JP2019514376A5 - - Google Patents
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- JP2019514376A5 JP2019514376A5 JP2018555963A JP2018555963A JP2019514376A5 JP 2019514376 A5 JP2019514376 A5 JP 2019514376A5 JP 2018555963 A JP2018555963 A JP 2018555963A JP 2018555963 A JP2018555963 A JP 2018555963A JP 2019514376 A5 JP2019514376 A5 JP 2019514376A5
- Authority
- JP
- Japan
- Prior art keywords
- molecule
- nucleic acid
- funa
- vector
- target
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 108020004707 nucleic acids Proteins 0.000 claims 13
- 102000039446 nucleic acids Human genes 0.000 claims 13
- 150000007523 nucleic acids Chemical class 0.000 claims 12
- 238000000034 method Methods 0.000 claims 8
- 229920001184 polypeptide Polymers 0.000 claims 6
- 102000004196 processed proteins & peptides Human genes 0.000 claims 6
- 108090000765 processed proteins & peptides Proteins 0.000 claims 6
- 241001517610 Funa Species 0.000 claims 3
- 230000006801 homologous recombination Effects 0.000 claims 2
- 238000002744 homologous recombination Methods 0.000 claims 2
- 108020004414 DNA Proteins 0.000 claims 1
- 102000053602 DNA Human genes 0.000 claims 1
- 241001465754 Metazoa Species 0.000 claims 1
- 230000000295 complement effect Effects 0.000 claims 1
- 230000004927 fusion Effects 0.000 claims 1
- 230000000813 microbial effect Effects 0.000 claims 1
- 125000006850 spacer group Chemical group 0.000 claims 1
- -1 spacer nucleic acid Chemical class 0.000 claims 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2022187824A JP2023018093A (ja) | 2016-04-29 | 2022-11-24 | 標的核酸の改変のための改善された方法 |
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP16167774 | 2016-04-29 | ||
| EP16167773 | 2016-04-29 | ||
| EP16167773.7 | 2016-04-29 | ||
| EP16167774.5 | 2016-04-29 | ||
| EP17156018 | 2017-02-14 | ||
| EP17156018.8 | 2017-02-14 | ||
| PCT/EP2017/059331 WO2017186550A1 (en) | 2016-04-29 | 2017-04-20 | Improved methods for modification of target nucleic acids |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022187824A Division JP2023018093A (ja) | 2016-04-29 | 2022-11-24 | 標的核酸の改変のための改善された方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2019514376A JP2019514376A (ja) | 2019-06-06 |
| JP2019514376A5 true JP2019514376A5 (enExample) | 2020-06-11 |
| JP7184648B2 JP7184648B2 (ja) | 2022-12-06 |
Family
ID=58640844
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018555963A Active JP7184648B2 (ja) | 2016-04-29 | 2017-04-20 | 標的核酸の改変のための改善された方法 |
| JP2022187824A Pending JP2023018093A (ja) | 2016-04-29 | 2022-11-24 | 標的核酸の改変のための改善された方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022187824A Pending JP2023018093A (ja) | 2016-04-29 | 2022-11-24 | 標的核酸の改変のための改善された方法 |
Country Status (12)
| Country | Link |
|---|---|
| US (5) | US11608499B2 (enExample) |
| EP (5) | EP3868880A1 (enExample) |
| JP (2) | JP7184648B2 (enExample) |
| KR (3) | KR102370675B1 (enExample) |
| CN (1) | CN109072207B (enExample) |
| AU (5) | AU2017256517B2 (enExample) |
| CA (1) | CA3022475A1 (enExample) |
| CL (1) | CL2018003074A1 (enExample) |
| DK (1) | DK3448990T5 (enExample) |
| IL (1) | IL262409B2 (enExample) |
| MX (2) | MX388092B (enExample) |
| WO (1) | WO2017186550A1 (enExample) |
