JP2019518071A - Nlrp活性に関連する状態を処置するための化合物および組成物 - Google Patents
Nlrp活性に関連する状態を処置するための化合物および組成物 Download PDFInfo
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- JP2019518071A JP2019518071A JP2019505347A JP2019505347A JP2019518071A JP 2019518071 A JP2019518071 A JP 2019518071A JP 2019505347 A JP2019505347 A JP 2019505347A JP 2019505347 A JP2019505347 A JP 2019505347A JP 2019518071 A JP2019518071 A JP 2019518071A
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- Prior art keywords
- alkyl
- ring
- hydroxy
- alkoxy
- optionally substituted
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- 0 CC*(CC1)C(C)(CC)*(*)CC2C1C(*)C1C2C1 Chemical compound CC*(CC1)C(C)(CC)*(*)CC2C1C(*)C1C2C1 0.000 description 11
- DVXXERRMWJBACR-UHFFFAOYSA-N CC(C)(c([s]1)cnc1S(N)(=O)=O)O Chemical compound CC(C)(c([s]1)cnc1S(N)(=O)=O)O DVXXERRMWJBACR-UHFFFAOYSA-N 0.000 description 1
- DSDCZVHJVIVWJK-UHFFFAOYSA-N CC(C)c(c(N)c1C(C)C)ccc1F Chemical compound CC(C)c(c(N)c1C(C)C)ccc1F DSDCZVHJVIVWJK-UHFFFAOYSA-N 0.000 description 1
- WPBHCIDEIFEAER-UHFFFAOYSA-N CC(C)c1cc(C(N)=O)cc(C(C)C)c1N Chemical compound CC(C)c1cc(C(N)=O)cc(C(C)C)c1N WPBHCIDEIFEAER-UHFFFAOYSA-N 0.000 description 1
- ZBLUGCVTVHUUCH-UHFFFAOYSA-N CC1(C2)C2(C)CCC1 Chemical compound CC1(C2)C2(C)CCC1 ZBLUGCVTVHUUCH-UHFFFAOYSA-N 0.000 description 1
- MUQXJCZNGGXGAN-UHFFFAOYSA-N COC(c1c[s]c(S(N)(=O)=O)c1)=O Chemical compound COC(c1c[s]c(S(N)(=O)=O)c1)=O MUQXJCZNGGXGAN-UHFFFAOYSA-N 0.000 description 1
- IAASRAYHXHBDQG-KCWJKURDSA-N C[C@@](/C(/C=C(/C)\N)=C/C)(N)[Zn] Chemical compound C[C@@](/C(/C=C(/C)\N)=C/C)(N)[Zn] IAASRAYHXHBDQG-KCWJKURDSA-N 0.000 description 1
- VOSGDHADLQGZRQ-UHFFFAOYSA-N NS(c1cc(C2(CC2)O)c[s]1)(=O)=O Chemical compound NS(c1cc(C2(CC2)O)c[s]1)(=O)=O VOSGDHADLQGZRQ-UHFFFAOYSA-N 0.000 description 1
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- C07D263/30—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D263/34—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
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- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D333/30—Hetero atoms other than halogen
- C07D333/34—Sulfur atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2603/00—Systems containing at least three condensed rings
- C07C2603/02—Ortho- or ortho- and peri-condensed systems
- C07C2603/04—Ortho- or ortho- and peri-condensed systems containing three rings
- C07C2603/06—Ortho- or ortho- and peri-condensed systems containing three rings containing at least one ring with less than six ring members
- C07C2603/10—Ortho- or ortho- and peri-condensed systems containing three rings containing at least one ring with less than six ring members containing five-membered rings
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| US201662324071P | 2016-04-18 | 2016-04-18 | |
| US62/324,071 | 2016-04-18 | ||
| US62/324,081 | 2016-04-18 | ||
| PCT/US2017/028167 WO2017184624A1 (en) | 2016-04-18 | 2017-04-18 | Compounds and compositions for treating conditions associated with nlrp activity |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
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| JP2023518044A (ja) * | 2020-03-16 | 2023-04-27 | ズーマゲン バイオサイエンシーズ エルティーディー | Nlrp3モジュレーター |
Families Citing this family (67)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR3046933B1 (fr) * | 2016-01-25 | 2018-03-02 | Galderma Research & Development | Inhibiteurs nlrp3 pour le traitement des pathologies cutanees inflammatoires |
