (1) | FIC20260014I1 (https=) |
| HK (1) | HK1253282B (https=) |
| HR (2) | HRP20190344T1 (https=) |
| HU (2) | HUE052837T2 (https=) |
| IL (2) | IL314107A (https=) |
| LT (2) | LT3482754T (https=) |
| MA (2) | MA43876B1 (https=) |
| MD (2) | MD3359146T2 (https=) |
| ME (1) | ME03340B (https=) |
| MX (2) | MX384447B (https=) |
| NZ (3) | NZ790895A (https=) |
| PL (2) | PL3482754T3 (https=) |
| PT (2) | PT3482754T (https=) |
| RS (2) | RS61442B1 (https=) |
| RU (1) | RU2749515C2 (https=) |
| SG (1) | SG11201901048VA (https=) |
| SI (2) | SI3359146T1 (https=) |
| SM (2) | SMT202100050T1 (https=) |
| TN (1) | TN2019000032A1 (https=) |
| WO (1) | WO2018029657A1 (https=) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK3359146T3 (en) * | 2016-08-11 | 2019-04-08 | Intrabio Ltd | PHARMACEUTICAL COMPOSITIONS AND USES AGAINST LYSOSOMAL STORAGE DISEASES |
| GB201709459D0 (en) | 2017-06-14 | 2017-07-26 | Intrabio Ltd | Treatment for migraine |
| EP3886986A1 (en) * | 2018-12-06 | 2021-10-06 | IntraBio Ltd | Deuterated analogs of acetyl-leucine |
| SMT202400334T1 (it) * | 2019-03-02 | 2024-09-16 | Intrabio Ltd | (n-)acetil-l-leucina per il trattamento di lesioni cerebrali traumatiche |
| RS67283B1 (sr) | 2019-06-28 | 2025-11-28 | Intrabio Ltd | Kombinovana terapija sa acetil-leucinom i miglustatom za lečenje bolesti lizozomskog skladištenja |
| WO2022264037A1 (en) * | 2021-06-14 | 2022-12-22 | Intrabio Ltd. | Branched-chain amino acid derivatives to treat disease |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2749512B1 (fr) * | 1996-06-10 | 1999-08-13 | Pf Medicament | Utilisation de l'acetyl dl leucine pour le traitement des tremblements |
| AU2001269923A1 (en) | 2000-06-19 | 2002-01-02 | Genzyme Corporation | Combination enzyme replacement, gene therapy and small molecule therapy for lysosomal storage diseases |
| FR2883180B1 (fr) | 2005-03-18 | 2007-05-25 | Pierre Fabre Medicament Sa | Utilisation de l'acetyl-leucine pour la preparation d'un medicament destine au traitement de troubles de l'equilibre |
| FR2905600B1 (fr) | 2006-09-13 | 2010-01-15 | Pf Medicament | Traitement des vertiges par l'acetyl-l-leucine. |
| WO2009114729A2 (en) * | 2008-03-14 | 2009-09-17 | Irm Llc | Compounds, compositions and methods for treating lysosomal storage diseases and disorders |
| TN2010000251A1 (fr) | 2010-06-03 | 2011-11-11 | Rekik Raouf | N-acetyl-dl-leucine medicament neuro et retino protecteur |
| TN2010000566A1 (en) | 2010-12-03 | 2012-05-24 | Rekik Raouf | Folic acid - ramipril combination : cell protective neuroprotective and retinoprotective ophtalmologic drugs |
| GB201114017D0 (en) | 2011-08-15 | 2011-09-28 | Univ Dundee | Inhibitors against endosomal/ysosomal enzymes |
| JP2015518872A (ja) | 2012-06-06 | 2015-07-06 | フォンダッツィオーネ・テレソン | アロステリックシャペロンおよびその使用 |
| KR102247701B1 (ko) | 2016-02-26 | 2021-05-03 | 한미정밀화학주식회사 | 폴리에틸렌글리콜 디알데히드 유도체의 제조방법 |
| WO2018029658A1 (en) | 2016-08-11 | 2018-02-15 | Intrabio Limited | Therapeutic agents for neurodegenerative diseases |
| DK3359146T3 (en) | 2016-08-11 | 2019-04-08 | Intrabio Ltd | PHARMACEUTICAL COMPOSITIONS AND USES AGAINST LYSOSOMAL STORAGE DISEASES |
-
2017
- 2017-08-11 DK DK17767933.9T patent/DK3359146T3/en active
- 2017-08-11 KR KR1020227039341A patent/KR20220154849A/ko not_active Ceased
- 2017-08-11 RU RU2019106493A patent/RU2749515C2/ru active
- 2017-08-11 EP EP18210763.1A patent/EP3482754B1/en active Active
- 2017-08-11 KR KR1020227009897A patent/KR102467953B1/ko active Active
- 2017-08-11 IL IL314107A patent/IL314107A/en unknown
- 2017-08-11 SG SG11201901048VA patent/SG11201901048VA/en unknown
