JP2019506400A5 - - Google Patents
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- JP2019506400A5 JP2019506400A5 JP2018538190A JP2018538190A JP2019506400A5 JP 2019506400 A5 JP2019506400 A5 JP 2019506400A5 JP 2018538190 A JP2018538190 A JP 2018538190A JP 2018538190 A JP2018538190 A JP 2018538190A JP 2019506400 A5 JP2019506400 A5 JP 2019506400A5
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- JP
- Japan
- Prior art keywords
- antibody
- agent
- antagonist
- activity
- blocks
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 238000000034 method Methods 0.000 claims 22
- 239000003795 chemical substances by application Substances 0.000 claims 10
- 101000868279 Homo sapiens Leukocyte surface antigen CD47 Proteins 0.000 claims 4
- 102100032913 Leukocyte surface antigen CD47 Human genes 0.000 claims 4
- 239000005557 antagonist Substances 0.000 claims 4
- 230000000694 effects Effects 0.000 claims 4
- 230000000139 costimulatory effect Effects 0.000 claims 3
- 230000001506 immunosuppresive effect Effects 0.000 claims 3
- 239000000556 agonist Substances 0.000 claims 2
- 230000037452 priming Effects 0.000 claims 2
- 238000009097 single-agent therapy Methods 0.000 claims 2
- 101150013553 CD40 gene Proteins 0.000 claims 1
- 102100039498 Cytotoxic T-lymphocyte protein 4 Human genes 0.000 claims 1
- 102100034458 Hepatitis A virus cellular receptor 2 Human genes 0.000 claims 1
- 101000889276 Homo sapiens Cytotoxic T-lymphocyte protein 4 Proteins 0.000 claims 1
- 101001068133 Homo sapiens Hepatitis A virus cellular receptor 2 Proteins 0.000 claims 1
- 101001137987 Homo sapiens Lymphocyte activation gene 3 protein Proteins 0.000 claims 1
- 101001117317 Homo sapiens Programmed cell death 1 ligand 1 Proteins 0.000 claims 1
- 102000017578 LAG3 Human genes 0.000 claims 1
- 241000124008 Mammalia Species 0.000 claims 1
- 206010028980 Neoplasm Diseases 0.000 claims 1
- 102100024216 Programmed cell death 1 ligand 1 Human genes 0.000 claims 1
- 101710165473 Tumor necrosis factor receptor superfamily member 4 Proteins 0.000 claims 1
- 102100022153 Tumor necrosis factor receptor superfamily member 4 Human genes 0.000 claims 1
- 102100040245 Tumor necrosis factor receptor superfamily member 5 Human genes 0.000 claims 1
- 230000002411 adverse Effects 0.000 claims 1
- 239000003173 antianemic agent Substances 0.000 claims 1
- 239000000427 antigen Substances 0.000 claims 1
- 102000036639 antigens Human genes 0.000 claims 1
- 108091007433 antigens Proteins 0.000 claims 1
- 201000011510 cancer Diseases 0.000 claims 1
- 229940079593 drug Drugs 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 229940125367 erythropoiesis stimulating agent Drugs 0.000 claims 1
- 238000009472 formulation Methods 0.000 claims 1
- 238000003318 immunodepletion Methods 0.000 claims 1
- 238000000338 in vitro Methods 0.000 claims 1
- 238000001727 in vivo Methods 0.000 claims 1
- 239000002502 liposome Substances 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- 230000004083 survival effect Effects 0.000 claims 1
- 230000008685 targeting Effects 0.000 claims 1
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2021196940A JP2022033899A (ja) | 2016-01-21 | 2021-12-03 | 免疫調節剤を併用するがんの治療 |
| JP2023047018A JP2023085370A (ja) | 2016-01-21 | 2023-03-23 | 免疫調節剤を併用するがんの治療 |
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662281571P | 2016-01-21 | 2016-01-21 | |
