JP2019507120A5 - - Google Patents
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- Publication number
- JP2019507120A5 JP2019507120A5 JP2018537810A JP2018537810A JP2019507120A5 JP 2019507120 A5 JP2019507120 A5 JP 2019507120A5 JP 2018537810 A JP2018537810 A JP 2018537810A JP 2018537810 A JP2018537810 A JP 2018537810A JP 2019507120 A5 JP2019507120 A5 JP 2019507120A5
- Authority
- JP
- Japan
- Prior art keywords
- compound
- alkyl
- formula
- pharmaceutically acceptable
- cyclopropyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 125000000217 alkyl group Chemical group 0.000 claims 10
- 150000001875 compounds Chemical class 0.000 claims 9
- 150000003839 salts Chemical class 0.000 claims 7
- 125000001559 cyclopropyl group Chemical group [H]C1([H])C([H])([H])C1([H])* 0.000 claims 6
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 claims 4
- 239000008194 pharmaceutical composition Substances 0.000 claims 4
- -1 2-pyridinyl Chemical group 0.000 claims 2
- 208000023275 Autoimmune disease Diseases 0.000 claims 2
- 208000003456 Juvenile Arthritis Diseases 0.000 claims 2
- 206010059176 Juvenile idiopathic arthritis Diseases 0.000 claims 2
- KPCZJLGGXRGYIE-UHFFFAOYSA-N [C]1=CC=CN=C1 Chemical group [C]1=CC=CN=C1 KPCZJLGGXRGYIE-UHFFFAOYSA-N 0.000 claims 2
- 208000026935 allergic disease Diseases 0.000 claims 2
- 201000002215 juvenile rheumatoid arthritis Diseases 0.000 claims 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 2
- 125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 claims 1
- 206010003267 Arthritis reactive Diseases 0.000 claims 1
- 206010009900 Colitis ulcerative Diseases 0.000 claims 1
- 208000011231 Crohn disease Diseases 0.000 claims 1
- 206010012434 Dermatitis allergic Diseases 0.000 claims 1
- 208000009329 Graft vs Host Disease Diseases 0.000 claims 1
- 208000022559 Inflammatory bowel disease Diseases 0.000 claims 1
- 208000005777 Lupus Nephritis Diseases 0.000 claims 1
- 201000004681 Psoriasis Diseases 0.000 claims 1
- 208000036824 Psoriatic arthropathy Diseases 0.000 claims 1
- 206010039085 Rhinitis allergic Diseases 0.000 claims 1
- 206010039710 Scleroderma Diseases 0.000 claims 1
- 201000002661 Spondylitis Diseases 0.000 claims 1
- 201000006704 Ulcerative Colitis Diseases 0.000 claims 1
- 206010046851 Uveitis Diseases 0.000 claims 1
- 201000010105 allergic rhinitis Diseases 0.000 claims 1
- 208000006673 asthma Diseases 0.000 claims 1
- 230000003796 beauty Effects 0.000 claims 1
- 208000019069 chronic childhood arthritis Diseases 0.000 claims 1
- 206010012601 diabetes mellitus Diseases 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 208000024908 graft versus host disease Diseases 0.000 claims 1
- 229910052736 halogen Inorganic materials 0.000 claims 1
- 150000002367 halogens Chemical class 0.000 claims 1
- 201000006417 multiple sclerosis Diseases 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 125000004076 pyridyl group Chemical group 0.000 claims 1
- 125000000246 pyrimidin-2-yl group Chemical group [H]C1=NC(*)=NC([H])=C1[H] 0.000 claims 1
- 125000000714 pyrimidinyl group Chemical group 0.000 claims 1
- 208000002574 reactive arthritis Diseases 0.000 claims 1
- 206010039073 rheumatoid arthritis Diseases 0.000 claims 1
- 201000000596 systemic lupus erythematosus Diseases 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662280746P | 2016-01-20 | 2016-01-20 | |
| US62/280,746 | 2016-01-20 | ||
| PCT/US2017/013841 WO2017127375A1 (en) | 2016-01-20 | 2017-01-18 | Pyrazinedihydropyrimidinone or pyridazinedihydropyrimidinone compounds as modulators of ror gamma |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2019507120A JP2019507120A (ja) | 2019-03-14 |
| JP2019507120A5 true JP2019507120A5 (enExample) | 2020-02-27 |
| JP6899391B2 JP6899391B2 (ja) | 2021-07-07 |
Family
ID=57910189
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018537810A Active JP6899391B2 (ja) | 2016-01-20 | 2017-01-18 | ガンマのモジュレータとしての化合物 |
Country Status (4)
| Country | Link |
|---|---|
| US (1) | US11358967B2 (enExample) |
| EP (1) | EP3405470B1 (enExample) |
| JP (1) | JP6899391B2 (enExample) |
| WO (1) | WO2017127375A1 (enExample) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2015160654A1 (en) * | 2014-04-14 | 2015-10-22 | Boehringer Ingelheim International Gmbh | Compounds as modulators of ror gamma |
| EP3405470B1 (en) * | 2016-01-20 | 2020-07-15 | Boehringer Ingelheim International GmbH | Pyrazinedihydropyrimidinone or pyridazinedihydropyrimidinone compounds as modulators of ror gamma |
| TW202000650A (zh) * | 2018-02-28 | 2020-01-01 | 日商日本煙草產業股份有限公司 | ４-甲基二氫嘧啶酮化合物及其醫藥用途 |
| US20210395185A1 (en) | 2018-10-18 | 2021-12-23 | Boehringer Ingelheim International Gmbh | Scalable synthesis of optically active 1-cyclopropylalkyl-1-amines |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20150007300A (ko) | 2012-05-08 | 2015-01-20 | 머크 샤프 앤드 돔 코포레이션 | Ror감마 활성의 억제를 위한 테트라히드로나프티리딘 및 관련 비시클릭 화합물 및 질환의 치료 |
| EP3027616B1 (en) | 2013-07-30 | 2018-01-10 | Boehringer Ingelheim International GmbH | Azaindole compounds as modulators of rorc |
| EP3041821B1 (en) | 2013-09-05 | 2018-05-30 | Boehringer Ingelheim International GmbH | Bicylic compounds as modulators of rorgamma |
| WO2015160654A1 (en) | 2014-04-14 | 2015-10-22 | Boehringer Ingelheim International Gmbh | Compounds as modulators of ror gamma |
| EP3405470B1 (en) * | 2016-01-20 | 2020-07-15 | Boehringer Ingelheim International GmbH | Pyrazinedihydropyrimidinone or pyridazinedihydropyrimidinone compounds as modulators of ror gamma |
-
2017
- 2017-01-18 EP EP17701982.5A patent/EP3405470B1/en active Active
- 2017-01-18 WO PCT/US2017/013841 patent/WO2017127375A1/en not_active Ceased
- 2017-01-18 US US16/071,147 patent/US11358967B2/en active Active
- 2017-01-18 JP JP2018537810A patent/JP6899391B2/ja active Active