JP2019523641A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2019523641A5 JP2019523641A5 JP2018561228A JP2018561228A JP2019523641A5 JP 2019523641 A5 JP2019523641 A5 JP 2019523641A5 JP 2018561228 A JP2018561228 A JP 2018561228A JP 2018561228 A JP2018561228 A JP 2018561228A JP 2019523641 A5 JP2019523641 A5 JP 2019523641A5
- Authority
- JP
- Japan
- Prior art keywords
- amplification
- copy number
- subject
- gain
- expression level
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 238000000034 method Methods 0.000 claims description 116
- 230000014509 gene expression Effects 0.000 claims description 74
- 102100039189 Transcription factor Maf Human genes 0.000 claims description 73
- 230000003321 amplification Effects 0.000 claims description 71
- 238000003199 nucleic acid amplification method Methods 0.000 claims description 71
- 108090000623 proteins and genes Proteins 0.000 claims description 41
- 239000000523 sample Substances 0.000 claims description 40
- 230000004083 survival effect Effects 0.000 claims description 37
- 206010006187 Breast cancer Diseases 0.000 claims description 36
- 208000026310 Breast neoplasm Diseases 0.000 claims description 36
- 238000007901 in situ hybridization Methods 0.000 claims description 24
- 201000010099 disease Diseases 0.000 claims description 19
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 19
- 108020004635 Complementary DNA Proteins 0.000 claims description 18
- 238000010804 cDNA synthesis Methods 0.000 claims description 18
- 239000002299 complementary DNA Substances 0.000 claims description 18
- 108020004999 messenger RNA Proteins 0.000 claims description 18
- 238000000338 in vitro Methods 0.000 claims description 17
- 230000010072 bone remodeling Effects 0.000 claims description 13
- 239000012634 fragment Substances 0.000 claims description 12
- 102000004169 proteins and genes Human genes 0.000 claims description 12
- XRASPMIURGNCCH-UHFFFAOYSA-N zoledronic acid Chemical compound OP(=O)(O)C(P(O)(O)=O)(O)CN1C=CN=C1 XRASPMIURGNCCH-UHFFFAOYSA-N 0.000 claims description 11
- 229960004276 zoledronic acid Drugs 0.000 claims description 11
- 239000003814 drug Substances 0.000 claims description 10
- 239000013068 control sample Substances 0.000 claims description 9
- 206010028980 Neoplasm Diseases 0.000 claims description 6
- 238000003752 polymerase chain reaction Methods 0.000 claims description 6
- 210000000988 bone and bone Anatomy 0.000 claims description 5
- 238000011002 quantification Methods 0.000 claims description 5
- 206010027476 Metastases Diseases 0.000 claims description 4
- 229910052709 silver Inorganic materials 0.000 claims description 4
- 239000004332 silver Substances 0.000 claims description 4
- 206010027452 Metastases to bone Diseases 0.000 claims description 3
- 208000003721 Triple Negative Breast Neoplasms Diseases 0.000 claims description 3
- 201000007280 estrogen-receptor negative breast cancer Diseases 0.000 claims description 3
- 208000022679 triple-negative breast carcinoma Diseases 0.000 claims description 3
- 108091032973 (ribonucleotides)n+m Proteins 0.000 claims description 2
- 108020004414 DNA Proteins 0.000 claims description 2
- 238000002965 ELISA Methods 0.000 claims description 2
- 101001012157 Homo sapiens Receptor tyrosine-protein kinase erbB-2 Proteins 0.000 claims description 2
- 102100030086 Receptor tyrosine-protein kinase erbB-2 Human genes 0.000 claims description 2