| US62/281,571 | 2016-01-21 | ||
| US201662301981P | 2016-03-01 | 2016-03-01 | |
| US62/301,981 | 2016-03-01 | ||
| PCT/US2017/014375 WO2017127707A1 (en) | 2016-01-21 | 2017-01-20 | Treatment of cancer with combinations of immunoregulatory agents |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021196940A Division JP2022033899A (ja) | 2016-01-21 | 2021-12-03 | 免疫調節剤を併用するがんの治療 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2019506400A JP2019506400A (ja) | 2019-03-07 |
| JP2019506400A5 true JP2019506400A5 (https=) | 2020-02-27 |
| JP7026047B2 JP7026047B2 (ja) | 2022-02-25 |
Family
ID=59360269
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018538190A Active JP7026047B2 (ja) | 2016-01-21 | 2017-01-20 | 免疫調節剤を併用するがんの治療 |
| JP2021196940A Pending JP2022033899A (ja) | 2016-01-21 | 2021-12-03 | 免疫調節剤を併用するがんの治療 |
| JP2023047018A Pending JP2023085370A (ja) | 2016-01-21 | 2023-03-23 | 免疫調節剤を併用するがんの治療 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021196940A Pending JP2022033899A (ja) | 2016-01-21 | 2021-12-03 | 免疫調節剤を併用するがんの治療 |
| JP2023047018A Pending JP2023085370A (ja) | 2016-01-21 | 2023-03-23 | 免疫調節剤を併用するがんの治療 |
Country Status (9)
| Country | Link |
|---|---|
| US (3) | US20170210803A1 (https=) |
| EP (2) | EP3405499A4 (https=) |
| JP (3) | JP7026047B2 (https=) |
| KR (1) | KR102833922B1 (https=) |
| CN (1) | CN109071676A (https=) |
| AU (2) | AU2017210224B2 (https=) |
| CA (1) | CA3011429A1 (https=) |
| SG (1) | SG11201806110QA (https=) |
| WO (1) | WO2017127707A1 (https=) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PT3402820T (pt) | 2016-01-11 | 2020-08-20 | Forty Seven Inc | Anticorpos monoclonais anti-cd47 quiméricos, de ratinho ou humanizados |
| CN111315783A (zh) * | 2017-10-18 | 2020-06-19 | 四十七公司 | 用抗cd47和抗pd-l1治疗卵巢癌 |
| JP7308191B2 (ja) * | 2017-10-18 | 2023-07-13 | フォーティ セブン， インコーポレイテッド | 抗ｃｄ４７剤ベースの卵巣癌療法 |
| SG11202004864TA (en) | 2017-12-01 | 2020-06-29 | Seattle Genetics Inc | Cd47 antibodies and uses thereof for treating cancer |
| EP3722312A4 (en) * | 2017-12-08 | 2021-07-21 | Hanx Biopharmaceutics, Inc | BISPECIFIC ANTI-PD-1 / CD47 ANTIBODIES AND ASSOCIATED APPLICATION |
| CN111699005A (zh) | 2018-02-12 | 2020-09-22 | 四十七公司 | 使用抗cd47抗体和抗cd20抗体的抗癌方案 |
| BR112021005585A2 (pt) | 2018-09-27 | 2021-06-29 | Celgene Corporation | proteínas de ligação a sirpa e métodos de uso das mesmas |
| US11591390B2 (en) | 2018-09-27 | 2023-02-28 | Celgene Corporation | SIRP-α binding proteins and methods of use thereof |
| US20210338681A1 (en) * | 2018-10-01 | 2021-11-04 | Secura Bio, Inc. | Combination therapies |
| US12331320B2 (en) | 2018-10-10 | 2025-06-17 | The Research Foundation For The State University Of New York | Genome edited cancer cell vaccines |
| CN109517073A (zh) * | 2018-11-30 | 2019-03-26 | 北京泽勤生物医药有限公司 | 一种靶向治疗肿瘤的融合肽及其应用 |
| MX2021007274A (es) * | 2018-12-21 | 2021-07-15 | Ose Immunotherapeutics | Molecula bifuncional anti-pd-1/sirpa. |
| WO2020163692A1 (en) * | 2019-02-08 | 2020-08-13 | The Board Of Trustees Of The Leland Stanford Junior University | Treatment of cutaneous t cell lymphoma with targeting of cd47 pathway |
| CN113645980A (zh) * | 2019-03-08 | 2021-11-12 | 北卡罗莱纳州立大学 | 用于增强的免疫疗法的生物响应抗体复合物 |
| EP4003375A4 (en) * | 2019-07-31 | 2023-09-06 | Forty Seven, Inc. | DEPLETION DIETS FOR MODIFIED T CELL OR NK CELL THERAPY |
