JP2019509737A - ＴＧＦβ１結合性免疫グロブリンおよびその使用 - Google Patents

ＴＧＦβ１結合性免疫グロブリンおよびその使用 Download PDF

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Publication number
JP2019509737A
JP2019509737A JP2018547346A JP2018547346A JP2019509737A JP 2019509737 A JP2019509737 A JP 2019509737A JP 2018547346 A JP2018547346 A JP 2018547346A JP 2018547346 A JP2018547346 A JP 2018547346A JP 2019509737 A JP2019509737 A JP 2019509737A
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Prior art keywords
antibody
tgfβ1
antigen
complex
binding portion
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JP2018547346A
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Japanese (ja)
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JP2019509737A5 (enExample
Inventor
トーマス シュルフ，
トーマス シュルフ，
グレゴリー ジェイ． カルヴェン，
グレゴリー ジェイ． カルヴェン，
アビシェク ダッタ，
アビシェク ダッタ，
キンバリー ロング，
キンバリー ロング，
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Scholar Rock Inc
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Scholar Rock Inc
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Application filed by Scholar Rock Inc filed Critical Scholar Rock Inc
Publication of JP2019509737A publication Critical patent/JP2019509737A/ja
Publication of JP2019509737A5 publication Critical patent/JP2019509737A5/ja
Priority to JP2021174552A priority Critical patent/JP2022028680A/ja
Priority to JP2021209374A priority patent/JP7794630B2/ja
Withdrawn legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/22—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/39558—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against tumor tissues, cells, antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/32—Immunoglobulins specific features characterized by aspects of specificity or valency specific for a neo-epitope on a complex, e.g. antibody-antigen or ligand-receptor
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Neurology (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Oncology (AREA)
  • Biomedical Technology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
JP2018547346A 2016-03-11 2017-03-10 ＴＧＦβ１結合性免疫グロブリンおよびその使用 Withdrawn JP2019509737A (ja)

Priority Applications (2)

Application Number Priority Date Filing Date Title
JP2021174552A JP2022028680A (ja) 2016-03-11 2021-10-26 ＴＧＦβ１結合性免疫グロブリンおよびその使用
JP2021209374A JP7794630B2 (ja) 2016-03-11 2021-12-23 ＴＧＦβ１結合性免疫グロブリンおよびその使用

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US201662307353P 2016-03-11 2016-03-11
US62/307,353 2016-03-11
US201762443615P 2017-01-06 2017-01-06
US62/443,615 2017-01-06
US201762452866P 2017-01-31 2017-01-31
US62/452,866 2017-01-31
PCT/US2017/021972 WO2017156500A1 (en) 2016-03-11 2017-03-10 Tgfb1-binding immunoglobulins and use thereof

Related Child Applications (2)

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JP2021174552A Division JP2022028680A (ja) 2016-03-11 2021-10-26 ＴＧＦβ１結合性免疫グロブリンおよびその使用
JP2021209374A Division JP7794630B2 (ja) 2016-03-11 2021-12-23 ＴＧＦβ１結合性免疫グロブリンおよびその使用

Publications (2)

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JP2019509737A true JP2019509737A (ja) 2019-04-11
JP2019509737A5 JP2019509737A5 (enExample) 2020-04-16

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JP2018547346A Withdrawn JP2019509737A (ja) 2016-03-11 2017-03-10 ＴＧＦβ１結合性免疫グロブリンおよびその使用
JP2021174552A Withdrawn JP2022028680A (ja) 2016-03-11 2021-10-26 ＴＧＦβ１結合性免疫グロブリンおよびその使用
JP2021209374A Active JP7794630B2 (ja) 2016-03-11 2021-12-23 ＴＧＦβ１結合性免疫グロブリンおよびその使用
JP2023100034A Withdrawn JP2023108057A (ja) 2016-03-11 2023-06-19 ＴＧＦβ１結合性免疫グロブリンおよびその使用

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JP2021174552A Withdrawn JP2022028680A (ja) 2016-03-11 2021-10-26 ＴＧＦβ１結合性免疫グロブリンおよびその使用
JP2021209374A Active JP7794630B2 (ja) 2016-03-11 2021-12-23 ＴＧＦβ１結合性免疫グロブリンおよびその使用
JP2023100034A Withdrawn JP2023108057A (ja) 2016-03-11 2023-06-19 ＴＧＦβ１結合性免疫グロブリンおよびその使用

Country Status (19)

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US (2) US11643459B2 (enExample)
EP (2) EP4169942A1 (enExample)
JP (4) JP2019509737A (enExample)
KR (3) KR20230088508A (enExample)
CN (1) CN109071646A (enExample)
AU (2) AU2017230103A1 (enExample)
BR (1) BR112018068340A2 (enExample)
CA (1) CA3055555A1 (enExample)
DK (1) DK3365368T3 (enExample)
EA (1) EA201891909A1 (enExample)
ES (1) ES2951648T3 (enExample)
FI (1) FI3365368T3 (enExample)
HU (1) HUE062976T2 (enExample)
IL (2) IL307835A (enExample)
MX (2) MX2018010948A (enExample)
PL (1) PL3365368T3 (enExample)
PT (1) PT3365368T (enExample)
SG (1) SG11201807176XA (enExample)
WO (1) WO2017156500A1 (enExample)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2022028680A (ja) * 2016-03-11 2022-02-16 スカラー ロック インコーポレイテッド ＴＧＦβ１結合性免疫グロブリンおよびその使用
JP2023510793A (ja) * 2020-01-11 2023-03-15 スカラー ロック インコーポレイテッド ＴＧＦβ阻害剤およびその使用
JP2023511255A (ja) * 2020-01-11 2023-03-17 スカラー ロック インコーポレイテッド ＴＧＦ－β阻害剤及びその使用

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US20210115122A1 (en) * 2018-02-23 2021-04-22 Chugai Seiyaku Kabushiki Kaisha Cross-species anti-latent tgf-beta 1 antibodies and methods of use
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