JP2019512495A - 急性骨髄性白血病の治療のための併用療法 - Google Patents

急性骨髄性白血病の治療のための併用療法 Download PDF

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JP2019512495A
JP2019512495A JP2018548236A JP2018548236A JP2019512495A JP 2019512495 A JP2019512495 A JP 2019512495A JP 2018548236 A JP2018548236 A JP 2018548236A JP 2018548236 A JP2018548236 A JP 2018548236A JP 2019512495 A JP2019512495 A JP 2019512495A
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salt
amino
acute myeloid
myeloid leukemia
methylpiperazin
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JP2019512495A5 (https=
Inventor
エルクット バーチェジ
エルクット バーチェジ
陽子 山木
陽子 山木
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Astellas Pharma Inc
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Astellas Pharma Inc
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4965—Non-condensed pyrazines
    • A61K31/497—Non-condensed pyrazines containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Oncology (AREA)
  • Molecular Biology (AREA)
  • Hematology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Nutrition Science (AREA)
  • Dermatology (AREA)
  • Physiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
JP2018548236A 2016-03-29 2017-03-27 急性骨髄性白血病の治療のための併用療法 Pending JP2019512495A (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201662314700P 2016-03-29 2016-03-29
US62/314700 2016-03-29
US201662368343P 2016-07-29 2016-07-29
US62/368343 2016-07-29
PCT/JP2017/012293 WO2017170348A1 (en) 2016-03-29 2017-03-27 Combination therapy for the treatment of acute myeloid leukemia

Publications (2)

Publication Number Publication Date
JP2019512495A true JP2019512495A (ja) 2019-05-16
JP2019512495A5 JP2019512495A5 (https=) 2020-04-09

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JP2018548236A Pending JP2019512495A (ja) 2016-03-29 2017-03-27 急性骨髄性白血病の治療のための併用療法

Country Status (10)

Country Link
US (2) US20190117649A1 (https=)
EP (1) EP3436014A4 (https=)
JP (1) JP2019512495A (https=)
KR (1) KR20180124055A (https=)
CN (1) CN108883109A (https=)
BR (1) BR112018069111A2 (https=)
CA (1) CA3018155A1 (https=)
MX (1) MX2018011975A (https=)
RU (1) RU2018134167A (https=)
WO (1) WO2017170348A1 (https=)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2018119142A1 (en) 2016-12-21 2018-06-28 Amgen Inc. Anti-tnf alpha antibody formulations
KR101954370B1 (ko) 2018-07-25 2019-03-05 한미약품 주식회사 피리미딘 화합물 및 이를 포함하는 암의 예방 또는 치료용 약학 조성물
PH12021551985A1 (en) * 2019-02-22 2022-08-22 Hanmi Pharmaceutical Co Ltd Pharmaceutical composition comprising flt3 inhibitor and hypomethylating agent for treating acute myeloid leukemia
EA202191984A1 (ru) * 2019-02-22 2021-11-19 Ханми Фарм. Ко., Лтд. Фармацевтическая композиция, содержащая ингибитор flt3 и гипометилирующий агент, для лечения острого миелолейкоза
KR20200102948A (ko) 2019-02-22 2020-09-01 한미약품 주식회사 Flt3 저해제 및 iap 길항제를 포함하는 급성 골수성 백혈병의 치료를 위한 약학적 조합물
WO2020204142A1 (ja) 2019-04-03 2020-10-08 アステラス製薬株式会社 医薬組成物
EA202290154A1 (ru) 2019-06-27 2022-03-29 Ханми Фарм. Ко., Лтд. Фармацевтическая композиция для лечения острого миелоидного лейкоза, содержащая ингибитор flt3 и химиотерапевтические агенты
EP4045049A1 (en) * 2019-10-14 2022-08-24 Astrazeneca AB Combination therapy for treating a hematological malignancy
AU2020370110A1 (en) * 2019-10-21 2022-05-26 Rhizen Pharmaceuticals Ag Compositions comprising a DHODH inhibitor for the treatment of acute myeloid leukemia
TW202340177A (zh) 2021-12-30 2023-10-16 美商拜歐米富士恩股份有限公司 作為 flt3抑制劑之吡嗪化合物
KR102559124B1 (ko) 2022-08-25 2023-07-26 주식회사 엔젠바이오 Flt3 유전자 증폭용 조성물 및 이의 용도

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
BLOOD, vol. 128, no. 22, JPN6020049994, 2 December 2016 (2016-12-02), pages 2830, ISSN: 0004417084 *
EXPERT REVIEW OF HEMATOLOGY, vol. 9, no. 5, JPN6020049991, 17 March 2016 (2016-03-17), pages 433 - 445, ISSN: 0004563950 *
LEUKEMIA, vol. 30, JPN6020049993, 15 January 2016 (2016-01-15), pages 1025 - 1032, ISSN: 0004563951 *

Also Published As

Publication number Publication date
EP3436014A4 (en) 2019-11-27
MX2018011975A (es) 2019-01-15
RU2018134167A (ru) 2020-04-29
EP3436014A1 (en) 2019-02-06
RU2018134167A3 (https=) 2020-06-30
BR112018069111A2 (pt) 2019-03-19
KR20180124055A (ko) 2018-11-20
WO2017170348A1 (en) 2017-10-05
CA3018155A1 (en) 2017-10-05
CN108883109A (zh) 2018-11-23
US20200360372A1 (en) 2020-11-19
US20190117649A1 (en) 2019-04-25

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