JP2019517523A5 - - Google Patents
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- JP2019517523A5 JP2019517523A5 JP2018563453A JP2018563453A JP2019517523A5 JP 2019517523 A5 JP2019517523 A5 JP 2019517523A5 JP 2018563453 A JP2018563453 A JP 2018563453A JP 2018563453 A JP2018563453 A JP 2018563453A JP 2019517523 A5 JP2019517523 A5 JP 2019517523A5
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- -1 PPAR delta agonist Substances 0.000 claims description 14
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- 230000001225 therapeutic effect Effects 0.000 claims description 5
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| EP2545964A1 (en) | 2011-07-13 | 2013-01-16 | Phenex Pharmaceuticals AG | Novel FXR (NR1H4) binding and activity modulating compounds |
| US11571431B2 (en) | 2013-12-04 | 2023-02-07 | Galmed Research And Development Ltd | Aramchol salts |
| IL243707A0 (en) | 2016-01-20 | 2016-05-01 | Galmed Res And Dev Ltd | Treatment to regulate the microbiota in the intestine |
| SG11201810602YA (en) * | 2016-06-03 | 2018-12-28 | Chemocentryx Inc | Method of treating liver fibrosis |
| MX385718B (es) | 2016-06-13 | 2025-03-18 | Gilead Sciences Inc | Compuestos moduladores de fxr (nr1h4). |
| CA3252823A1 (en) | 2016-06-13 | 2025-02-25 | Gilead Sciences, Inc. | Substituted tert-butyl-3-(2-chloro-phenyl)-3-hydroxyazetidine-1-carboxylate compounds |
| US11197870B2 (en) | 2016-11-10 | 2021-12-14 | Galmed Research And Development Ltd | Treatment for hepatic fibrosis |
| IL311409A (en) * | 2016-11-10 | 2024-05-01 | Galmed Res And Development Ltd | Use of Amcol for the treatment of fibrosis |
| PT3600309T (pt) | 2017-03-28 | 2022-10-03 | Gilead Sciences Inc | Combinações terapêuticas para o tratamento de doenças hepáticas |
| US11707472B2 (en) | 2017-06-05 | 2023-07-25 | Viking Therapeutics, Inc. | Compositions for the treatment of fibrosis |
| US11542256B2 (en) | 2017-09-03 | 2023-01-03 | Angion Biomedica Corp. | Vinylheterocycles as Rho-associated coiled-coil kinase (ROCK) inhibitors |
| WO2019149089A1 (zh) | 2018-02-02 | 2019-08-08 | 四川科伦博泰生物医药股份有限公司 | 含有羧酸基团的苯并氮杂环类化合物及其制备方法和用途 |
| ES3053674T3 (en) | 2018-03-22 | 2026-01-23 | Viking Therapeutics Inc | Crystalline forms and methods of producing crystalline forms of a compound |
| CN111801324B (zh) * | 2018-06-12 | 2021-10-22 | 四川海思科制药有限公司 | 甲状腺激素受体激动剂及其用途 |
| US20210322324A1 (en) * | 2018-08-14 | 2021-10-21 | Avolynt | Method for treating primary sclerosing cholangitis |
| GB201813678D0 (en) * | 2018-08-22 | 2018-10-03 | Keybioscience Ag | Acylated calcitonin mimetics |
| WO2020117962A1 (en) | 2018-12-05 | 2020-06-11 | Viking Therapeutics, Inc. | Compositions for the treatment of fibrosis and inflammation |
| EP3911647B1 (en) | 2019-01-15 | 2023-12-13 | Gilead Sciences, Inc. | Isoxazole compound as fxr agonist and pharmaceutical compositions comprising same |
| CA3233305A1 (en) | 2019-02-19 | 2020-08-27 | Gilead Sciences, Inc. | Solid forms of fxr agonists |
| WO2020181163A1 (en) * | 2019-03-06 | 2020-09-10 | Tobira Therapeutics, Inc. | Lipid-based formulation of cenicriviroc |
| GEP20247637B (en) | 2019-05-08 | 2024-06-25 | Aligos Therapeutics Inc | Modulators of thr-b and methods of use thereof |
| EP4006552A2 (en) * | 2019-07-30 | 2022-06-01 | Kobiolabs, Inc. | Kit for predicting or diagnosing nonalcoholic fatty liver disease, and method for diagnosing nonalcoholic fatty liver disease |
| JP7303372B2 (ja) * | 2019-07-30 | 2023-07-04 | コバイオラブス，インコーポレーテッド | 肝損傷予防、改善、または治療用組成物、および肝損傷予防、改善、または治療方法 |
| CN114929214A (zh) * | 2019-11-22 | 2022-08-19 | 阿沃林特有限公司 | Sglt2抑制剂治疗原发性胆汁性胆管炎的用途 |
| CN116942684A (zh) * | 2020-02-20 | 2023-10-27 | 甘莱制药有限公司 | 一种用于治疗脂肪性肝炎的药物组合物及其制备方法 |
| US11478533B2 (en) * | 2020-04-27 | 2022-10-25 | Novo Nordisk A/S | Semaglutide for use in medicine |
| WO2022075756A1 (ko) * | 2020-10-08 | 2022-04-14 | 주식회사 큐롬바이오사이언스 | 베타-라파촌을 유효성분으로 포함하는 담즙 정체성 간질환 예방 또는 치료용 약학 조성물 |