| CA3164623A1 (en) | 2019-12-17 | 2021-06-24 | Pfizer Inc. | Antibodies specific for cd47, pd-l1, and uses thereof |
| WO2022087416A1 (en) * | 2020-10-22 | 2022-04-28 | Actinium Pharmaceuticals, Inc. | Combination radioimmunotherapy and cd47 blockade in the treatment of cancer |
| JP2024503822A (ja) * | 2021-01-05 | 2024-01-29 | ナショナル インスティテュート オブ バイオロジカル サイエンシズ，ベイジン | Ｇｐｃ３及びｃｄ４７を標的とする二重特異性抗体 |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8377448B2 (en) | 2006-05-15 | 2013-02-19 | The Board Of Trustees Of The Leland Standford Junior University | CD47 related compositions and methods for treating immunological diseases and disorders |
| CA2771336C (en) * | 2009-09-15 | 2019-11-26 | The Board Of Trustees Of The Leland Stanford Junior University | Synergistic anti-cd47 therapy for hematologic cancers |
| BR112012017164A2 (pt) * | 2009-12-22 | 2019-09-24 | Novartis Ag | proteína de fusão de região constante de anticorpo-cd47 tetravalente |
| PT2569013T (pt) | 2010-05-14 | 2017-02-08 | Univ Leland Stanford Junior | Anticorpos monoclonais humanizados e quiméricos para cd47 |
| WO2013112942A1 (en) * | 2012-01-25 | 2013-08-01 | Dna Trix, Inc. | Biomarkers and combination therapies using oncolytic virus and immunomodulation |
| DK3725807T3 (da) * | 2012-12-03 | 2026-01-12 | Novimmune Sa | Anti-cd47 antistoffer og fremgangsmåder til anvendelse deraf |
| BR112015013431A2 (pt) * | 2012-12-12 | 2017-11-14 | Vasculox Inc | anticorpos monoclonais ou respectivos fragmentos ligantes de antígenos, composição farmacêutica, e usos de anticorpo monoclonal ou respectivo fragmento ligante de antígenos |
| CN112245586A (zh) * | 2013-03-15 | 2021-01-22 | 小利兰·斯坦福大学托管委员会 | 用于实现治疗有效剂量的抗cd47剂的方法 |
| TWI681969B (zh) * | 2014-01-23 | 2020-01-11 | 美商再生元醫藥公司 | 針對ｐｄ-１的人類抗體 |
| WO2016023001A1 (en) * | 2014-08-08 | 2016-02-11 | The Board Of Trustees Of The Leland Stanford Junior University | Multispecific high affinity pd-1 agents and methods of use |
| WO2017068164A1 (en) * | 2015-10-21 | 2017-04-27 | Ose Immunotherapeutics | Methods and compositions for modifying macrophage polarization into pro-inflammatory cells to treat cancer |
| CN107459578B (zh) * | 2016-05-31 | 2021-11-26 | 泰州迈博太科药业有限公司 | 一种靶向cd47与pd-l1的双功能融合蛋白 |
-
2017
- 2017-01-20 US US15/411,623 patent/US20170210803A1/en not_active Abandoned
- 2017-01-20 KR KR1020187023116A patent/KR102833922B1/ko active Active
- 2017-01-20 JP JP2018538190A patent/JP7026047B2/ja active Active
- 2017-01-20 CA CA3011429A patent/CA3011429A1/en active Pending
- 2017-01-20 AU AU2017210224A patent/AU2017210224B2/en active Active
- 2017-01-20 EP EP17742028.8A patent/EP3405499A4/en not_active Ceased
- 2017-01-20 CN CN201780018358.9A patent/CN109071676A/zh active Pending
- 2017-01-20 EP EP22175627.3A patent/EP4070812A1/en active Pending
- 2017-01-20 SG SG11201806110QA patent/SG11201806110QA/en unknown
- 2017-01-20 WO PCT/US2017/014375 patent/WO2017127707A1/en not_active Ceased
-
2021
- 2021-04-08 US US17/225,668 patent/US20210230276A1/en not_active Abandoned
- 2021-12-03 JP JP2021196940A patent/JP2022033899A/ja active Pending
-
2023
- 2023-03-23 JP JP2023047018A patent/JP2023085370A/ja active Pending
-
2024
- 2024-05-02 AU AU2024202900A patent/AU2024202900A1/en active Pending
- 2024-11-06 US US18/939,377 patent/US20250066473A1/en active Pending
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