JP2019507602A5 - - Google Patents
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- Publication number
- JP2019507602A5 JP2019507602A5 JP2018547340A JP2018547340A JP2019507602A5 JP 2019507602 A5 JP2019507602 A5 JP 2019507602A5 JP 2018547340 A JP2018547340 A JP 2018547340A JP 2018547340 A JP2018547340 A JP 2018547340A JP 2019507602 A5 JP2019507602 A5 JP 2019507602A5
- Authority
- JP
- Japan
- Prior art keywords
- cells
- microfluidic channel
- channel network
- epithelial cells
- mesenchymal
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 210000004027 cell Anatomy 0.000 claims 27
- 210000002919 epithelial cell Anatomy 0.000 claims 22
- 238000000034 method Methods 0.000 claims 15
- 238000004113 cell culture Methods 0.000 claims 6
- 230000004069 differentiation Effects 0.000 claims 4
- 239000010410 layer Substances 0.000 claims 4
- 239000002243 precursor Substances 0.000 claims 4
- 239000012736 aqueous medium Substances 0.000 claims 2
- 238000012258 culturing Methods 0.000 claims 2
- 201000010099 disease Diseases 0.000 claims 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 2
- 210000005260 human cell Anatomy 0.000 claims 2
- 210000004962 mammalian cell Anatomy 0.000 claims 2
- 239000000203 mixture Substances 0.000 claims 2
- 238000012544 monitoring process Methods 0.000 claims 2
- 230000035755 proliferation Effects 0.000 claims 2
- 239000002356 single layer Substances 0.000 claims 2
- 208000006545 Chronic Obstructive Pulmonary Disease Diseases 0.000 claims 1
- 201000003883 Cystic fibrosis Diseases 0.000 claims 1
- 206010061218 Inflammation Diseases 0.000 claims 1
- 208000022559 Inflammatory bowel disease Diseases 0.000 claims 1
- 206010028980 Neoplasm Diseases 0.000 claims 1
- 238000010521 absorption reaction Methods 0.000 claims 1
- 210000001789 adipocyte Anatomy 0.000 claims 1
- 208000006673 asthma Diseases 0.000 claims 1
- 210000004082 barrier epithelial cell Anatomy 0.000 claims 1
- 230000004888 barrier function Effects 0.000 claims 1
- 210000002469 basement membrane Anatomy 0.000 claims 1
- 230000002457 bidirectional effect Effects 0.000 claims 1
- 201000011510 cancer Diseases 0.000 claims 1
- 210000001612 chondrocyte Anatomy 0.000 claims 1
- 238000003501 co-culture Methods 0.000 claims 1
- 150000001875 compounds Chemical class 0.000 claims 1
- 230000004890 epithelial barrier function Effects 0.000 claims 1
- 210000002782 epithelial mesenchymal cell Anatomy 0.000 claims 1
- 210000002950 fibroblast Anatomy 0.000 claims 1
- 239000001963 growth medium Substances 0.000 claims 1
- 230000004054 inflammatory process Effects 0.000 claims 1
- 244000005700 microbiome Species 0.000 claims 1
- 210000000651 myofibroblast Anatomy 0.000 claims 1
- 230000003287 optical effect Effects 0.000 claims 1
- 210000000963 osteoblast Anatomy 0.000 claims 1
- 238000000059 patterning Methods 0.000 claims 1
- 210000000329 smooth muscle myocyte Anatomy 0.000 claims 1
- 210000004085 squamous epithelial cell Anatomy 0.000 claims 1
- 210000002341 stratified epithelial cell Anatomy 0.000 claims 1
- 210000002536 stromal cell Anatomy 0.000 claims 1
- 231100000041 toxicology testing Toxicity 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| NL2016404A NL2016404B1 (en) | 2016-03-09 | 2016-03-09 | Double tubular structures. |
| NL2016404 | 2016-03-09 | ||
| PCT/NL2017/050145 WO2017155399A1 (en) | 2016-03-09 | 2017-03-09 | Double tubular structures |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2019507602A JP2019507602A (ja) | 2019-03-22 |
| JP2019507602A5 true JP2019507602A5 (enExample) | 2020-04-23 |
| JP7117245B2 JP7117245B2 (ja) | 2022-08-12 |
Family
ID=55967375
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018547340A Active JP7117245B2 (ja) | 2016-03-09 | 2017-03-09 | 二重管状構造体 |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US20190076842A1 (enExample) |
| EP (1) | EP3426769B1 (enExample) |
| JP (1) | JP7117245B2 (enExample) |
| KR (1) | KR102403435B1 (enExample) |
| CN (1) | CN109072184A (enExample) |
| AU (1) | AU2017231580B2 (enExample) |
| BR (1) | BR112018068303A2 (enExample) |
| CA (1) | CA3017100A1 (enExample) |
| NL (1) | NL2016404B1 (enExample) |
| RU (1) | RU2756404C1 (enExample) |
| WO (1) | WO2017155399A1 (enExample) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA3076500C (en) * | 2017-09-21 | 2025-07-08 | Emulate Inc | REOLOGICALLY BIOMIMITED FLUID SUBSTITUTE |
| NL2020518B1 (en) | 2018-03-02 | 2019-09-12 | Mimetas B V | Device and method for performing electrical measurements |
