JP2019523761A5 - - Google Patents
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- JP2019523761A5 JP2019523761A5 JP2018562186A JP2018562186A JP2019523761A5 JP 2019523761 A5 JP2019523761 A5 JP 2019523761A5 JP 2018562186 A JP2018562186 A JP 2018562186A JP 2018562186 A JP2018562186 A JP 2018562186A JP 2019523761 A5 JP2019523761 A5 JP 2019523761A5
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- Japan
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- pab
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- Prior art date
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Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2021143103A JP7403507B2 (ja) | 2016-05-31 | 2021-09-02 | 薬物としてアマトキシンの誘導体を有する抗体薬物コンジュゲート |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662343825P | 2016-05-31 | 2016-05-31 | |
| US62/343,825 | 2016-05-31 | ||
| PCT/US2017/035206 WO2017210288A1 (en) | 2016-05-31 | 2017-05-31 | Antibody drug conjugates having derivatives of amatoxin as the drug |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021143103A Division JP7403507B2 (ja) | 2016-05-31 | 2021-09-02 | 薬物としてアマトキシンの誘導体を有する抗体薬物コンジュゲート |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2019523761A JP2019523761A (ja) | 2019-08-29 |
| JP2019523761A5 true JP2019523761A5 (enExample) | 2020-07-09 |
| JP7103953B2 JP7103953B2 (ja) | 2022-07-20 |
Family
ID=60421192
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018562186A Expired - Fee Related JP7103953B2 (ja) | 2016-05-31 | 2017-05-31 | 薬物としてアマトキシンの誘導体を有する抗体薬物コンジュゲート |
| JP2021143103A Active JP7403507B2 (ja) | 2016-05-31 | 2021-09-02 | 薬物としてアマトキシンの誘導体を有する抗体薬物コンジュゲート |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021143103A Active JP7403507B2 (ja) | 2016-05-31 | 2021-09-02 | 薬物としてアマトキシンの誘導体を有する抗体薬物コンジュゲート |
Country Status (6)
| Country | Link |
|---|---|
| US (2) | US11013816B2 (enExample) |
| EP (1) | EP3471771A4 (enExample) |
| JP (2) | JP7103953B2 (enExample) |
| CN (2) | CN115645544A (enExample) |
| CA (1) | CA3025931A1 (enExample) |
| WO (1) | WO2017210288A1 (enExample) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US11013816B2 (en) * | 2016-05-31 | 2021-05-25 | Sorrento Therapeutics, Inc. | Antibody drug conjugates having derivatives of amatoxin as the drug |
| CN109641051A (zh) | 2016-06-17 | 2019-04-16 | 美真达治疗公司 | 用于耗尽细胞的组合物和方法 |
| SG11201906319XA (en) | 2017-01-20 | 2019-08-27 | Magenta Therapeutics Inc | Compositions and methods for the depletion of cd137+ cells |
| EP3773740A1 (en) | 2018-04-13 | 2021-02-17 | Heidelberg Pharma Research GmbH | Targeted amatoxin conjugate for the treatment of solid tumors |
| CA3128264A1 (en) * | 2019-01-31 | 2020-08-06 | Hangzhou Dac Biotech Co., Ltd | A conjugate of an amanita toxin with branched linkers |
| WO2020216947A1 (en) * | 2019-04-24 | 2020-10-29 | Heidelberg Pharma Research Gmbh | Amatoxin antibody-drug conjugates and uses thereof |
| CA3144784A1 (en) * | 2019-06-24 | 2020-12-30 | Hangzhou Dac Biotech Co., Ltd | A conjugate of a cytotoxic agent to a cell binding molecule with branched linkers |
| CA3175048A1 (en) * | 2020-03-25 | 2021-09-30 | Jiangsu Hengrui Pharmaceuticals Co., Ltd. | Preparation method for antibody medicament conjugate |
| WO2022184082A1 (en) | 2021-03-03 | 2022-09-09 | Sorrento Therapeutics, Inc. | Antibody-drug conjugates comprising an anti-bcma antibody |
| MX2023011031A (es) | 2021-03-19 | 2023-12-14 | Heidelberg Pharma Res Gmbh | Conjugados de amatoxina y anticuerpo especificos de linfocitos b. |
