JP2019512465A5 - - Google Patents
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- JP2019512465A5 JP2019512465A5 JP2018544186A JP2018544186A JP2019512465A5 JP 2019512465 A5 JP2019512465 A5 JP 2019512465A5 JP 2018544186 A JP2018544186 A JP 2018544186A JP 2018544186 A JP2018544186 A JP 2018544186A JP 2019512465 A5 JP2019512465 A5 JP 2019512465A5
- Authority
- JP
- Japan
- Prior art keywords
- item
- alkyl
- substituted
- compound according
- hydrogen
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 150000001875 compounds Chemical class 0.000 claims description 80
- 125000000217 alkyl group Chemical group 0.000 claims description 47
- 125000000623 heterocyclic group Chemical group 0.000 claims description 36
- 229910052739 hydrogen Inorganic materials 0.000 claims description 36
- 239000001257 hydrogen Substances 0.000 claims description 36
- 229910052799 carbon Inorganic materials 0.000 claims description 32
- 125000003342 alkenyl group Chemical group 0.000 claims description 30
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims description 29
- 125000003118 aryl group Chemical group 0.000 claims description 29
- 125000001072 heteroaryl group Chemical group 0.000 claims description 27
- 229910052760 oxygen Inorganic materials 0.000 claims description 22
- 125000000304 alkynyl group Chemical group 0.000 claims description 18
- 229910052736 halogen Inorganic materials 0.000 claims description 12
- 150000002367 halogens Chemical class 0.000 claims description 12
- 229910052717 sulfur Inorganic materials 0.000 claims description 11
- 229910052757 nitrogen Inorganic materials 0.000 claims description 10
- 125000004433 nitrogen atom Chemical group N* 0.000 claims description 10
- 125000004450 alkenylene group Chemical group 0.000 claims description 9
- 125000002947 alkylene group Chemical group 0.000 claims description 9
- 150000002431 hydrogen Chemical class 0.000 claims description 7
- 206010028980 Neoplasm Diseases 0.000 claims description 3
- 125000004419 alkynylene group Chemical group 0.000 claims description 3
- 201000011510 cancer Diseases 0.000 claims description 3
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims description 3
- 150000003839 salts Chemical class 0.000 claims description 3
- 125000001424 substituent group Chemical group 0.000 claims description 3
- 239000003814 drug Substances 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 238000000034 method Methods 0.000 description 35
- 102100025064 Cellular tumor antigen p53 Human genes 0.000 description 30
- 125000004432 carbon atom Chemical group C* 0.000 description 12
- 238000003556 assay Methods 0.000 description 5
- YBJHBAHKTGYVGT-ZKWXMUAHSA-N (+)-Biotin Chemical compound N1C(=O)N[C@@H]2[C@H](CCCCC(=O)O)SC[C@@H]21 YBJHBAHKTGYVGT-ZKWXMUAHSA-N 0.000 description 4
- 238000002866 fluorescence resonance energy transfer Methods 0.000 description 4
- 150000001413 amino acids Chemical class 0.000 description 3
- 239000013068 control sample Substances 0.000 description 3
- 230000035772 mutation Effects 0.000 description 3
- 108010090804 Streptavidin Proteins 0.000 description 2
- 108010004469 allophycocyanin Proteins 0.000 description 2
- 230000006907 apoptotic process Effects 0.000 description 2
- 229960002685 biotin Drugs 0.000 description 2
- 235000020958 biotin Nutrition 0.000 description 2
- 239000011616 biotin Substances 0.000 description 2
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 description 1
- 206010006187 Breast cancer Diseases 0.000 description 1
- 208000026310 Breast neoplasm Diseases 0.000 description 1
- 206010058467 Lung neoplasm malignant Diseases 0.000 description 1
- 206010033128 Ovarian cancer Diseases 0.000 description 1
- 206010061535 Ovarian neoplasm Diseases 0.000 description 1
- 230000004913 activation Effects 0.000 description 1
- 230000025084 cell cycle arrest Effects 0.000 description 1
