JP2019520818A5 - - Google Patents
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- Publication number
- JP2019520818A5 JP2019520818A5 JP2018564217A JP2018564217A JP2019520818A5 JP 2019520818 A5 JP2019520818 A5 JP 2019520818A5 JP 2018564217 A JP2018564217 A JP 2018564217A JP 2018564217 A JP2018564217 A JP 2018564217A JP 2019520818 A5 JP2019520818 A5 JP 2019520818A5
- Authority
- JP
- Japan
- Prior art keywords
- tgf
- beta
- binding affinity
- less
- human
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB1610044.8 | 2016-06-08 | ||
| GBGB1610044.8A GB201610044D0 (en) | 2016-06-08 | 2016-06-08 | Antibodies |
| PCT/EP2017/063796 WO2017211873A1 (en) | 2016-06-08 | 2017-06-07 | Antagonist antibodies that t bind to human tgfb1, tgfb2 and to tgfb3 and their use for the treatment of lung fibrosis |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2019520818A JP2019520818A (ja) | 2019-07-25 |
| JP2019520818A5 true JP2019520818A5 (https=) | 2021-10-07 |
Family
ID=56508288
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018564217A Pending JP2019520818A (ja) | 2016-06-08 | 2017-06-07 | ヒトｔｇｆｂ１、ｔｇｆｂ２及びｔｇｆｂ３に結合するアンタゴニスト抗体、及び肺線維症を治療するためのそれらの使用 |
Country Status (20)
| Country | Link |
|---|---|
| US (2) | US10766956B2 (https=) |
| EP (1) | EP3468992A1 (https=) |
| JP (1) | JP2019520818A (https=) |
| KR (1) | KR20190015497A (https=) |
| CN (1) | CN109311970A (https=) |
| AR (1) | AR108779A1 (https=) |
| AU (1) | AU2017276685A1 (https=) |
| BR (1) | BR112018074869A2 (https=) |
| CA (1) | CA3024011A1 (https=) |
| CL (1) | CL2018003510A1 (https=) |
| CO (1) | CO2018012513A2 (https=) |
| EA (1) | EA201892774A1 (https=) |
| GB (1) | GB201610044D0 (https=) |
| IL (1) | IL263425A (https=) |
| MX (1) | MX2018014376A (https=) |
| RU (1) | RU2746926C2 (https=) |
| SG (1) | SG11201810311WA (https=) |
| TW (1) | TW201802115A (https=) |
| UY (1) | UY37279A (https=) |
| WO (1) | WO2017211873A1 (https=) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2018119142A1 (en) | 2016-12-21 | 2018-06-28 | Amgen Inc. | Anti-tnf alpha antibody formulations |
| SG11201907299XA (en) | 2017-02-08 | 2019-09-27 | Dragonfly Therapeutics Inc | Multi-specific binding proteins for activation of natural killer cells and therapeutic uses thereof to treat cancer |
| IL268755B2 (en) | 2017-02-20 | 2025-12-01 | Dragonfly Therapeutics Inc | Proteins that bind her2, nkg2d, and cd16 |
| EA202091887A1 (ru) | 2018-02-08 | 2020-10-23 | Драгонфлай Терапьютикс, Инк. | Комбинированная терапия рака с применением мультиспецифических связывающих белков, которые активируют естественные клетки-киллеры |
| DK3749346T3 (da) | 2018-02-08 | 2024-09-09 | Dragonfly Therapeutics Inc | Antistof variable domænekombinationer rettet mod nkg2d-receptoren |
| WO2019164930A1 (en) | 2018-02-20 | 2019-08-29 | Dragonfly Therapeutics, Inc. | Multi-specific binding proteins that bind cd33, nkg2d, and cd16, and methods of use |
| MX2021000347A (es) | 2018-07-11 | 2021-04-19 | Scholar Rock Inc | Inhibidores de tgf?1 selectivos de isoforma, de alta afinidad y usos de los mismos. |
| WO2020033630A1 (en) | 2018-08-08 | 2020-02-13 | Dragonfly Therapeutics, Inc. | Multi-specific binding proteins that bind bcma, nkg2d and cd16, and methods of use |
| US12378318B2 (en) | 2018-08-08 | 2025-08-05 | Dragonfly Therapeutics, Inc. | Proteins binding NKG2D, CD16 and a tumor-associated antigen |
| EA202091888A1 (ru) | 2018-08-08 | 2020-10-23 | Драгонфлай Терапьютикс, Инк. | Вариабельные домены антител, нацеленные на рецептор nkg2d |
| JP2022548776A (ja) * | 2019-09-19 | 2022-11-21 | ノースウェスタン ユニバーシティ | ヒト人工多能性幹細胞のための費用効果の高い培地およびプロトコル |
| KR102270700B1 (ko) * | 2019-11-01 | 2021-06-30 | 한국과학기술연구원 | 폐 섬유증의 예방 또는 치료를 위한 올리고뉴클레오티드 중합체와 생체 적합성 양이온성 펩타이드로 이루어지는 폐 특이적 약물 전달체 및 이의 이용 |
