JP2019515908A - カルビドパ及びｌ−ドパプロドラッグ並びに使用方法 - Google Patents

カルビドパ及びｌ−ドパプロドラッグ並びに使用方法 Download PDF

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Publication number
JP2019515908A
JP2019515908A JP2018554585A JP2018554585A JP2019515908A JP 2019515908 A JP2019515908 A JP 2019515908A JP 2018554585 A JP2018554585 A JP 2018554585A JP 2018554585 A JP2018554585 A JP 2018554585A JP 2019515908 A JP2019515908 A JP 2019515908A
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Prior art keywords
compound
formula
pharmaceutically acceptable
acceptable salt
hydrogen
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Pending
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JP2018554585A
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Japanese (ja)
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JP2019515908A5 (enExample
Inventor
キム，フィリップ・アール
ボイト，エリック
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アッヴィ・インコーポレイテッド
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Publication of JP2019515908A publication Critical patent/JP2019515908A/ja
Publication of JP2019515908A5 publication Critical patent/JP2019515908A5/ja
Priority to JP2021140920A priority Critical patent/JP2022000428A/ja
Priority to JP2023179367A priority patent/JP2024020212A/ja
Priority to JP2025134679A priority patent/JP2025163273A/ja
Pending legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/661—Phosphorus acids or esters thereof not having P—C bonds, e.g. fosfosal, dichlorvos, malathion or mevinphos
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • A61K31/05—Phenols
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/095—Sulfur, selenium, or tellurium compounds, e.g. thiols
    • A61K31/10—Sulfides; Sulfoxides; Sulfones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4468—Non condensed piperidines, e.g. piperocaine having a nitrogen directly attached in position 4, e.g. clebopride, fentanyl
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7012—Compounds having a free or esterified carboxyl group attached, directly or through a carbon chain, to a carbon atom of the saccharide radical, e.g. glucuronic acid, neuraminic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/06—Phosphorus compounds without P—C bonds
    • C07F9/08—Esters of oxyacids of phosphorus
    • C07F9/09—Esters of phosphoric acids
    • C07F9/12—Esters of phosphoric acids with hydroxyaryl compounds

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Neurology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Biochemistry (AREA)
  • Psychology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Saccharide Compounds (AREA)
JP2018554585A 2016-04-20 2017-04-20 カルビドパ及びｌ−ドパプロドラッグ並びに使用方法 Pending JP2019515908A (ja)

Priority Applications (3)

Application Number Priority Date Filing Date Title
JP2021140920A JP2022000428A (ja) 2016-04-20 2021-08-31 カルビドパ及びｌ−ドパプロドラッグ並びに使用方法
JP2023179367A JP2024020212A (ja) 2016-04-20 2023-10-18 カルビドパ及びｌ－ドパプロドラッグ並びに使用方法
JP2025134679A JP2025163273A (ja) 2016-04-20 2025-08-13 カルビドパ及びｌ－ドパプロドラッグ並びに使用方法

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201662325200P 2016-04-20 2016-04-20
US62/325,200 2016-04-20
PCT/US2017/028646 WO2017184871A1 (en) 2016-04-20 2017-04-20 Carbidopa and l-dopa prodrugs and methods of use

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2021140920A Division JP2022000428A (ja) 2016-04-20 2021-08-31 カルビドパ及びｌ−ドパプロドラッグ並びに使用方法

Publications (2)

Publication Number Publication Date
JP2019515908A true JP2019515908A (ja) 2019-06-13
JP2019515908A5 JP2019515908A5 (enExample) 2020-06-18

Family

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Family Applications (4)

Application Number Title Priority Date Filing Date
JP2018554585A Pending JP2019515908A (ja) 2016-04-20 2017-04-20 カルビドパ及びｌ−ドパプロドラッグ並びに使用方法
JP2021140920A Pending JP2022000428A (ja) 2016-04-20 2021-08-31 カルビドパ及びｌ−ドパプロドラッグ並びに使用方法
JP2023179367A Pending JP2024020212A (ja) 2016-04-20 2023-10-18 カルビドパ及びｌ－ドパプロドラッグ並びに使用方法
JP2025134679A Pending JP2025163273A (ja) 2016-04-20 2025-08-13 カルビドパ及びｌ－ドパプロドラッグ並びに使用方法

