JP2019514913A5 - - Google Patents

Info

Publication number

JP2019514913A5

JP2019514913A5 JP2018556332A JP2018556332A JP2019514913A5 JP 2019514913 A5 JP2019514913 A5 JP 2019514913A5 JP 2018556332 A JP2018556332 A JP 2018556332A JP 2018556332 A JP2018556332 A JP 2018556332A JP 2019514913 A5 JP2019514913 A5 JP 2019514913A5

Authority

JP

Japan

Prior art keywords

agent

optionally

polypeptide

antibody

adhesion

Prior art date

2017-05-01

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

• Espacenet
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• 239000003795 chemical substances by application Substances 0.000 claims 19
• 239000003814 drug Substances 0.000 claims 15
• 229940079593 drug Drugs 0.000 claims 15
• 102000004196 processed proteins & peptides Human genes 0.000 claims 11
• 108090000765 processed proteins & peptides Proteins 0.000 claims 11
• 229920001184 polypeptide Polymers 0.000 claims 9
• 101000863873 Homo sapiens Tyrosine-protein phosphatase non-receptor type substrate 1 Proteins 0.000 claims 8
• 102100029948 Tyrosine-protein phosphatase non-receptor type substrate 1 Human genes 0.000 claims 8
• 239000012634 fragment Substances 0.000 claims 8
• 101000868279 Homo sapiens Leukocyte surface antigen CD47 Proteins 0.000 claims 7
• 102100032913 Leukocyte surface antigen CD47 Human genes 0.000 claims 7
• 230000015572 biosynthetic process Effects 0.000 claims 7
• 230000002757 inflammatory effect Effects 0.000 claims 7
• 102000003735 Mesothelin Human genes 0.000 claims 6
• 108090000015 Mesothelin Proteins 0.000 claims 6
• 210000003714 granulocyte Anatomy 0.000 claims 6
• 210000002540 macrophage Anatomy 0.000 claims 6
• 210000005033 mesothelial cell Anatomy 0.000 claims 6
• 238000000034 method Methods 0.000 claims 6
• 108090000623 proteins and genes Proteins 0.000 claims 6
• 230000007115 recruitment Effects 0.000 claims 6
• 101710155857 C-C motif chemokine 2 Proteins 0.000 claims 4
• 102000000018 Chemokine CCL2 Human genes 0.000 claims 4
• WQZGKKKJIJFFOK-QTVWNMPRSA-N D-mannopyranose Chemical compound OC[C@H]1OC(O)[C@@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-QTVWNMPRSA-N 0.000 claims 4
• 102100038853 Uroplakin-1b Human genes 0.000 claims 3
• 210000000440 neutrophil Anatomy 0.000 claims 3
• 238000001356 surgical procedure Methods 0.000 claims 3
• 108091032973 (ribonucleotides)n+m Proteins 0.000 claims 2
• 101001007348 Arachis hypogaea Galactose-binding lectin Proteins 0.000 claims 2
• 102100036166 C-X-C chemokine receptor type 1 Human genes 0.000 claims 2
• 102100028989 C-X-C chemokine receptor type 2 Human genes 0.000 claims 2
