JP2019513139A5 - - Google Patents
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- Publication number
- JP2019513139A5 JP2019513139A5 JP2018550588A JP2018550588A JP2019513139A5 JP 2019513139 A5 JP2019513139 A5 JP 2019513139A5 JP 2018550588 A JP2018550588 A JP 2018550588A JP 2018550588 A JP2018550588 A JP 2018550588A JP 2019513139 A5 JP2019513139 A5 JP 2019513139A5
- Authority
- JP
- Japan
- Prior art keywords
- solution
- cyclodextrin
- panobinostat
- adduct
- csf
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000000243 solution Substances 0.000 claims 28
- 238000000034 method Methods 0.000 claims 21
- 229960005184 panobinostat Drugs 0.000 claims 18
- 210000001175 cerebrospinal fluid Anatomy 0.000 claims 17
- IAZDPXIOMUYVGZ-UHFFFAOYSA-N Dimethylsulphoxide Chemical compound CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 claims 16
- 239000007864 aqueous solution Substances 0.000 claims 12
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 claims 9
- WEVYAHXRMPXWCK-UHFFFAOYSA-N Acetonitrile Chemical compound CC#N WEVYAHXRMPXWCK-UHFFFAOYSA-N 0.000 claims 9
- YMWUJEATGCHHMB-UHFFFAOYSA-N Dichloromethane Chemical compound ClCCl YMWUJEATGCHHMB-UHFFFAOYSA-N 0.000 claims 9
- ZMXDDKWLCZADIW-UHFFFAOYSA-N N,N-Dimethylformamide Chemical compound CN(C)C=O ZMXDDKWLCZADIW-UHFFFAOYSA-N 0.000 claims 9
- WYURNTSHIVDZCO-UHFFFAOYSA-N Tetrahydrofuran Chemical compound C1CCOC1 WYURNTSHIVDZCO-UHFFFAOYSA-N 0.000 claims 6
- 239000007787 solid Substances 0.000 claims 6
- 229920000858 Cyclodextrin Polymers 0.000 claims 4
- FWZRWHZDXBDTFK-ZHACJKMWSA-N panobinostat Chemical compound CC1=NC2=CC=C[CH]C2=C1CCNCC1=CC=C(\C=C\C(=O)NO)C=C1 FWZRWHZDXBDTFK-ZHACJKMWSA-N 0.000 claims 4
- HFHDHCJBZVLPGP-UHFFFAOYSA-N schardinger α-dextrin Chemical compound O1C(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(O)C2O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC2C(O)C(O)C1OC2CO HFHDHCJBZVLPGP-UHFFFAOYSA-N 0.000 claims 4
- 208000032612 Glial tumor Diseases 0.000 claims 3
- 206010018338 Glioma Diseases 0.000 claims 3
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 claims 3
- 238000001035 drying Methods 0.000 claims 3
- YLQBMQCUIZJEEH-UHFFFAOYSA-N tetrahydrofuran Natural products C=1C=COC=1 YLQBMQCUIZJEEH-UHFFFAOYSA-N 0.000 claims 3
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 3
- 208000003174 Brain Neoplasms Diseases 0.000 claims 2
- 239000008215 water for injection Substances 0.000 claims 2
- KRKNYBCHXYNGOX-UHFFFAOYSA-K Citrate Chemical compound [O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O KRKNYBCHXYNGOX-UHFFFAOYSA-K 0.000 claims 1
- 210000004556 brain Anatomy 0.000 claims 1
- 208000028919 diffuse intrinsic pontine glioma Diseases 0.000 claims 1
- 238000001914 filtration Methods 0.000 claims 1
- 239000012530 fluid Substances 0.000 claims 1
- 239000002105 nanoparticle Substances 0.000 claims 1
- 239000002071 nanotube Substances 0.000 claims 1
- 239000003960 organic solvent Substances 0.000 claims 1
- 239000012266 salt solution Substances 0.000 claims 1
- 230000001954 sterilising effect Effects 0.000 claims 1
- ODLHGICHYURWBS-LKONHMLTSA-N trappsol cyclo Chemical compound CC(O)COC[C@H]([C@H]([C@@H]([C@H]1O)O)O[C@H]2O[C@@H]([C@@H](O[C@H]3O[C@H](COCC(C)O)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](COCC(C)O)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](COCC(C)O)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](COCC(C)O)[C@H]([C@@H]([C@H]3O)O)O3)[C@H](O)[C@H]2O)COCC(O)C)O[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@@H]3O[C@@H]1COCC(C)O ODLHGICHYURWBS-LKONHMLTSA-N 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB201605406 | 2016-03-31 | ||
| GB1605406.6 | 2016-03-31 | ||
| GB1610440.8 | 2016-06-15 | ||
| GBGB1610440.8A GB201610440D0 (en) | 2016-06-15 | 2016-06-15 | Pharmaceutical formulations |
| PCT/EP2017/057472 WO2017167837A1 (en) | 2016-03-31 | 2017-03-29 | Cyclodextrin-panobinostat adduct |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2019513139A JP2019513139A (ja) | 2019-05-23 |