- 125000000753 cycloalkyl group Chemical group 0.000 description 1
- 238000002868 homogeneous time resolved fluorescence Methods 0.000 description 1
- 230000001939 inductive effect Effects 0.000 description 1
- 238000001990 intravenous administration Methods 0.000 description 1
- 201000005202 lung cancer Diseases 0.000 description 1
- 208000020816 lung neoplasm Diseases 0.000 description 1
- 238000007920 subcutaneous administration Methods 0.000 description 1
- 230000000699 topical effect Effects 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662297450P | 2016-02-19 | 2016-02-19 | |
| US62/297,450 | 2016-02-19 | ||
| PCT/US2017/018511 WO2017143291A1 (en) | 2016-02-19 | 2017-02-17 | METHODS AND COMPOUNDS FOR RESTORING MUTANT p53 FUNCTION |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2019512465A JP2019512465A (ja) | 2019-05-16 |
| JP2019512465A5 true JP2019512465A5 (OSRAM) | 2020-03-26 |
| JP6956098B2 JP6956098B2 (ja) | 2021-10-27 |
Family
ID=59625486
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018544186A Active JP6956098B2 (ja) | 2016-02-19 | 2017-02-17 | 変異体ｐ５３機能を復元させるための方法および化合物 |
Country Status (10)
| Country | Link |
|---|---|
| US (4) | US10138219B2 (OSRAM) |
| EP (1) | EP3416638A4 (OSRAM) |
| JP (1) | JP6956098B2 (OSRAM) |
| KR (1) | KR102868217B1 (OSRAM) |
| CN (2) | CN109069481A (OSRAM) |
| AU (1) | AU2017221472B2 (OSRAM) |
| CA (2) | CA3010847C (OSRAM) |
| IL (2) | IL286839B (OSRAM) |
| MX (1) | MX383904B (OSRAM) |
| WO (1) | WO2017143291A1 (OSRAM) |
Families Citing this family (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP6956098B2 (ja) | 2016-02-19 | 2021-10-27 | ピーエムブイ ファーマシューティカルズ， インコーポレイテッド | 変異体ｐ５３機能を復元させるための方法および化合物 |
| PH12022550707A1 (en) | 2019-09-23 | 2023-03-27 | Pmv Pharmaceuticals Inc | METHODS AND COMPOUNDS FOR RESTORING MUTANT p53 FUNCTION |
| WO2021231474A1 (en) * | 2020-05-12 | 2021-11-18 | Pmv Pharmaceuticals, Inc. | METHODS AND COMPOUNDS FOR RESTORING MUTANT p53 FUNCTION |
| CN113750246B (zh) * | 2020-06-04 | 2023-12-05 | 华南理工大学 | ZIF-8纳米材料在降解广谱突变p53蛋白中的应用 |
| CN111686127B (zh) * | 2020-06-04 | 2022-02-15 | 华南理工大学 | 锌铁纳米材料在降解突变p53蛋白中的应用 |
| WO2021262684A1 (en) * | 2020-06-22 | 2021-12-30 | Pmv Pharmaceuticals, Inc. | METHODS AND COMPOUNDS FOR RESTORING MUTANT p53 FUNCTION |
| US20230024905A1 (en) * | 2020-06-22 | 2023-01-26 | Pmv Pharmaceuticals, Inc. | Uses of p53 x-ray co-crystal structures |
| EP4167982A4 (en) * | 2020-06-22 | 2024-08-07 | PMV Pharmaceuticals, Inc. | METHODS AND COMPOUNDS FOR RESTORING FUNCTION OF P53 MUTANTS |
| CN116249689A (zh) * | 2020-06-24 | 2023-06-09 | 皮姆维制药公司 | 用于再激活突变p53的化合物的伴随诊断工具 |
| WO2021262483A1 (en) * | 2020-06-24 | 2021-12-30 | Pmv Pharmaceuticals, Inc. | METHODS AND COMPOUNDS FOR RESTORING MUTANT p53 FUNCTION |
| MX2022015793A (es) * | 2020-06-24 | 2023-02-27 | Pmv Pharmaceuticals Inc | Terapia de combinacion para tratamiento de cancer. |
| EP4267553A1 (en) | 2020-12-24 | 2023-11-01 | Escient Pharmaceuticals, Inc. | Modulators of mas-related g-protein receptor x2 and related products and methods |
| WO2022213975A1 (en) * | 2021-04-08 | 2022-10-13 | Jacobio Pharmaceuticals Co., Ltd. | Compounds targeting y220c mutant of p53 |
| TW202322796A (zh) * | 2021-08-10 | 2023-06-16 | 大陸商北京加科思新藥研發有限公司 | 靶向p53突變體的化合物 |
| WO2023025324A1 (zh) * | 2021-08-27 | 2023-03-02 | 杭州紫晶医药科技有限公司 | 作为p53调节剂的化合物 |
| CN118891041A (zh) | 2022-01-27 | 2024-11-01 | 皮姆维制药公司 | 用于恢复突变p53功能的氘代化合物 |
| WO2024017384A1 (zh) * | 2022-07-22 | 2024-01-25 | 深圳众格生物科技有限公司 | 恢复p53突变功能的化合物及其应用 |
| WO2024041503A1 (en) * | 2022-08-22 | 2024-02-29 | Jacobio Pharmaceuticals Co., Ltd. | Compounds targeting y220c mutant of p53 |
| CN120077047A (zh) * | 2022-10-21 | 2025-05-30 | 正大天晴药业集团股份有限公司 | 大环类化合物及其医药用途 |
| WO2024120471A1 (en) * | 2022-12-08 | 2024-06-13 | Jacobio Pharmaceuticals Co., Ltd. | Compounds targeting mutant of p53 |
| WO2025031471A1 (zh) * | 2023-08-09 | 2025-02-13 | 德睿智药(苏州)新药研发有限公司 | 用于调节p53功能的新型杂环类化合物 |
