JP2019506143A5 - - Google Patents

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Publication number
JP2019506143A5
JP2019506143A5 JP2018530845A JP2018530845A JP2019506143A5 JP 2019506143 A5 JP2019506143 A5 JP 2019506143A5 JP 2018530845 A JP2018530845 A JP 2018530845A JP 2018530845 A JP2018530845 A JP 2018530845A JP 2019506143 A5 JP2019506143 A5 JP 2019506143A5
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JP
Japan
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polypeptide
item
polypeptide region
region
chimeric
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JP2018530845A
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English (en)
Japanese (ja)
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JP2019506143A (ja
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Priority claimed from PCT/US2016/066371 external-priority patent/WO2017106185A2/en
Publication of JP2019506143A publication Critical patent/JP2019506143A/ja
Publication of JP2019506143A5 publication Critical patent/JP2019506143A5/ja
Priority to JP2021200645A priority Critical patent/JP2022031906A/ja
Priority to JP2024105062A priority patent/JP2024120105A/ja
Priority to JP2024105063A priority patent/JP7807108B2/ja
Withdrawn legal-status Critical Current

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JP2018530845A 2015-12-14 2016-12-13 治療用細胞の活性化及び排除のための二重コントロール Withdrawn JP2019506143A (ja)

Priority Applications (3)

Application Number Priority Date Filing Date Title
JP2021200645A JP2022031906A (ja) 2015-12-14 2021-12-10 治療用細胞の活性化及び排除のための二重コントロール
JP2024105062A JP2024120105A (ja) 2015-12-14 2024-06-28 治療用細胞の活性化及び排除のための二重コントロール
JP2024105063A JP7807108B2 (ja) 2015-12-14 2024-06-28 治療用細胞の活性化及び排除のための二重コントロール

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201562267277P 2015-12-14 2015-12-14
US62/267,277 2015-12-14
PCT/US2016/066371 WO2017106185A2 (en) 2015-12-14 2016-12-13 Dual controls for therapeutic cell activation or elimination

Related Child Applications (1)

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JP2021200645A Division JP2022031906A (ja) 2015-12-14 2021-12-10 治療用細胞の活性化及び排除のための二重コントロール

Publications (2)

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JP2019506143A JP2019506143A (ja) 2019-03-07
JP2019506143A5 true JP2019506143A5 (https=) 2020-01-16

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Family Applications (4)

Application Number Title Priority Date Filing Date
JP2018530845A Withdrawn JP2019506143A (ja) 2015-12-14 2016-12-13 治療用細胞の活性化及び排除のための二重コントロール
JP2021200645A Withdrawn JP2022031906A (ja) 2015-12-14 2021-12-10 治療用細胞の活性化及び排除のための二重コントロール
JP2024105062A Pending JP2024120105A (ja) 2015-12-14 2024-06-28 治療用細胞の活性化及び排除のための二重コントロール
JP2024105063A Active JP7807108B2 (ja) 2015-12-14 2024-06-28 治療用細胞の活性化及び排除のための二重コントロール

Family Applications After (3)

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JP2021200645A Withdrawn JP2022031906A (ja) 2015-12-14 2021-12-10 治療用細胞の活性化及び排除のための二重コントロール
JP2024105062A Pending JP2024120105A (ja) 2015-12-14 2024-06-28 治療用細胞の活性化及び排除のための二重コントロール
JP2024105063A Active JP7807108B2 (ja) 2015-12-14 2024-06-28 治療用細胞の活性化及び排除のための二重コントロール

Country Status (9)

Country Link
US (3) US20170166877A1 (https=)
EP (1) EP3390434A2 (https=)
JP (4) JP2019506143A (https=)
KR (1) KR20180087423A (https=)
CN (2) CN108779163A (https=)
AU (1) AU2016370470B2 (https=)
CA (1) CA3007473A1 (https=)
SG (1) SG11201804694SA (https=)
WO (1) WO2017106185A2 (https=)