- 201000007281 estrogen-receptor positive breast cancer Diseases 0.000 claims description 2
- 238000009396 hybridization Methods 0.000 claims description 2
- 238000003364 immunohistochemistry Methods 0.000 claims description 2
- 230000009401 metastasis Effects 0.000 claims description 2
- 239000002773 nucleotide Substances 0.000 claims description 2
- 125000003729 nucleotide group Chemical group 0.000 claims description 2
- 238000003498 protein array Methods 0.000 claims description 2
- 238000003753 real-time PCR Methods 0.000 claims description 2
- 210000001519 tissue Anatomy 0.000 claims description 2
- 238000001262 western blot Methods 0.000 claims description 2
- 238000004519 manufacturing process Methods 0.000 claims 8
- MPBVHIBUJCELCL-UHFFFAOYSA-N Ibandronate Chemical compound CCCCCN(C)CCC(O)(P(O)(O)=O)P(O)(O)=O MPBVHIBUJCELCL-UHFFFAOYSA-N 0.000 claims 7
- 229960002286 clodronic acid Drugs 0.000 claims 7
- ACSIXWWBWUQEHA-UHFFFAOYSA-N clodronic acid Chemical compound OP(O)(=O)C(Cl)(Cl)P(O)(O)=O ACSIXWWBWUQEHA-UHFFFAOYSA-N 0.000 claims 7
- 229940015872 ibandronate Drugs 0.000 claims 7
- 210000000481 breast Anatomy 0.000 claims 2
- 239000002253 acid Substances 0.000 claims 1
- 230000002265 prevention Effects 0.000 claims 1
- 239000003112 inhibitor Substances 0.000 description 14
- 102000014128 RANK Ligand Human genes 0.000 description 13
- 108010025832 RANK Ligand Proteins 0.000 description 13
- 239000003795 chemical substances by application Substances 0.000 description 7
- 206010061289 metastatic neoplasm Diseases 0.000 description 6
- 229940122361 Bisphosphonate Drugs 0.000 description 5
- 229940091171 VEGFR-2 tyrosine kinase inhibitor Drugs 0.000 description 5
- 150000004663 bisphosphonates Chemical class 0.000 description 5
- 230000009977 dual effect Effects 0.000 description 5
- 229940124302 mTOR inhibitor Drugs 0.000 description 4
- 239000003628 mammalian target of rapamycin inhibitor Substances 0.000 description 4
- 229940124297 CDK 4/6 inhibitor Drugs 0.000 description 3
- 102000055006 Calcitonin Human genes 0.000 description 3
- 108060001064 Calcitonin Proteins 0.000 description 3
- 102100030074 Dickkopf-related protein 1 Human genes 0.000 description 3
- 101710099518 Dickkopf-related protein 1 Proteins 0.000 description 3
- 108090000445 Parathyroid hormone Proteins 0.000 description 3
- 102000001332 SRC Human genes 0.000 description 3
- 229960004015 calcitonin Drugs 0.000 description 3
- BBBFJLBPOGFECG-VJVYQDLKSA-N calcitonin Chemical compound N([C@H](C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC=1NC=NC=1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)NCC(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H]([C@@H](C)O)C(=O)N1[C@@H](CCC1)C(N)=O)C(C)C)C(=O)[C@@H]1CSSC[C@H](N)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H]([C@@H](C)O)C(=O)N1 BBBFJLBPOGFECG-VJVYQDLKSA-N 0.000 description 3
- 229940111134 coxibs Drugs 0.000 description 3
- 239000003255 cyclooxygenase 2 inhibitor Substances 0.000 description 3
- 238000001794 hormone therapy Methods 0.000 description 3
- 229940043355 kinase inhibitor Drugs 0.000 description 3
- 230000003472 neutralizing effect Effects 0.000 description 3
- 239000003757 phosphotransferase inhibitor Substances 0.000 description 3
- 102000004196 processed proteins & peptides Human genes 0.000 description 3
- 108090000765 processed proteins & peptides Proteins 0.000 description 3
