RU2016141570A - Комбинации ингибитора fgfr и ингибитора igf1r - Google Patents
Комбинации ингибитора fgfr и ингибитора igf1r Download PDFInfo
- Publication number
- RU2016141570A RU2016141570A RU2016141570A RU2016141570A RU2016141570A RU 2016141570 A RU2016141570 A RU 2016141570A RU 2016141570 A RU2016141570 A RU 2016141570A RU 2016141570 A RU2016141570 A RU 2016141570A RU 2016141570 A RU2016141570 A RU 2016141570A
- Authority
- RU
- Russia
- Prior art keywords
- combination according
- inhibitor
- pharmaceutically acceptable
- cancer
- dimethoxyphenyl
- Prior art date
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/498—Pyrazines or piperazines ortho- and peri-condensed with carbocyclic ring systems, e.g. quinoxaline, phenazine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
Claims (11)
1. Комбинация ингибитора FGFR и ингибитора IGF1R.
2. Комбинация по п.1, где ингибитор FGFR выбран из N-(3,5-диметоксифенил)-N'-(1-метилэтил)-N-[3-(1-метил-1H-пиразол-4-ил)хиноксалин-6-ил]этан-1,2-диамина или его фармацевтически приемлемой соли или его сольвата и N-(2-фтор-3,5-диметоксифенил)-N-(1H-имидазол-2-илметил)-3-(1-метил-1H-пиразол-4-ил)пиридо[2,3-b]пиразин-6-амина или его фармацевтически приемлемой соли или его сольвата.
3. Комбинация по п.2, где ингибитор FGFR является N-(3,5-диметоксифенил)-N'-(1-метилэтил)-N-[3-(1-метил-1H-пиразол-4-ил)хиноксалин-6-ил]этан-1,2-диамином или его фармацевтически приемлемой солью или его сольватом.
4. Комбинация по п.2, где ингибитор FGFR является N-(2-фтор-3,5-диметоксифенил)-N-(1H-имидазол-2-илметил)-3-(1-метил-1H-пиразол-4-ил)пиридо[2,3-b]пиразин-6-амином или его фармацевтически приемлемой солью или его сольватом.
5. Комбинация по любому из предыдущих пунктов, где ингибитор IGF1R выбран из GSK1838705A и BMS-754807.
6. Фармацевтическая композиция, включающая фармацевтически приемлемый носитель и комбинацию по любому из предыдущих пунктов.
7. Комбинация по любому из пп.1-5 или фармацевтическая композиция по п.6 для применения в качестве лекарственного средства.
8. Применение комбинации по любому из пп.1-5 или фармацевтической композиции по п.6 для производства лекарственного средства для профилактики или лечения, в особенности для лечения, рака.
9. Способ профилактики или лечения рака, включающий введение субъекту, нуждающемуся в этом, комбинации по любому из пп.1-5 или фармацевтической композиции по п.6.
10. Применение по п.8 или способ по п.9 для лечения рака легких, мочевого пузыря, молочной железы, желудка или гепатоцеллюлярного рака.
11. Фармацевтический продукт, содержащий комбинацию по любому из пп.1-5 в качестве комбинированного препарата для одновременного, отдельного или последовательного применения в лечении рака.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP14161841.3 | 2014-03-26 | ||
| EP14161841 | 2014-03-26 | ||
| PCT/EP2015/056518 WO2015144808A1 (en) | 2014-03-26 | 2015-03-26 | Combinations of an fgfr inhibitor and an igf1r inhibitor |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| RU2016141570A true RU2016141570A (ru) | 2018-04-26 |
| RU2016141570A3 RU2016141570A3 (ru) | 2018-11-19 |
| RU2715893C2 RU2715893C2 (ru) | 2020-03-04 |
Family
ID=50389859
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2016141570A RU2715893C2 (ru) | 2014-03-26 | 2015-03-26 | Комбинации ингибитора fgfr и ингибитора igf1r |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US10736900B2 (ru) |
| EP (1) | EP3122359B1 (ru) |
| JP (2) | JP6980385B2 (ru) |
| KR (1) | KR102479696B1 (ru) |
| CN (1) | CN106456648B (ru) |
| AU (1) | AU2015238305B2 (ru) |
| BR (1) | BR112016022062B1 (ru) |
| CA (1) | CA2943687C (ru) |
| DK (1) | DK3122359T3 (ru) |
| HR (1) | HRP20210319T1 (ru) |
| HU (1) | HUE053653T2 (ru) |
| LT (1) | LT3122359T (ru) |
| MX (1) | MX2016012368A (ru) |