Family Applications After (3)

Application Number Title Priority Date Filing Date
JP2021140920A Pending JP2022000428A (ja) 2016-04-20 2021-08-31 カルビドパ及びｌ−ドパプロドラッグ並びに使用方法
JP2023179367A Pending JP2024020212A (ja) 2016-04-20 2023-10-18 カルビドパ及びｌ－ドパプロドラッグ並びに使用方法
JP2025134679A Pending JP2025163273A (ja) 2016-04-20 2025-08-13 カルビドパ及びｌ－ドパプロドラッグ並びに使用方法

Country Status (4)

Country Link
US (1) US20190224220A1 (enExample)
EP (2) EP4295909A3 (enExample)
JP (4) JP2019515908A (enExample)
WO (1) WO2017184871A1 (enExample)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RS58972B1 (sr) 2014-10-21 2019-08-30 Abbvie Inc Karbidopa i l-dopa prolekovi i njihova primena za lečenje parkinsonove bolesti
WO2019097120A1 (en) 2017-11-16 2019-05-23 Orion Corporation New use and pharmaceutical dosage forms
MX2020005366A (es) 2017-11-24 2020-08-13 H Lundbeck As Nuevos profarmacos de catecolamina para uso en el tratamiento de la enfermedad de parkinson.
EP3880210A1 (en) 2018-11-15 2021-09-22 Abbvie Inc. Pharmaceutical formulations for subcutaneous administration
JP7346571B2 (ja) * 2018-12-05 2023-09-19 ビー．ジー．ネゲブ テクノロジーズ アンド アプリケーションズ リミテッド， アット ベン‐グリオン ユニバーシティー ドーパミン応答性障害の治療のための糖にコンジュゲートされたｌ－ｄｏｐａ及び／またはｄｏｐａデカルボキシラーゼ阻害剤
US11104697B2 (en) 2019-05-20 2021-08-31 H. Lundbeck A/S Process for the manufacture of (2S,3S,4S,5R,6S)-3,4,5-trihydroxy-6-(((4AR,10AR)-7-hydroxy-1- propyl-1,2,3,4,4A,5,10,10A-octahydrobenzo[g]quinolin-6-yl)oxy)tetrahydro-2H-pyran-2-carboxylic acid
US11168056B2 (en) 2019-05-20 2021-11-09 H. Lundbeck A/S Process for the manufacturing of (6aR,10aR)-7-propyl-6,6a,7,8,9,10,10a,11-octahydro-[1,3]dioxolo[4′,5′:5,6]benzo[1,2-G]quinoline and (4aR,10aR)-1-propyl-1,2,3,4,4a,5,10,10a-octahydro-benzo[G]quinoline-6,7-diol
US11130775B2 (en) 2019-05-20 2021-09-28 H. Lundbeck A/S Solid forms of (2S,3S,4S,5R,6S)-3,4,5-trihydroxy-6-(((4aR,10aR)-7-hydroxy-1-propyl-1,2,3,4,4A,5,10,10A-octahydrobenzo[g]quinolin-6-yl)oxy)tetrahydro-2H-pyran-2-carboxylic acid
US11111263B2 (en) 2019-05-20 2021-09-07 H. Lundbeck A/S Process for the manufacture of (2S,3S,4S,5R,6S)-3,4,5-trihydroxy-6-(((4aR,10aR)-7-hydroxy-1-propyl-1,2,3,4,4a,5,10,10a-octahydrobenzo[g]quinolin-6-yl)oxy)tetrahydro-2H-pyran-2-carboxylic acid
CN119707810A (zh) 2019-05-21 2025-03-28 H.隆德贝克有限公司 用于治疗帕金森病的新儿茶酚胺前药
CN113677675B (zh) 2019-05-21 2024-07-26 H.隆德贝克有限公司 用于治疗帕金森病的新儿茶酚胺前药
CN113727979B (zh) 2019-05-21 2024-09-20 H.隆德贝克有限公司 用于治疗帕金森病的新儿茶酚胺前药
CN113727712B (zh) 2019-05-21 2024-11-15 H.隆德贝克有限公司 用于治疗帕金森病的儿茶酚胺氨基甲酸酯前药
JP2024010252A (ja) 2021-03-10 2024-01-24 田辺三菱製薬株式会社 パーキンソン病治療のための組合せ医薬
WO2024104331A1 (zh) * 2022-11-14 2024-05-23 江苏恒瑞医药股份有限公司 一种左旋多巴的前药