| CN120899882A (zh) * | 2025-06-16 | 2025-11-07 | 中国疾病预防控制中心寄生虫病预防控制所(国家热带病研究中心) | Klb蛋白在制备治疗血吸虫感染的药物上的应用 |
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| AR049386A1 (es) * | 2004-05-26 | 2006-07-26 | Janssen Pharmaceutica Nv | Mercaptoimidazoles como antagonistas del receptor ccr2 |
| ES2440965T3 (es) | 2005-01-14 | 2014-01-31 | Chemocentryx, Inc. | Heteroaril-sulfonamidas y CCR2 |
| US7622583B2 (en) | 2005-01-14 | 2009-11-24 | Chemocentryx, Inc. | Heteroaryl sulfonamides and CCR2 |
| WO2007053498A1 (en) * | 2005-11-01 | 2007-05-10 | Millennium Pharmaceuticals, Inc. | Compounds useful as antagonists of ccr2 |
| US20070219245A1 (en) | 2006-03-14 | 2007-09-20 | Cuifen Hou | Method of use for substituted dipiperidine ccr2 antagonists |
| US7683176B2 (en) * | 2006-07-14 | 2010-03-23 | Chemocentryx, Inc. | Triazolyl pyridyl benzenesulfonamides |
| US8519135B2 (en) * | 2006-07-14 | 2013-08-27 | Chemocentryx, Inc. | Heteroaryl sulfonamides and CCR2/CCR9 |
| US7776877B2 (en) * | 2007-06-22 | 2010-08-17 | Chemocentryx, Inc. | N-(2-(hetaryl)aryl) arylsulfonamides and N-(2-(hetaryl) hetaryl arylsulfonamides |
| PL2175859T3 (pl) * | 2007-07-12 | 2012-09-28 | Chemocentryx Inc | Skondensowane heteroarylopirydylo- i fenylo-benzenosulfonamidy jako modulatory CCR2 do leczenia zapalenia |
| PE20100156A1 (es) * | 2008-06-03 | 2010-02-23 | Boehringer Ingelheim Int | Tratamiento de nafld |
| JP5685535B2 (ja) | 2008-08-18 | 2015-03-18 | ファイザー インコーポレイティッド | Ｃｃｒ２に対する抗体 |
| ES2674275T3 (es) | 2009-12-17 | 2018-06-28 | Centrexion Therapeutics Corporation | Antagonistas del receptor CCR2 y usos de los mismos |
| CN103391931A (zh) * | 2011-02-25 | 2013-11-13 | 辉瑞有限公司 | 治疗肝纤维化的方法 |
| ES2869884T3 (es) * | 2011-09-16 | 2021-10-26 | Galectin Therapeutics Inc | Composiciones de galacto-ramnogalacturonato para el tratamiento de la esteatohepatitis no alcohólica y la enfermedad de hígado graso no alcohólico |
| AU2013258109A1 (en) * | 2012-05-09 | 2014-10-30 | Boehringer Ingelheim International Gmbh | Pharmaceutical combinations for the treatment of metabolic disorders |
| TWI696462B (zh) * | 2013-07-10 | 2020-06-21 | 日商興和股份有限公司 | 非酒精性脂肪性肝疾病治療劑 |
| BR112017004708A2 (pt) * | 2014-09-12 | 2017-12-05 | Tobira Therapeutics Inc | terapia de combinação de cenicriviroc para o tratamento de fibrose |
| SG11201810602YA (en) * | 2016-06-03 | 2018-12-28 | Chemocentryx Inc | Method of treating liver fibrosis |
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2017
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- 2017-06-02 WO PCT/US2017/035628 patent/WO2017210526A1/en not_active Ceased
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- 2017-06-02 SG SG10202012080UA patent/SG10202012080UA/en unknown
- 2017-06-02 EP EP17807548.7A patent/EP3463350B1/en active Active
- 2017-06-02 JP JP2018563453A patent/JP2019517523A/ja not_active Withdrawn
- 2017-06-02 BR BR112018074452-2A patent/BR112018074452A2/pt not_active Application Discontinuation
- 2017-06-02 KR KR1020187037797A patent/KR102444366B1/ko active Active
- 2017-06-02 MX MX2018014743A patent/MX387070B/es unknown
- 2017-06-02 ES ES17807548T patent/ES2966111T3/es active Active
- 2017-06-02 RU RU2018145459A patent/RU2740902C2/ru active
- 2017-06-02 CA CA3025671A patent/CA3025671C/en active Active
- 2017-06-02 CN CN202210819034.8A patent/CN115154467B/zh active Active
- 2017-06-02 CN CN201780048523.5A patent/CN109475537A/zh active Pending
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2018
- 2018-11-25 IL IL263245A patent/IL263245B/en unknown
- 2018-11-26 ZA ZA2018/07992A patent/ZA201807992B/en unknown
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2020
- 2020-05-06 US US16/867,956 patent/US11357760B2/en active Active
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2022
- 2022-05-11 US US17/662,979 patent/US20220313668A1/en not_active Abandoned
- 2022-11-30 JP JP2022191906A patent/JP7431931B2/ja active Active
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