- HCWPIIXVSYCSAN-OIOBTWANSA-N radium-223 Chemical compound [223Ra] HCWPIIXVSYCSAN-OIOBTWANSA-N 0.000 description 3
- 229960005562 radium-223 Drugs 0.000 description 3
- 108010087686 src-Family Kinases Proteins 0.000 description 3
- 229940079488 strontium ranelate Drugs 0.000 description 3
- XXUZFRDUEGQHOV-UHFFFAOYSA-J strontium ranelate Chemical compound [Sr+2].[Sr+2].[O-]C(=O)CN(CC([O-])=O)C=1SC(C([O-])=O)=C(CC([O-])=O)C=1C#N XXUZFRDUEGQHOV-UHFFFAOYSA-J 0.000 description 3
- 229940122156 Cathepsin K inhibitor Drugs 0.000 description 2
- 101001135738 Homo sapiens Parathyroid hormone-related protein Proteins 0.000 description 2
- 239000002176 L01XE26 - Cabozantinib Substances 0.000 description 2
- 102000008108 Osteoprotegerin Human genes 0.000 description 2
- 108010035042 Osteoprotegerin Proteins 0.000 description 2
- 102100036899 Parathyroid hormone-related protein Human genes 0.000 description 2
- 108010003723 Single-Domain Antibodies Proteins 0.000 description 2
- 229960001292 cabozantinib Drugs 0.000 description 2
- ONIQOQHATWINJY-UHFFFAOYSA-N cabozantinib Chemical group C=12C=C(OC)C(OC)=CC2=NC=CC=1OC(C=C1)=CC=C1NC(=O)C1(C(=O)NC=2C=CC(F)=CC=2)CC1 ONIQOQHATWINJY-UHFFFAOYSA-N 0.000 description 2
- 230000015556 catabolic process Effects 0.000 description 2
- 239000003067 chemokine receptor CCR5 antagonist Substances 0.000 description 2
- 230000002950 deficient Effects 0.000 description 2
- 238000006731 degradation reaction Methods 0.000 description 2
- 229960001251 denosumab Drugs 0.000 description 2
- 229940121647 egfr inhibitor Drugs 0.000 description 2
- 239000002834 estrogen receptor modulator Substances 0.000 description 2
- 230000002401 inhibitory effect Effects 0.000 description 2
- XXUPLYBCNPLTIW-UHFFFAOYSA-N octadec-7-ynoic acid Chemical compound CCCCCCCCCCC#CCCCCCC(O)=O XXUPLYBCNPLTIW-UHFFFAOYSA-N 0.000 description 2
- 102100035875 C-C chemokine receptor type 5 Human genes 0.000 description 1
- 101710149870 C-C chemokine receptor type 5 Proteins 0.000 description 1
- 102000004171 Cathepsin K Human genes 0.000 description 1
- 108090000625 Cathepsin K Proteins 0.000 description 1
- 239000005557 antagonist Substances 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 102000015694 estrogen receptors Human genes 0.000 description 1
- 108010038795 estrogen receptors Proteins 0.000 description 1
- 230000004927 fusion Effects 0.000 description 1
- 238000011272 standard treatment Methods 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2022026587A JP2022060489A (ja) | 2016-05-25 | 2022-02-24 | ｃ－ＭＡＦの状態に基づく乳がんの治療的処置 |
| JP2024184425A JP2025003539A (ja) | 2016-05-25 | 2024-10-18 | ｃ－ＭＡＦの状態に基づく乳がんの治療的処置 |
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662341333P | 2016-05-25 | 2016-05-25 | |
| US62/341,333 | 2016-05-25 | ||
| US201662344836P | 2016-06-02 | 2016-06-02 | |
| US62/344,836 | 2016-06-02 | ||
| PCT/IB2017/053094 WO2017203468A1 (en) | 2016-05-25 | 2017-05-25 | Therapeutic treatment of breast cancer based on c-maf status |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022026587A Division JP2022060489A (ja) | 2016-05-25 | 2022-02-24 | ｃ－ＭＡＦの状態に基づく乳がんの治療的処置 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2019523641A JP2019523641A (ja) | 2019-08-29 |
| JP2019523641A5 true JP2019523641A5 (OSRAM) | 2020-07-09 |
| JP7032329B2 JP7032329B2 (ja) | 2022-03-08 |
Family
ID=59055237
