JP2019514913A5 - - Google Patents
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- JP2019514913A5 JP2019514913A5 JP2018556332A JP2018556332A JP2019514913A5 JP 2019514913 A5 JP2019514913 A5 JP 2019514913A5 JP 2018556332 A JP2018556332 A JP 2018556332A JP 2018556332 A JP2018556332 A JP 2018556332A JP 2019514913 A5 JP2019514913 A5 JP 2019514913A5
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- JP
- Japan
- Prior art keywords
- agent
- optionally
- polypeptide
- antibody
- adhesion
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 239000003795 chemical substances by application Substances 0.000 claims 19
- 239000003814 drug Substances 0.000 claims 15
- 229940079593 drug Drugs 0.000 claims 15
- 102000004196 processed proteins & peptides Human genes 0.000 claims 11
- 108090000765 processed proteins & peptides Proteins 0.000 claims 11
- 229920001184 polypeptide Polymers 0.000 claims 9
- 101000863873 Homo sapiens Tyrosine-protein phosphatase non-receptor type substrate 1 Proteins 0.000 claims 8
- 102100029948 Tyrosine-protein phosphatase non-receptor type substrate 1 Human genes 0.000 claims 8
- 239000012634 fragment Substances 0.000 claims 8
- 101000868279 Homo sapiens Leukocyte surface antigen CD47 Proteins 0.000 claims 7
- 102100032913 Leukocyte surface antigen CD47 Human genes 0.000 claims 7
- 230000015572 biosynthetic process Effects 0.000 claims 7
- 230000002757 inflammatory effect Effects 0.000 claims 7
- 102000003735 Mesothelin Human genes 0.000 claims 6
- 108090000015 Mesothelin Proteins 0.000 claims 6
- 210000003714 granulocyte Anatomy 0.000 claims 6
- 210000002540 macrophage Anatomy 0.000 claims 6
- 210000005033 mesothelial cell Anatomy 0.000 claims 6
- 238000000034 method Methods 0.000 claims 6
- 108090000623 proteins and genes Proteins 0.000 claims 6
- 230000007115 recruitment Effects 0.000 claims 6
- 101710155857 C-C motif chemokine 2 Proteins 0.000 claims 4
- 102000000018 Chemokine CCL2 Human genes 0.000 claims 4
- WQZGKKKJIJFFOK-QTVWNMPRSA-N D-mannopyranose Chemical compound OC[C@H]1OC(O)[C@@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-QTVWNMPRSA-N 0.000 claims 4
- 102100038853 Uroplakin-1b Human genes 0.000 claims 3
- 210000000440 neutrophil Anatomy 0.000 claims 3
- 238000001356 surgical procedure Methods 0.000 claims 3
- 108091032973 (ribonucleotides)n+m Proteins 0.000 claims 2
- 101001007348 Arachis hypogaea Galactose-binding lectin Proteins 0.000 claims 2
- 102100036166 C-X-C chemokine receptor type 1 Human genes 0.000 claims 2
- 102100028989 C-X-C chemokine receptor type 2 Human genes 0.000 claims 2
- 102100024209 CD177 antigen Human genes 0.000 claims 2
- 108050006947 CXC Chemokine Proteins 0.000 claims 2
- 102000019388 CXC chemokine Human genes 0.000 claims 2
- 102100025470 Carcinoembryonic antigen-related cell adhesion molecule 8 Human genes 0.000 claims 2
