JP2019514461A - ナノフィブリルセルロースを含む医療用製品の製造方法、および医療用製品 - Google Patents
ナノフィブリルセルロースを含む医療用製品の製造方法、および医療用製品 Download PDFInfo
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Abstract
Description
ナノフィブリルセルロースの水性分散液を提供することと、
ガーゼの層を提供することと、
ナノフィブリルセルロースの水性分散液をガーゼの層に含浸させることと、
含浸させたガーゼを脱水することとを含む。
1つの出発材料は、サブミクロン範囲の直径を有するセルロース小繊維を含むか、または当該セルロース小繊維からなるナノフィブリルセルロースを含む。ナノフィブリルセルロースは、低濃度においてさえ、自己凝集したヒドロゲル網状体を形成する。これらのナノフィブリルセルロースのゲルは、高度にせん断減粘性であり、天然の疑似プラスチックである。
ナノフィブリルセルロースは通常、植物起源のセルロース原材料から作製される。原材料は、セルロースを含む任意の植物材料に基づいてもよい。原材料は、特定の細菌発酵処理に由来してもよい。一実施形態において、植物材料は、木材である。木材は、トウヒ、マツ、モミ、カラマツ、ダグラスファー、もしくはツガなどの針葉樹、またはカバノキ、アスペン、ポプラ、ハンノキ、ユーカリノキ、オーク、ブナ、もしくはアカシアなどの広葉樹、または針葉樹および広葉樹の混合物から形成されてもよい。一実施形態において、ナノフィブリルセルロースは、木材パルプから得られる。一実施形態において、ナノフィブリルセルロースは、広葉樹パルプから得られる。一例において、広葉樹は、カバノキである。一実施形態において、ナノフィブリルセルロースは、広葉樹パルプから得られる。
ナノフィブリルセルロースを含む分散液を作製するための方法は、まず、ナノフィブリルセルロースと、任意に補助的薬剤、たとえば非ナノフィブリル化パルプまたは他の薬剤とを提供し、続いてそれらを所望量で含む分散液を形成することとを含む。一実施形態において、分散液は、水性分散液である。
一実施形態は、医療用製品を作製するための方法であって、ナノフィブリルセルロースの水性分散液を提供し、ガーゼの層を提供することを含む方法を提供し、ナノフィブリルセルロースは、本明細書に記載された分散液であってもよく、ガーゼは、本明細書に記載されたガーゼであってもよい。
表1は、様々なガーゼを用いた様々な含浸試験の結果を示す。試験AE5〜AE7は、1つのImprexニップによって行われた。AE9には3つのニップがあり、AE10には2つのニップがあった。試験AH1〜AH5は、それぞれ、3、4、4、5および4回の含浸処理で、1つのImprexニップを用いて行われた。乾燥温度は、全ての試験で90℃であった。試験AE5〜AE10において、乾燥圧力は2バールであり、試験AH1〜AH5において、乾燥圧力は5バールであった。乾燥は、テフロンプレートと布との間のプレスドライヤにおいて実施された。ゲル濃度は、全ての試験において0.8%であった。含浸処理は、含浸、ニップにおける押圧、および脱水を含む。使用されたガーゼは、パルプ−ポリプロピレン−ポリエステルガーゼ(AE7,AE9,AE10,AH3,AH4)、パルプ−ポリプロピレン−ポリエステルガーゼ(AE5)、パルプ−ポリプロピレンガーゼ(AH1,AH2)、パルプ系ガーゼ(AH5)であった。
製品の透気度に対する含浸処理(含浸、ニップにおける押圧、および脱水を含む含浸通過)の回数の影響が試験された(表2)。ガーゼは、実施例1の説明と同様であった。
様々なガーゼから作製された様々な医療用製品の特性が試験された。AJ1、AJ2、AK2およびAK3は、パルプ−ポリプロピレンガーゼである。AK1は、パルプ−ポリプロピレン−ポリエステルガーゼである。坪量および透気度は、調湿試料から測定された。この結果は、表3に示される。Md=縦方向、cd=横方向
様々なガーゼHA1〜HA7の特性が分析された。坪量は、調湿試料から測定された。この結果は、表4および5に示される。Md=縦方向、cd=横方向
Claims (21)
- 医療用製品を作製するための方法であって、当該医療用製品を得るために、
ナノフィブリルセルロース水性分散液を提供することと、
ガーゼの層を提供することと、
ナノフィブリルセルロース水性分散液をガーゼの層に含浸させることと、
含浸させたガーゼを脱水することとを含むことを特徴とする方法。 - ニップ、たとえばニップロールにおける脱水前に、含浸させたガーゼを押圧することを含むことを特徴とする請求項1に記載の方法。
- 含浸および脱水は、医療用製品が、25〜80g/m2、たとえば30〜70g/m2、たとえば35〜65g/m2の範囲内の坪量に達するまで繰り返されることを特徴とする請求項1または2に記載の方法。
- ガーゼは、天然ガーゼ、たとえば、綿ガーゼ、合成ガーゼもしくは半合成ガーゼ、たとえば、ビスコースガーゼ、ポリプロピレンガーゼもしくはポリエステルガーゼ、またはそれらの混合物を含むことを特徴とする請求項1〜3のいずれか1項に記載の方法。
- ナノフィブリルセルロースは、水に分散されたとき、0.8%(w/w)の濃度および10rpmにおいて測定された、少なくとも2000mPa・s、たとえば少なくとも3000mPa・s、たとえば少なくとも10000mPa・sのブルックフィールド粘度を提供することを特徴とする請求項1〜4のいずれか1項に記載の方法。
- ナノフィブリルセルロースは、非修飾ナノフィブリルセルロースを含むことを特徴とする請求項1〜5のいずれか1項に記載の方法。
- ナノフィブリルセルロースは、修飾されたセルロース、たとえば化学修飾ナノフィブリルセルロース、たとえば、アニオン修飾ナノフィブリルセルロースまたは酵素修飾ナノフィブリルセルロースを含むことを特徴とする請求項1〜6のいずれか1項に記載の方法。