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| MA55695A (fr) | 2017-01-23 | 2022-02-23 | Genentech Inc | Composés chimiques comme inhibiteurs de l'activité interleukine-1 |
| CA3059458A1 (en) | 2017-05-24 | 2018-11-29 | The University Of Queensland | Novel compounds and uses |
| DK3661925T3 (da) | 2017-07-07 | 2022-02-28 | Inflazome Ltd | Hidtil ukendte sulfonamidcarboxamidforbindelser |
| US11370776B2 (en) | 2017-07-07 | 2022-06-28 | Inflazome Limited | Sulfonylureas and sulfonylthioureas as NLRP3 inhibitors |
| WO2019023145A1 (en) * | 2017-07-24 | 2019-01-31 | IFM Tre, Inc. | COMPOUNDS AND COMPOSITIONS FOR THE TREATMENT OF PATHOLOGICAL CONDITIONS ASSOCIATED WITH NLRP ACTIVITY |
| HRP20240521T1 (hr) | 2017-07-24 | 2024-07-05 | Novartis Ag | Spojevi i pripravci za liječenje stanja povezanih s aktivnošću nlrp |
| TW201910317A (zh) * | 2017-08-15 | 2019-03-16 | 愛爾蘭商英弗雷佐姆有限公司 | 新穎化合物 |
| MA49903A (fr) | 2017-08-15 | 2020-06-24 | Inflazome Ltd | Sulfonylureés et sulfonylthioureés en tant qu'inhibiteurs de nlrp3 |
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| WO2019043610A1 (en) | 2017-08-31 | 2019-03-07 | Cadila Healthcare Limited | NEW SUBSTITUTED SULFONYLUREA DERIVATIVES |
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| WO2020102100A1 (en) | 2018-11-13 | 2020-05-22 | Novartis Inflammasome Research, Inc. | Compounds and compositions for treating conditions associated with nlrp activity |
| JP2022507505A (ja) * | 2018-11-16 | 2022-01-18 | ノバルティス アーゲー | Nlrp活性に関連する状態を治療するための化合物及び組成物 |
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| KR20230028425A (ko) | 2020-06-19 | 2023-02-28 | 에이씨 이뮨 에스에이 | Nlrp3 인플라마좀 경로를 조절하는 디하이드로옥사졸 및 티오우레아 또는 우레아 유도체 |
| WO2022023907A1 (en) | 2020-07-31 | 2022-02-03 | Novartis Ag | Methods of selecting and treating patients at elevated risk of major adverse cardiac events |
| CN117279903A (zh) * | 2021-02-10 | 2023-12-22 | 杭州英创医药科技有限公司 | 作为nlrp3抑制剂的化合物 |
| US11319319B1 (en) | 2021-04-07 | 2022-05-03 | Ventus Therapeutics U.S., Inc. | Compounds for inhibiting NLRP3 and uses thereof |
| US11932630B2 (en) | 2021-04-16 | 2024-03-19 | Novartis Ag | Heteroaryl aminopropanol derivatives |
| WO2022237780A1 (zh) * | 2021-05-10 | 2022-11-17 | 成都百裕制药股份有限公司 | 酰胺衍生物及其应用 |
| CN118355000A (zh) * | 2021-12-03 | 2024-07-16 | 辰欣药业股份有限公司 | 二甲基亚磺酰亚胺衍生物的盐型及晶型 |
| US20250109126A1 (en) | 2021-12-22 | 2025-04-03 | Ac Immune Sa | Dihydro-oxazol derivative compounds |
| WO2024013395A1 (en) | 2022-07-14 | 2024-01-18 | Ac Immune Sa | Pyrrolotriazine and imidazotriazine derivatives as modulators of the nlrp3 inflammasome pathway |
| IL318406A (en) | 2022-07-28 | 2025-03-01 | Ac Immune Sa | New compounds |
| US12331048B2 (en) | 2022-10-31 | 2025-06-17 | Ventus Therapeutics U.S., Inc. | Pyrido-[3,4-d]pyridazine amine derivatives useful as NLRP3 inhibitors |
| WO2024249539A1 (en) | 2023-06-02 | 2024-12-05 | Merck Sharp & Dohme Llc | 5,6 unsaturated bicyclic heterocyles useful as inhibitors of nod-like receptor protein 3 |
| WO2025133307A1 (en) | 2023-12-22 | 2025-06-26 | Ac Immune Sa | Heterocyclic modulators of the nlrp3 inflammasome pathway |
| WO2025153532A1 (en) | 2024-01-16 | 2025-07-24 | NodThera Limited | Nlrp3 inhibitors and glp-1 agonists combination therapies |
| WO2025153625A1 (en) | 2024-01-17 | 2025-07-24 | Ac Immune Sa | Imidazo[1,2-d][1,2,4]triazine derivatives for use as inhibitors of the nlrp3 inflammasome pathway |
| WO2025153624A1 (en) | 2024-01-17 | 2025-07-24 | Ac Immune Sa | Imidazo[1,2-d][1,2,4]triazine derivatives for use as inhibitors of the nlrp3 inflammasome pathway |
