JP2014505093A - 微小繊維状セルロースの抗炎症効果 - Google Patents
微小繊維状セルロースの抗炎症効果 Download PDFInfo
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Abstract
【選択図】なし
Description
セルロースは有機化合物であり、β(1,4)グリコシド結合により結びついた直鎖状の数個のD-グルコースユニットからなる多糖である。セルロースの多くの特徴は、ひとつのポリマー分子を作り上げるグルコースユニットの数であるその鎖長または重合度によって決定される。セルロースは主に木材パルプ及び綿から得られるが、ある種のバイオフィルムを形成するバクテリアによっても分泌されうる。
以下の通り本発明は添付の図を参照して説明できる。
本発明によれば、皮膚の炎症状態に対する活性などの有益な皮膚効果を提供するケラチン物質の治療のための天然成分の使用方法および使用を提供する。
本願に記載される微小繊維状セルロースは、いわゆるセルロースウィスカー(セルロースナノウィスカー、セルロースナノクリスタル、セルロースナノロッド、棒状セルロースマイクロクリスタルまたはセルロースナノワイヤーとしても知られている)と同じ材料ではない。いくつかのケースにおいて、両材料について類似した用語が使用されている。
たとえば、Kuthcarlapatiら(Metals Materials and Processes 20(3):307-314, 2008)では、セルロースナノウィスカーと明確に言及していたが、ここで検討された材料は「セルロースナノファイバー」と称されていた。通常これらの材料はマイクロ繊維セルロース(microfibrillar cellulose)のように繊維状構造に沿った非結晶部分を有さず、これがより堅固な構造をもたらす。
微小繊維状セルロース(MFC)は、種々の皮膚生物学関連in vitroモデルを用いて皮膚における効果を評価した。皮膚抗炎症効果および水分およびバリア機能を評価した。正常ヒト表皮ケラチノサイト(NHEK)におけるin vitro 試験のための、MFCの試験濃度は0.01% (0.00016% 有効成分)であった。培養条件37℃、5% CO2 における正常ヒト表皮ケラチノサイト(NHEK)の細胞タイプを使用した。NHEKの培養培地は、表皮成長因子(EGF) 0.25 ng/ml、下垂体抽出物(PE) 25μg/mlおよびゲンタマイシン25μg/mlを追加したケラチノサイト(keratinosyte)−無血清培地(SFM)からなる。試験および結果は実施例1.1−1.2においてより詳細に記載する。
MFC化合物の抗炎症効果(すなわち緩和、鎮静特性)をポリ(I:C)および炎症性サイトカインの会合で刺激した正常ヒト表皮ケラチノサイト(NEHK)の遺伝子発現プロファイルで評価した。炎症性サイトカインは多種の免疫学的及び炎症性現象に関与する微量天然タンパク分子である。RT-qPCRテクノロジーを用いて、該化合物の効果を細胞層から抽出したmRNAに対する遺伝子発現プロファイルで評価した。抽出したmRNAは、2つのハウスキーピング遺伝子を含む皮膚の炎症における重要性およびアトピー性皮膚炎における関与を対象に選ばれた32のターゲット遺伝子を含有する専用PCRアレイで解析した。
MFCの化合物の皮膚の水分やバリア機能に及ぼす効果を、正常ヒト表皮ケラチノサイト(NEHK)の遺伝子発現プロファイルを基本条件において評価した。ケラチノサイトに及ぼす化合物の効果を、RT-qPCRテクノロジーを用いて、細胞層から抽出したmRNAで評価した。抽出したmRNAを、3つのハウスキーピング遺伝子を含むケラノサイト分化、成長および表皮再生における重要性のために選ばれた64のターゲット遺伝子含有専用PCRアレイで解析した。
Claims (12)
- 湿疹、乾癬、かぶれた肌および炎症誘導ケラチノサイトの脱分化から選択される皮膚状態及び疾患における抗炎症剤としての微小繊維状セルロースの使用。
- 微小繊維状セルロースが、軟膏、セラム、水性ゲル、フォーム、クリーム、水相と油相のエマルジョン、ローション、ペースト、水分散液、湿ったまたは乾燥した膜、不織布または織物に含まれている請求項1に記載の使用。
- 湿疹がアトピー性皮膚炎である請求項1に記載の使用。
- 微小繊維状セルロースが炎症誘導ケラチノサイトの脱分化の予防に使用される請求項1に記載の使用。
- 皮膚の炎症の治療のための抗炎症剤としての微小繊維状セルロースの使用方法。
- 微小繊維状セルロースが、軟膏、セラム、水性ゲル、フォーム、クリーム、水相と油相のエマルジョン、ローションまたはペーストに含まれる請求項5に記載の方法。
- 炎症誘導ケラチノサイトの脱分化の予防における微小繊維状セルロースの使用方法。
- 微小繊維状セルロースが、軟膏、セラム、水性ゲル、フォーム、クリーム、水相と油相のエマルジョン、ローションまたはペーストに含まれている請求項7に記載の方法。
- アトピー性皮膚炎の治療における微小繊維状セルロースの使用方法。
- 微小繊維状セルロースが、軟膏、セラム、水性ゲル、フォーム、クリーム、水相と油相のエマルジョン、ローションまたはペーストに含まれる請求項9に記載の方法。
- 乾癬の治療における微小繊維状セルロースの使用方法。
- 微小繊維状セルロースが軟膏、セラム、水性ゲル、フォーム、クリーム、水相と油相のエマルジョン、ローションまたはペーストに含まれる請求項11に記載の方法。
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FI20115135A FI126259B (fi) | 2011-02-11 | 2011-02-11 | Mikrofibrilloitu selluloosa käytettäväksi erityisesti atooppisen ihotulehduksen ja psoriasiksen hoidossa |
FI20115135 | 2011-02-11 | ||
PCT/FI2012/050129 WO2012107648A1 (en) | 2011-02-11 | 2012-02-10 | Anti-inflammatory effect of microfibrillated cellulose |