Families Citing this family (58)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2013066438A2 (en) | 2011-07-22 | 2013-05-10 | President And Fellows Of Harvard College | Evaluation and improvement of nuclease cleavage specificity |
| US9163284B2 (en) | 2013-08-09 | 2015-10-20 | President And Fellows Of Harvard College | Methods for identifying a target site of a Cas9 nuclease |
| US9359599B2 (en) | 2013-08-22 | 2016-06-07 | President And Fellows Of Harvard College | Engineered transcription activator-like effector (TALE) domains and uses thereof |
| US9340799B2 (en) | 2013-09-06 | 2016-05-17 | President And Fellows Of Harvard College | MRNA-sensing switchable gRNAs |
| US9526784B2 (en) | 2013-09-06 | 2016-12-27 | President And Fellows Of Harvard College | Delivery system for functional nucleases |
| US9322037B2 (en) | 2013-09-06 | 2016-04-26 | President And Fellows Of Harvard College | Cas9-FokI fusion proteins and uses thereof |
| US20150166984A1 (en) | 2013-12-12 | 2015-06-18 | President And Fellows Of Harvard College | Methods for correcting alpha-antitrypsin point mutations |
| AU2015298571B2 (en) | 2014-07-30 | 2020-09-03 | President And Fellows Of Harvard College | Cas9 proteins including ligand-dependent inteins |
| EP3204496A1 (en) | 2014-10-10 | 2017-08-16 | Editas Medicine, Inc. | Compositions and methods for promoting homology directed repair |
| WO2016073990A2 (en) | 2014-11-07 | 2016-05-12 | Editas Medicine, Inc. | Methods for improving crispr/cas-mediated genome-editing |
| CA2999500A1 (en) | 2015-09-24 | 2017-03-30 | Editas Medicine, Inc. | Use of exonucleases to improve crispr/cas-mediated genome editing |
| WO2017070632A2 (en) | 2015-10-23 | 2017-04-27 | President And Fellows Of Harvard College | Nucleobase editors and uses thereof |
| WO2017165826A1 (en) | 2016-03-25 | 2017-09-28 | Editas Medicine, Inc. | Genome editing systems comprising repair-modulating enzyme molecules and methods of their use |
| US11236313B2 (en) | 2016-04-13 | 2022-02-01 | Editas Medicine, Inc. | Cas9 fusion molecules, gene editing systems, and methods of use thereof |
| JP2019517261A (ja) * | 2016-06-01 | 2019-06-24 | カーヴェーエス ザート ソシエタス・ヨーロピアＫｗｓ Ｓａａｔ Ｓｅ | ゲノム操作のためのハイブリッド核酸配列 |
| WO2018027078A1 (en) | 2016-08-03 | 2018-02-08 | President And Fellows Of Harard College | Adenosine nucleobase editors and uses thereof |
| AU2017308889B2 (en) | 2016-08-09 | 2023-11-09 | President And Fellows Of Harvard College | Programmable Cas9-recombinase fusion proteins and uses thereof |
| WO2018039438A1 (en) | 2016-08-24 | 2018-03-01 | President And Fellows Of Harvard College | Incorporation of unnatural amino acids into proteins using base editing |
| KR20240007715A (ko) | 2016-10-14 | 2024-01-16 | 프레지던트 앤드 펠로우즈 오브 하바드 칼리지 | 핵염기 에디터의 aav 전달 |
| US20190330620A1 (en) * | 2016-10-14 | 2019-10-31 | Emendobio Inc. | Rna compositions for genome editing |
| WO2018094356A2 (en) * | 2016-11-18 | 2018-05-24 | Genedit Inc. | Compositions and methods for target nucleic acid modification |
| WO2018119359A1 (en) | 2016-12-23 | 2018-06-28 | President And Fellows Of Harvard College | Editing of ccr5 receptor gene to protect against hiv infection |