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004000863A1 (ja) * 2002-06-20 2003-12-31 Nippon Suisan Kaisha, Ltd. プロドラッグ、その医薬としての使用、およびその製法
JP2007504143A (ja) * 2003-08-29 2007-03-01 トランスフォーム・ファーマシューティカルズ・インコーポレイテッド 医薬組成物及びレボドパ及びカルビドパの使用方法
JP2007509972A (ja) * 2003-10-31 2007-04-19 アルザ・コーポレーシヨン レボドパ及びカルビドパの投与
JP2008505898A (ja) * 2004-07-06 2008-02-28 アボット・ラボラトリーズ Ｈｉｖプロテアーゼ阻害薬のプロドラッグ
JP2013545745A (ja) * 2010-11-15 2013-12-26 ニューロダーム リミテッド Ｌ−ドーパ、ドーパデカルボキシラーゼ阻害剤、カテコール−ｏ−メチルトランスフェラーゼ阻害剤、およびそれらのための組成物の継続的投与

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0393781B1 (en) * 1989-04-20 1995-02-08 ZAMBON GROUP S.p.A. Dopamine pro-drug
GB9102812D0 (en) * 1991-02-11 1991-03-27 Enzymatix Ltd Compounds
IT1255471B (it) * 1992-07-30 1995-11-02 Zambon Spa Derivati di catecolammine,processo per la loro preparazione e composizioni farmaceutiche che li contengono
US6204257B1 (en) * 1998-08-07 2001-03-20 Universtiy Of Kansas Water soluble prodrugs of hindered alcohols
AU2003293423A1 (en) * 2002-12-06 2004-06-30 Xenoport, Inc. Carbidopa prodrugs and uses thereof
MX339690B (es) * 2004-06-04 2016-06-06 Xenoport Inc Profarmacos de levodopa y sus composiciones y usos.
TW200843732A (en) * 2006-12-21 2008-11-16 Xenoport Inc Levodopa dimethyl-substituted diester prodrugs, compositions, and methods of use
AU2009249067A1 (en) * 2008-05-20 2009-11-26 Neurogesx, Inc. Water-soluble acetaminophen analogs
RS58972B1 (sr) * 2014-10-21 2019-08-30 Abbvie Inc Karbidopa i l-dopa prolekovi i njihova primena za lečenje parkinsonove bolesti

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004000863A1 (ja) * 2002-06-20 2003-12-31 Nippon Suisan Kaisha, Ltd. プロドラッグ、その医薬としての使用、およびその製法
JP2007504143A (ja) * 2003-08-29 2007-03-01 トランスフォーム・ファーマシューティカルズ・インコーポレイテッド 医薬組成物及びレボドパ及びカルビドパの使用方法
JP2007509972A (ja) * 2003-10-31 2007-04-19 アルザ・コーポレーシヨン レボドパ及びカルビドパの投与
JP2008505898A (ja) * 2004-07-06 2008-02-28 アボット・ラボラトリーズ Ｈｉｖプロテアーゼ阻害薬のプロドラッグ
JP2013545745A (ja) * 2010-11-15 2013-12-26 ニューロダーム リミテッド Ｌ−ドーパ、ドーパデカルボキシラーゼ阻害剤、カテコール−ｏ−メチルトランスフェラーゼ阻害剤、およびそれらのための組成物の継続的投与

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
PHARMACEUTICAL RESEARCH, vol. 10(9), JPN6021007107, 1993, pages 1350 - 1355, ISSN: 0004623349 *
日本産婦人科学会雑誌, vol. 52(12), JPN6021007106, 2000, pages 433 - 437, ISSN: 0004623348 *

Also Published As

Publication number Publication date
JP2025163273A (ja) 2025-10-28
US20190224220A1 (en) 2019-07-25
EP4295909A3 (en) 2024-07-17
JP2022000428A (ja) 2022-01-04
EP3445346A1 (en) 2019-02-27
WO2017184871A1 (en) 2017-10-26
WO2017184871A9 (en) 2018-01-25
EP4295909A2 (en) 2023-12-27
JP2024020212A (ja) 2024-02-14

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