CA3055555A1 - Tgf.beta.1-binding immunoglobulins and use thereof - Google Patents

Tgf.beta.1-binding immunoglobulins and use thereof Download PDF

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Publication number
CA3055555A1
CA3055555A1 CA3055555A CA3055555A CA3055555A1 CA 3055555 A1 CA3055555 A1 CA 3055555A1 CA 3055555 A CA3055555 A CA 3055555A CA 3055555 A CA3055555 A CA 3055555A CA 3055555 A1 CA3055555 A1 CA 3055555A1
Authority
CA
Canada
Prior art keywords
antibody
tgf
complex
antigen binding
beta
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CA3055555A
Other languages
English (en)
French (fr)
Inventor
Thomas SCHURPF
Gregory J. Carven
Abhishek Datta
Kimberly LONG
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Scholar Rock Inc
Original Assignee
Long Kimberly
Scholar Rock Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=58503696&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CA3055555(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Long Kimberly, Scholar Rock Inc filed Critical Long Kimberly
Publication of CA3055555A1 publication Critical patent/CA3055555A1/en
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/22—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/39558—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against tumor tissues, cells, antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/32—Immunoglobulins specific features characterized by aspects of specificity or valency specific for a neo-epitope on a complex, e.g. antibody-antigen or ligand-receptor
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Neurology (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Oncology (AREA)
  • Biomedical Technology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
CA3055555A 2016-03-11 2017-03-10 Tgf.beta.1-binding immunoglobulins and use thereof Pending CA3055555A1 (en)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US201662307353P 2016-03-11 2016-03-11
US62/307,353 2016-03-11
US201762443615P 2017-01-06 2017-01-06
US62/443,615 2017-01-06
US201762452866P 2017-01-31 2017-01-31
US62/452,866 2017-01-31
PCT/US2017/021972 WO2017156500A1 (en) 2016-03-11 2017-03-10 Tgfb1-binding immunoglobulins and use thereof

Publications (1)

Publication Number Publication Date
CA3055555A1 true CA3055555A1 (en) 2017-09-14

Family

ID=58503696

Family Applications (1)

Application Number Title Priority Date Filing Date
CA3055555A Pending CA3055555A1 (en) 2016-03-11 2017-03-10 Tgf.beta.1-binding immunoglobulins and use thereof

Country Status (19)

Country Link
US (2) US11643459B2 (enExample)
EP (2) EP4169942A1 (enExample)
JP (4) JP2019509737A (enExample)
KR (3) KR20230088508A (enExample)
CN (1) CN109071646A (enExample)
AU (2) AU2017230103A1 (enExample)
BR (1) BR112018068340A2 (enExample)
CA (1) CA3055555A1 (enExample)
DK (1) DK3365368T3 (enExample)
EA (1) EA201891909A1 (enExample)
ES (1) ES2951648T3 (enExample)
FI (1) FI3365368T3 (enExample)
HU (1) HUE062976T2 (enExample)
IL (2) IL307835A (enExample)
MX (2) MX2018010948A (enExample)
PL (1) PL3365368T3 (enExample)
PT (1) PT3365368T (enExample)
SG (1) SG11201807176XA (enExample)
WO (1) WO2017156500A1 (enExample)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN113613725A (zh) * 2018-11-05 2021-11-05 路德维格癌症研究所有限公司 人源化和变体TGF-β1特异性抗体及其方法和用途
CN120131938A (zh) * 2025-03-19 2025-06-13 广州奥奇生物技术有限公司 一种益生菌制剂的制备方法及其在改善睡眠中的应用

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FI3621694T3 (fi) 2017-05-09 2023-08-28 Scholar Rock Inc Lrrc33-inhibiittoreita ja niiden käyttö
US12358992B2 (en) 2017-07-28 2025-07-15 Scholar Rock, Inc. LTBP complex-specific inhibitors of TGF-beta 1 and uses thereof
EP3694552A1 (en) 2017-10-10 2020-08-19 Tilos Therapeutics, Inc. Anti-lap antibodies and uses thereof
US20210115122A1 (en) * 2018-02-23 2021-04-22 Chugai Seiyaku Kabushiki Kaisha Cross-species anti-latent tgf-beta 1 antibodies and methods of use
HRP20212034T1 (hr) 2018-07-11 2022-04-01 Scholar Rock, Inc. Izoformno selektivni inhibitori tgfbeta1 i njihove uporabe
US20210340238A1 (en) 2018-07-11 2021-11-04 Scholar Rock, Inc. TGFß1 INHIBITORS AND USE THEREOF
US12252531B2 (en) * 2018-07-11 2025-03-18 Scholar Rock, Inc. Methods of screening for high-affinity, isoform-selective TGFβ1 inhibitors
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CA3167427A1 (en) * 2020-01-11 2021-07-15 Scholar Rock, Inc. Tgfb inhibitors and use thereof
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JP7280400B2 (ja) * 2021-02-26 2023-05-23 中外製薬株式会社 種交差性抗潜在型ＴＧＦ－β１抗体の使用
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EP4650366A1 (en) * 2023-01-09 2025-11-19 Beijing Tuo Jie Biopharmaceutical Co. Ltd. Tgfbeta1 binding molecule, garp-tgfbeta1 binding molecule and medical use thereof
EP4662245A1 (en) 2023-02-10 2025-12-17 Chugai Seiyaku Kabushiki Kaisha Anti-latent tgf-beta 1 antibodies and methods of use
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Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN113613725A (zh) * 2018-11-05 2021-11-05 路德维格癌症研究所有限公司 人源化和变体TGF-β1特异性抗体及其方法和用途
CN120131938A (zh) * 2025-03-19 2025-06-13 广州奥奇生物技术有限公司 一种益生菌制剂的制备方法及其在改善睡眠中的应用

Also Published As

Publication number Publication date
MX2018010948A (es) 2019-06-20
PT3365368T (pt) 2023-08-17
US20230348583A1 (en) 2023-11-02
MX2024005811A (es) 2024-05-28
FI3365368T3 (fi) 2023-06-13
WO2017156500A1 (en) 2017-09-14
IL261442A (en) 2018-10-31
EP3365368B1 (en) 2023-05-17
EP3365368A1 (en) 2018-08-29
WO2017156500A8 (en) 2018-01-25
CN109071646A (zh) 2018-12-21
US20190071493A1 (en) 2019-03-07
BR112018068340A2 (pt) 2019-01-15
SG11201807176XA (en) 2018-09-27
JP2023108057A (ja) 2023-08-03
WO2017156500A9 (en) 2018-02-22
KR20180122397A (ko) 2018-11-12
JP2019509737A (ja) 2019-04-11
EA201891909A1 (ru) 2019-02-28
JP7794630B2 (ja) 2026-01-06
US11643459B2 (en) 2023-05-09
JP2022031403A (ja) 2022-02-18
ES2951648T3 (es) 2023-10-24
JP2022028680A (ja) 2022-02-16
AU2024202692A1 (en) 2024-05-30
HUE062976T2 (hu) 2023-12-28
DK3365368T3 (da) 2023-06-26
KR20250011248A (ko) 2025-01-21
AU2017230103A1 (en) 2018-09-06
KR20230088508A (ko) 2023-06-19
IL307835A (en) 2023-12-01
PL3365368T3 (pl) 2023-08-21
EP4169942A1 (en) 2023-04-26

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