JP2019520389A5 - - Google Patents
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- Publication number
- JP2019520389A5 JP2019520389A5 JP2019500259A JP2019500259A JP2019520389A5 JP 2019520389 A5 JP2019520389 A5 JP 2019520389A5 JP 2019500259 A JP2019500259 A JP 2019500259A JP 2019500259 A JP2019500259 A JP 2019500259A JP 2019520389 A5 JP2019520389 A5 JP 2019520389A5
- Authority
- JP
- Japan
- Prior art keywords
- substituted
- membered ring
- ring containing
- unsubstituted
- compound
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 229910052760 oxygen Inorganic materials 0.000 claims 16
- 229910052717 sulfur Inorganic materials 0.000 claims 16
- 229910052799 carbon Inorganic materials 0.000 claims 14
- 229910052757 nitrogen Inorganic materials 0.000 claims 14
- 125000000217 alkyl group Chemical group 0.000 claims 10
- 150000001875 compounds Chemical class 0.000 claims 10
- 125000003545 alkoxy group Chemical group 0.000 claims 9
- 229910052736 halogen Inorganic materials 0.000 claims 9
- 150000002367 halogens Chemical class 0.000 claims 9
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 9
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims 9
- 239000008194 pharmaceutical composition Substances 0.000 claims 9
- 125000006376 (C3-C10) cycloalkyl group Chemical group 0.000 claims 8
- 150000003839 salts Chemical class 0.000 claims 7
- 238000007363 ring formation reaction Methods 0.000 claims 5
- KPRZOPQOBJRYSW-UHFFFAOYSA-N o-hydroxybenzylamine Natural products NCC1=CC=CC=C1O KPRZOPQOBJRYSW-UHFFFAOYSA-N 0.000 claims 4
- 206010003658 Atrial Fibrillation Diseases 0.000 claims 2
- 239000003937 drug carrier Substances 0.000 claims 2
- 206010003130 Arrhythmia supraventricular Diseases 0.000 claims 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 230000000694 effects Effects 0.000 claims 1
- 230000002265 prevention Effects 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662359705P | 2016-07-07 | 2016-07-07 | |
| US62/359,705 | 2016-07-07 | ||
| PCT/US2017/041211 WO2018009875A1 (en) | 2016-07-07 | 2017-07-07 | Prevention and treatment of atrial fibrillation/flutter with gamma-ketoaldehyde scavengers |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2019520389A JP2019520389A (ja) | 2019-07-18 |
| JP2019520389A5 true JP2019520389A5 (enExample) | 2020-08-06 |
| JP7179353B2 JP7179353B2 (ja) | 2022-11-29 |
Family
ID=60913210
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019500259A Active JP7179353B2 (ja) | 2016-07-07 | 2017-07-07 | γ－ケトアルデヒドスカベンジャーによる心房細動／粗動の予防及び治療 |
Country Status (10)
| Country | Link |
|---|---|
| US (2) | US20190247375A1 (enExample) |
| EP (1) | EP3481505B1 (enExample) |
| JP (1) | JP7179353B2 (enExample) |
| CN (1) | CN110022936A (enExample) |
| AU (1) | AU2017293950B2 (enExample) |
| BR (1) | BR112019000251A2 (enExample) |
| CA (1) | CA3030149A1 (enExample) |
| ES (1) | ES3040735T3 (enExample) |
| MX (1) | MX393913B (enExample) |
| WO (1) | WO2018009875A1 (enExample) |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6620836B1 (en) * | 1997-01-22 | 2003-09-16 | Jay Patrick | Antiarrhythmic and tranquilizer composition and treatment |
| US8822542B2 (en) | 2004-10-20 | 2014-09-02 | Vanderbilt University | Isoketal scavengers and mitigation of disorders involving oxidative injury |
| WO2007121588A1 (en) * | 2006-04-25 | 2007-11-01 | Medicure International Inc. | Treatment of atrial fibrillation |
| EP2477594A4 (en) * | 2009-07-15 | 2013-03-13 | Univ Vanderbilt | ISOKETAL CATCHER AND TREATMENT OF DISEASES WITH OXIDATIVE INJURY |
| PL2731597T3 (pl) * | 2011-07-12 | 2024-04-29 | Vanderbilt University | Sposoby leczenia stanu zapalnego i nadciśnienia tętniczego za pomocą wychwytywaczy gamma-ketoaldehydowych |
-
2017
- 2017-07-07 CA CA3030149A patent/CA3030149A1/en active Pending
- 2017-07-07 BR BR112019000251-0A patent/BR112019000251A2/pt not_active Application Discontinuation
- 2017-07-07 CN CN201780054986.2A patent/CN110022936A/zh active Pending
- 2017-07-07 JP JP2019500259A patent/JP7179353B2/ja active Active
- 2017-07-07 MX MX2019000120A patent/MX393913B/es unknown
- 2017-07-07 ES ES17825031T patent/ES3040735T3/es active Active
- 2017-07-07 US US16/314,852 patent/US20190247375A1/en not_active Abandoned
- 2017-07-07 WO PCT/US2017/041211 patent/WO2018009875A1/en not_active Ceased
- 2017-07-07 EP EP17825031.2A patent/EP3481505B1/en active Active
- 2017-07-07 AU AU2017293950A patent/AU2017293950B2/en active Active
-
2024
- 2024-01-16 US US18/414,316 patent/US20240189291A1/en not_active Abandoned
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