- 脱水は、非接触乾燥、たとえば、赤外線ドライヤ、フローティングドライヤもしくはインピンジメントドライヤによって、または接触乾燥、たとえば、プレスドライヤ、シリンダドライヤもしくはベルトドライヤによって実施されることを特徴とする請求項1〜7のいずれか1項に記載の方法。
- ナノフィブリルセルロースを含浸させたガーゼの層を含むことを特徴とする医療用製品。
- ガーゼは、天然ガーゼ、たとえばセルロースガーゼもしくは綿ガーゼ、合成ガーゼもしくは半合成ガーゼ、たとえばビスコースもしくはポリエステル、またはそれらの混合物、たとえば、ポリプロピレンとセルロースとの混合物、またはポリプロピレンとポリエステルとセルロースとの混合物を含むことを特徴とする請求項10に記載の医療用製品。
- ナノフィブリルセルロースは、水に分散したとき、0.8%(w/w)の濃度および10rpmにおいて測定された、少なくとも2000mPa・s、たとえば少なくとも3000mPa・s、たとえば少なくとも10000mPa・sのブルックフィールド粘度を提供することを特徴とする請求項9または10に記載の医療用製品。
- ナノフィブリルセルロースは、非修飾ナノフィブリルセルロースを含むことを特徴とする請求項9〜11のいずれか1項に記載の医療用製品。
- ナノフィブリルセルロースは、修飾されたセルロース、たとえば化学修飾ナノフィブリルセルロース、たとえば、アニオン修飾ナノフィブリルセルロースまたは酵素修飾ナノフィブリルセルロースを含むことを特徴とする請求項9〜12のいずれか1項に記載の医療用製品。
- 25〜80g/m2、たとえば30〜70g/m2、たとえば35〜65g/m2の範囲内の坪量を有することを特徴とする請求項9〜13のいずれか1項に記載の医療用製品。
- 請求項1〜8のいずれか1項に記載の方法を用いて得られることを特徴とする請求項9〜14のいずれか1項に記載の医療用製品。
- 治療薬を含むことを特徴とする請求項9〜15のいずれか1項に記載の医療用製品。
- 美容用薬剤を含むことを特徴とする請求項9〜16のいずれか1項に記載の医療用製品。
- 請求項9〜17のいずれか1項に記載の医療用製品を含むことを特徴とする医療用包帯または貼付剤。
- 皮膚創傷または他の損傷を治療するため、および/または覆うため、たとえば、皮膚移植片などの移植片で皮膚創傷を覆うための使用のための、請求項9〜17のいずれか1項に記載の医療用製品。
- 治療薬を投与するための使用のための、請求項9〜17のいずれか1項に記載の医療用製品。
- 請求項9〜15または17のいずれか1項に記載の医療用製品を含むことを特徴とする、包帯または貼付剤などの美容用製品。
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Publication number | Priority date | Publication date | Assignee | Title |
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FI126042B (en) * | 2014-03-31 | 2016-06-15 | Upm Kymmene Corp | Method for producing nanofibril cellulose and nanofibril cellulose product |
US11497837B2 (en) * | 2015-01-14 | 2022-11-15 | Innovative Plastics And Molding, Inc. | Molded parts with thermoplastic cellulose biopolymer compositions having oriented fibers for medical devices and implants |
DK3533458T3 (en) * | 2018-03-02 | 2023-06-26 | Upm Kymmene Corp | A medical product comprising a bioactive molecule immobilized to nanofibrillar cellulose, and a method for preparing thereof |
KR20200000579A (ko) * | 2018-06-25 | 2020-01-03 | 네이처코스텍 주식회사 | 변성 셀룰로오스를 함유하는 피부미용 증진용 조성물 |
EP3616730A1 (en) | 2018-08-28 | 2020-03-04 | UPM-Kymmene Corporation | Composition or matrix for storage of bacteriophages comprising nanofibrillar cellulose |
SE542946C2 (en) | 2018-11-28 | 2020-09-22 | Stora Enso Oyj | Process for production of free standing film comprising cellulosic nanomaterial |
KR20210128020A (ko) * | 2019-03-15 | 2021-10-25 | 이엘씨 매니지먼트 엘엘씨 | 장시간 지속성 피부관리 조성물 |
EP3816338A1 (en) * | 2019-10-31 | 2021-05-05 | UPM-Kymmene Corporation | Medical product and method for preparing thereof |