Families Citing this family (69)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10967298B2 (en) 2012-03-15 2021-04-06 Flodesign Sonics, Inc. Driver and control for variable impedence load
US9745548B2 (en) 2012-03-15 2017-08-29 Flodesign Sonics, Inc. Acoustic perfusion devices
US9950282B2 (en) 2012-03-15 2018-04-24 Flodesign Sonics, Inc. Electronic configuration and control for acoustic standing wave generation
US9458450B2 (en) 2012-03-15 2016-10-04 Flodesign Sonics, Inc. Acoustophoretic separation technology using multi-dimensional standing waves
US10322949B2 (en) 2012-03-15 2019-06-18 Flodesign Sonics, Inc. Transducer and reflector configurations for an acoustophoretic device
US9752113B2 (en) 2012-03-15 2017-09-05 Flodesign Sonics, Inc. Acoustic perfusion devices
US10689609B2 (en) 2012-03-15 2020-06-23 Flodesign Sonics, Inc. Acoustic bioreactor processes
US10704021B2 (en) 2012-03-15 2020-07-07 Flodesign Sonics, Inc. Acoustic perfusion devices
US10737953B2 (en) 2012-04-20 2020-08-11 Flodesign Sonics, Inc. Acoustophoretic method for use in bioreactors
EP2934532B1 (en) 2012-12-20 2019-10-23 Purdue Research Foundation Chimeric antigen receptor-expressing t cells as anti-cancer therapeutics
US9745569B2 (en) 2013-09-13 2017-08-29 Flodesign Sonics, Inc. System for generating high concentration factors for low cell density suspensions
WO2015105955A1 (en) 2014-01-08 2015-07-16 Flodesign Sonics, Inc. Acoustophoresis device with dual acoustophoretic chamber
US9744483B2 (en) 2014-07-02 2017-08-29 Flodesign Sonics, Inc. Large scale acoustic separation device
US10888608B2 (en) 2014-09-02 2021-01-12 Bellicum Pharmaceuticals, Inc. Costimulation of chimeric antigen receptors by MyD88 and CD40 polypeptides
JP2018510627A (ja) * 2015-03-10 2018-04-19 レイデン ユニバーシティ メディカル センター メラノーマ優先発現抗原に対して向けられたt細胞レセプターおよびその使用
US11377651B2 (en) 2016-10-19 2022-07-05 Flodesign Sonics, Inc. Cell therapy processes utilizing acoustophoresis
US11021699B2 (en) 2015-04-29 2021-06-01 FioDesign Sonics, Inc. Separation using angled acoustic waves
US11708572B2 (en) 2015-04-29 2023-07-25 Flodesign Sonics, Inc. Acoustic cell separation techniques and processes
US11474085B2 (en) 2015-07-28 2022-10-18 Flodesign Sonics, Inc. Expanded bed affinity selection
US11459540B2 (en) 2015-07-28 2022-10-04 Flodesign Sonics, Inc. Expanded bed affinity selection
RU2729116C2 (ru) 2015-12-16 2020-08-04 Гритстоун Онколоджи, Инк. Идентификация, производство и применение неоантигенов
US11325948B2 (en) 2016-03-19 2022-05-10 Exuma Biotech Corp. Methods and compositions for genetically modifying lymphocytes to express polypeptides comprising the intracellular domain of MPL
US12590321B2 (en) 2016-03-19 2026-03-31 Exuma Biotech Corp. Methods and compositions for genetically modifying and expanding lymphocytes and regulating the activity thereof
US11111505B2 (en) 2016-03-19 2021-09-07 Exuma Biotech, Corp. Methods and compositions for transducing lymphocytes and regulating the activity thereof
JP7282521B2 (ja) 2016-04-08 2023-05-29 パーデュー・リサーチ・ファウンデイション Car t細胞療法のための方法および組成物