| WO2025163069A1 (en) | 2024-01-31 | 2025-08-07 | Ac Immune Sa | Novel compounds |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH04234382A (ja) * | 1990-07-17 | 1992-08-24 | Eli Lilly & Co | 抗腫瘍剤 |
| JPH0649052A (ja) * | 1992-03-13 | 1994-02-22 | Eli Lilly & Co | 抗腫瘍剤 |
| JP2003509378A (ja) * | 1999-09-14 | 2003-03-11 | ファイザー・プロダクツ・インク | IL−1raとIL−1プロセシング・放出阻害化合物の併用療法 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2110524A1 (en) | 1992-12-10 | 1994-06-11 | Gerald Burr Grindey | Antitumor compositions and methods of treatment |
| EP0964849B1 (en) * | 1997-01-29 | 2003-06-04 | Pfizer Inc. | Sulfonyl urea derivatives and their use in the control of interleukin-1 activity |
| EP0987552A3 (en) * | 1998-08-31 | 2000-06-07 | Pfizer Products Inc. | Diarylsulfonylurea binding proteins |
| CA2369967A1 (en) * | 2001-02-12 | 2002-08-12 | Joseph Anthony Cornicelli | Methods of treating nuclear factor-kappa b mediated diseases and disorders |
| CA2468706A1 (en) * | 2001-11-30 | 2003-06-05 | Mark Anthony Dombroski | Combination of an il-1/18 inhibitor with a tnf inhibitor for the treatment of inflammation |
| DK200600313A (da) * | 2006-03-03 | 2006-03-13 | Novo Nordisk As | Treating type 2 diabetes or metabolic syndrome with an interleukin 1beta inhibitor or an interleukin 1beta synthesis or release inhibitor |
| CA2913154A1 (en) | 2013-05-21 | 2014-11-27 | Virginia Commonwealth University | Cryopyrin inhibitors for preventing and treating inflammation |
| IL253661B2 (en) | 2015-02-16 | 2024-01-01 | Univ Queensland | Sulfonylureas bearing a five-membered ring, and pharmaceutical compositions and uses thereof |
| JP7050751B2 (ja) | 2016-04-18 | 2022-04-08 | ノバルティス アーゲー | Nlrp活性に関連する状態を処置するための化合物および組成物 |
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- 2017-04-18 WO PCT/US2017/028167 patent/WO2017184624A1/en not_active Ceased
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- 2017-04-18 MA MA056008A patent/MA56008A/fr unknown
- 2017-04-18 EP EP20208882.9A patent/EP3872070A1/en not_active Withdrawn
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Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH04234382A (ja) * | 1990-07-17 | 1992-08-24 | Eli Lilly & Co | 抗腫瘍剤 |
| JPH0649052A (ja) * | 1992-03-13 | 1994-02-22 | Eli Lilly & Co | 抗腫瘍剤 |
| JP2003509378A (ja) * | 1999-09-14 | 2003-03-11 | ファイザー・プロダクツ・インク | IL−1raとIL−1プロセシング・放出阻害化合物の併用療法 |
Non-Patent Citations (1)
| Title |
|---|
| REGISTRY(STN)[ONLINE], JPN7021001154, 12 October 2004 (2004-10-12), ISSN: 0004721688 * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2023518044A (ja) * | 2020-03-16 | 2023-04-27 | ズーマゲン バイオサイエンシーズ エルティーディー | Nlrp3モジュレーター |
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| US11597706B2 (en) | 2023-03-07 |
| US20190119224A1 (en) | 2019-04-25 |
| AU2017254523B2 (en) | 2021-09-02 |
| AU2017254522B2 (en) | 2021-09-23 |
| EP3445756A1 (en) | 2019-02-27 |
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| ES2927777T3 (es) | 2022-11-10 |
| EP3445756B1 (en) | 2022-07-06 |
| EP3445757B1 (en) | 2020-11-25 |
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| US11339136B2 (en) | 2022-05-24 |
| MA56008A (fr) | 2022-04-06 |
| EP3445757A1 (en) | 2019-02-27 |
| WO2017184624A1 (en) | 2017-10-26 |
| AU2017254523A1 (en) | 2018-11-01 |
| WO2017184623A1 (en) | 2017-10-26 |
| US20230099258A1 (en) | 2023-03-30 |
| EP3872070A1 (en) | 2021-09-01 |
| MA44729A (fr) | 2021-05-12 |
| AU2017254522A1 (en) | 2018-11-01 |
| JP2019515952A (ja) | 2019-06-13 |
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