JP2019521087A - 抗ｃＭｅｔ抗体薬物複合体及びその使用方法 - Google Patents

抗ｃＭｅｔ抗体薬物複合体及びその使用方法 Download PDF

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JP2019521087A
JP2019521087A JP2018559845A JP2018559845A JP2019521087A JP 2019521087 A JP2019521087 A JP 2019521087A JP 2018559845 A JP2018559845 A JP 2018559845A JP 2018559845 A JP2018559845 A JP 2018559845A JP 2019521087 A JP2019521087 A JP 2019521087A
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cmet
antibody
adc
seq
administered
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JP2019521087A5 (https=
Inventor
ライリー，エドワード・ビー
ナウモフスキ，ルーイ
アラン，クリスティアン・ビー
ワン，ジエイー
アンダーソン，マーク・ジー
アファール，ダニエル・イー
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AbbVie Inc
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AbbVie Inc
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    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
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    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6801—Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
    • A61K47/6803—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates
    • A61K47/68031—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates the drug being an auristatin
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    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
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  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
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  • Epidemiology (AREA)
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  • Cell Biology (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Oncology (AREA)
  • Pulmonology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
JP2018559845A 2016-05-17 2017-05-17 抗ｃＭｅｔ抗体薬物複合体及びその使用方法 Pending JP2019521087A (ja)

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US201662337796P 2016-05-17 2016-05-17
US62/337,796 2016-05-17
PCT/US2017/033176 WO2017201204A1 (en) 2016-05-17 2017-05-17 ANTI-cMet ANTIBODY DRUG CONJUGATES AND METHODS FOR THEIR USE

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JP2021068144A Active JP7150087B2 (ja) 2016-05-17 2021-04-14 抗ｃＭｅｔ抗体薬物複合体及びその使用方法
JP2022152185A Pending JP2022185003A (ja) 2016-05-17 2022-09-26 抗ｃＭｅｔ抗体薬物複合体及びその使用方法

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JP2022152185A Pending JP2022185003A (ja) 2016-05-17 2022-09-26 抗ｃＭｅｔ抗体薬物複合体及びその使用方法

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US (5) US20170348429A1 (https=)
EP (4) EP3804765A1 (https=)
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KR (3) KR102449294B1 (https=)
CN (3) CN114177308B (https=)
AU (1) AU2017268342B2 (https=)
BR (1) BR112018073574A2 (https=)
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CY (2) CY1123256T1 (https=)
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HR (2) HRP20201186T1 (https=)
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JP2022543771A (ja) * 2019-07-30 2022-10-14 ミシック セラピューティクス インコーポレイテッド 抗原結合タンパク質構築物及びその使用
JP2023542301A (ja) * 2020-09-12 2023-10-06 メディミューン リミテッド 抗ｂ７ｈ４抗体薬物コンジュゲート療法のためのスコア化方法
JP2024505577A (ja) * 2021-02-03 2024-02-06 ミシク セラピューティクス， インコーポレイテッド 抗体およびその使用

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RS61659B1 (sr) * 2016-05-17 2021-04-29 Abbvie Biotherapeutics Inc Konjugati antitelo lek anti-cmet i metode za njihovu upotrebu
TWI782930B (zh) 2016-11-16 2022-11-11 美商再生元醫藥公司 抗ｍｅｔ抗體，結合ｍｅｔ之雙特異性抗原結合分子及其使用方法
HUE054500T2 (hu) * 2016-11-23 2021-09-28 Lilly Co Eli MET antitest hatóanyag konjugátumok
CN110144325A (zh) * 2018-02-12 2019-08-20 深圳宾德生物技术有限公司 一种靶向性t淋巴细胞及其制备方法和应用
ES2958933T3 (es) 2018-03-13 2024-02-16 Zymeworks Bc Inc Conjugados de anticuerpo biparatópico anti-HER2-fármaco y métodos de uso
WO2019183633A1 (en) 2018-03-23 2019-09-26 Case Western Reserve Univeristy Psma targeted conjugate compounds and uses thereof
CA3094827A1 (en) * 2018-03-28 2019-10-03 Mitsubishi Tanabe Pharma Corporation Drug conjugates of cmet monoclonal binding agents, and uses thereof
CN112543771B (zh) * 2018-09-30 2023-04-11 江苏豪森药业集团有限公司 抗b7h3抗体-依喜替康类似物偶联物及其医药用途
US12331320B2 (en) 2018-10-10 2025-06-17 The Research Foundation For The State University Of New York Genome edited cancer cell vaccines
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