• 102100024209 CD177 antigen Human genes 0.000 claims 2
• 108050006947 CXC Chemokine Proteins 0.000 claims 2
• 102000019388 CXC chemokine Human genes 0.000 claims 2
• 102100025470 Carcinoembryonic antigen-related cell adhesion molecule 8 Human genes 0.000 claims 2
• 108020004414 DNA Proteins 0.000 claims 2
• 101000947174 Homo sapiens C-X-C chemokine receptor type 1 Proteins 0.000 claims 2
• 101000980845 Homo sapiens CD177 antigen Proteins 0.000 claims 2
• 101000914320 Homo sapiens Carcinoembryonic antigen-related cell adhesion molecule 8 Proteins 0.000 claims 2
• 101000694615 Homo sapiens Membrane primary amine oxidase Proteins 0.000 claims 2
• 102100022875 Hypoxia-inducible factor 1-alpha Human genes 0.000 claims 2
• 108010018951 Interleukin-8B Receptors Proteins 0.000 claims 2
• 102100027159 Membrane primary amine oxidase Human genes 0.000 claims 2
• 102000003729 Neprilysin Human genes 0.000 claims 2
• 108090000028 Neprilysin Proteins 0.000 claims 2
• 108010043958 Peptoids Proteins 0.000 claims 2
• RTIXKCRFFJGDFG-UHFFFAOYSA-N chrysin Chemical compound C=1C(O)=CC(O)=C(C(C=2)=O)C=1OC=2C1=CC=CC=C1 RTIXKCRFFJGDFG-UHFFFAOYSA-N 0.000 claims 2
• 239000003550 marker Substances 0.000 claims 2
• 239000008194 pharmaceutical composition Substances 0.000 claims 2
• 229920001606 poly(lactic acid-co-glycolic acid) Polymers 0.000 claims 2
• CWERGRDVMFNCDR-UHFFFAOYSA-M thioglycolate(1-) Chemical compound [O-]C(=O)CS CWERGRDVMFNCDR-UHFFFAOYSA-M 0.000 claims 2
• BPBPYQWMFCTCNG-UHFFFAOYSA-N 2-(butan-2-yldisulfanyl)-1H-imidazole Chemical compound CCC(C)SSC1=NC=CN1 BPBPYQWMFCTCNG-UHFFFAOYSA-N 0.000 claims 1
• KKAJSJJFBSOMGS-UHFFFAOYSA-N 3,6-diamino-10-methylacridinium chloride Chemical compound [Cl-].C1=C(N)C=C2[N+](C)=C(C=C(N)C=C3)C3=CC2=C1 KKAJSJJFBSOMGS-UHFFFAOYSA-N 0.000 claims 1
• XVUOIWIIQVGWAJ-UHFFFAOYSA-N 3-[[(2,4-dinitrophenyl)-oxomethyl]amino]benzoic acid [2-(4-methylphenyl)-2-oxoethyl] ester Chemical compound C1=CC(C)=CC=C1C(=O)COC(=O)C1=CC=CC(NC(=O)C=2C(=CC(=CC=2)[N+]([O-])=O)[N+]([O-])=O)=C1 XVUOIWIIQVGWAJ-UHFFFAOYSA-N 0.000 claims 1
• CSCOJWVRGOZGPK-UHFFFAOYSA-N 3-[[2-[4-(2-adamantyl)phenoxy]-1-oxoethyl]amino]-4-hydroxybenzoic acid methyl ester Chemical compound COC(=O)C1=CC=C(O)C(NC(=O)COC=2C=CC(=CC=2)C2C3CC4CC(C3)CC2C4)=C1 CSCOJWVRGOZGPK-UHFFFAOYSA-N 0.000 claims 1
• RPJFWRZEEKJTGN-UHFFFAOYSA-N 4-[2-(4-hydroxyphenyl)propan-2-yl]-2,6-dimethylphenol Chemical compound CC1=C(O)C(C)=CC(C(C)(C)C=2C=CC(O)=CC=2)=C1 RPJFWRZEEKJTGN-UHFFFAOYSA-N 0.000 claims 1
• NYCXYKOXLNBYID-UHFFFAOYSA-N 5,7-Dihydroxychromone Natural products O1C=CC(=O)C=2C1=CC(O)=CC=2O NYCXYKOXLNBYID-UHFFFAOYSA-N 0.000 claims 1
