JP2019508507A5 - - Google Patents
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- Publication number
- JP2019508507A5 JP2019508507A5 JP2019500223A JP2019500223A JP2019508507A5 JP 2019508507 A5 JP2019508507 A5 JP 2019508507A5 JP 2019500223 A JP2019500223 A JP 2019500223A JP 2019500223 A JP2019500223 A JP 2019500223A JP 2019508507 A5 JP2019508507 A5 JP 2019508507A5
- Authority
- JP
- Japan
- Prior art keywords
- mammal
- body weight
- per
- polysaccharide preparation
- amount
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
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- 241000124008 Mammalia Species 0.000 claims description 102
- 239000000203 mixture Substances 0.000 claims description 67
- 150000004676 glycans Chemical class 0.000 claims description 54
- 229920001282 polysaccharide Polymers 0.000 claims description 54
- 239000005017 polysaccharide Substances 0.000 claims description 54
- 235000002595 Solanum tuberosum Nutrition 0.000 claims description 52
- 244000061456 Solanum tuberosum Species 0.000 claims description 52
- 230000037396 body weight Effects 0.000 claims description 46
- 229910001959 inorganic nitrate Inorganic materials 0.000 claims description 45
- BUGBHKTXTAQXES-UHFFFAOYSA-N Selenium Chemical compound [Se] BUGBHKTXTAQXES-UHFFFAOYSA-N 0.000 claims description 43
- 229910052711 selenium Inorganic materials 0.000 claims description 43
- 239000011669 selenium Substances 0.000 claims description 43
- MWUXSHHQAYIFBG-UHFFFAOYSA-N Nitric oxide Chemical compound O=[N] MWUXSHHQAYIFBG-UHFFFAOYSA-N 0.000 claims description 22
- 210000004027 cell Anatomy 0.000 claims description 19
- 235000015872 dietary supplement Nutrition 0.000 claims description 14
- 206010021143 Hypoxia Diseases 0.000 claims description 12
- 229960002718 selenomethionine Drugs 0.000 claims description 12
- RJFAYQIBOAGBLC-BYPYZUCNSA-N Selenium-L-methionine Chemical compound C[Se]CC[C@H](N)C(O)=O RJFAYQIBOAGBLC-BYPYZUCNSA-N 0.000 claims description 10
- 230000007954 hypoxia Effects 0.000 claims description 10
- 229910002651 NO3 Inorganic materials 0.000 claims description 9
- NHNBFGGVMKEFGY-UHFFFAOYSA-N Nitrate Chemical compound [O-][N+]([O-])=O NHNBFGGVMKEFGY-UHFFFAOYSA-N 0.000 claims description 9
- 230000015572 biosynthetic process Effects 0.000 claims description 9
- 230000002438 mitochondrial effect Effects 0.000 claims description 9
- 229920001184 polypeptide Polymers 0.000 claims description 7
- 102000004196 processed proteins & peptides Human genes 0.000 claims description 7
- 108090000765 processed proteins & peptides Proteins 0.000 claims description 7
- 201000010099 disease Diseases 0.000 claims description 6
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 6
- 208000024827 Alzheimer disease Diseases 0.000 claims description 4
- 210000001789 adipocyte Anatomy 0.000 claims description 4
- 210000002064 heart cell Anatomy 0.000 claims description 4
- 210000005260 human cell Anatomy 0.000 claims description 4
- 208000028867 ischemia Diseases 0.000 claims description 4
- 210000003292 kidney cell Anatomy 0.000 claims description 4
- 210000000663 muscle cell Anatomy 0.000 claims description 4
- 210000002569 neuron Anatomy 0.000 claims description 4
- 210000004927 skin cell Anatomy 0.000 claims description 4
- 210000001519 tissue Anatomy 0.000 claims description 4
- 210000005167 vascular cell Anatomy 0.000 claims description 4
- 102100021503 ATP-binding cassette sub-family B member 6 Human genes 0.000 claims description 2
- 208000024172 Cardiovascular disease Diseases 0.000 claims description 2
- 208000006545 Chronic Obstructive Pulmonary Disease Diseases 0.000 claims description 2
- 102100032903 Copper chaperone for superoxide dismutase Human genes 0.000 claims description 2