| EA201991809A1 (ru) * | 2017-01-30 | 2020-02-05 | КВС ЗААТ СЕ & КО. КГаА | Сцепление матрицы для репарации с эндонуклеазами для геномной инженерии |
| KR20190123328A (ko) | 2017-03-09 | 2019-10-31 | 프레지던트 앤드 펠로우즈 오브 하바드 칼리지 | 암 백신 |
| WO2018165504A1 (en) | 2017-03-09 | 2018-09-13 | President And Fellows Of Harvard College | Suppression of pain by gene editing |
| CN110914310A (zh) | 2017-03-10 | 2020-03-24 | 哈佛大学的校长及成员们 | 胞嘧啶至鸟嘌呤碱基编辑器 |
| IL306092A (en) | 2017-03-23 | 2023-11-01 | Harvard College | Nucleic base editors that include nucleic acid programmable DNA binding proteins |
| US11560566B2 (en) | 2017-05-12 | 2023-01-24 | President And Fellows Of Harvard College | Aptazyme-embedded guide RNAs for use with CRISPR-Cas9 in genome editing and transcriptional activation |
| MY200418A (en) | 2017-06-15 | 2023-12-25 | Univ California | Targeted non-viral dna insertions |
| EP3652312A1 (en) | 2017-07-14 | 2020-05-20 | Editas Medicine, Inc. | Systems and methods for targeted integration and genome editing and detection thereof using integrated priming sites |
| EP3658573A1 (en) | 2017-07-28 | 2020-06-03 | President and Fellows of Harvard College | Methods and compositions for evolving base editors using phage-assisted continuous evolution (pace) |
| EP3676376B1 (en) | 2017-08-30 | 2025-01-15 | President and Fellows of Harvard College | High efficiency base editors comprising gam |
| KR102907044B1 (ko) | 2017-10-02 | 2026-01-02 | 진에딧 인코포레이티드 | 변형된 cpf1 가이드 rna |
| CA3082251A1 (en) | 2017-10-16 | 2019-04-25 | The Broad Institute, Inc. | Uses of adenosine base editors |
| SG11202003798TA (en) | 2017-10-27 | 2020-05-28 | Univ California | Targeted replacement of endogenous t cell receptors |
| US12406749B2 (en) | 2017-12-15 | 2025-09-02 | The Broad Institute, Inc. | Systems and methods for predicting repair outcomes in genetic engineering |
| US11268092B2 (en) | 2018-01-12 | 2022-03-08 | GenEdit, Inc. | Structure-engineered guide RNA |
| WO2019226953A1 (en) | 2018-05-23 | 2019-11-28 | The Broad Institute, Inc. | Base editors and uses thereof |
| EP3820495A4 (en) | 2018-07-09 | 2022-07-20 | The Broad Institute Inc. | RNA-PROGRAMMABLE EPIGENETIC RNA MODIFIERS AND THEIR USES |
| AU2019327449B2 (en) | 2018-08-28 | 2026-04-09 | Flagship Pioneering Innovations Vi, Llc | Methods and compositions for modulating a genome |
| WO2020092453A1 (en) | 2018-10-29 | 2020-05-07 | The Broad Institute, Inc. | Nucleobase editors comprising geocas9 and uses thereof |
| KR102298105B1 (ko) | 2019-01-08 | 2021-09-03 | 주식회사 엘지에너지솔루션 | 스웰링 게이지를 구비한 배터리 모듈 및 이를 포함하는 배터리 팩 |
| US12351837B2 (en) | 2019-01-23 | 2025-07-08 | The Broad Institute, Inc. | Supernegatively charged proteins and uses thereof |
| WO2020191241A1 (en) | 2019-03-19 | 2020-09-24 | The Broad Institute, Inc. | Methods and compositions for editing nucleotide sequences |
| WO2020214842A1 (en) | 2019-04-17 | 2020-10-22 | The Broad Institute, Inc. | Adenine base editors with reduced off-target effects |
| US12435330B2 (en) | 2019-10-10 | 2025-10-07 | The Broad Institute, Inc. | Methods and compositions for prime editing RNA |
| KR20220149567A (ko) | 2020-03-04 | 2022-11-08 | 바스프 에스이 | 이. 콜라이 및 바실루스에서의 발현을 위한 셔틀 벡터 |