Citations (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS58194811A (ja) * | 1982-05-10 | 1983-11-12 | Daicel Chem Ind Ltd | 湿布材料 |
JPH09268122A (ja) * | 1996-04-02 | 1997-10-14 | Kao Corp | 貼付剤組成物 |
JP2002530157A (ja) * | 1998-11-24 | 2002-09-17 | ジョンソン・アンド・ジョンソン・コンシューマー・カンパニーズ・インコーポレイテッド | 吸収包帯と包帯上の活性成分の分配器として有効なコーティング |
JP2008536536A (ja) * | 2005-02-28 | 2008-09-11 | ミリケン・アンド・カンパニー | 創傷処置デバイス |
JP2009529367A (ja) * | 2006-03-10 | 2009-08-20 | ジュ−ヨン キム | 銀結合抗菌性湿潤創傷被覆材を製造する方法及び該方法により製造された湿潤創傷被覆材 |
JP2014505093A (ja) * | 2011-02-11 | 2014-02-27 | ユー ピー エム キュンメネ コーポレーション | 微小繊維状セルロースの抗炎症効果 |
WO2015101711A1 (en) * | 2013-12-30 | 2015-07-09 | Upm-Kymmene Corporation | Patterned membrane |
Family Cites Families (24)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3580253A (en) * | 1968-12-09 | 1971-05-25 | Kimberly Clark Co | Sanitary napkin and flushable wrapper therefor |
US3678933A (en) * | 1970-07-17 | 1972-07-25 | Moore Perk Corp | Surgical sponge or bandage |
FI105112B (fi) | 1997-01-03 | 2000-06-15 | Megatrex Oy | Menetelmä ja laite kuitupitoisen materiaalin kuiduttamiseksi |
US6333093B1 (en) * | 1997-03-17 | 2001-12-25 | Westaim Biomedical Corp. | Anti-microbial coatings having indicator properties and wound dressings |
JPH11170413A (ja) * | 1997-12-11 | 1999-06-29 | Asahi Chem Ind Co Ltd | 不織布複合低密度織物 |
EP1465673B1 (en) * | 2001-12-20 | 2007-01-24 | Noble Fiber Technologies, LLC | Wound dressings comprising metallic silver |
US8951551B2 (en) * | 2005-08-31 | 2015-02-10 | Board Of Regents, The University Of Texas System | Multiribbon nanocellulose as a matrix for wound healing |
US20070048358A1 (en) * | 2005-08-31 | 2007-03-01 | Schorr Phillip A | Antimicrobial substrates |
US20130012857A1 (en) * | 2010-03-16 | 2013-01-10 | North American Rescue, Llc | Wound Dressing |
PL2386682T3 (pl) * | 2010-04-27 | 2014-08-29 | Omya Int Ag | Sposób wytwarzania materiałów strukturalnych z użyciem nanowłóknistych żeli celulozowych |
US20110319805A1 (en) * | 2010-06-29 | 2011-12-29 | Bryan Knicely Morris | Topical composition for treating the skin |
US20130019374A1 (en) * | 2011-01-04 | 2013-01-24 | Schwartz Alan N | Gel-based seals and fixation devices and associated systems and methods |
CN102552965B (zh) * | 2012-01-17 | 2014-10-15 | 东华大学 | 一种在线培养制备纳米纤维素抗菌复合材料的方法 |
US20150147410A1 (en) * | 2012-05-21 | 2015-05-28 | Novatec Healthcare Company Limited | Wound Dressing Comprising Bio-Cellulose and Silver Nanoparticles |
CN103800940B (zh) * | 2012-11-14 | 2015-08-19 | 天津禹王生物医药科技有限公司 | 一种止血敷料及制备方法 |
CN102961777B (zh) * | 2012-12-11 | 2014-03-26 | 北京科技大学 | 改性纳米纤维素多孔复合型高吸渗止血敷料的制备方法 |