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JP2014505093A true JP2014505093A (ja) | 2014-02-27 |
JP2014505093A5 JP2014505093A5 (ja) | 2018-05-31 |
JP6386226B2 JP6386226B2 (ja) | 2018-09-05 |
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JP2013552997A Active JP6386226B2 (ja) | 2011-02-11 | 2012-02-10 | 微小繊維状セルロースの抗炎症効果 |
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US (1) | US9018189B2 (ja) |
EP (1) | EP2672950B1 (ja) |
JP (1) | JP6386226B2 (ja) |
DK (1) | DK2672950T3 (ja) |
ES (1) | ES2661582T3 (ja) |
FI (1) | FI126259B (ja) |
NO (1) | NO2672950T3 (ja) |
WO (1) | WO2012107648A1 (ja) |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2017510730A (ja) * | 2014-03-12 | 2017-04-13 | ナノレフィックス オサケユキテュアNanorefix Oy | ナノセルロースおよびその前駆体の製造および使用のための方法 |
JP2019514461A (ja) * | 2016-04-06 | 2019-06-06 | ウーペーエム−キュンメネ コーポレイションUPM−Kymmene Corporation | ナノフィブリルセルロースを含む医療用製品の製造方法、および医療用製品 |
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FI126513B (fi) * | 2011-01-20 | 2017-01-13 | Upm Kymmene Corp | Menetelmä lujuuden ja retention parantamiseksi ja paperituote |
US9370478B2 (en) | 2012-11-09 | 2016-06-21 | Johnson & Johnson Consumer Inc. | Skin care compositions containing cotton and citrus-derived materials |
US20140134218A1 (en) | 2012-11-09 | 2014-05-15 | Johnson & Johnson Consumer Companies, Inc. | Rinse-off skin care compositions containing cellulosic materials |
US20140134217A1 (en) | 2012-11-09 | 2014-05-15 | Johnson & Johnson Consumer Companies, Inc. | Leave-on compositions containing cellulose materials |
FI126109B (en) | 2013-02-22 | 2016-06-30 | Upm Kymmene Corp | Nanofibril polysaccharide for use in the control and prevention of constriction and scarring |
FR3016296B1 (fr) * | 2014-01-14 | 2021-06-25 | Feeligreen | Dispositif pour l'electrostimulation et/ou l'iontophorese |
FI125758B (en) | 2014-12-22 | 2016-02-15 | Upm Kymmene Corp | A method for reducing the viscosity of nanofibrillar cellulose hydrogel |
FI129934B (en) | 2015-02-13 | 2022-11-15 | Upm Kymmene Corp | Sewing thread, method of making sewing thread and its use |
US10266793B2 (en) | 2016-09-30 | 2019-04-23 | Novaflux, Inc. | Compositions for cleaning and decontamination |
EP3833362A4 (en) * | 2018-08-06 | 2022-05-18 | Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd | CELLULOSE-BASED TOPICAL FORMULATIONS |
US11918677B2 (en) | 2019-10-03 | 2024-03-05 | Protegera, Inc. | Oral cavity cleaning composition method and apparatus |
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JP2006274245A (ja) * | 2005-03-01 | 2006-10-12 | Chisso Corp | 硫酸化セルロース及びその塩から選ばれた化合物並びに皮膚炎治療剤 |
