JP2019512464A5 - - Google Patents
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- JP2019512464A5 JP2019512464A5 JP2018543153A JP2018543153A JP2019512464A5 JP 2019512464 A5 JP2019512464 A5 JP 2019512464A5 JP 2018543153 A JP2018543153 A JP 2018543153A JP 2018543153 A JP2018543153 A JP 2018543153A JP 2019512464 A5 JP2019512464 A5 JP 2019512464A5
- Authority
- JP
- Japan
- Prior art keywords
- antibody
- seq
- chain variable
- variable region
- heavy chain
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 238000000034 method Methods 0.000 claims description 24
- 239000002254 cytotoxic agent Substances 0.000 claims description 18
- 229940127089 cytotoxic agent Drugs 0.000 claims description 17
- NFGXHKASABOEEW-UHFFFAOYSA-N 1-methylethyl 11-methoxy-3,7,11-trimethyl-2,4-dodecadienoate Chemical compound COC(C)(C)CCCC(C)CC=CC(C)=CC(=O)OC(C)C NFGXHKASABOEEW-UHFFFAOYSA-N 0.000 claims description 16
- 206010028980 Neoplasm Diseases 0.000 claims description 14
- 201000011510 cancer Diseases 0.000 claims description 14
- 125000003275 alpha amino acid group Chemical group 0.000 claims description 12
- 230000033581 fucosylation Effects 0.000 claims description 12
- 239000008194 pharmaceutical composition Substances 0.000 claims description 11
- SHZGCJCMOBCMKK-UHFFFAOYSA-N D-mannomethylose Natural products CC1OC(O)C(O)C(O)C1O SHZGCJCMOBCMKK-UHFFFAOYSA-N 0.000 claims description 9
- PNNNRSAQSRJVSB-SLPGGIOYSA-N Fucose Natural products C[C@H](O)[C@@H](O)[C@H](O)[C@H](O)C=O PNNNRSAQSRJVSB-SLPGGIOYSA-N 0.000 claims description 9
- SHZGCJCMOBCMKK-DHVFOXMCSA-N L-fucopyranose Chemical compound C[C@@H]1OC(O)[C@@H](O)[C@H](O)[C@@H]1O SHZGCJCMOBCMKK-DHVFOXMCSA-N 0.000 claims description 9
- 208000026278 immune system disease Diseases 0.000 claims description 9
- 230000002489 hematologic effect Effects 0.000 claims description 8
- 230000001404 mediated effect Effects 0.000 claims description 8
- 201000000596 systemic lupus erythematosus Diseases 0.000 claims description 8
- BGFTWECWAICPDG-UHFFFAOYSA-N 2-[bis(4-chlorophenyl)methyl]-4-n-[3-[bis(4-chlorophenyl)methyl]-4-(dimethylamino)phenyl]-1-n,1-n-dimethylbenzene-1,4-diamine Chemical compound C1=C(C(C=2C=CC(Cl)=CC=2)C=2C=CC(Cl)=CC=2)C(N(C)C)=CC=C1NC(C=1)=CC=C(N(C)C)C=1C(C=1C=CC(Cl)=CC=1)C1=CC=C(Cl)C=C1 BGFTWECWAICPDG-UHFFFAOYSA-N 0.000 claims description 7
- 102000006942 B-Cell Maturation Antigen Human genes 0.000 claims description 7
- 108010008014 B-Cell Maturation Antigen Proteins 0.000 claims description 7
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 7
- 201000003793 Myelodysplastic syndrome Diseases 0.000 claims description 6
- 208000015914 Non-Hodgkin lymphomas Diseases 0.000 claims description 6
- 206010035226 Plasma cell myeloma Diseases 0.000 claims description 6
- 150000008267 fucoses Chemical class 0.000 claims description 6
- 210000004027 cell Anatomy 0.000 claims description 5
- 208000035475 disorder Diseases 0.000 claims description 5
- 239000003937 drug carrier Substances 0.000 claims description 5
- 208000023328 Basedow disease Diseases 0.000 claims description 4
- 208000008439 Biliary Liver Cirrhosis Diseases 0.000 claims description 4
- 208000033222 Biliary cirrhosis primary Diseases 0.000 claims description 4