| JP2019513139A5 true JP2019513139A5 (enExample) | 2019-06-27 |
| JP6880058B2 JP6880058B2 (ja) | 2021-06-02 |
Family
ID=58489304
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018550588A Active JP6880058B2 (ja) | 2016-03-31 | 2017-03-29 | シクロデキストリン−パノビノスタット付加物 |
Country Status (12)
| Country | Link |
|---|---|
| US (2) | US10722597B2 (enExample) |
| EP (1) | EP3347055B1 (enExample) |
| JP (1) | JP6880058B2 (enExample) |
| KR (1) | KR102416050B1 (enExample) |
| CN (1) | CN109310783B (enExample) |
| AU (2) | AU2017242544B2 (enExample) |
| CA (1) | CA3018923A1 (enExample) |
| ES (1) | ES2743740T3 (enExample) |
| MX (1) | MX374165B (enExample) |
| PL (1) | PL3347055T3 (enExample) |
| PT (1) | PT3347055T (enExample) |
| WO (1) | WO2017167837A1 (enExample) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MX2019000342A (es) * | 2016-07-08 | 2019-09-04 | Ranedis Pharmaceuticals Llc | Composiciones y metodos para tratar y/o prevenir enfermedades de almacenamiento lisosomal y otras enfermedades metabolicas monogeneticas. |
| CN110114068A (zh) * | 2016-12-26 | 2019-08-09 | 富士胶片株式会社 | 脂质粒子组合物及医药组合物 |
| GB202020359D0 (en) | 2020-12-22 | 2021-02-03 | Midatech Pharma Wales Ltd | Pharmaceutical compositions and use thereof in combination therapy for brain cancer |
| WO2024041744A1 (en) * | 2022-08-26 | 2024-02-29 | Biodexa Ltd. | Combination therapy for brain cancer |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP4922507B2 (ja) * | 2000-08-10 | 2012-04-25 | 武田薬品工業株式会社 | 医薬組成物 |
| CA2685447C (en) | 2000-08-10 | 2013-05-28 | Takeda Pharmaceutical Company Limited | Pharmaceutical composition |
| CA2606598C (en) | 2005-05-13 | 2014-12-23 | Topotarget Uk Limited | Pharmaceutical formulations of hdac inhibitors |
| EP2023949A4 (en) | 2006-04-26 | 2009-08-26 | Univ California | COMPOSITIONS AND METHODS FOR CONVECTION-REINFORCED RELEASE OF NEUROTHERAPEUTICS WITH HIGH MOLECULAR WEIGHT |
| US20100008923A1 (en) | 2006-06-26 | 2010-01-14 | Novartis Ag | Organic Compounds |
| ITRM20070038A1 (it) * | 2007-01-26 | 2008-07-27 | Uni Degli Studi Di Roma La Sapienza | Forme solubili di complessi di inclusione di inibitori dell istone deacetilasi e ciclodestrine loro processi di preparazione e impieghi in campo farmaceutico |
| CL2008002786A1 (es) * | 2007-09-20 | 2009-05-15 | Novartis Ag | Torta farmceuticamente aceptable, formada por liofilizacion, que comprende: n-hidroxi-3-[4-[[[2-(2-metil-1h-indol-3-il]-etil]-amino]-metil]-fenil]-2e-2-propenamida o una sal, un regulador de ph seleciondo de lactato o acidop lactico, fodfato o acido fosforico o una combinacion y un agente de volumen; proceso de elaboracion. |
| GB201204263D0 (en) * | 2012-03-12 | 2012-04-25 | Renishaw Plc | Giloma treatment |
| US10413517B2 (en) * | 2014-06-12 | 2019-09-17 | University Of Notre Dame Du Lac | Composition and method for the treatment of neurological diseases and cerebral injury |
| GB201601773D0 (en) | 2016-02-01 | 2016-03-16 | Renishaw Plc | Method |
-
2017
- 2017-03-29 US US16/081,694 patent/US10722597B2/en active Active
- 2017-03-29 PL PL17715654T patent/PL3347055T3/pl unknown
- 2017-03-29 PT PT17715654T patent/PT3347055T/pt unknown
- 2017-03-29 CA CA3018923A patent/CA3018923A1/en active Pending
- 2017-03-29 ES ES17715654T patent/ES2743740T3/es active Active
- 2017-03-29 MX MX2018011760A patent/MX374165B/es active IP Right Grant
- 2017-03-29 KR KR1020187029287A patent/KR102416050B1/ko active Active
- 2017-03-29 WO PCT/EP2017/057472 patent/WO2017167837A1/en not_active Ceased
- 2017-03-29 JP JP2018550588A patent/JP6880058B2/ja active Active
- 2017-03-29 EP EP17715654.4A patent/EP3347055B1/en active Active
- 2017-03-29 AU AU2017242544A patent/AU2017242544B2/en active Active
- 2017-03-29 CN CN201780021581.9A patent/CN109310783B/zh active Active
-
2020
- 2020-06-11 US US16/899,408 patent/US11235068B2/en active Active
-
2023
- 2023-02-23 AU AU2023201091A patent/AU2023201091B2/en active Active
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