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018561228A Active JP7032329B2 (ja) | 2016-05-25 | 2017-05-25 | ｃ－ＭＡＦの状態に基づく乳がんの治療的処置 |
| JP2022026587A Withdrawn JP2022060489A (ja) | 2016-05-25 | 2022-02-24 | ｃ－ＭＡＦの状態に基づく乳がんの治療的処置 |
| JP2024184425A Pending JP2025003539A (ja) | 2016-05-25 | 2024-10-18 | ｃ－ＭＡＦの状態に基づく乳がんの治療的処置 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022026587A Withdrawn JP2022060489A (ja) | 2016-05-25 | 2022-02-24 | ｃ－ＭＡＦの状態に基づく乳がんの治療的処置 |
| JP2024184425A Pending JP2025003539A (ja) | 2016-05-25 | 2024-10-18 | ｃ－ＭＡＦの状態に基づく乳がんの治療的処置 |
Country Status (15)
| Country | Link |
|---|---|
| US (2) | US11596642B2 (OSRAM) |
| EP (2) | EP3458610B1 (OSRAM) |
| JP (3) | JP7032329B2 (OSRAM) |
| KR (2) | KR102571924B1 (OSRAM) |
| CN (2) | CN117230193A (OSRAM) |
| AU (1) | AU2017271385B2 (OSRAM) |
| CA (1) | CA3025264A1 (OSRAM) |
| DK (2) | DK3458610T3 (OSRAM) |
| ES (2) | ES2877757T3 (OSRAM) |
| HR (1) | HRP20210921T1 (OSRAM) |
| LT (1) | LT3458610T (OSRAM) |
| MX (1) | MX2018014279A (OSRAM) |
| PL (1) | PL3458610T3 (OSRAM) |
| PT (1) | PT3458610T (OSRAM) |
| WO (1) | WO2017203468A1 (OSRAM) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2011311452B2 (en) | 2010-10-06 | 2016-09-01 | Fundacio Institut De Recerca Biomedica (Irb Barcelona) | Method for the diagnosis, prognosis and treatment of breast cancer metastasis |
| EP2650682A1 (en) | 2012-04-09 | 2013-10-16 | Fundació Privada Institut de Recerca Biomèdica | Method for the prognosis and treatment of cancer metastasis |
| CA2875918A1 (en) | 2012-06-06 | 2013-12-12 | Fundacio Institut De Recerca Biomedica (Irb Barcelona) | Method for the diagnosis, prognosis and treatment of lung cancer metastasis |
| HK1213946A1 (zh) | 2012-10-12 | 2016-07-15 | Inbiomotion S.L. | 用於使用c-maf对前列腺癌转移进行诊断、预後和治疗的方法 |
| US10119171B2 (en) | 2012-10-12 | 2018-11-06 | Inbiomotion S.L. | Method for the diagnosis, prognosis and treatment of prostate cancer metastasis |
| EP2975138A2 (en) | 2013-03-15 | 2016-01-20 | Fundació Institut de Recerca Biomèdica (IRB Barcelona) | Method for the diagnosis, prognosis and treatment of cancer metastasis |
| CA2967224C (en) | 2014-12-11 | 2023-08-22 | Inbiomotion S.L. | Binding members for human c-maf |
| WO2017203468A1 (en) | 2016-05-25 | 2017-11-30 | Inbiomotion S.L. | Therapeutic treatment of breast cancer based on c-maf status |
| AU2018372762B2 (en) | 2017-11-22 | 2025-08-21 | Inbiomotion S.L. | Therapeutic treatment of breast cancer based on c-maf status |
| KR102191049B1 (ko) | 2019-02-22 | 2020-12-15 | 엘지전자 주식회사 | 워터 디스펜싱 장치 |
| US20220195059A1 (en) * | 2019-04-30 | 2022-06-23 | Instituto de Medicina Molecular João Lobo Antunes | Rank Pathway Inhibitors in Combination with CDK Inhibitors |
| JP7509400B2 (ja) * | 2020-02-18 | 2024-07-02 | 国立研究開発法人量子科学技術研究開発機構 | 投与施設ユニット |
| KR20250030194A (ko) | 2023-08-24 | 2025-03-05 | 코웨이 주식회사 | 출수 장치 |
Family Cites Families (53)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB8308235D0 (en) | 1983-03-25 | 1983-05-05 | Celltech Ltd | Polypeptides |
| US4816567A (en) | 1983-04-08 | 1989-03-28 | Genentech, Inc. | Recombinant immunoglobin preparations |
| DE4013632A1 (de) | 1990-04-27 | 1991-10-31 | Max Planck Gesellschaft | Liposomen mit positiver ueberschussladung |
| EP0946725B1 (en) | 1996-12-23 | 2011-01-26 | Immunex Corporation | Receptor activator of nf-kappa b, receptor is member of tnf receptor superfamily |