| US20210341462A1 (en) | 2018-10-05 | 2021-11-04 | The Trustees Of The University Of Pennsylvania | Artificial human pulmonary airway and methods of preparation |
| CN109926112A (zh) * | 2019-04-10 | 2019-06-25 | 中南大学 | 三维微结构聚合物微流控芯片的叠层制造方法 |
| NL2024202B1 (en) * | 2019-11-08 | 2021-07-20 | Mimetas B V | Microfluidic cell culture system |
| WO2022225602A1 (en) * | 2021-04-23 | 2022-10-27 | Massachusetts Institute Of Technology | Fluidic platforms for perfusable vascularized tissues with infiltrates |
| US20250263654A1 (en) * | 2021-06-25 | 2025-08-21 | The J. David Gladstone Institutes, A Testamentary Trust Established Under The Will Of J. David | Primordial germ cells |
| CN115301301A (zh) * | 2022-07-29 | 2022-11-08 | 江苏艾玮得生物科技有限公司 | 微流控芯片 |
| WO2024073159A1 (en) * | 2022-09-30 | 2024-04-04 | Xellar, Inc. | Techniques and systems for creating spatially controlled fluidic flows in surface functionalized microfluidic devices |
| PL443644A1 (pl) * | 2023-01-31 | 2024-08-05 | Politechnika Warszawska | System mikroprzepływowy do wielonarządowej hodowli komórkowej i jego zastosowanie |
| WO2025232822A1 (en) * | 2024-05-09 | 2025-11-13 | Anivance Ai Corporation | Chip, microfluidic cell culture device including the same, and method for cell culture using the same |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4829000A (en) | 1985-08-30 | 1989-05-09 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Reconstituted basement membrane complex with biological activity |
| US9157060B2 (en) * | 2005-06-09 | 2015-10-13 | The United States Of America, As Represented By The Secretary Of The Navy | Micro blood vessels and tissue ducts |
| US8287854B2 (en) * | 2005-10-21 | 2012-10-16 | Cellresearch Corporation Pte Ltd | Skin equivalents derived from umbilical cord mesenchymal stem/progenitor cells and umbilical cord epithelial stem/progenitor cells |
| WO2008079320A1 (en) | 2006-12-22 | 2008-07-03 | The Regents Of The University Of California | Microfluidic platform for cell culture and assay |
| JP2010517578A (ja) * | 2007-02-09 | 2010-05-27 | ザ ジェネラル ホスピタル コーポレイション | Ｉｓｌｅｔ１＋系統に入るように細胞を誘導する方法およびそれを拡大する方法 |
| US9303245B2 (en) * | 2008-06-20 | 2016-04-05 | Universiteit Maastricht | Self-assembling tissue modules |
| EP2213364A1 (en) | 2009-01-30 | 2010-08-04 | Albert-Ludwigs-Universität Freiburg | Phase guide patterns for liquid manipulation |
| US9752124B2 (en) | 2009-02-03 | 2017-09-05 | Koninklijke Nederlandse Akademie Van Wetenschappen | Culture medium for epithelial stem cells and organoids comprising the stem cells |
| TW201137121A (en) * | 2010-04-26 | 2011-11-01 | Univ Nat Changhua Education | Cell culture real-time observation system |
| CA2828110C (en) * | 2011-02-28 | 2020-03-31 | President And Fellows Of Harvard College | Cell culture system |
| GB201103917D0 (en) | 2011-03-08 | 2011-04-20 | Univ Leiden | Apparatus for and methods of processing liquids or liquid based substances |
| CN103087912A (zh) * | 2011-10-27 | 2013-05-08 | 中国科学院大连化学物理研究所 | 一种产生稳定浓度梯度的微流控芯片及细胞共培养方法 |
| US20140335496A1 (en) | 2011-12-05 | 2014-11-13 | Research Triangle Institute | Human conducting airway model comprising multiple fluidic pathways |
| CN106399094A (zh) | 2012-04-01 | 2017-02-15 | Emd密理博公司 | 细胞培养和梯度迁移化验方法和装置 |
| GB2505706A (en) * | 2012-09-10 | 2014-03-12 | Univ Leiden | Apparatus comprising meniscus alignment barriers |
| EP3140394A4 (en) * | 2014-05-05 | 2017-12-27 | National University of Singapore | Methods of producing tissue-mimetic constructs and uses thereof |
| WO2015178427A1 (ja) | 2014-05-20 | 2015-11-26 | 国立大学法人 東京大学 | 中空マイクロファイバ |
| EP3362554B1 (en) * | 2015-10-16 | 2025-09-03 | Wake Forest University Health Sciences | Multi-layer airway organoids and methods of making and using the same |
-
2016
- 2016-03-09 NL NL2016404A patent/NL2016404B1/en active
-
2017
- 2017-03-09 WO PCT/NL2017/050145 patent/WO2017155399A1/en not_active Ceased
- 2017-03-09 KR KR1020187029134A patent/KR102403435B1/ko active Active
- 2017-03-09 CN CN201780028395.8A patent/CN109072184A/zh active Pending
- 2017-03-09 US US16/083,372 patent/US20190076842A1/en active Pending
- 2017-03-09 EP EP17715816.9A patent/EP3426769B1/en active Active
- 2017-03-09 BR BR112018068303A patent/BR112018068303A2/pt not_active Application Discontinuation
- 2017-03-09 AU AU2017231580A patent/AU2017231580B2/en active Active
- 2017-03-09 JP JP2018547340A patent/JP7117245B2/ja active Active
- 2017-03-09 CA CA3017100A patent/CA3017100A1/en active Pending
- 2017-03-09 RU RU2018132008A patent/RU2756404C1/ru active
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