FI126089B (en) * | 2012-12-20 | 2016-06-30 | Kemira Oyj | PROCEDURE FOR PREPARING DRAINED MICROFIBRILLARY CELLULOSA |
FI126109B (en) * | 2013-02-22 | 2016-06-30 | Upm Kymmene Corp | Nanofibril polysaccharide for use in the control and prevention of constriction and scarring |
FR3003580B1 (fr) * | 2013-03-20 | 2015-07-03 | Ahlstroem Oy | Non-tisse par voie humide comprenant des nanofibrilles de cellulose |
FI128835B (en) * | 2013-05-14 | 2021-01-15 | Upm Kymmene Corp | Method and apparatus for producing nanofibril cellulose |
FI129421B (fi) * | 2014-03-12 | 2022-02-15 | Maelkki Yrjoe | Nanoselluloosan ja sen esiasteiden valmistus ja käyttö |
JP5883478B2 (ja) * | 2014-06-23 | 2016-03-15 | 北越紀州製紙株式会社 | 多孔質体及びその製造方法 |
FI126754B (en) * | 2015-11-25 | 2017-05-15 | Teknologian Tutkimuskeskus Vtt Oy | Functionalization of cellulose with lignin for the production of high added value products |
EP3187195B1 (en) * | 2015-12-31 | 2018-10-17 | UPM-Kymmene Corporation | A medical multi-layer product comprising nanofibrillar cellulose and a method for preparing thereof |
-
2016
- 2016-04-06 DK DK16397510.5T patent/DK3228329T3/da active
- 2016-04-06 EP EP16397510.5A patent/EP3228329B1/en active Active
-
2017
- 2017-04-05 JP JP2018552753A patent/JP7071281B2/ja active Active
- 2017-04-05 CN CN201780034693.8A patent/CN109310797B/zh active Active
- 2017-04-05 US US16/090,320 patent/US20190111175A1/en not_active Abandoned
- 2017-04-05 WO PCT/FI2017/050241 patent/WO2017174874A1/en active Application Filing
-
2021
- 2021-12-03 JP JP2021197397A patent/JP7311576B2/ja active Active
Patent Citations (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS58194811A (ja) * | 1982-05-10 | 1983-11-12 | Daicel Chem Ind Ltd | 湿布材料 |
JPH09268122A (ja) * | 1996-04-02 | 1997-10-14 | Kao Corp | 貼付剤組成物 |
JP2002530157A (ja) * | 1998-11-24 | 2002-09-17 | ジョンソン・アンド・ジョンソン・コンシューマー・カンパニーズ・インコーポレイテッド | 吸収包帯と包帯上の活性成分の分配器として有効なコーティング |
JP2008536536A (ja) * | 2005-02-28 | 2008-09-11 | ミリケン・アンド・カンパニー | 創傷処置デバイス |
JP2009529367A (ja) * | 2006-03-10 | 2009-08-20 | ジュ−ヨン キム | 銀結合抗菌性湿潤創傷被覆材を製造する方法及び該方法により製造された湿潤創傷被覆材 |
JP2014505093A (ja) * | 2011-02-11 | 2014-02-27 | ユー ピー エム キュンメネ コーポレーション | 微小繊維状セルロースの抗炎症効果 |
WO2015101711A1 (en) * | 2013-12-30 | 2015-07-09 | Upm-Kymmene Corporation | Patterned membrane |
JP2017506924A (ja) * | 2013-12-30 | 2017-03-16 | ユー ピー エム キュンメネ コーポレーション | パターニングされたメンブレン |
Non-Patent Citations (1)
Title |
---|
日本食品工業学会誌, vol. 第17巻第5号, JPN6021029508, 1970, pages 211 - 220, ISSN: 0004562691 * |
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