| RU (1) | RU2715893C2 (ru) |
| SI (1) | SI3122359T1 (ru) |
| WO (1) | WO2015144808A1 (ru) |
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| GB201118652D0 (en) | 2011-10-28 | 2011-12-07 | Astex Therapeutics Ltd | New compounds |
| GB201118654D0 (en) | 2011-10-28 | 2011-12-07 | Astex Therapeutics Ltd | New compounds |
| GB201118656D0 (en) | 2011-10-28 | 2011-12-07 | Astex Therapeutics Ltd | New compounds |
| GB201118675D0 (en) | 2011-10-28 | 2011-12-14 | Astex Therapeutics Ltd | New compounds |
| GB201209609D0 (en) | 2012-05-30 | 2012-07-11 | Astex Therapeutics Ltd | New compounds |
| GB201209613D0 (en) | 2012-05-30 | 2012-07-11 | Astex Therapeutics Ltd | New compounds |
| GB201307577D0 (en) | 2013-04-26 | 2013-06-12 | Astex Therapeutics Ltd | New compounds |
| JO3512B1 (ar) | 2014-03-26 | 2020-07-05 | Astex Therapeutics Ltd | مشتقات كينوكسالين مفيدة كمعدلات لإنزيم fgfr كيناز |
| ES2856482T3 (es) | 2014-03-26 | 2021-09-27 | Astex Therapeutics Ltd | Combinaciones de inhibidores de FGFR y cMet para el tratamiento del cáncer |
| HUE053653T2 (hu) | 2014-03-26 | 2021-07-28 | Astex Therapeutics Ltd | FGFR inhibitor és IGF1R inhibitor kombinációi |
| JOP20200201A1 (ar) | 2015-02-10 | 2017-06-16 | Astex Therapeutics Ltd | تركيبات صيدلانية تشتمل على n-(3.5- ثنائي ميثوكسي فينيل)-n'-(1-ميثيل إيثيل)-n-[3-(ميثيل-1h-بيرازول-4-يل) كينوكسالين-6-يل]إيثان-1.2-ثنائي الأمين |
| US10478494B2 (en) | 2015-04-03 | 2019-11-19 | Astex Therapeutics Ltd | FGFR/PD-1 combination therapy for the treatment of cancer |
| US11155555B2 (en) | 2015-09-23 | 2021-10-26 | Janssen Pharmaceutica Nv | Compounds |
| HUE057090T2 (hu) | 2015-09-23 | 2022-04-28 | Janssen Pharmaceutica Nv | BI-heteroaril-szubsztituált 1,4-benzodiazepinek és alkalmazásuk rák kezelésében |
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-
2015
- 2015-03-26 HU HUE15735860A patent/HUE053653T2/hu unknown
- 2015-03-26 WO PCT/EP2015/056518 patent/WO2015144808A1/en active Application Filing
- 2015-03-26 DK DK15735860.7T patent/DK3122359T3/da active
- 2015-03-26 RU RU2016141570A patent/RU2715893C2/ru active
- 2015-03-26 US US15/128,347 patent/US10736900B2/en active Active
- 2015-03-26 BR BR112016022062-5A patent/BR112016022062B1/pt active IP Right Grant
- 2015-03-26 CN CN201580027659.9A patent/CN106456648B/zh active Active
- 2015-03-26 MX MX2016012368A patent/MX2016012368A/es active IP Right Grant
- 2015-03-26 JP JP2016558671A patent/JP6980385B2/ja active Active
- 2015-03-26 SI SI201531534T patent/SI3122359T1/sl unknown
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- 2015-03-26 KR KR1020167029757A patent/KR102479696B1/ko active IP Right Grant
- 2015-03-26 LT LTEP15735860.7T patent/LT3122359T/lt unknown
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| RU2715893C2 (ru) | 2020-03-04 |
| AU2015238305A1 (en) | 2016-11-10 |
| KR102479696B1 (ko) | 2022-12-22 |
| KR20160128432A (ko) | 2016-11-07 |
| CA2943687C (en) | 2024-02-13 |
| RU2016141570A3 (ru) | 2018-11-19 |
| BR112016022062A8 (pt) | 2021-07-20 |
| US20170100406A1 (en) | 2017-04-13 |
| MX2016012368A (es) | 2017-02-23 |
| BR112016022062B1 (pt) | 2023-04-11 |
| CA2943687A1 (en) | 2015-10-01 |
| US10736900B2 (en) | 2020-08-11 |
| DK3122359T3 (da) | 2021-03-08 |
| SI3122359T1 (sl) | 2021-05-31 |
| JP2020114822A (ja) | 2020-07-30 |
| JP6980385B2 (ja) | 2021-12-15 |
| LT3122359T (lt) | 2021-03-25 |
| WO2015144808A1 (en) | 2015-10-01 |
| JP2017512792A (ja) | 2017-05-25 |
| EP3122359B1 (en) | 2020-12-16 |
| EP3122359A1 (en) | 2017-02-01 |
| CN106456648B (zh) | 2021-11-02 |
| HUE053653T2 (hu) | 2021-07-28 |
| HRP20210319T1 (hr) | 2021-04-30 |
| CN106456648A (zh) | 2017-02-22 |
| AU2015238305B2 (en) | 2020-06-18 |
| BR112016022062A2 (pt) | 2017-08-22 |
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