US11214789B2 (en) 2016-05-03 2022-01-04 Flodesign Sonics, Inc. Concentration and washing of particles with acoustics
US11085035B2 (en) 2016-05-03 2021-08-10 Flodesign Sonics, Inc. Therapeutic cell washing, concentration, and separation utilizing acoustophoresis
CA3041517A1 (en) 2016-10-19 2018-04-26 Flodesign Sonics, Inc. Affinity cell extraction by acoustics
JP7206214B2 (ja) 2016-12-13 2023-01-17 シアトル チルドレンズ ホスピタル (ディービーエイ シアトル チルドレンズ リサーチ インスティテュート) インビトロ及びインビボで操作された細胞において発現された化学誘導シグナル伝達複合体の外因性薬物活性化の方法
CN110612119B (zh) 2017-02-07 2024-10-29 西雅图儿童医院(Dba西雅图儿童研究所) 磷脂醚(ple)car t细胞肿瘤靶向(ctct)剂
JP7178355B2 (ja) 2017-02-28 2022-11-25 エンドサイト・インコーポレイテッド Car t細胞療法のための組成物および方法
WO2018208849A1 (en) 2017-05-09 2018-11-15 Bellicum Pharmaceuticals, Inc. Methods to augment or alter signal transduction
AU2018316166A1 (en) 2017-08-07 2020-02-06 The Regents Of The University Of California Platform for generating safe cell therapeutics
CN111479921B (zh) * 2017-09-18 2024-08-02 埃克苏马生物技术公司 用于以基因方式修饰且扩增淋巴细胞以及调节其活性的方法及组合物
KR20260039788A (ko) 2017-10-10 2026-03-20 시애틀 프로젝트 코포레이션 핫스팟을 이용한 신생항원 동정
CA3083097A1 (en) 2017-11-22 2019-05-31 Gritstone Oncology, Inc. Reducing junction epitope presentation for neoantigens
EP3720479A2 (en) 2017-12-08 2020-10-14 Bellicum Pharmaceuticals, Inc. Methods for enhancing and maintaining car-t cell efficacy
WO2019118921A1 (en) 2017-12-14 2019-06-20 Flodesign Sonics, Inc. Acoustic transducer drive and controller
WO2019126344A1 (en) 2017-12-20 2019-06-27 Bellicum Pharmaceuticals, Inc. Multimeric piperidine derivatives
CA3083779A1 (en) 2017-12-22 2019-06-27 Fate Therapeutics, Inc. Enhanced immune effector cells and use thereof
JP7549303B2 (ja) 2018-01-22 2024-09-11 エンドサイト・インコーポレイテッド Car t細胞の使用方法
SG11202007426XA (en) 2018-02-06 2020-09-29 Seattle Childrens Hospital Dba Seattle Childrens Res Inst Fluorescein-specific cars exhibiting optimal t cell function against fl-ple labelled tumors
CN112105382A (zh) 2018-02-23 2020-12-18 恩多塞特公司 用于car t细胞疗法的顺序方法
CN119851752A (zh) 2018-02-27 2025-04-18 磨石生物公司 利用泛等位基因模型进行的新抗原鉴别
JP7575271B2 (ja) 2018-03-29 2024-10-29 フェイト セラピューティクス,インコーポレイテッド 操作された免疫エフェクター細胞およびその使用
CA3091490A1 (en) 2018-04-27 2019-10-31 Seattle Children's Hospital (dba Seattle Children's Research Institute) Rapamycin resistant cells
WO2019222579A1 (en) 2018-05-17 2019-11-21 St. Jude Children's Research Hospital, Inc. Chimeric antigen receptors with myd88 and cd40 costimulatory domains
EP4601102A3 (en) 2018-07-26 2025-08-27 LG Energy Solution, Ltd. Separator and electrochemical device comprising same
KR102943217B1 (ko) 2018-12-02 2026-03-25 페이트 세러퓨틱스, 인코포레이티드 향상된 iPSC 유래 효과기 세포를 사용한 면역요법
CA3122421A1 (en) * 2018-12-13 2020-06-18 Bellicum Pharmaceuticals, Inc. Psca car-t cells
WO2020163408A2 (en) * 2019-02-04 2020-08-13 Oisin Biotechnologies, Inc. Fusogenic lipid nanoparticles for the target cell-specific production of rapamycin inducible therapeutic proteins
US20220204575A1 (en) * 2019-04-23 2022-06-30 The Regents Of The University Of California Modulating survival of therapeutic cells and methods, cells and nucleic acids related thereto