| CN119350323B (zh) * | 2023-10-20 | 2025-06-13 | 上海宇道生物技术有限公司 | 一类靶向p53突变的N-磺酰酰胺含氮稠杂环类化合物及其应用 |
| WO2025242903A1 (en) * | 2024-05-24 | 2025-11-27 | Onco3R Therapeutics Bv | Compounds and pharmaceutical compositions thereof for the treatment of proliferative diseases |
Family Cites Families (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EA003326B1 (ru) * | 1998-12-02 | 2003-04-24 | Пфайзер Продактс Инк. | Способ лечения рака |
| US6770652B2 (en) * | 2001-10-18 | 2004-08-03 | Duquesne University Of The Holy Ghost | Multiple acting anti-angiogenic and cytotoxic compounds and methods for using the same |
| EP1689710A1 (en) | 2003-11-25 | 2006-08-16 | Novo Nordisk A/S | Indole derivatives for use as chemical uncoupler |
| JP2008505910A (ja) | 2004-07-08 | 2008-02-28 | ベーリンガー インゲルハイム ファーマシューティカルズ インコーポレイテッド | Ｐｋｃ−シータのインヒビターとして有用なピリミジン誘導体 |
| WO2006136823A1 (en) | 2005-06-21 | 2006-12-28 | Astex Therapeutics Limited | Heterocyclic containing amines as kinase b inhibitors |
| WO2009112075A1 (en) * | 2008-03-13 | 2009-09-17 | Universita' Degli Studi Di Trieste | Peptides and aptamers thereof as specific modulators of mutant p53 function |
| KR20160067981A (ko) * | 2008-04-16 | 2016-06-14 | 카로 바이오 아베 | 신규한 에스트로겐 수용체 리간드 |
| GB0808282D0 (en) | 2008-05-07 | 2008-06-11 | Medical Res Council | Compounds for use in stabilizing p53 mutants |
| PL2410844T3 (pl) | 2009-03-27 | 2016-08-31 | Merck Sharp & Dohme | Inhibitory replikacji wirusa zapalenia wątroby typu c |
| DE102010049877A1 (de) | 2010-11-01 | 2012-05-03 | Merck Patent Gmbh | 7-((1,2,3)Triazol-4-yl)-pyrrolo(2,3) pyrazinderivate |
| EP2665707B1 (en) | 2011-01-20 | 2017-01-18 | Merck Sharp & Dohme Corp. | Mineralocorticoid receptor antagonists |
| GB201110390D0 (en) * | 2011-06-20 | 2011-08-03 | Medical Res Council | Compounds for use in stabilising p53 mutants |
| WO2013036208A1 (en) * | 2011-09-09 | 2013-03-14 | Agency For Science, Technology And Research | P53 activating peptides |
| US8859780B2 (en) | 2011-12-28 | 2014-10-14 | Allergan, Inc. | Benzimidazole derivatives as selective blockers of persistent sodium current |
| US8822689B2 (en) | 2012-09-19 | 2014-09-02 | Merial Limited | Aryloazol-2-yl cyanoethylamino compounds, method of making and method of using thereof |
| JP6427599B2 (ja) * | 2014-05-19 | 2018-11-21 | チャンスー ヘンルイ メディシン カンパニー，リミテッド | チロシンキナーゼ阻害剤としての置換エチニルヘテロ二環式化合物 |
| WO2016004513A1 (en) * | 2014-07-11 | 2016-01-14 | Simon Fraser University | Anti-bacterial pyruvate kinase modulator compounds, compositions, uses and methods |
| CN104672241B (zh) * | 2015-01-29 | 2018-04-24 | 王磊 | 吡咯并[2,3-d]嘧啶类化合物及其用途 |
| JP6956098B2 (ja) | 2016-02-19 | 2021-10-27 | ピーエムブイ ファーマシューティカルズ， インコーポレイテッド | 変異体ｐ５３機能を復元させるための方法および化合物 |
-
2017
- 2017-02-17 JP JP2018544186A patent/JP6956098B2/ja active Active
- 2017-02-17 CN CN201780013450.6A patent/CN109069481A/zh active Pending
- 2017-02-17 CA CA3010847A patent/CA3010847C/en active Active
- 2017-02-17 CN CN202411302298.1A patent/CN119161324B/zh active Active
- 2017-02-17 MX MX2018009947A patent/MX383904B/es unknown
- 2017-02-17 IL IL286839A patent/IL286839B/en unknown
- 2017-02-17 EP EP17753995.4A patent/EP3416638A4/en not_active Withdrawn
- 2017-02-17 US US15/436,333 patent/US10138219B2/en active Active
- 2017-02-17 CA CA3215564A patent/CA3215564A1/en active Pending
- 2017-02-17 WO PCT/US2017/018511 patent/WO2017143291A1/en not_active Ceased
- 2017-02-17 KR KR1020187026965A patent/KR102868217B1/ko active Active
- 2017-02-17 AU AU2017221472A patent/AU2017221472B2/en active Active
-
2018
- 2018-08-15 IL IL261175A patent/IL261175B/en unknown
- 2018-10-18 US US16/163,829 patent/US10640485B2/en active Active
-
2020
- 2020-03-16 US US16/819,934 patent/US11339141B2/en active Active
-
2022
- 2022-02-24 US US17/679,568 patent/US20220213062A1/en active Pending
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