- 102100029767 Copper transport protein ATOX1 Human genes 0.000 claims description 2
- 102100027591 Copper-transporting ATPase 2 Human genes 0.000 claims description 2
- 102100036222 Cytochrome c oxidase assembly factor 3 homolog, mitochondrial Human genes 0.000 claims description 2
- 102100031596 Cytochrome c oxidase assembly factor 4 homolog, mitochondrial Human genes 0.000 claims description 2
- 102100027476 Cytochrome c oxidase assembly protein COX19 Human genes 0.000 claims description 2
- 102100036035 Cytochrome c oxidase copper chaperone Human genes 0.000 claims description 2
- 102100028202 Cytochrome c oxidase subunit 6C Human genes 0.000 claims description 2
- 102100025644 Cytochrome c oxidase subunit 7A2, mitochondrial Human genes 0.000 claims description 2
- 102100038835 Cytochrome c oxidase subunit 7B, mitochondrial Human genes 0.000 claims description 2
- 102100039259 Cytochrome c oxidase subunit 8A, mitochondrial Human genes 0.000 claims description 2
- 108010058076 D-xylulose reductase Proteins 0.000 claims description 2
- 102100027618 Heme transporter HRG1 Human genes 0.000 claims description 2
- 101000677883 Homo sapiens ATP-binding cassette sub-family B member 6 Proteins 0.000 claims description 2
- 101000868241 Homo sapiens Copper chaperone for superoxide dismutase Proteins 0.000 claims description 2
- 101000727865 Homo sapiens Copper transport protein ATOX1 Proteins 0.000 claims description 2
- 101000936280 Homo sapiens Copper-transporting ATPase 2 Proteins 0.000 claims description 2
- 101000874993 Homo sapiens Cytochrome c oxidase assembly factor 3 homolog, mitochondrial Proteins 0.000 claims description 2
- 101000993410 Homo sapiens Cytochrome c oxidase assembly factor 4 homolog, mitochondrial Proteins 0.000 claims description 2
- 101000725442 Homo sapiens Cytochrome c oxidase assembly protein COX19 Proteins 0.000 claims description 2
- 101000875933 Homo sapiens Cytochrome c oxidase copper chaperone Proteins 0.000 claims description 2
- 101000861049 Homo sapiens Cytochrome c oxidase subunit 6C Proteins 0.000 claims description 2
- 101000856741 Homo sapiens Cytochrome c oxidase subunit 7A2, mitochondrial Proteins 0.000 claims description 2
- 101000957492 Homo sapiens Cytochrome c oxidase subunit 7B, mitochondrial Proteins 0.000 claims description 2
- 101000745956 Homo sapiens Cytochrome c oxidase subunit 8A, mitochondrial Proteins 0.000 claims description 2
- 101000591936 Homo sapiens Molybdopterin synthase catalytic subunit Proteins 0.000 claims description 2
- 101000963255 Homo sapiens Molybdopterin synthase sulfur carrier subunit Proteins 0.000 claims description 2
- 101000919980 Homo sapiens Protoheme IX farnesyltransferase, mitochondrial Proteins 0.000 claims description 2
- 125000000659 L-selenomethionine group Chemical group [H]N([H])[C@]([H])(C(=O)[*])C([H])([H])C([H])([H])[Se]C([H])([H])[H] 0.000 claims description 2
- 102100033490 Molybdopterin synthase catalytic subunit Human genes 0.000 claims description 2
- 102000007561 NF-E2-Related Factor 2 Human genes 0.000 claims description 2
- 108010071382 NF-E2-Related Factor 2 Proteins 0.000 claims description 2
- 108090000913 Nitrate Reductases Proteins 0.000 claims description 2
- 102100030729 Protoheme IX farnesyltransferase, mitochondrial Human genes 0.000 claims description 2
- 108091007579 SLC48A1 Proteins 0.000 claims description 2
- 102100026974 Sorbitol dehydrogenase Human genes 0.000 claims description 2
- 208000020832 chronic kidney disease Diseases 0.000 claims description 2
- 208000028208 end stage renal disease Diseases 0.000 claims description 2
- 201000000523 end stage renal failure Diseases 0.000 claims description 2
- 208000010706 fatty liver disease Diseases 0.000 claims description 2
- 230000001146 hypoxic effect Effects 0.000 claims description 2