- 206010012438 Dermatitis atopic Diseases 0.000 claims description 4
- 208000009329 Graft vs Host Disease Diseases 0.000 claims description 4
- 206010072579 Granulomatosis with polyangiitis Diseases 0.000 claims description 4
- 208000015023 Graves' disease Diseases 0.000 claims description 4
- 208000030836 Hashimoto thyroiditis Diseases 0.000 claims description 4
- 208000012654 Primary biliary cholangitis Diseases 0.000 claims description 4
- 201000004681 Psoriasis Diseases 0.000 claims description 4
- 206010039085 Rhinitis allergic Diseases 0.000 claims description 4
- 208000021386 Sjogren Syndrome Diseases 0.000 claims description 4
- 206010043561 Thrombocytopenic purpura Diseases 0.000 claims description 4
- 206010067584 Type 1 diabetes mellitus Diseases 0.000 claims description 4
- 201000010105 allergic rhinitis Diseases 0.000 claims description 4
- 208000006673 asthma Diseases 0.000 claims description 4
- 201000008937 atopic dermatitis Diseases 0.000 claims description 4
- 210000003719 b-lymphocyte Anatomy 0.000 claims description 4
- 208000024908 graft versus host disease Diseases 0.000 claims description 4
- 210000002865 immune cell Anatomy 0.000 claims description 4
- 201000006417 multiple sclerosis Diseases 0.000 claims description 4
- 206010039073 rheumatoid arthritis Diseases 0.000 claims description 4
- 201000008827 tuberculosis Diseases 0.000 claims description 4
- MFRNYXJJRJQHNW-DEMKXPNLSA-N (2s)-2-[[(2r,3r)-3-methoxy-3-[(2s)-1-[(3r,4s,5s)-3-methoxy-5-methyl-4-[methyl-[(2s)-3-methyl-2-[[(2s)-3-methyl-2-(methylamino)butanoyl]amino]butanoyl]amino]heptanoyl]pyrrolidin-2-yl]-2-methylpropanoyl]amino]-3-phenylpropanoic acid Chemical compound CN[C@@H](C(C)C)C(=O)N[C@@H](C(C)C)C(=O)N(C)[C@@H]([C@@H](C)CC)[C@H](OC)CC(=O)N1CCC[C@H]1[C@H](OC)[C@@H](C)C(=O)N[C@H](C(O)=O)CC1=CC=CC=C1 MFRNYXJJRJQHNW-DEMKXPNLSA-N 0.000 claims description 3
- 208000011691 Burkitt lymphomas Diseases 0.000 claims description 3
- 239000012626 DNA minor groove binder Substances 0.000 claims description 3
- 208000017604 Hodgkin disease Diseases 0.000 claims description 3
- 208000021519 Hodgkin lymphoma Diseases 0.000 claims description 3
- 208000010747 Hodgkins lymphoma Diseases 0.000 claims description 3
- 102000009490 IgG Receptors Human genes 0.000 claims description 3
- 108010073807 IgG Receptors Proteins 0.000 claims description 3
- 206010025323 Lymphomas Diseases 0.000 claims description 3
- 208000034578 Multiple myelomas Diseases 0.000 claims description 3
- 208000033559 Waldenström macroglobulinemia Diseases 0.000 claims description 3
- IEDXPSOJFSVCKU-HOKPPMCLSA-N [4-[[(2S)-5-(carbamoylamino)-2-[[(2S)-2-[6-(2,5-dioxopyrrolidin-1-yl)hexanoylamino]-3-methylbutanoyl]amino]pentanoyl]amino]phenyl]methyl N-[(2S)-1-[[(2S)-1-[[(3R,4S,5S)-1-[(2S)-2-[(1R,2R)-3-[[(1S,2R)-1-hydroxy-1-phenylpropan-2-yl]amino]-1-methoxy-2-methyl-3-oxopropyl]pyrrolidin-1-yl]-3-methoxy-5-methyl-1-oxoheptan-4-yl]-methylamino]-3-methyl-1-oxobutan-2-yl]amino]-3-methyl-1-oxobutan-2-yl]-N-methylcarbamate Chemical group CC[C@H](C)[C@@H]([C@@H](CC(=O)N1CCC[C@H]1[C@H](OC)[C@@H](C)C(=O)N[C@H](C)[C@@H](O)c1ccccc1)OC)N(C)C(=O)[C@@H](NC(=O)[C@H](C(C)C)N(C)C(=O)OCc1ccc(NC(=O)[C@H](CCCNC(N)=O)NC(=O)[C@@H](NC(=O)CCCCCN2C(=O)CCC2=O)C(C)C)cc1)C(C)C IEDXPSOJFSVCKU-HOKPPMCLSA-N 0.000 claims description 3