- 108020004414 DNA Proteins 0.000 claims 2
- 101000947174 Homo sapiens C-X-C chemokine receptor type 1 Proteins 0.000 claims 2
- 101000980845 Homo sapiens CD177 antigen Proteins 0.000 claims 2
- 101000914320 Homo sapiens Carcinoembryonic antigen-related cell adhesion molecule 8 Proteins 0.000 claims 2
- 101000694615 Homo sapiens Membrane primary amine oxidase Proteins 0.000 claims 2
- 102100022875 Hypoxia-inducible factor 1-alpha Human genes 0.000 claims 2
- 108010018951 Interleukin-8B Receptors Proteins 0.000 claims 2
- 102100027159 Membrane primary amine oxidase Human genes 0.000 claims 2
- 102000003729 Neprilysin Human genes 0.000 claims 2
- 108090000028 Neprilysin Proteins 0.000 claims 2
- 108010043958 Peptoids Proteins 0.000 claims 2
- RTIXKCRFFJGDFG-UHFFFAOYSA-N chrysin Chemical compound C=1C(O)=CC(O)=C(C(C=2)=O)C=1OC=2C1=CC=CC=C1 RTIXKCRFFJGDFG-UHFFFAOYSA-N 0.000 claims 2
- 239000003550 marker Substances 0.000 claims 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 2
- 229920001606 poly(lactic acid-co-glycolic acid) Polymers 0.000 claims 2
- CWERGRDVMFNCDR-UHFFFAOYSA-M thioglycolate(1-) Chemical compound [O-]C(=O)CS CWERGRDVMFNCDR-UHFFFAOYSA-M 0.000 claims 2
- BPBPYQWMFCTCNG-UHFFFAOYSA-N 2-(butan-2-yldisulfanyl)-1H-imidazole Chemical compound CCC(C)SSC1=NC=CN1 BPBPYQWMFCTCNG-UHFFFAOYSA-N 0.000 claims 1
- KKAJSJJFBSOMGS-UHFFFAOYSA-N 3,6-diamino-10-methylacridinium chloride Chemical compound [Cl-].C1=C(N)C=C2[N+](C)=C(C=C(N)C=C3)C3=CC2=C1 KKAJSJJFBSOMGS-UHFFFAOYSA-N 0.000 claims 1
- XVUOIWIIQVGWAJ-UHFFFAOYSA-N 3-[[(2,4-dinitrophenyl)-oxomethyl]amino]benzoic acid [2-(4-methylphenyl)-2-oxoethyl] ester Chemical compound C1=CC(C)=CC=C1C(=O)COC(=O)C1=CC=CC(NC(=O)C=2C(=CC(=CC=2)[N+]([O-])=O)[N+]([O-])=O)=C1 XVUOIWIIQVGWAJ-UHFFFAOYSA-N 0.000 claims 1
- CSCOJWVRGOZGPK-UHFFFAOYSA-N 3-[[2-[4-(2-adamantyl)phenoxy]-1-oxoethyl]amino]-4-hydroxybenzoic acid methyl ester Chemical compound COC(=O)C1=CC=C(O)C(NC(=O)COC=2C=CC(=CC=2)C2C3CC4CC(C3)CC2C4)=C1 CSCOJWVRGOZGPK-UHFFFAOYSA-N 0.000 claims 1
- RPJFWRZEEKJTGN-UHFFFAOYSA-N 4-[2-(4-hydroxyphenyl)propan-2-yl]-2,6-dimethylphenol Chemical compound CC1=C(O)C(C)=CC(C(C)(C)C=2C=CC(O)=CC=2)=C1 RPJFWRZEEKJTGN-UHFFFAOYSA-N 0.000 claims 1
- NYCXYKOXLNBYID-UHFFFAOYSA-N 5,7-Dihydroxychromone Natural products O1C=CC(=O)C=2C1=CC(O)=CC=2O NYCXYKOXLNBYID-UHFFFAOYSA-N 0.000 claims 1
- 206010000050 Abdominal adhesions Diseases 0.000 claims 1
- 102100039398 C-X-C motif chemokine 2 Human genes 0.000 claims 1
- AUJXLBOHYWTPFV-BLWRDSOESA-N CS[C@H]1SC[C@H]2N(C)C(=O)[C@@H](C)NC(=O)[C@H](COC(=O)[C@@H](C(C)C)N(C)C(=O)[C@@H]1N(C)C(=O)[C@@H](C)NC(=O)[C@H](COC(=O)[C@@H](C(C)C)N(C)C2=O)NC(=O)c1cnc2ccccc2n1)NC(=O)c1cnc2ccccc2n1 Chemical group CS[C@H]1SC[C@H]2N(C)C(=O)[C@@H](C)NC(=O)[C@H](COC(=O)[C@@H](C(C)C)N(C)C(=O)[C@@H]1N(C)C(=O)[C@@H](C)NC(=O)[C@H](COC(=O)[C@@H](C(C)C)N(C)C2=O)NC(=O)c1cnc2ccccc2n1)NC(=O)c1cnc2ccccc2n1 AUJXLBOHYWTPFV-BLWRDSOESA-N 0.000 claims 1
