RU2756404C1 - Двойные трубчатые структуры - Google Patents

Двойные трубчатые структуры Download PDF

Info

Publication number
RU2756404C1
RU2756404C1 RU2018132008A RU2018132008A RU2756404C1 RU 2756404 C1 RU2756404 C1 RU 2756404C1 RU 2018132008 A RU2018132008 A RU 2018132008A RU 2018132008 A RU2018132008 A RU 2018132008A RU 2756404 C1 RU2756404 C1 RU 2756404C1
Authority
RU
Russia
Prior art keywords
cells
epithelial
network
mesenchymal
microfluidic
Prior art date
Application number
RU2018132008A
Other languages
English (en)
Russian (ru)
Inventor
Паул ВУЛЬТО
Дорота Малгожата КУРЕК
Адрианус Теодорус ЙОРЕ
Себастиан Йоханнес ТРИТС
Генриетта Леонора ЛАНЦ
Original Assignee
Миметас Б.В.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Миметас Б.В. filed Critical Миметас Б.В.
Application granted granted Critical
Publication of RU2756404C1 publication Critical patent/RU2756404C1/ru

Links

Images

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502761—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip specially adapted for handling suspended solids or molecules independently from the bulk fluid flow, e.g. for trapping or sorting beads, for physically stretching molecules
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M23/00—Constructional details, e.g. recesses, hinges
    • C12M23/02—Form or structure of the vessel
    • C12M23/16—Microfluidic devices; Capillary tubes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M31/00—Means for providing, directing, scattering or concentrating light
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M41/00—Means for regulation, monitoring, measurement or control, e.g. flow regulation
    • C12M41/46—Means for regulation, monitoring, measurement or control, e.g. flow regulation of cellular or enzymatic activity or functionality, e.g. cell viability
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0697—Artificial constructs associating cells of different lineages, e.g. tissue equivalents
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0809—Geometry, shape and general structure rectangular shaped
    • B01L2300/0816—Cards, e.g. flat sample carriers usually with flow in two horizontal directions
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/089—Virtual walls for guiding liquids
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/16—Surface properties and coatings
    • B01L2300/161—Control and use of surface tension forces, e.g. hydrophobic, hydrophilic
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/16—Surface properties and coatings
    • B01L2300/161—Control and use of surface tension forces, e.g. hydrophobic, hydrophilic
    • B01L2300/163—Biocompatibility
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0403—Moving fluids with specific forces or mechanical means specific forces
    • B01L2400/0457—Moving fluids with specific forces or mechanical means specific forces passive flow or gravitation
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
    • C12N2506/13—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from connective tissue cells, from mesenchymal cells
    • C12N2506/1346—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from connective tissue cells, from mesenchymal cells from mesenchymal stem cells
    • C12N2506/1392—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from connective tissue cells, from mesenchymal cells from mesenchymal stem cells from mesenchymal stem cells from other natural sources
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
    • C12N2506/23—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from cells of the gastro-intestinal tract
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2513/00—3D culture
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2531/00—Microcarriers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2533/00—Supports or coatings for cell culture, characterised by material
    • C12N2533/90—Substrates of biological origin, e.g. extracellular matrix, decellularised tissue

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biomedical Technology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Cell Biology (AREA)
  • Analytical Chemistry (AREA)
  • Dispersion Chemistry (AREA)
  • Clinical Laboratory Science (AREA)
  • Sustainable Development (AREA)
  • Physics & Mathematics (AREA)
  • Fluid Mechanics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hematology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
RU2018132008A 2016-03-09 2017-03-09 Двойные трубчатые структуры RU2756404C1 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
NL2016404A NL2016404B1 (en) 2016-03-09 2016-03-09 Double tubular structures.
NL2016404 2016-03-09
PCT/NL2017/050145 WO2017155399A1 (en) 2016-03-09 2017-03-09 Double tubular structures

Publications (1)

Publication Number Publication Date
RU2756404C1 true RU2756404C1 (ru) 2021-09-30

Family

ID=55967375

Family Applications (1)

Application Number Title Priority Date Filing Date
RU2018132008A RU2756404C1 (ru) 2016-03-09 2017-03-09 Двойные трубчатые структуры

Country Status (11)