- 239000000824 cytostatic agent Substances 0.000 claims description 3
- 208000032839 leukemia Diseases 0.000 claims description 3
- 201000000564 macroglobulinemia Diseases 0.000 claims description 3
- 201000000050 myeloid neoplasm Diseases 0.000 claims description 3
- 230000002071 myeloproliferative effect Effects 0.000 claims description 3
- 208000011580 syndromic disease Diseases 0.000 claims description 3
- 101000801255 Homo sapiens Tumor necrosis factor receptor superfamily member 17 Proteins 0.000 claims description 2
- 102000046935 human TNFRSF17 Human genes 0.000 claims description 2
- 239000000203 mixture Substances 0.000 claims 15
- 239000001963 growth medium Substances 0.000 claims 11
- 102000039446 nucleic acids Human genes 0.000 claims 3
- 108020004707 nucleic acids Proteins 0.000 claims 3
- 150000007523 nucleic acids Chemical class 0.000 claims 3
- SQTFKIKSQNCWGJ-KCDKBNATSA-N (2s,3r,4r,5s)-2-fluoro-3,4,5-trihydroxyhexanal Chemical compound C[C@H](O)[C@@H](O)[C@@H](O)[C@H](F)C=O SQTFKIKSQNCWGJ-KCDKBNATSA-N 0.000 claims 2
- 238000012258 culturing Methods 0.000 claims 2
- 231100000599 cytotoxic agent Toxicity 0.000 claims 2
- 102000004190 Enzymes Human genes 0.000 claims 1
- 108090000790 Enzymes Proteins 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 201000005787 hematologic cancer Diseases 0.000 description 7
- 208000024200 hematopoietic and lymphoid system neoplasm Diseases 0.000 description 7
- 201000010099 disease Diseases 0.000 description 2
- 231100000433 cytotoxic Toxicity 0.000 description 1
- 230000001472 cytotoxic effect Effects 0.000 description 1
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2022030779A JP2022069488A (ja) | 2016-02-17 | 2022-03-01 | 癌及び免疫学的障害を治療するためのｂｃｍａ抗生物質及びその使用 |
| JP2023216464A JP2024019677A (ja) | 2016-02-17 | 2023-12-22 | 癌及び免疫学的障害を治療するためのｂｃｍａ抗生物質及びその使用 |
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662296594P | 2016-02-17 | 2016-02-17 | |
| US62/296,594 | 2016-02-17 | ||
| US201662396084P | 2016-09-16 | 2016-09-16 | |
| US62/396,084 | 2016-09-16 | ||
| PCT/US2017/018177 WO2017143069A1 (en) | 2016-02-17 | 2017-02-16 | Bcma antibodies and use of same to treat cancer and immunological disorders |
Related Child Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020024261A Division JP2020073605A (ja) | 2016-02-17 | 2020-02-17 | 癌及び免疫学的障害を治療するためのｂｃｍａ抗生物質及びその使用 |
| JP2022030779A Division JP2022069488A (ja) | 2016-02-17 | 2022-03-01 | 癌及び免疫学的障害を治療するためのｂｃｍａ抗生物質及びその使用 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2019512464A JP2019512464A (ja) | 2019-05-16 |
| JP2019512464A5 true JP2019512464A5 (enExample) | 2020-03-26 |
| JP7152309B2 JP7152309B2 (ja) | 2022-10-12 |
Family
ID=59562012
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018543153A Active JP7152309B2 (ja) | 2016-02-17 | 2017-02-16 | 癌及び免疫学的障害を治療するためのｂｃｍａ抗生物質及びその使用 |
| JP2020024261A Pending JP2020073605A (ja) | 2016-02-17 | 2020-02-17 | 癌及び免疫学的障害を治療するためのｂｃｍａ抗生物質及びその使用 |
| JP2022030779A Withdrawn JP2022069488A (ja) | 2016-02-17 | 2022-03-01 | 癌及び免疫学的障害を治療するためのｂｃｍａ抗生物質及びその使用 |
| JP2023216464A Pending JP2024019677A (ja) | 2016-02-17 | 2023-12-22 | 癌及び免疫学的障害を治療するためのｂｃｍａ抗生物質及びその使用 |