CN110079504A (zh) * 2019-05-06 2019-08-02 山东大学第二医院 一种含有不稳定结构域的car-t细胞及其制备方法和调节car-t细胞功能方法
BR112022000641A2 (pt) 2019-07-17 2022-03-29 Fate Therapeutics Inc Modificação genética de célula efetora imune e uso da mesma
WO2021030482A1 (en) * 2019-08-12 2021-02-18 Bellicum Pharmaceuticals, Inc. Improved formulations for immune cells
CN110592014A (zh) * 2019-08-14 2019-12-20 广东美赛尔细胞生物科技有限公司 一种在nk细胞治疗中免辐照体外体内持续去除饲养细胞的方法
CN112430578A (zh) * 2019-08-26 2021-03-02 深圳宾德生物技术有限公司 携带安全开关并靶向Her2的嵌合抗原受体T细胞及其制备方法和应用
AU2020340424A1 (en) * 2019-08-30 2022-03-31 Shattuck Labs, Inc. Chimeric proteins in autoimmunity
WO2021155369A1 (en) * 2020-01-31 2021-08-05 The Board Of Trustees Of The Leland Stanford Junior University Systems and methods to identify genetic silencers and applications thereof
AU2021217003A1 (en) 2020-02-04 2022-09-15 Seattle Children's Hospital (dba Seattle Children's Research Institute) Anti-dinitrophenol chimeric antigen receptors
WO2021231806A1 (en) * 2020-05-13 2021-11-18 Rapa Therapeutics, Llc Antigen presenting t cells, sensitized, manufactured t cells and methods of treatment using the same
WO2021257574A1 (en) * 2020-06-15 2021-12-23 Kiromic Biopharma Inc. Tri-switch technology for multi-dimensional control of cell therapy
AU2021292695A1 (en) 2020-06-19 2023-02-02 Fate Therapeutics, Inc. Combining iPSC-derived effector cell types for immunotherapy use
CN112575035B (zh) * 2020-12-09 2022-11-29 贵州医科大学 一种诱导细胞凋亡的载体系统
EP4504914A4 (en) 2022-04-08 2026-04-29 Fate Therapeutics Inc Cells having solid tumor targeting backbone and use thereof
CA3247010A1 (en) 2022-04-08 2023-10-12 Ono Pharmaceutical Co., Ltd. CHIMERIC ANTIGEN RECEPTOR FOR TUMOR TARGETING
CN119654336A (zh) * 2022-05-16 2025-03-18 儿童医疗中心有限公司 治疗心脏病的组合物和方法
EP4634216A1 (en) 2022-12-16 2025-10-22 Repertoire Immune Medicines, Inc. T cell receptors binding hpv-16 epitopes
AU2024337093A1 (en) * 2023-09-05 2026-04-02 Remedium Bio, Inc. Genetic elements for adjustment of expression

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6187757B1 (en) * 1995-06-07 2001-02-13 Ariad Pharmaceuticals, Inc. Regulation of biological events using novel compounds
CA2318402A1 (en) * 1998-01-15 1999-07-22 Ariad Gene Therapeutics, Inc. Regulation of biological events using multimeric chimeric proteins
WO2014151960A2 (en) * 2013-03-14 2014-09-25 Bellicum Pharmaceuticals, Inc. Methods for controlling t cell proliferation
CA2912172A1 (en) * 2013-06-05 2014-12-11 Bellicum Pharmaceuticals, Inc. Methods for inducing partial apoptosis using caspase polypeptides
WO2015017214A1 (en) * 2013-07-29 2015-02-05 Bluebird Bio, Inc. Multipartite signaling proteins and uses thereof
US10934346B2 (en) * 2014-02-14 2021-03-02 Bellicum Pharmaceuticals, Inc. Modified T cell comprising a polynucleotide encoding an inducible stimulating molecule comprising MyD88, CD40 and FKBP12
GB201503133D0 (en) * 2015-02-24 2015-04-08 Ucl Business Plc And Syncona Partners Llp Chimeric protein

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