| EP4114954A1 (en) | 2020-03-04 | 2023-01-11 | Basf Se | Method for the production of constitutive bacterial promoters conferring low to medium expression |
| IL296095A (en) | 2020-03-04 | 2022-11-01 | Flagship Pioneering Innovations Vi Llc | Improved methods and compositions for genome modulation |
| CA3177481A1 (en) | 2020-05-08 | 2021-11-11 | David R. Liu | Methods and compositions for simultaneous editing of both strands of a target double-stranded nucleotide sequence |
| CN112111505B (zh) * | 2020-09-17 | 2022-03-15 | 江南大学 | 一种氧化葡萄糖酸杆菌中基因敲除的方法 |
| WO2022251179A1 (en) * | 2021-05-26 | 2022-12-01 | Inscripta, Inc. | Crispr editing in diploid genomes |
| EP4384616A4 (en) * | 2021-08-11 | 2025-08-27 | Univ Leland Stanford Junior | HIGH-THROUGHPUT PRECISION GENOME EDITING IN HUMAN CELLS |
| MX2024003887A (es) | 2021-10-14 | 2024-07-09 | Arsenal Biosciences Inc | Células inmunitarias que tienen arnch coespresados y sistemas de compuerta lógica. |
| US20250304934A1 (en) * | 2021-12-14 | 2025-10-02 | The Broad Institute, Inc. | Reprogrammable fanzor polynucleotides and uses thereof |
| EP4486879A1 (en) | 2022-03-01 | 2025-01-08 | Wageningen Universiteit | Cas12a nickases |
| CN114774420B (zh) * | 2022-04-27 | 2023-09-22 | 扬州大学 | 一种水稻增强子及基于CRISPR/Cas9技术评估水稻增强子活性的方法 |
| CN116179576B (zh) * | 2022-10-25 | 2026-05-15 | 中国科学院微生物研究所 | 一种非典型毕赤酵母基因编辑系统及其应用 |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK0733059T3 (da) | 1993-12-09 | 2000-10-16 | Univ Jefferson | Forbindelser og fremgangsmåder til site-rettede mutationer i eukaryote celler |
| US6027945A (en) | 1997-01-21 | 2000-02-22 | Promega Corporation | Methods of isolating biological target materials using silica magnetic particles |
| US6555732B1 (en) | 1998-09-14 | 2003-04-29 | Pioneer Hi-Bred International, Inc. | Rac-like genes and methods of use |
| EP1152058A1 (en) * | 2000-05-03 | 2001-11-07 | Institut Curie | Methods and compositions for effecting homologous recombination |
| EP2325332B1 (en) | 2005-08-26 | 2012-10-31 | DuPont Nutrition Biosciences ApS | Use of CRISPR associated genes (CAS) |
| ES2749624T3 (es) | 2013-03-14 | 2020-03-23 | Caribou Biosciences Inc | Composiciones y métodos de ácidos nucleicos dirigidos a ácido nucleico |
| SG11201510327TA (en) | 2013-06-17 | 2016-01-28 | Broad Inst Inc | Delivery, engineering and optimization of systems, methods and compositions for targeting and modeling diseases and disorders of post mitotic cells |
| US11306328B2 (en) * | 2013-07-26 | 2022-04-19 | President And Fellows Of Harvard College | Genome engineering |
| BR112016002851B1 (pt) | 2013-08-12 | 2022-02-22 | BASF Agro B.V. | Molécula de ácido nucleico, constructo de ácido nucleico, vetor, polipeptídeo ppo, método para controlar vegetação indesejada e uso do ácido nucleico |
| CA2933002C (en) | 2013-12-18 | 2023-08-15 | BASF Agro B.V. | Plants having an increased tolerance to protoporphyrinogen oxidase (ppo) herbicides |
| CA3208184A1 (en) * | 2014-03-14 | 2015-09-17 | Cibus Us Llc | Methods and compositions for increasing efficiency of targeted gene modification using oligonucleotide-mediated gene repair |
| WO2015191693A2 (en) * | 2014-06-10 | 2015-12-17 | Massachusetts Institute Of Technology | Method for gene editing |