Family Applications After (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020024261A Pending JP2020073605A (ja) | 2016-02-17 | 2020-02-17 | 癌及び免疫学的障害を治療するためのｂｃｍａ抗生物質及びその使用 |
| JP2022030779A Withdrawn JP2022069488A (ja) | 2016-02-17 | 2022-03-01 | 癌及び免疫学的障害を治療するためのｂｃｍａ抗生物質及びその使用 |
| JP2023216464A Pending JP2024019677A (ja) | 2016-02-17 | 2023-12-22 | 癌及び免疫学的障害を治療するためのｂｃｍａ抗生物質及びその使用 |
Country Status (14)
| Country | Link |
|---|---|
| US (6) | US20190194338A1 (enExample) |
| EP (1) | EP3416687A4 (enExample) |
| JP (4) | JP7152309B2 (enExample) |
| KR (1) | KR102816905B1 (enExample) |
| CN (2) | CN116063503A (enExample) |
| AU (2) | AU2017219747B2 (enExample) |
| BR (1) | BR112018016697A2 (enExample) |
| CA (1) | CA3011900A1 (enExample) |
| HK (1) | HK1259075A1 (enExample) |
| IL (2) | IL311107A (enExample) |
| MA (1) | MA44254A (enExample) |
| MX (2) | MX2018009700A (enExample) |
| SG (2) | SG10202007836WA (enExample) |
| WO (1) | WO2017143069A1 (enExample) |
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| IL311107A (en) | 2016-02-17 | 2024-04-01 | Seagen Inc | BCMA antibodies and their use for the treatment of cancer and immune disorders |
| US11166985B2 (en) | 2017-05-12 | 2021-11-09 | Crispr Therapeutics Ag | Materials and methods for engineering cells and uses thereof in immuno-oncology |
| MY201573A (en) | 2017-05-12 | 2024-03-02 | Crispr Therapeutics Ag | Materials and methods for engineering cells and uses thereof in immuno-oncology |
| JP7542441B2 (ja) | 2018-05-11 | 2024-08-30 | クリスパー セラピューティクス アクチェンゲゼルシャフト | 癌を治療するための方法及び組成物 |
| CN112105391B (zh) * | 2018-06-26 | 2024-05-14 | 爱必乐生物公司 | 抗-bcma抗体及其用途 |
| MD3823665T2 (ro) | 2018-07-19 | 2024-05-31 | Regeneron Pharma | Receptori antigenci chimerici cu specificitate BCMA și utilizările acestora |
| TWI838389B (zh) | 2018-07-19 | 2024-04-11 | 美商再生元醫藥公司 | 雙特異性抗-BCMAｘ抗-CD3抗體及其用途 |
| AU2019372673A1 (en) | 2018-11-01 | 2021-05-27 | Gracell Biotechnologies (Shanghai) Co., Ltd. | Compositions and methods for T cell engineering |
| JP2022514299A (ja) * | 2018-12-19 | 2022-02-10 | シージェン インコーポレイテッド | 抗体の制御されたフコシル化 |
| AU2020228367A1 (en) * | 2019-02-26 | 2021-10-14 | Vivasor, Inc. | Antigen binding proteins that bind BCMA |
| MX2021011141A (es) | 2019-03-21 | 2022-01-19 | Regeneron Pharma | Combinacion de inhibidores de la via de il-4/il-13 y ablacion de celulas plasmaticas para el tratamiento de alergia. |
| US20220249558A1 (en) | 2019-04-30 | 2022-08-11 | Crispr Therapeutics Ag | Allogeneic cell therapy of b cell malignancies using genetically engineered t cells targeting cd19 |
| SG11202112382WA (en) * | 2019-05-07 | 2021-12-30 | Gracell Biotechnologies Shanghai Co Ltd | Engineered immune cell targeting bcma and use thereof |
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| BR112022001546A2 (pt) * | 2019-07-30 | 2022-03-22 | Jiangsu Hansoh Pharmaceutical Group Co Ltd | Anticorpo anti-bcma, fragmento de ligação ao antígeno do mesmo e uso médico do mesmo |
| CN112409482B (zh) * | 2019-08-20 | 2022-08-26 | 杭州尚健生物技术有限公司 | Bcma抗体 |
| US12479922B2 (en) * | 2019-10-10 | 2025-11-25 | Cytolynx Therapeutics Hong Kong Limited | Humanized monoclonal antibody targeting BCMA and having human monkey cross-reactivity |
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| CN113248611A (zh) * | 2020-02-13 | 2021-08-13 | 湖南华康恒健生物技术有限公司 | 抗bcma抗体、其药物组合物及应用 |