| US20240252665A1 (en) * | 2021-06-02 | 2024-08-01 | Sichuan Kelun-Biotech Biopharmaceutical Co., Ltd. | Chemical coupling linker and use thereof |
| CN113980909B (zh) * | 2021-11-16 | 2022-06-14 | 江南大学 | 一种α-鹅膏蕈碱人工抗原、单克隆抗体、杂交瘤细胞株及应用 |
| JP2025509286A (ja) | 2022-03-10 | 2025-04-11 | ビバソル， インコーポレイテッド | 抗体－薬物コンジュゲートおよびその使用 |
| CN121985963A (zh) | 2023-04-05 | 2026-05-05 | 维硕公司 | 抗体偶联药物及其用途 |
| WO2024211234A1 (en) | 2023-04-05 | 2024-10-10 | Sorrento Therapeutics, Inc. | Antibody-drug conjugates and uses thereof |
| WO2024211236A2 (en) | 2023-04-05 | 2024-10-10 | Sorrento Therapeutics, Inc. | Antibody-drug conjugates and uses thereof |
| WO2024243706A1 (en) * | 2023-06-02 | 2024-12-05 | The University Of British Columbia | Amatoxin analogs and uses thereof |
| CN117683079B (zh) * | 2023-12-12 | 2025-04-04 | 九洲药业(杭州)有限公司 | 一种抗体偶联药物连接子的固相合成方法 |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BRPI0510909A2 (pt) * | 2004-05-19 | 2008-12-16 | Medarex Inc | composto de ligaÇço fÁrmaco-ligante citotàxico, formulaÇço farmacÊutica, mÉtodo para matar uma cÉlula e mÉtodo para retardar ou interromper o crescimento de tumor |
| EP3192529B1 (en) | 2009-04-08 | 2020-03-25 | Faulstich, Heinz, Dr. | Amatoxin-armed therapeutic cell surface binding components designed for tumour therapy |
| FR2947320B1 (fr) | 2009-06-30 | 2011-07-22 | Valeo Systemes Thermiques | Vanne de commande pour un circuit de refroidissement d'un moteur de vehicule automobile |
| ES2402254T3 (es) | 2010-09-30 | 2013-04-30 | Heidelberg Pharma Ag | Conjugados de amatoxinas con ligadores mejorados |
| CN104640572B (zh) * | 2012-05-15 | 2018-04-27 | 索伦托医疗有限公司 | 药物偶联物，偶联方法，及其用途 |
| US20150218220A1 (en) * | 2012-09-12 | 2015-08-06 | Brian Alan MENDELSOHN | Amatoxin derivatives and cell-permeable conjugates thereof as inhibitors of rna polymerase |
| MX369758B (es) * | 2013-05-31 | 2019-11-20 | Genentech Inc | Anticuerpos anti-acido teicoico de pared y conjugados. |
| AU2014337317A1 (en) * | 2013-10-15 | 2016-09-15 | Sorrento Therapeutics Inc. | Drug-conjugates with a targeting molecule and two different drugs |
| US9239324B2 (en) | 2013-12-06 | 2016-01-19 | Gang Chen | Antibody-binding protein-drug conjugate and methods of use |
| UA118113C2 (uk) * | 2013-12-16 | 2018-11-26 | Дженентек, Інк. | Пептидоміметичні сполуки та їх кон'югати антитіла з лікарським засобом |
| US10973920B2 (en) * | 2014-06-30 | 2021-04-13 | Glykos Finland Oy | Saccharide derivative of a toxic payload and antibody conjugates thereof |
| EP3164420A4 (en) * | 2014-06-30 | 2018-05-23 | Tarveda Therapeutics, Inc. | Targeted conjugates and particles and formulations thereof |
| US11013816B2 (en) * | 2016-05-31 | 2021-05-25 | Sorrento Therapeutics, Inc. | Antibody drug conjugates having derivatives of amatoxin as the drug |
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2017
- 2017-05-31 US US15/609,858 patent/US11013816B2/en not_active Expired - Fee Related
- 2017-05-31 JP JP2018562186A patent/JP7103953B2/ja not_active Expired - Fee Related
- 2017-05-31 CN CN202211405532.4A patent/CN115645544A/zh active Pending
- 2017-05-31 EP EP17807392.0A patent/EP3471771A4/en not_active Withdrawn
- 2017-05-31 WO PCT/US2017/035206 patent/WO2017210288A1/en not_active Ceased
- 2017-05-31 CA CA3025931A patent/CA3025931A1/en active Pending
- 2017-05-31 CN CN201780033085.5A patent/CN109195631B/zh not_active Expired - Fee Related
-
2021
- 2021-04-26 US US17/240,700 patent/US20210260211A1/en not_active Abandoned
- 2021-09-02 JP JP2021143103A patent/JP7403507B2/ja active Active