- 2017-08-11 NZ NZ790895A patent/NZ790895A/en unknown
- 2017-08-11 RS RS20210064A patent/RS61442B1/sr unknown
- 2017-08-11 ES ES18210763T patent/ES2849566T3/es active Active
- 2017-08-11 SI SI201730032T patent/SI3359146T1/sl unknown
- 2017-08-11 PT PT182107631T patent/PT3482754T/pt unknown
- 2017-08-11 JP JP2019507811A patent/JP7393943B2/ja active Active
- 2017-08-11 ES ES17767933T patent/ES2716133T3/es active Active
- 2017-08-11 NZ NZ790894A patent/NZ790894A/en unknown
- 2017-08-11 SM SM20210050T patent/SMT202100050T1/it unknown
- 2017-08-11 HK HK18112571.2A patent/HK1253282B/en unknown
- 2017-08-11 IL IL264610A patent/IL264610B2/en unknown
- 2017-08-11 HR HRP20190344TT patent/HRP20190344T1/hr unknown
- 2017-08-11 WO PCT/IB2017/054928 patent/WO2018029657A1/en not_active Ceased
- 2017-08-11 MA MA43876A patent/MA43876B1/fr unknown
- 2017-08-11 KR KR1020247021734A patent/KR20240110078A/ko active Pending
- 2017-08-11 PT PT17767933T patent/PT3359146T/pt unknown
- 2017-08-11 DK DK18210763.1T patent/DK3482754T3/da active
- 2017-08-11 SM SM20190154T patent/SMT201900154T1/it unknown
- 2017-08-11 RS RS20190334A patent/RS58478B1/sr unknown
- 2017-08-11 PL PL18210763T patent/PL3482754T3/pl unknown
- 2017-08-11 CN CN201780062740.XA patent/CN109843275B/zh active Active
- 2017-08-11 LT LTEP18210763.1T patent/LT3482754T/lt unknown
- 2017-08-11 EP EP17767933.9A patent/EP3359146B1/en active Active
- 2017-08-11 LT LTEP17767933.9T patent/LT3359146T/lt unknown
- 2017-08-11 MA MA055947A patent/MA55947A/fr unknown
- 2017-08-11 HU HUE18210763A patent/HUE052837T2/hu unknown
- 2017-08-11 CA CA3033557A patent/CA3033557A1/en active Pending
- 2017-08-11 SI SI201730613T patent/SI3482754T1/sl unknown
- 2017-08-11 ME MEP-2019-60A patent/ME03340B/me unknown
- 2017-08-11 MD MDE20181131T patent/MD3359146T2/ro unknown
- 2017-08-11 MD MDE20190593T patent/MD3482754T2/ro unknown
- 2017-08-11 EP EP24154769.4A patent/EP4342461A3/en active Pending
- 2017-08-11 TN TNP/2019/000032A patent/TN2019000032A1/en unknown
- 2017-08-11 CN CN202511761192.2A patent/CN121360107A/zh active Pending
- 2017-08-11 KR KR1020197007024A patent/KR102412724B1/ko active Active
- 2017-08-11 MX MX2019001577A patent/MX384447B/es unknown
- 2017-08-11 HU HUE17767933A patent/HUE041914T2/hu unknown
- 2017-08-11 AU AU2017308864A patent/AU2017308864B2/en active Active
- 2017-08-11 NZ NZ750391A patent/NZ750391A/en unknown
- 2017-08-11 PL PL17767933T patent/PL3359146T3/pl unknown
- 2017-08-11 US US16/324,301 patent/US11400067B2/en active Active
- 2017-08-11 CN CN202511761193.7A patent/CN121360108A/zh active Pending
- 2017-08-11 EP EP20215877.0A patent/EP3865126A1/en active Pending
-
2019
- 2019-02-07 MX MX2021008432A patent/MX2021008432A/es unknown
- 2019-03-08 CY CY20191100279T patent/CY1121345T1/el unknown
-
2021
- 2021-01-12 CY CY20211100017T patent/CY1123844T1/el unknown
- 2021-01-29 HR HRP20210153TT patent/HRP20210153T1/hr unknown
-
2022
- 2022-01-07 JP JP2022001694A patent/JP2022050564A/ja active Pending
- 2022-06-30 US US17/854,027 patent/US12433862B2/en active Active
-
2023
- 2023-05-10 AU AU2023202903A patent/AU2023202903B2/en active Active
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2024
- 2024-02-02 US US18/430,858 patent/US12433863B2/en active Active
- 2024-02-27 JP JP2024027864A patent/JP7757446B2/ja active Active
-
2025
- 2025-05-14 AU AU2025203479A patent/AU2025203479A1/en active Pending
- 2025-08-06 US US19/292,431 patent/US20260027077A1/en active Pending
- 2025-10-08 JP JP2025170034A patent/JP2025188157A/ja active Pending
-
2026
- 2026-04-27 FI FIC20260014C patent/FIC20260014I1/fi unknown
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