| WO2016065364A1 (en) * | 2014-10-24 | 2016-04-28 | Life Technologies Corporation | Compositions and methods for enhancing homologous recombination |
| CN107614680A (zh) * | 2015-05-14 | 2018-01-19 | 南加利福尼亚大学 | 利用重组核酸内切酶系统的最佳化基因编辑 |
| US9790490B2 (en) * | 2015-06-18 | 2017-10-17 | The Broad Institute Inc. | CRISPR enzymes and systems |
| WO2017024047A1 (en) | 2015-08-03 | 2017-02-09 | Emendobio Inc. | Compositions and methods for increasing nuclease induced recombination rate in cells |
| WO2017064546A1 (en) * | 2015-09-24 | 2017-04-20 | Crispr Therapeutics Ag | Novel family of rna-programmable endonucleases and their uses in genome editing and other applications |
| WO2017059241A1 (en) * | 2015-10-02 | 2017-04-06 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Lentiviral protein delivery system for rna-guided genome editing |
| CN106811479B (zh) * | 2015-11-30 | 2019-10-25 | 中国农业科学院作物科学研究所 | 利用CRISPR/Cas9系统定点修饰ALS基因获得抗除草剂水稻的系统及其应用 |
| WO2017180711A1 (en) * | 2016-04-13 | 2017-10-19 | Editas Medicine, Inc. | Grna fusion molecules, gene editing systems, and methods of use thereof |
| WO2018094356A2 (en) * | 2016-11-18 | 2018-05-24 | Genedit Inc. | Compositions and methods for target nucleic acid modification |
-
2017
- 2017-04-20 KR KR1020187030717A patent/KR102370675B1/ko active Active
- 2017-04-20 EP EP21162462.2A patent/EP3868880A1/en not_active Withdrawn
- 2017-04-20 AU AU2017256517A patent/AU2017256517B2/en active Active
- 2017-04-20 KR KR1020237007132A patent/KR20230038804A/ko not_active Ceased
- 2017-04-20 WO PCT/EP2017/059331 patent/WO2017186550A1/en not_active Ceased
- 2017-04-20 EP EP22193654.5A patent/EP4166661A1/en active Pending
- 2017-04-20 CA CA3022475A patent/CA3022475A1/en active Pending
- 2017-04-20 EP EP22193652.9A patent/EP4166660A1/en not_active Withdrawn
- 2017-04-20 KR KR1020227006922A patent/KR102506185B1/ko active Active
- 2017-04-20 MX MX2018013256A patent/MX388092B/es unknown
- 2017-04-20 DK DK17720040.9T patent/DK3448990T5/da active
- 2017-04-20 EP EP17720040.9A patent/EP3448990B1/en not_active Revoked
- 2017-04-20 EP EP22193659.4A patent/EP4166662A1/en not_active Withdrawn
- 2017-04-20 US US16/097,300 patent/US11608499B2/en active Active
- 2017-04-20 IL IL262409A patent/IL262409B2/en unknown
- 2017-04-20 CN CN201780025990.6A patent/CN109072207B/zh active Active
- 2017-04-20 JP JP2018555963A patent/JP7184648B2/ja active Active
-
2018
- 2018-10-29 CL CL2018003074A patent/CL2018003074A1/es unknown
- 2018-10-29 MX MX2021009235A patent/MX2021009235A/es unknown
-
2022
- 2022-09-16 US US17/933,005 patent/US20230183686A1/en active Pending
- 2022-09-16 US US17/933,023 patent/US20230107997A1/en active Pending
- 2022-09-16 US US17/933,015 patent/US20230049124A1/en not_active Abandoned
- 2022-09-16 US US17/933,003 patent/US20230024869A1/en not_active Abandoned
- 2022-11-04 AU AU2022100155A patent/AU2022100155A4/en not_active Expired
- 2022-11-04 AU AU2022100157A patent/AU2022100157A4/en not_active Expired
- 2022-11-04 AU AU2022100158A patent/AU2022100158A4/en not_active Expired
- 2022-11-14 AU AU2022100170A patent/AU2022100170A4/en not_active Expired
- 2022-11-24 JP JP2022187824A patent/JP2023018093A/ja active Pending
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