Country Link
US (1) US20190076842A1 (enExample)
EP (1) EP3426769B1 (enExample)
JP (1) JP7117245B2 (enExample)
KR (1) KR102403435B1 (enExample)
CN (1) CN109072184A (enExample)
AU (1) AU2017231580B2 (enExample)
BR (1) BR112018068303A2 (enExample)
CA (1) CA3017100A1 (enExample)
NL (1) NL2016404B1 (enExample)
RU (1) RU2756404C1 (enExample)
WO (1) WO2017155399A1 (enExample)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA3076500C (en) * 2017-09-21 2025-07-08 Emulate Inc REOLOGICALLY BIOMIMITED FLUID SUBSTITUTE
NL2020518B1 (en) 2018-03-02 2019-09-12 Mimetas B V Device and method for performing electrical measurements
US20210341462A1 (en) 2018-10-05 2021-11-04 The Trustees Of The University Of Pennsylvania Artificial human pulmonary airway and methods of preparation
CN109926112A (zh) * 2019-04-10 2019-06-25 中南大学 三维微结构聚合物微流控芯片的叠层制造方法
NL2024202B1 (en) * 2019-11-08 2021-07-20 Mimetas B V Microfluidic cell culture system
WO2022225602A1 (en) * 2021-04-23 2022-10-27 Massachusetts Institute Of Technology Fluidic platforms for perfusable vascularized tissues with infiltrates
US20250263654A1 (en) * 2021-06-25 2025-08-21 The J. David Gladstone Institutes, A Testamentary Trust Established Under The Will Of J. David Primordial germ cells
CN115301301A (zh) * 2022-07-29 2022-11-08 江苏艾玮得生物科技有限公司 微流控芯片
WO2024073159A1 (en) * 2022-09-30 2024-04-04 Xellar, Inc. Techniques and systems for creating spatially controlled fluidic flows in surface functionalized microfluidic devices
PL443644A1 (pl) * 2023-01-31 2024-08-05 Politechnika Warszawska System mikroprzepływowy do wielonarządowej hodowli komórkowej i jego zastosowanie
WO2025232822A1 (en) * 2024-05-09 2025-11-13 Anivance Ai Corporation Chip, microfluidic cell culture device including the same, and method for cell culture using the same

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2015171074A1 (en) * 2014-05-05 2015-11-12 National University Of Singapore Methods of producing tissue-mimetic constructs and uses thereof

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4829000A (en) 1985-08-30 1989-05-09 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Reconstituted basement membrane complex with biological activity
US9157060B2 (en) * 2005-06-09 2015-10-13 The United States Of America, As Represented By The Secretary Of The Navy Micro blood vessels and tissue ducts
US8287854B2 (en) * 2005-10-21 2012-10-16 Cellresearch Corporation Pte Ltd Skin equivalents derived from umbilical cord mesenchymal stem/progenitor cells and umbilical cord epithelial stem/progenitor cells
WO2008079320A1 (en) 2006-12-22 2008-07-03 The Regents Of The University Of California Microfluidic platform for cell culture and assay
JP2010517578A (ja) * 2007-02-09 2010-05-27 ザ ジェネラル ホスピタル コーポレイション Ｉｓｌｅｔ１＋系統に入るように細胞を誘導する方法およびそれを拡大する方法
US9303245B2 (en) * 2008-06-20 2016-04-05 Universiteit Maastricht Self-assembling tissue modules
EP2213364A1 (en) 2009-01-30 2010-08-04 Albert-Ludwigs-Universität Freiburg Phase guide patterns for liquid manipulation
US9752124B2 (en) 2009-02-03 2017-09-05 Koninklijke Nederlandse Akademie Van Wetenschappen Culture medium for epithelial stem cells and organoids comprising the stem cells
TW201137121A (en) * 2010-04-26 2011-11-01 Univ Nat Changhua Education Cell culture real-time observation system
CA2828110C (en) * 2011-02-28 2020-03-31 President And Fellows Of Harvard College Cell culture system
GB201103917D0 (en) 2011-03-08 2011-04-20 Univ Leiden Apparatus for and methods of processing liquids or liquid based substances
CN103087912A (zh) * 2011-10-27 2013-05-08 中国科学院大连化学物理研究所 一种产生稳定浓度梯度的微流控芯片及细胞共培养方法
US20140335496A1 (en) 2011-12-05 2014-11-13 Research Triangle Institute Human conducting airway model comprising multiple fluidic pathways
CN106399094A (zh) 2012-04-01 2017-02-15 Emd密理博公司 细胞培养和梯度迁移化验方法和装置
GB2505706A (en) * 2012-09-10 2014-03-12 Univ Leiden Apparatus comprising meniscus alignment barriers
WO2015178427A1 (ja) 2014-05-20 2015-11-26 国立大学法人 東京大学 中空マイクロファイバ
EP3362554B1 (en) * 2015-10-16 2025-09-03 Wake Forest University Health Sciences Multi-layer airway organoids and methods of making and using the same