| TWI867190B (zh) * | 2020-03-19 | 2024-12-21 | 美商建南德克公司 | 同功型選擇性抗-TGF-β抗體及其使用方法 |
| MX2022013944A (es) | 2020-05-06 | 2022-11-30 | Dragonfly Therapeutics Inc | Proteinas que se unen al receptor activador de celulas asesinas naturales grupo 2 miembro d (nkg2d), cumulo de diferenciacion (cd16) y miembro a de la familia de dominios de lectina tipo c 12 (clec12a). |
| CA3199324A1 (en) * | 2020-11-17 | 2022-05-27 | Adam Marc Silverstein | Inhaled imatinib for pulmonary hypertension field |
| JP2024508894A (ja) | 2021-03-03 | 2024-02-28 | ドラゴンフライ セラピューティクス， インコーポレイテッド | Ｎｋｇ２ｄ、ｃｄ１６、及び腫瘍関連抗原に結合する多特異性結合タンパク質を使用して癌を治療する方法 |
| CN112961240B (zh) * | 2021-04-06 | 2022-07-05 | 明济生物制药（北京）有限公司 | 一种靶向TGF-β1的单克隆抗体及其与间充质干细胞外泌体的联合应用 |
| CN112940119B (zh) * | 2021-04-26 | 2022-05-20 | 北京芳渟阳生生物科技有限公司 | 一种单克隆抗体及其与间充质干细胞外泌体的联合应用 |
| US20250127716A1 (en) * | 2022-02-04 | 2025-04-24 | Justus-Liebig-Universitaet Giessen | Inhaled imatinib for treatment of pulmonary hypertension |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20020141995A1 (en) * | 1997-06-10 | 2002-10-03 | Irvin Charles G. | Method for treatment of inflammatory disease |
| EP1636270B1 (en) * | 2003-06-16 | 2016-07-20 | UCB Pharma S.A. | Antibodies specific for sclerostin and methods for increasing bone mineralization |
| CN1961003B (zh) * | 2004-03-31 | 2013-03-27 | 健泰科生物技术公司 | 人源化抗TGF-β抗体 |
| WO2006086469A2 (en) * | 2005-02-08 | 2006-08-17 | Genzyme Corporation | Antibodies to tgfbeta |
| JP2009521496A (ja) | 2005-12-23 | 2009-06-04 | イーライ リリー アンド カンパニー | ＴＧＦ−β結合組成物 |
| DK2083863T3 (da) * | 2006-10-03 | 2015-06-22 | Genzyme Corp | Antistoffer mod tgf-beta til anvendelse til behandling af spædbørn med risiko for udvikling af bronkopulmonal dysplasi |
| SG195253A1 (en) * | 2011-06-03 | 2013-12-30 | Xoma Technology Ltd | Antibodies specific for tgf-beta |
| PT2971048T (pt) | 2013-03-11 | 2019-02-06 | Genzyme Corp | Anticorpos anti-tgf-beta manipulados e fragmentos de ligação a antigénios |
| CN106794233B (zh) | 2014-08-01 | 2021-11-12 | 布里格姆及妇女医院股份有限公司 | 与肺动脉高压的治疗有关的组合物和方法 |
| JP2019511911A (ja) | 2016-02-17 | 2019-05-09 | ノバルティス アーゲー | Ｔｇｆベータ２抗体 |
| EP3571227A1 (en) | 2017-01-20 | 2019-11-27 | Sanofi | Anti-tgf-beta antibodies and their use |
-
2016
- 2016-06-08 GB GBGB1610044.8A patent/GB201610044D0/en not_active Ceased
-
2017
- 2017-06-07 SG SG11201810311WA patent/SG11201810311WA/en unknown
- 2017-06-07 RU RU2018146158A patent/RU2746926C2/ru active
- 2017-06-07 EA EA201892774A patent/EA201892774A1/ru unknown
- 2017-06-07 CN CN201780035444.0A patent/CN109311970A/zh active Pending
- 2017-06-07 BR BR112018074869-2A patent/BR112018074869A2/pt not_active Application Discontinuation
- 2017-06-07 JP JP2018564217A patent/JP2019520818A/ja active Pending
- 2017-06-07 CA CA3024011A patent/CA3024011A1/en not_active Abandoned
- 2017-06-07 WO PCT/EP2017/063796 patent/WO2017211873A1/en not_active Ceased
- 2017-06-07 EP EP17729444.4A patent/EP3468992A1/en active Pending
- 2017-06-07 KR KR1020197000199A patent/KR20190015497A/ko not_active Ceased
- 2017-06-07 MX MX2018014376A patent/MX2018014376A/es unknown
- 2017-06-07 AU AU2017276685A patent/AU2017276685A1/en not_active Abandoned
- 2017-06-07 US US16/307,444 patent/US10766956B2/en active Active
- 2017-06-07 AR ARP170101556A patent/AR108779A1/es unknown
- 2017-06-08 UY UY0001037279A patent/UY37279A/es not_active Application Discontinuation
- 2017-06-08 TW TW106119141A patent/TW201802115A/zh unknown
-
2018
- 2018-11-22 CO CONC2018/0012513A patent/CO2018012513A2/es unknown
- 2018-12-02 IL IL263425A patent/IL263425A/en unknown
- 2018-12-06 CL CL2018003510A patent/CL2018003510A1/es unknown
-
2020
- 2020-07-09 US US16/925,281 patent/US11518803B2/en active Active
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