- GVKKJJOMQCNPGB-JTQLQIEISA-N Cryptotanshinone Chemical compound O=C1C(=O)C2=C3CCCC(C)(C)C3=CC=C2C2=C1[C@@H](C)CO2 GVKKJJOMQCNPGB-JTQLQIEISA-N 0.000 claims 1
- GVKKJJOMQCNPGB-UHFFFAOYSA-N Cryptotanshinone Natural products O=C1C(=O)C2=C3CCCC(C)(C)C3=CC=C2C2=C1C(C)CO2 GVKKJJOMQCNPGB-UHFFFAOYSA-N 0.000 claims 1
- 108010009858 Echinomycin Proteins 0.000 claims 1
- 102100034221 Growth-regulated alpha protein Human genes 0.000 claims 1
- 101000889128 Homo sapiens C-X-C motif chemokine 2 Proteins 0.000 claims 1
- 101001069921 Homo sapiens Growth-regulated alpha protein Proteins 0.000 claims 1
- 101001046870 Homo sapiens Hypoxia-inducible factor 1-alpha Proteins 0.000 claims 1
- 101000808114 Homo sapiens Uroplakin-1b Proteins 0.000 claims 1
- 108050009527 Hypoxia-inducible factor-1 alpha Proteins 0.000 claims 1
- 206010060932 Postoperative adhesion Diseases 0.000 claims 1
- 229940023020 acriflavine Drugs 0.000 claims 1
- 229940043370 chrysin Drugs 0.000 claims 1
- 235000015838 chrysin Nutrition 0.000 claims 1
- 230000000779 depleting effect Effects 0.000 claims 1
- BNJOZDZCRHCODO-UHFFFAOYSA-N dimethyloxalylglycine Chemical compound COC(=O)CNC(=O)C(=O)OC BNJOZDZCRHCODO-UHFFFAOYSA-N 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 239000003596 drug target Substances 0.000 claims 1
- 230000000694 effects Effects 0.000 claims 1
- 210000002074 inflammatory monocyte Anatomy 0.000 claims 1
- 230000002401 inhibitory effect Effects 0.000 claims 1
- 230000001483 mobilizing effect Effects 0.000 claims 1
- 230000002265 prevention Effects 0.000 claims 1
- 230000001737 promoting effect Effects 0.000 claims 1
- AUJXLBOHYWTPFV-UHFFFAOYSA-N quinomycin A Natural products CN1C(=O)C(C)NC(=O)C(NC(=O)C=2N=C3C=CC=CC3=NC=2)COC(=O)C(C(C)C)N(C)C(=O)C2N(C)C(=O)C(C)NC(=O)C(NC(=O)C=3N=C4C=CC=CC4=NC=3)COC(=O)C(C(C)C)N(C)C(=O)C1CSC2SC AUJXLBOHYWTPFV-UHFFFAOYSA-N 0.000 claims 1
- 229940071127 thioglycolate Drugs 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662329666P | 2016-04-29 | 2016-04-29 | |
| US62/329,666 | 2016-04-29 | ||
| PCT/US2017/030454 WO2017190148A1 (en) | 2016-04-29 | 2017-05-01 | Methods and compositions for the prevention and treatment of surgical adhesions |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2019514913A JP2019514913A (ja) | 2019-06-06 |
| JP2019514913A5 true JP2019514913A5 (https=) | 2020-05-28 |
| JP7160683B2 JP7160683B2 (ja) | 2022-10-25 |
Family
ID=60161169
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018556332A Active JP7160683B2 (ja) | 2016-04-29 | 2017-05-01 | 術後癒着の予防及び治療のための方法及び組成物 |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US10934355B2 (https=) |
| EP (1) | EP3448421B1 (https=) |
| JP (1) | JP7160683B2 (https=) |
| CA (1) | CA3019841A1 (https=) |
| ES (1) | ES2903210T3 (https=) |
| PL (1) | PL3448421T3 (https=) |
