JP2019516717A5 - - Google Patents
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- Publication number
- JP2019516717A5 JP2019516717A5 JP2018560585A JP2018560585A JP2019516717A5 JP 2019516717 A5 JP2019516717 A5 JP 2019516717A5 JP 2018560585 A JP2018560585 A JP 2018560585A JP 2018560585 A JP2018560585 A JP 2018560585A JP 2019516717 A5 JP2019516717 A5 JP 2019516717A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- halo
- optionally substituted
- compound
- haloalkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 0 C[C@](**)[C@@](C(*)CC1C2[C@]([C@]3*)O)C1(C)C(*)CC2[C@@](C)(CC1)C3=CC1=O Chemical compound C[C@](**)[C@@](C(*)CC1C2[C@]([C@]3*)O)C1(C)C(*)CC2[C@@](C)(CC1)C3=CC1=O 0.000 description 3
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB1608779.3 | 2016-05-18 | ||
| GBGB1608779.3A GB201608779D0 (en) | 2016-05-18 | 2016-05-18 | Methods and compounds |
| PCT/GB2017/051393 WO2017199039A1 (en) | 2016-05-18 | 2017-05-18 | Steroid 6.7.beta.-epoxides as chemical intermediates |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2019516717A JP2019516717A (ja) | 2019-06-20 |
| JP2019516717A5 true JP2019516717A5 (https=) | 2020-07-02 |
| JP7034092B2 JP7034092B2 (ja) | 2022-03-11 |
Family
ID=56320631
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018560585A Active JP7034092B2 (ja) | 2016-05-18 | 2017-05-18 | 化学的中間体としてのステロイド６．７．β－エポキシド |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US20190153023A1 (https=) |
| EP (1) | EP3458468B1 (https=) |
| JP (1) | JP7034092B2 (https=) |
| KR (1) | KR102509432B1 (https=) |
| CN (1) | CN109415403A (https=) |
| AU (1) | AU2017265925A1 (https=) |
| BR (1) | BR112018073490A2 (https=) |
| CA (1) | CA3024285A1 (https=) |
| EA (1) | EA037742B1 (https=) |
| ES (1) | ES2857869T3 (https=) |
| GB (1) | GB201608779D0 (https=) |
| MX (1) | MX377644B (https=) |
| WO (1) | WO2017199039A1 (https=) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB201608776D0 (en) * | 2016-05-18 | 2016-06-29 | Dextra Lab Ltd | Methods and compounds |
| GB201608777D0 (en) | 2016-05-18 | 2016-06-29 | Dextra Lab Ltd | Compounds |
| EP3431486A1 (en) * | 2017-07-18 | 2019-01-23 | Bionice, S.L.U. | Process and intermediates for the synthesis of obeticholic acid and derivatives thereof |
| GB201812382D0 (en) | 2018-07-30 | 2018-09-12 | Nzp Uk Ltd | Compounds |
| CN111072744B (zh) * | 2019-12-03 | 2021-09-14 | 江苏佳尔科药业集团股份有限公司 | 一种以ba为原料合成熊去氧胆酸的方法 |
| CN113912661B (zh) * | 2021-11-11 | 2023-04-21 | 湖南科瑞生物制药股份有限公司 | 一种7-羟基甾体化合物的合成方法 |
| CN114702542B (zh) * | 2022-05-11 | 2023-11-24 | 上海其正医药科技有限责任公司 | 一种25-羟基-7-去氢胆固醇的制备方法 |
| CN115974950A (zh) * | 2022-12-23 | 2023-04-18 | 上海彩迩文生化科技有限公司 | 一种3-烷基化的甾体中间体及其制备和应用 |
| CN118852307A (zh) * | 2024-07-28 | 2024-10-29 | 湖北共同甾体药物研究院有限公司 | 一种熊去氧胆酸中间体的制备方法 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ITMI20050912A1 (it) * | 2005-05-19 | 2006-11-20 | Erregierre Spa | Processo di preparazione di acidi 3-a-ya(b)-diidrossi-6-a(b)-alchil-5b-colanici |
| CN101374854A (zh) * | 2006-01-12 | 2009-02-25 | 三菱化学株式会社 | 甾类化合物的制备方法 |
| JP2007210888A (ja) * | 2006-01-12 | 2007-08-23 | Mitsubishi Chemicals Corp | ステロイド化合物の製造方法 |
| CN107207559B (zh) * | 2014-11-19 | 2019-10-25 | Nzp英国有限公司 | 作为制备类固醇fxr调节剂的中间体的6-烷基-7-羟基-4-烯-3-酮类固醇 |
| KR102527821B1 (ko) * | 2014-11-19 | 2023-05-02 | 엔제트피 유케이 리미티드 | 스테로이드 FXR 조절인자를 제조하기 위한 중간체로서의 6α-알킬-6,7-다이온 스테로이드 |
| KR102546748B1 (ko) * | 2014-11-19 | 2023-06-22 | 엔제트피 유케이 리미티드 | 스테로이드 FXR 조절인자를 제조하기 위한 중간체로서의 6α-알킬-3,7-다이온 스테로이드 |
| EA033445B1 (ru) * | 2014-11-19 | 2019-10-31 | Nzp Uk Ltd | 5-бета-6-алкил-7-гидрокси-3-оновые стероиды в качестве промежуточных соединений для получения стероидных модуляторов fxr |
-
2016
- 2016-05-18 GB GBGB1608779.3A patent/GB201608779D0/en not_active Ceased
-
2017
- 2017-05-18 WO PCT/GB2017/051393 patent/WO2017199039A1/en not_active Ceased
- 2017-05-18 CN CN201780030408.5A patent/CN109415403A/zh not_active Withdrawn
- 2017-05-18 ES ES17725744T patent/ES2857869T3/es active Active
- 2017-05-18 JP JP2018560585A patent/JP7034092B2/ja active Active
- 2017-05-18 BR BR112018073490-0A patent/BR112018073490A2/pt not_active Application Discontinuation
- 2017-05-18 EP EP17725744.1A patent/EP3458468B1/en active Active
- 2017-05-18 EA EA201892515A patent/EA037742B1/ru unknown
- 2017-05-18 AU AU2017265925A patent/AU2017265925A1/en not_active Abandoned
- 2017-05-18 CA CA3024285A patent/CA3024285A1/en active Pending
- 2017-05-18 US US16/302,058 patent/US20190153023A1/en not_active Abandoned
- 2017-05-18 MX MX2018014128A patent/MX377644B/es active IP Right Grant
- 2017-05-18 KR KR1020187035836A patent/KR102509432B1/ko active Active
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