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2015171074A1 (en) * 2014-05-05 2015-11-12 National University Of Singapore Methods of producing tissue-mimetic constructs and uses thereof

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
BAUER M. et al. "3D microchannel co-culture: method and biological validation", Integrative Biology, 2010; 2 (7-8): 371-378; DOI: 10.1039/c0ib00001a; стр. 372, 373. BAUER M. et al. "3D microchannel co-culture: method and biological validation", Integrative Biology, 2010; 2 (7-8): 371-378; DOI: 10.1039/c0ib00001a; стр. 372,373. SUNG K.E. et al. "Transition to invasion in breast cancer: a microfluidic in vitro model enables examination of spatial and temporal effects", Integrative Biology. 2011; 3 (4): 439-450; DOI: 10.1039/c0ib00063a; abstract. *
BAUER M. et al. "3D microchannel co-culture: method and biological validation", Integrative Biology, 2010; 2 (7-8): 371-378; DOI: 10.1039/c0ib00001a; стр. 372,373. *
SUNG K.E. et al. "Transition to invasion in breast cancer: a microfluidic in vitro model enables examination of spatial and temporal effects", Integrative Biology. 2011; 3 (4): 439-450; DOI: 10.1039/c0ib00063a; abstract. *
КОЛОКОЛЬЦОВА Т.Д. и др. Культуры клеток человека и животных: выделение, культивирование, криоконсервация и контроль, Патогенез, 2015, т. 13, N 3, с. 50-65. *

Also Published As

Publication number Publication date
JP2019507602A (ja) 2019-03-22
KR102403435B1 (ko) 2022-05-30
KR20180131569A (ko) 2018-12-10
EP3426769B1 (en) 2024-09-25
EP3426769A1 (en) 2019-01-16
AU2017231580A1 (en) 2018-09-27
CA3017100A1 (en) 2017-09-14
EP3426769C0 (en) 2024-09-25
CN109072184A (zh) 2018-12-21
NL2016404B1 (en) 2017-09-26
AU2017231580B2 (en) 2023-03-30
US20190076842A1 (en) 2019-03-14
JP7117245B2 (ja) 2022-08-12
WO2017155399A1 (en) 2017-09-14
BR112018068303A2 (pt) 2019-03-06
NL2016404A (en) 2017-09-19

Similar Documents

Publication Publication Date Title
RU2756404C1 (ru) Двойные трубчатые структуры
Miller et al. In vitro models to study human lung development, disease and homeostasis
US11193110B2 (en) Methods to generate gastrointestinal epithelial tissue constructs
CN109072179A (zh) 细胞培养基、培养方法以及类器官
Huang et al. Organoids as innovative models for bone and joint diseases
KR20180068994A (ko) 다층 기도 오가노이드 및 그의 제조 및 사용 방법
CN108619572A (zh) 用于体外研究用途的工程化组织、其阵列及其制备方法
US10472610B2 (en) Method for generating pancreatic bud cells and therapeutic agent for pancreatic disease containing pancreatic bud cells
CA3093585A1 (en) Formation of arrays of planar intestinal crypts possessing a stem/proliferattve cell compartment and differentiated cell zone
Rizzuti et al. Shaping the neurovascular unit exploiting human brain organoids
Zhang et al. Advances in gut–brain organ chips
Jeon et al. Biomaterials and bioengineering to guide tissue morphogenesis in epithelial organoids
Ostrovidov et al. Latest developments in engineered skeletal muscle tissues for drug discovery and development
US8647867B2 (en) Cell cultivation method and cell culture
Wang et al. Deciphering and reconstitution of positional information in the human brain development
EP4495227A1 (en) Co-cultures of organoids and stromal cells
Mondrinos et al. Lungs
US20250163373A1 (en) An innervated cellular composite
Snyder Bioengineering the Intestinal Niche on a Chip: Investigating Signal Transmission Between the Epithelium and Enteric Neurons
Cordiale et al. An Innovative “Tooth‐On‐Chip” Microfluidic Device Emulating the Structure and Physiology of the Dental Pulp Tissue
Chawla et al. Next Generation Tissue Engineering Strategies by Combination of Organoid Formation and 3D Bioprinting
Rivron Engineering vascular development for tissue regeneration
Sances Influence of Microvascular Cells on Stem Cell Derived Spinal Motor Neurons
Mondrinos et al. Some of the authors of this publication are also working on these related projects
Belchior et al. Author's Accepted Manuscript