- 208000001072 type 2 diabetes mellitus Diseases 0.000 claims description 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 14
- 150000002823 nitrates Chemical class 0.000 claims 7
- 239000003795 chemical substances by application Substances 0.000 claims 2
- 238000009472 formulation Methods 0.000 claims 1
- 238000000034 method Methods 0.000 description 26
- 235000021436 nutraceutical agent Nutrition 0.000 description 2
- 208000024891 symptom Diseases 0.000 description 2
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662307931P | 2016-03-14 | 2016-03-14 | |
| US62/307,931 | 2016-03-14 | ||
| PCT/US2017/022017 WO2017160678A1 (en) | 2016-03-14 | 2017-03-13 | Materials and methods for treating hypoxic conditions |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2019508507A JP2019508507A (ja) | 2019-03-28 |
| JP2019508507A5 true JP2019508507A5 (enExample) | 2020-04-16 |
Family
ID=59850970
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019500223A Ceased JP2019508507A (ja) | 2016-03-14 | 2017-03-13 | 低酸素状態を処置するための材料および方法 |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US20190076461A1 (enExample) |
| EP (1) | EP3429373A4 (enExample) |
| JP (1) | JP2019508507A (enExample) |
| AU (1) | AU2017234662A1 (enExample) |
| CA (1) | CA3017763A1 (enExample) |
| WO (1) | WO2017160678A1 (enExample) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2014321711B2 (en) | 2013-09-19 | 2019-11-14 | The Research Foundation For The State University Of New York | Methods and materials for treating diabetes or liver steatosis |
| WO2016160594A1 (en) | 2015-03-27 | 2016-10-06 | The Research Foundation For The State University Of New York | Methods and materials for reducing amyloid beta levels within a mammal |
| CN108835122B (zh) * | 2018-08-09 | 2020-11-03 | 中国农业科学院深圳农业基因组研究所 | Abc转运蛋白作为靶点在防治害虫上的应用 |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US659290A (en) * | 1898-03-30 | 1900-10-09 | Toledo Glass Co | Glass-blowing machine. |
| EP1113804A2 (en) * | 1998-09-17 | 2001-07-11 | Akesis Pharmaceuticals, Inc. | Combinations of chromium or vanadium with antidiabetics for glucose metabolism disorders |
| US6592908B1 (en) * | 2002-09-23 | 2003-07-15 | Albert Crum | Nutritional or therapeutic compositions |
| US20050202521A1 (en) * | 2004-03-10 | 2005-09-15 | Albert Crum | Methods of assessing the need for and the effectiveness of therapy with antioxidants |
| US20070190114A1 (en) * | 2006-02-10 | 2007-08-16 | Smart William J | Antioxidant health lozenges |
| WO2013148282A1 (en) * | 2012-03-28 | 2013-10-03 | The Research Foundation Of State University Of New York | Methods and materials related to nutritional supplement compositions containing a potato polysaccharide preparation |
| GB201223365D0 (en) * | 2012-12-24 | 2013-02-06 | Provexis Natural Products Ltd | Compositions |
| RU2663127C2 (ru) * | 2013-03-15 | 2018-08-01 | Олтек, Инк. | Селенсодержащие композиции и их применение для лечения и предотвращения заболеваний или состояний, связанных с митохондриальной дисфункцией |
| WO2015080984A1 (en) * | 2013-11-27 | 2015-06-04 | BioPharmX, Inc. | Solid oral dosage form for breast symptoms |
| CA2940283C (en) * | 2014-03-14 | 2021-03-30 | Alltech, Inc. | Compositions of selenoorganic compounds and methods of use thereof |
-
2017
- 2017-03-13 AU AU2017234662A patent/AU2017234662A1/en not_active Abandoned
- 2017-03-13 EP EP17767240.9A patent/EP3429373A4/en not_active Withdrawn
- 2017-03-13 US US16/084,775 patent/US20190076461A1/en not_active Abandoned
- 2017-03-13 JP JP2019500223A patent/JP2019508507A/ja not_active Ceased
- 2017-03-13 CA CA3017763A patent/CA3017763A1/en not_active Abandoned
- 2017-03-13 WO PCT/US2017/022017 patent/WO2017160678A1/en not_active Ceased
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