| PT (1) | PT3448421T (https=) |
| SI (1) | SI3448421T1 (https=) |
| WO (1) | WO2017190148A1 (https=) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108795867A (zh) * | 2018-06-05 | 2018-11-13 | 华东理工大学 | 用于构建结肠癌细胞腹膜转移体外三维模型的方法 |
| BR112021005585A2 (pt) | 2018-09-27 | 2021-06-29 | Celgene Corporation | proteínas de ligação a sirpa e métodos de uso das mesmas |
| US11591390B2 (en) | 2018-09-27 | 2023-02-28 | Celgene Corporation | SIRP-α binding proteins and methods of use thereof |
| EP3917515A1 (en) | 2019-01-29 | 2021-12-08 | Helmholtz Zentrum München - Deutsches Forschungszentrum für Gesundheit und Umwelt (GmbH) | Treating the causative agent in adhesiogenesis |
| US20200386772A1 (en) * | 2019-06-05 | 2020-12-10 | Mark D. Noar | Method For Detecting Bodily Adhesions By Identifying Markers In Circulating Cells |
| CN115175673A (zh) * | 2020-02-26 | 2022-10-11 | 上海科技大学 | 双硫仑在抗冠状病毒中的应用 |
| CA3202048A1 (en) * | 2020-12-14 | 2022-06-23 | Joel ZINDEL | Treatment of peritoneal, pleural, and pericardium adhesions |
| US12440285B2 (en) | 2021-01-22 | 2025-10-14 | Cilag Gmbh International | Prediction of hemostasis issues based on biomarker monitoring |
| US12011163B2 (en) | 2021-01-22 | 2024-06-18 | Cilag Gmbh International | Prediction of tissue irregularities based on biomarker monitoring |
| US20220233135A1 (en) * | 2021-01-22 | 2022-07-28 | Ethicon Llc | Prediction of adhesions based on biomarker monitoring |
| US12543982B2 (en) | 2021-01-22 | 2026-02-10 | Cilag Gmbh International | Method of adjusting a surgical parameter based on biomarker measurements |
| CN113244400B (zh) * | 2021-05-21 | 2022-12-16 | 华北理工大学 | 一种C5aRA在制备治疗和/或预防腹腔粘连的产品中的应用 |
| KR20240099431A (ko) * | 2021-11-05 | 2024-06-28 | 헬름홀츠 젠트룸 뮌헨-도이체스 포르슝스젠트룸 퓌르 게준드하이트 운트 움벨트 게엠베하 | 중피 ecm 이동의 조절제 |
Family Cites Families (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5985660A (en) | 1994-06-15 | 1999-11-16 | Systemix, Inc. | Method of identifying biological response modifiers involved in dendritic and/or lymphoid progenitor cell proliferation and/or differentiation |
| US5639468A (en) * | 1995-06-07 | 1997-06-17 | University Of Southern California | Method for reducing or preventing post-surgical adhesion formation using manoalide and analogs thereof |
| WO1999020297A1 (en) * | 1997-10-16 | 1999-04-29 | Nederlandse Organisatie Voor Toegepast-Natuurwetenschappelijk Onderzoek Tno | Prevention and treatment of adhesion formation |
| US6812220B2 (en) * | 2001-08-29 | 2004-11-02 | University Of British Columbia | Pharmaceutical compositions and methods relating to fucans |
| US20050163781A1 (en) * | 2002-01-29 | 2005-07-28 | Philippe Koninckx | Tissue adhesion formation control |
| US20040131600A1 (en) * | 2002-03-11 | 2004-07-08 | Diamond Michael P. | Method of preventing adhesions by apoptosis of adhesion peritoneal cells |