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DE4328871A1 (de) | 1993-08-27 | 1995-03-02 | Beiersdorf Ag | Mittel gegen empfindliche, hyperreaktive Hautzustände, atopische Dermatiden, Pruritus, Psoriasis Prurigo, Photodermatosen und Ichthyosis |
FR2730252B1 (fr) | 1995-02-08 | 1997-04-18 | Generale Sucriere Sa | Cellulose microfibrillee et son procede d'obtention a partir de pulpe de vegetaux a parois primaires, notamment a partir de pulpe de betteraves sucrieres. |
FR2744632B1 (fr) | 1996-02-13 | 1998-03-27 | Oreal | Utilisation d'une suspension aqueuse de microfibrilles d'origine naturelle pour la preparation de compositions cosmetiques ou dermatologiques, compositions cosmetiques ou dermatologiques et applications |
JPH09275424A (ja) | 1996-04-04 | 1997-10-21 | Matsushita Electric Ind Co Ltd | 送信装置 |
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FR2769836B1 (fr) * | 1997-10-21 | 2000-03-10 | Rhodia Chimie Sa | Utilisation de nanofibrilles de cellulose essentiellement amorphes associees a au moins un compose organique polyhydroxyle dans des formulations cosmetiques |
FR2822679A1 (fr) | 2001-03-30 | 2002-10-04 | Oreal | Composition cosmetique comprenant un melange de fibres |
US8951551B2 (en) | 2005-08-31 | 2015-02-10 | Board Of Regents, The University Of Texas System | Multiribbon nanocellulose as a matrix for wound healing |
JP5600005B2 (ja) * | 2007-09-05 | 2014-10-01 | 太陽化学株式会社 | 水溶性電界紡糸シート |
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- 2012-02-10 WO PCT/FI2012/050129 patent/WO2012107648A1/en active Application Filing
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Publication number | Priority date | Publication date | Assignee | Title |
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JPS6239507A (ja) * | 1985-08-13 | 1987-02-20 | Daicel Chem Ind Ltd | 皮膚手入れ用化粧料 |
JP2006274245A (ja) * | 2005-03-01 | 2006-10-12 | Chisso Corp | 硫酸化セルロース及びその塩から選ばれた化合物並びに皮膚炎治療剤 |
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2017510730A (ja) * | 2014-03-12 | 2017-04-13 | ナノレフィックス オサケユキテュアNanorefix Oy | ナノセルロースおよびその前駆体の製造および使用のための方法 |
JP2019514461A (ja) * | 2016-04-06 | 2019-06-06 | ウーペーエム−キュンメネ コーポレイションUPM−Kymmene Corporation | ナノフィブリルセルロースを含む医療用製品の製造方法、および医療用製品 |
JP7071281B2 (ja) | 2016-04-06 | 2022-05-18 | ウーペーエム-キュンメネ コーポレイション | ナノフィブリルセルロースを含む医療用製品の製造方法、および医療用製品 |
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US9018189B2 (en) | 2015-04-28 |
ES2661582T3 (es) | 2018-04-02 |
DK2672950T3 (en) | 2018-02-12 |
EP2672950B1 (en) | 2017-12-13 |
FI20115135A (fi) | 2012-08-12 |
FI20115135A0 (fi) | 2011-02-11 |
FI20115135L (fi) | 2012-08-12 |
FI126259B (fi) | 2016-09-15 |
EP2672950A1 (en) | 2013-12-18 |
US20140045785A1 (en) | 2014-02-13 |
JP6386226B2 (ja) | 2018-09-05 |
NO2672950T3 (ja) | 2018-05-12 |
WO2012107648A1 (en) | 2012-08-16 |
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