| US6316408B1 (en) | 1997-04-16 | 2001-11-13 | Amgen Inc. | Methods of use for osetoprotegerin binding protein receptors |
| US6274338B1 (en) | 1998-02-24 | 2001-08-14 | President And Fellows Of Harvard College | Human c-Maf compositions and methods of use thereof |
| EA200100972A1 (ru) | 1999-03-15 | 2002-02-28 | Аксис Фармасьютикалз, Инк. | Новые соединения и композиции как ингибиторы протеаз |
| AU779855B2 (en) | 2000-01-06 | 2005-02-17 | Axys Pharmaceuticals, Inc. | Novel compounds and compositions as protease inhibitors |
| PL222211B1 (pl) | 2001-06-26 | 2016-07-29 | Amgen Fremont Inc | Przeciwciało przeciwko OPGL, kompozycja je zawierająca, jego zastosowanie i sposób jego wytwarzania, sposób wykrywania poziomu OPGL, kompozycja obejmująca polinukleotydy i komórka gosodarza |
| GB0121033D0 (en) | 2001-08-30 | 2001-10-24 | Novartis Ag | Organic compounds |
| AR036375A1 (es) | 2001-08-30 | 2004-09-01 | Novartis Ag | Compuestos pirrolo [2,3-d] pirimidina -2- carbonitrilo, un proceso para su preparacion, una composicion farmaceutica y el uso de dichos compuestos para la preparacion de medicamentos |
| KR100485271B1 (ko) | 2002-01-16 | 2005-04-27 | 메타볼랩(주) | 전사인자 ｃ－ｍａｆ의 전사 활성 억제제로서의 니발레놀및 그를 포함하는 약제학적 조성물 |
| SE0201980D0 (sv) | 2002-06-24 | 2002-06-24 | Astrazeneca Ab | Novel compounds |
| DE10235624A1 (de) | 2002-08-02 | 2004-02-19 | Aventis Pharma Deutschland Gmbh | Endiandric acid H und ihre Derivate, Verfahren zu ihrer Herstellung und Verwendung derselben |
| WO2004063355A2 (en) | 2003-01-10 | 2004-07-29 | Protein Design Labs, Inc. | Novel methods of diagnosis of metastatic cancer, compositions and methods of screening for modulators of matastatic cancer |
| EP1668354A2 (en) | 2003-09-24 | 2006-06-14 | Oncotherapy Science, Inc. | Method of diagnosing breast cancer |
| AU2003286499A1 (en) | 2003-10-17 | 2004-06-06 | The Government Of The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Interference with c-maf function in multiple myeloma |
| WO2005060722A2 (en) | 2003-12-18 | 2005-07-07 | President And Fellows Of Hardvard College | Modulation of immune system function by modulation of polypeptide arginine methyltransferases |
| TW200526224A (en) | 2003-12-22 | 2005-08-16 | Alcon Inc | Short form c-Maf transcription factor antagonists for treatment of glaucoma |
| JP2007527247A (ja) | 2004-03-05 | 2007-09-27 | ロゼッタ インファーマティクス エルエルシー | 臨床的基準および情報提供性遺伝子セットの組合せを使用する乳癌患者の分類 |
| US20080131940A1 (en) | 2004-06-25 | 2008-06-05 | Robert Chiu | Target Cell-Specific Short Interfering Rna and Methods of Use Thereof |
| WO2006135436A2 (en) | 2004-10-22 | 2006-12-21 | University Of Florida Research Foundation, Inc. | Inhibition of gene expression and therapeutic uses thereof |
| EP3211086B1 (en) | 2005-09-20 | 2021-06-09 | Menarini Silicon Biosystems S.p.A. | Methods and composition to generate unique sequence dna probes, labeling of dna probes and the use of these probes |
| US9134237B2 (en) | 2005-09-20 | 2015-09-15 | Janssen Diagnotics, LLC | High sensitivity multiparameter method for rare event analysis in a biological sample |
| US20080219996A1 (en) | 2005-09-26 | 2008-09-11 | Thea Kalebic | Molecular Markers Associated with Bone Metastasis |
| WO2008098351A1 (en) | 2007-02-14 | 2008-08-21 | University Health Network | Treatment of d-cyclin mediated proliferative diseases and hemotological malignancies |