| CN115279781B (zh) * | 2020-03-26 | 2025-05-09 | 上海翰森生物医药科技有限公司 | 抗体药物偶联物及其医药用途 |
| IL296723A (en) * | 2020-03-26 | 2022-11-01 | Seagen Inc | Methods of treating multiple myeloma |
| US20230173093A1 (en) | 2020-04-10 | 2023-06-08 | Seagen Inc. | Charge variant linkers |
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| US12036286B2 (en) | 2021-03-18 | 2024-07-16 | Seagen Inc. | Selective drug release from internalized conjugates of biologically active compounds |
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| WO2022251850A1 (en) | 2021-05-28 | 2022-12-01 | Seagen Inc. | Anthracycline antibody conjugates |
| KR20240135599A (ko) | 2021-08-12 | 2024-09-11 | 상하이 제이엠티-바이오 테크노로지 컴퍼니 리미티드 | GPC3 표적 항체-인터페론α 융합 단백질 및 이의 용도 |
| CN116745325A (zh) * | 2021-08-16 | 2023-09-12 | 上海优替济生生物医药有限公司 | Bcma靶向抗体、嵌合抗原受体及其应用 |
| TW202327650A (zh) | 2021-09-23 | 2023-07-16 | 美商思進公司 | 治療多發性骨髓瘤之方法 |
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2017
- 2017-02-16 IL IL311107A patent/IL311107A/en unknown
- 2017-02-16 MX MX2018009700A patent/MX2018009700A/es unknown
- 2017-02-16 US US15/999,346 patent/US20190194338A1/en not_active Abandoned
- 2017-02-16 EP EP17753839.4A patent/EP3416687A4/en active Pending
- 2017-02-16 MA MA044254A patent/MA44254A/fr unknown
- 2017-02-16 CA CA3011900A patent/CA3011900A1/en active Pending
- 2017-02-16 US US15/434,921 patent/US20170233484A1/en not_active Abandoned
- 2017-02-16 KR KR1020187021211A patent/KR102816905B1/ko active Active
- 2017-02-16 CN CN202211055564.6A patent/CN116063503A/zh active Pending
- 2017-02-16 CN CN201780011604.8A patent/CN108778329B/zh active Active
- 2017-02-16 WO PCT/US2017/018177 patent/WO2017143069A1/en not_active Ceased
- 2017-02-16 JP JP2018543153A patent/JP7152309B2/ja active Active
- 2017-02-16 SG SG10202007836WA patent/SG10202007836WA/en unknown
- 2017-02-16 AU AU2017219747A patent/AU2017219747B2/en active Active
- 2017-02-16 BR BR112018016697A patent/BR112018016697A2/pt unknown
- 2017-02-16 IL IL260732A patent/IL260732B2/en unknown
- 2017-02-16 HK HK19101575.0A patent/HK1259075A1/zh unknown
- 2017-02-16 SG SG11201806261XA patent/SG11201806261XA/en unknown
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2018
- 2018-08-09 MX MX2023000889A patent/MX2023000889A/es unknown
- 2018-10-03 US US16/151,012 patent/US20190023801A1/en not_active Abandoned
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2019
- 2019-05-14 US US16/411,867 patent/US11078291B2/en active Active
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2020
- 2020-02-17 JP JP2020024261A patent/JP2020073605A/ja active Pending
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2021
- 2021-06-25 US US17/358,642 patent/US11767365B2/en active Active
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2022
- 2022-03-01 JP JP2022030779A patent/JP2022069488A/ja not_active Withdrawn
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2023
- 2023-08-15 US US18/449,876 patent/US20240109975A1/en not_active Abandoned
- 2023-12-14 AU AU2023282281A patent/AU2023282281A1/en active Pending
- 2023-12-22 JP JP2023216464A patent/JP2024019677A/ja active Pending
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