• 206010000050 Abdominal adhesions Diseases 0.000 claims 1
• 102100039398 C-X-C motif chemokine 2 Human genes 0.000 claims 1
• AUJXLBOHYWTPFV-BLWRDSOESA-N CS[C@H]1SC[C@H]2N(C)C(=O)[C@@H](C)NC(=O)[C@H](COC(=O)[C@@H](C(C)C)N(C)C(=O)[C@@H]1N(C)C(=O)[C@@H](C)NC(=O)[C@H](COC(=O)[C@@H](C(C)C)N(C)C2=O)NC(=O)c1cnc2ccccc2n1)NC(=O)c1cnc2ccccc2n1 Chemical group CS[C@H]1SC[C@H]2N(C)C(=O)[C@@H](C)NC(=O)[C@H](COC(=O)[C@@H](C(C)C)N(C)C(=O)[C@@H]1N(C)C(=O)[C@@H](C)NC(=O)[C@H](COC(=O)[C@@H](C(C)C)N(C)C2=O)NC(=O)c1cnc2ccccc2n1)NC(=O)c1cnc2ccccc2n1 AUJXLBOHYWTPFV-BLWRDSOESA-N 0.000 claims 1
• GVKKJJOMQCNPGB-JTQLQIEISA-N Cryptotanshinone Chemical compound O=C1C(=O)C2=C3CCCC(C)(C)C3=CC=C2C2=C1[C@@H](C)CO2 GVKKJJOMQCNPGB-JTQLQIEISA-N 0.000 claims 1
• GVKKJJOMQCNPGB-UHFFFAOYSA-N Cryptotanshinone Natural products O=C1C(=O)C2=C3CCCC(C)(C)C3=CC=C2C2=C1C(C)CO2 GVKKJJOMQCNPGB-UHFFFAOYSA-N 0.000 claims 1
• 108010009858 Echinomycin Proteins 0.000 claims 1
• 102100034221 Growth-regulated alpha protein Human genes 0.000 claims 1
• 101000889128 Homo sapiens C-X-C motif chemokine 2 Proteins 0.000 claims 1
• 101001069921 Homo sapiens Growth-regulated alpha protein Proteins 0.000 claims 1
• 101001046870 Homo sapiens Hypoxia-inducible factor 1-alpha Proteins 0.000 claims 1
• 101000808114 Homo sapiens Uroplakin-1b Proteins 0.000 claims 1
• 108050009527 Hypoxia-inducible factor-1 alpha Proteins 0.000 claims 1
• 206010060932 Postoperative adhesion Diseases 0.000 claims 1
• 229940023020 acriflavine Drugs 0.000 claims 1
• 229940043370 chrysin Drugs 0.000 claims 1
• 235000015838 chrysin Nutrition 0.000 claims 1
• 230000000779 depleting effect Effects 0.000 claims 1
• BNJOZDZCRHCODO-UHFFFAOYSA-N dimethyloxalylglycine Chemical compound COC(=O)CNC(=O)C(=O)OC BNJOZDZCRHCODO-UHFFFAOYSA-N 0.000 claims 1
• 239000003937 drug carrier Substances 0.000 claims 1
• 239000003596 drug target Substances 0.000 claims 1
• 230000000694 effects Effects 0.000 claims 1
• 210000002074 inflammatory monocyte Anatomy 0.000 claims 1
• 230000002401 inhibitory effect Effects 0.000 claims 1
• 230000001483 mobilizing effect Effects 0.000 claims 1
• 230000002265 prevention Effects 0.000 claims 1
• 230000001737 promoting effect Effects 0.000 claims 1
• AUJXLBOHYWTPFV-UHFFFAOYSA-N quinomycin A Natural products CN1C(=O)C(C)NC(=O)C(NC(=O)C=2N=C3C=CC=CC3=NC=2)COC(=O)C(C(C)C)N(C)C(=O)C2N(C)C(=O)C(C)NC(=O)C(NC(=O)C=3N=C4C=CC=CC4=NC=3)COC(=O)C(C(C)C)N(C)C(=O)C1CSC2SC AUJXLBOHYWTPFV-UHFFFAOYSA-N 0.000 claims 1
• 229940071127 thioglycolate Drugs 0.000 claims 1