| EP1961825A1 (en) | 2007-02-26 | 2008-08-27 | INSERM (Institut National de la Santé et de la Recherche Medicale) | Method for predicting the occurrence of metastasis in breast cancer patients |
| NZ581097A (en) | 2007-05-24 | 2012-03-30 | Ablynx Nv | Amino acid sequences directed against rank-l and polypeptides comprising the same for the treatment of bone diseases and disorders |
| WO2008145125A1 (en) | 2007-05-31 | 2008-12-04 | Dako Denmark A/S | Methods for utilizing esr copy number changes in breast cancer treatments and prognoses |
| NZ562237A (en) | 2007-10-05 | 2011-02-25 | Pacific Edge Biotechnology Ltd | Proliferation signature and prognosis for gastrointestinal cancer |
| US20110123617A1 (en) | 2007-10-18 | 2011-05-26 | University Health Network | Clioquinol for the treatment of hematological malignancies |
| US20110130296A1 (en) | 2008-03-14 | 2011-06-02 | The Regents Of The University Of California | Multi-gene classifiers and prognostic indicators for cancers |
| WO2009146546A1 (en) | 2008-06-06 | 2009-12-10 | University Health Network | 8-hydroxyquinoline derivatives for the treatment of hematological malignancies |
| ES2338843B1 (es) | 2008-07-02 | 2011-01-24 | Centro De Investigaciones Energeticas, Medioambientales Y Tecnologicas | Huella genomica de cancer de mama. |
| US8642270B2 (en) | 2009-02-09 | 2014-02-04 | Vm Institute Of Research | Prognostic biomarkers to predict overall survival and metastatic disease in patients with triple negative breast cancer |
| SG176073A1 (en) | 2009-05-29 | 2011-12-29 | Hoffmann La Roche | Modulators for her2 signaling in her2 expressing patients with gastric cancer |
| WO2011017687A1 (en) | 2009-08-06 | 2011-02-10 | Ray Partha S | Diagnosis of primary and metastatic basal-like breast cancer and other cancer types |
| AU2011311452B2 (en) * | 2010-10-06 | 2016-09-01 | Fundacio Institut De Recerca Biomedica (Irb Barcelona) | Method for the diagnosis, prognosis and treatment of breast cancer metastasis |
| CA2826657A1 (en) | 2011-02-04 | 2012-08-09 | Bioarray Therapeutics, Inc. | Methods of using gene expression signatures to select a method of treatment, predict prognosis, survival, and/or predict response to treatment |
| EP2685988A4 (en) | 2011-03-15 | 2014-08-20 | Univ North Carolina | Methods of treating breast cancer with anthracycline therapy |
| EP2780469A1 (en) | 2011-11-18 | 2014-09-24 | Vanderbilt University | Markers of triple-negative breast cancer and uses thereof |
| EP2650682A1 (en) | 2012-04-09 | 2013-10-16 | Fundació Privada Institut de Recerca Biomèdica | Method for the prognosis and treatment of cancer metastasis |
| CA2875918A1 (en) | 2012-06-06 | 2013-12-12 | Fundacio Institut De Recerca Biomedica (Irb Barcelona) | Method for the diagnosis, prognosis and treatment of lung cancer metastasis |
| HK1213946A1 (zh) * | 2012-10-12 | 2016-07-15 | Inbiomotion S.L. | 用於使用c-maf对前列腺癌转移进行诊断、预後和治疗的方法 |
| US10119171B2 (en) | 2012-10-12 | 2018-11-06 | Inbiomotion S.L. | Method for the diagnosis, prognosis and treatment of prostate cancer metastasis |
| AU2014229505B2 (en) | 2013-03-15 | 2020-02-27 | Fundacio Institut De Recerca Biomedica (Irb Barcelona) | Method for the prognosis and treatment of cancer metastasis |
| EP2975138A2 (en) | 2013-03-15 | 2016-01-20 | Fundació Institut de Recerca Biomèdica (IRB Barcelona) | Method for the diagnosis, prognosis and treatment of cancer metastasis |