| JP4224586B2 (ja) * | 2004-04-28 | 2009-02-18 | 国立大学法人群馬大学 | マクロファージ活性化剤並びにその製造方法及びスクリーニング方法 |
| CA2585268A1 (en) * | 2004-10-25 | 2006-05-04 | Ajay Verman | Methods for lowering hif-1 mediated gene expression |
| EP1861425B1 (en) * | 2005-03-10 | 2012-05-16 | Morphotek, Inc. | Anti-mesothelin antibodies |
| WO2007008300A2 (en) * | 2005-05-31 | 2007-01-18 | ECOLE POLYTECHNIQUE FéDéRALE DE LAUSANNE | Triblock copolymers for cytoplasmic delivery of gene-based drugs |
| EP1940439B1 (en) * | 2005-08-11 | 2010-10-27 | University Of Saskatchewan | Reducing post-operative adhesion formation with intraperitoneal glutamine |
| WO2008011726A1 (en) * | 2006-07-27 | 2008-01-31 | Ottawa Health Research Institute | Staged immune-response modulation in oncolytic therapy |
| ES2526355T3 (es) * | 2007-10-01 | 2015-01-09 | Bristol-Myers Squibb Company | Anticuerpos humanos que se adhieren a mesotelina, y usos de los mismos |
| ES2582340T3 (es) | 2008-01-15 | 2016-09-12 | The Board Of Trustees Of The Leland Stanford Junior University | Métodos para manipular fagocitosis mediada por CD47 |
| ES2325724B1 (es) * | 2008-03-11 | 2010-05-31 | FUNDACION DE LA COMUNIDAD VALENCIANA "CENTRO DE INVESTIGACIONES PRINCIPE FELIPE" | Composicion farmaceutica para inhibir el factor de transcripcion inducible por hipoxia. moduladores de procesos patologicos de angiogenesis, oncogenesis, inflamacion, apoptosis y terapia celular. |
| EP2411416A1 (en) | 2009-03-24 | 2012-02-01 | The Government of the United States of America as represented by The Secretary of the Department of Health and Human Services | Anti-mesothelin antibodies |
| CA2771336C (en) | 2009-09-15 | 2019-11-26 | The Board Of Trustees Of The Leland Stanford Junior University | Synergistic anti-cd47 therapy for hematologic cancers |
| JP2011195574A (ja) * | 2010-02-25 | 2011-10-06 | Kwansei Gakuin | ビスフェノールａ誘導体を含有するｈｉｆ阻害剤 |
| ES2816647T3 (es) * | 2012-01-17 | 2021-04-05 | Univ Leland Stanford Junior | Reactivos SIRP-alfa de alta afinidad |
| US8962577B2 (en) * | 2012-03-16 | 2015-02-24 | The Johns Hopkins University | Controlled release formulations for the delivery of HIF-1 inhibitors |
| CN112245586A (zh) | 2013-03-15 | 2021-01-22 | 小利兰·斯坦福大学托管委员会 | 用于实现治疗有效剂量的抗cd47剂的方法 |
-
2017
- 2017-05-01 JP JP2018556332A patent/JP7160683B2/ja active Active
- 2017-05-01 SI SI201731041T patent/SI3448421T1/sl unknown
- 2017-05-01 PT PT177906492T patent/PT3448421T/pt unknown
- 2017-05-01 CA CA3019841A patent/CA3019841A1/en active Pending
- 2017-05-01 EP EP17790649.2A patent/EP3448421B1/en active Active
- 2017-05-01 PL PL17790649T patent/PL3448421T3/pl unknown
- 2017-05-01 ES ES17790649T patent/ES2903210T3/es active Active
- 2017-05-01 US US16/079,927 patent/US10934355B2/en active Active
- 2017-05-01 WO PCT/US2017/030454 patent/WO2017190148A1/en not_active Ceased
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