| WO2014184679A2 (en) | 2013-03-15 | 2014-11-20 | Inbiomotion S.L. | Method for the prognosis and treatment of renal cell carcinoma metastasis |
| ES2727904T3 (es) | 2013-10-09 | 2019-10-21 | Fundacio Inst De Recerca Biomedica Irb Barcelona | Método para el pronóstico y tratamiento de cáncer metastatizante del hueso que se origina a partir de cáncer de mama |
| CA2967224C (en) | 2014-12-11 | 2023-08-22 | Inbiomotion S.L. | Binding members for human c-maf |
| WO2017203468A1 (en) | 2016-05-25 | 2017-11-30 | Inbiomotion S.L. | Therapeutic treatment of breast cancer based on c-maf status |
| EP3296431A1 (en) | 2016-09-15 | 2018-03-21 | Ecole Polytechnique Fédérale de Lausanne (EPFL) | Method of synthesis of an electrode for use as a catalyst of oxygen evolution reaction |
| AU2018372762B2 (en) | 2017-11-22 | 2025-08-21 | Inbiomotion S.L. | Therapeutic treatment of breast cancer based on c-maf status |
-
2017
- 2017-05-25 WO PCT/IB2017/053094 patent/WO2017203468A1/en not_active Ceased
- 2017-05-25 PT PT177299245T patent/PT3458610T/pt unknown
- 2017-05-25 EP EP17729924.5A patent/EP3458610B1/en active Active
- 2017-05-25 ES ES17729924T patent/ES2877757T3/es active Active
- 2017-05-25 LT LTEP17729924.5T patent/LT3458610T/lt unknown
- 2017-05-25 DK DK17729924.5T patent/DK3458610T3/da active
- 2017-05-25 PL PL17729924T patent/PL3458610T3/pl unknown
- 2017-05-25 EP EP21172098.2A patent/EP3901283B1/en active Active
- 2017-05-25 CN CN202311196940.8A patent/CN117230193A/zh active Pending
- 2017-05-25 JP JP2018561228A patent/JP7032329B2/ja active Active
- 2017-05-25 DK DK21172098.2T patent/DK3901283T3/da active
- 2017-05-25 AU AU2017271385A patent/AU2017271385B2/en active Active
- 2017-05-25 ES ES21172098T patent/ES3043607T3/es active Active
- 2017-05-25 US US16/303,945 patent/US11596642B2/en active Active
- 2017-05-25 KR KR1020187037303A patent/KR102571924B1/ko active Active
- 2017-05-25 CA CA3025264A patent/CA3025264A1/en active Pending
- 2017-05-25 KR KR1020237028682A patent/KR102867720B1/ko active Active
- 2017-05-25 CN CN201780042410.4A patent/CN109790582B/zh active Active
- 2017-05-25 HR HRP20210921TT patent/HRP20210921T1/hr unknown
- 2017-05-25 MX MX2018014279A patent/MX2018014279A/es unknown
-
2022
- 2022-02-24 JP JP2022026587A patent/JP2022060489A/ja not_active Withdrawn
-
2023
- 2023-02-15 US US18/169,537 patent/US20230381209A1/en active Pending
-
2024
- 2024-10-18 JP JP2024184425A patent/JP2025003539A/ja active Pending
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2019523641A5 (OSRAM) | ||
| JP6781184B2 (ja) | がん転移の予後診断および処置のための方法 | |
| CN105324491B (zh) | 用于癌症转移的诊断和治疗的方法 | |
| CN109790582B (zh) | 基于c-maf状态的乳腺癌治疗性治疗 | |
| JP2016516403A5 (OSRAM) | ||
| JP6386450B2 (ja) | 肺がん転移の診断、予後診断および処置のための方法 | |
| CN105980576B (zh) | 用于源自乳腺癌的骨转移癌的预后和治疗的方法 | |
| JP2016105731A5 (OSRAM) | ||
| JP2018078911A5 (OSRAM) | ||
| JP2015521050A5 (OSRAM) | ||
| JP2016539625A5 (OSRAM) | ||
| JP2018078911A (ja) | ｃ−ＭＡＦを用いた前立腺がん転移の診断、予後診断および処置のための方法 | |
| CN111565725A (zh) | 基于c-maf状态的乳腺癌的治疗性处理 | |
| HK40026235A (en) | Therapeutic treatment of breast cancer based on c-maf status | |
| BR112018074076B1 (pt) | Métodos in vitro para projetar uma terapia customizada para um indivíduo que tem câncer de mama e para prever sobrevivência sem doença invasiva | |
| HK1263074A1 (en) | Therapeutic treatment of breast cancer based on c-maf status | |
| HK1263074B (en) | Therapeutic treatment of breast cancer based on c-maf status |