JP2019504718A - 可変多焦点眼内レンズ - Google Patents
可変多焦点眼内レンズ Download PDFInfo
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- JP2019504718A JP2019504718A JP2018542743A JP2018542743A JP2019504718A JP 2019504718 A JP2019504718 A JP 2019504718A JP 2018542743 A JP2018542743 A JP 2018542743A JP 2018542743 A JP2018542743 A JP 2018542743A JP 2019504718 A JP2019504718 A JP 2019504718A
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- 230000003287 optical effect Effects 0.000 claims abstract description 103
- XUIMIQQOPSSXEZ-UHFFFAOYSA-N Silicon Chemical compound [Si] XUIMIQQOPSSXEZ-UHFFFAOYSA-N 0.000 claims abstract description 55
- 229910052710 silicon Inorganic materials 0.000 claims abstract description 55
- 239000010703 silicon Substances 0.000 claims abstract description 55
- 239000000463 material Substances 0.000 claims description 18
- 230000002209 hydrophobic effect Effects 0.000 claims description 14
- 229920000058 polyacrylate Polymers 0.000 claims description 11
- 230000000750 progressive effect Effects 0.000 claims description 9
- 150000002148 esters Chemical class 0.000 claims description 4
- 239000012779 reinforcing material Substances 0.000 claims description 3
- 239000012780 transparent material Substances 0.000 claims description 3
- 230000008878 coupling Effects 0.000 abstract 1
- 238000010168 coupling process Methods 0.000 abstract 1
- 238000005859 coupling reaction Methods 0.000 abstract 1
- 210000000695 crystalline len Anatomy 0.000 description 61
- 210000003205 muscle Anatomy 0.000 description 6
- 239000000853 adhesive Substances 0.000 description 5
- 230000001070 adhesive effect Effects 0.000 description 5
- 239000002775 capsule Substances 0.000 description 5
- 238000000465 moulding Methods 0.000 description 4
- 238000010586 diagram Methods 0.000 description 3
- 230000004438 eyesight Effects 0.000 description 3
- 238000004519 manufacturing process Methods 0.000 description 3
- 229920001296 polysiloxane Polymers 0.000 description 3
- 239000002210 silicon-based material Substances 0.000 description 3
- GNSFRPWPOGYVLO-UHFFFAOYSA-N 3-hydroxypropyl 2-methylprop-2-enoate Chemical compound CC(=C)C(=O)OCCCO GNSFRPWPOGYVLO-UHFFFAOYSA-N 0.000 description 2
- YKXAYLPDMSGWEV-UHFFFAOYSA-N 4-hydroxybutyl 2-methylprop-2-enoate Chemical compound CC(=C)C(=O)OCCCCO YKXAYLPDMSGWEV-UHFFFAOYSA-N 0.000 description 2
- 208000002177 Cataract Diseases 0.000 description 2
- 239000013078 crystal Substances 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 210000001328 optic nerve Anatomy 0.000 description 2
- OMIGHNLMNHATMP-UHFFFAOYSA-N 2-hydroxyethyl prop-2-enoate Chemical compound OCCOC(=O)C=C OMIGHNLMNHATMP-UHFFFAOYSA-N 0.000 description 1
- WOBHKFSMXKNTIM-UHFFFAOYSA-N Hydroxyethyl methacrylate Chemical compound CC(=C)C(=O)OCCO WOBHKFSMXKNTIM-UHFFFAOYSA-N 0.000 description 1
- 150000001252 acrylic acid derivatives Chemical class 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 239000013013 elastic material Substances 0.000 description 1
- 239000000835 fiber Substances 0.000 description 1
- 239000011521 glass Substances 0.000 description 1
- 150000002734 metacrylic acid derivatives Chemical class 0.000 description 1
- 239000000178 monomer Substances 0.000 description 1
- QRWZCJXEAOZAAW-UHFFFAOYSA-N n,n,2-trimethylprop-2-enamide Chemical compound CN(C)C(=O)C(C)=C QRWZCJXEAOZAAW-UHFFFAOYSA-N 0.000 description 1
- JMCVCHBBHPFWBF-UHFFFAOYSA-N n,n-diethyl-2-methylprop-2-enamide Chemical compound CCN(CC)C(=O)C(C)=C JMCVCHBBHPFWBF-UHFFFAOYSA-N 0.000 description 1
- OVHHHVAVHBHXAK-UHFFFAOYSA-N n,n-diethylprop-2-enamide Chemical compound CCN(CC)C(=O)C=C OVHHHVAVHBHXAK-UHFFFAOYSA-N 0.000 description 1
- YLGYACDQVQQZSW-UHFFFAOYSA-N n,n-dimethylprop-2-enamide Chemical compound CN(C)C(=O)C=C YLGYACDQVQQZSW-UHFFFAOYSA-N 0.000 description 1
- 230000005855 radiation Effects 0.000 description 1
- 239000007779 soft material Substances 0.000 description 1
- 125000003011 styrenyl group Chemical class [H]\C(*)=C(/[H])C1=C([H])C([H])=C([H])C([H])=C1[H] 0.000 description 1
- 230000004304 visual acuity Effects 0.000 description 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/14—Eye parts, e.g. lenses, corneal implants; Implanting instruments specially adapted therefor; Artificial eyes
- A61F2/16—Intraocular lenses
- A61F2/1613—Intraocular lenses having special lens configurations, e.g. multipart lenses; having particular optical properties, e.g. pseudo-accommodative lenses, lenses having aberration corrections, diffractive lenses, lenses for variably absorbing electromagnetic radiation, lenses having variable focus
- A61F2/1616—Pseudo-accommodative, e.g. multifocal or enabling monovision
- A61F2/1618—Multifocal lenses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/14—Eye parts, e.g. lenses, corneal implants; Implanting instruments specially adapted therefor; Artificial eyes
- A61F2/16—Intraocular lenses
- A61F2/1613—Intraocular lenses having special lens configurations, e.g. multipart lenses; having particular optical properties, e.g. pseudo-accommodative lenses, lenses having aberration corrections, diffractive lenses, lenses for variably absorbing electromagnetic radiation, lenses having variable focus
- A61F2/1624—Intraocular lenses having special lens configurations, e.g. multipart lenses; having particular optical properties, e.g. pseudo-accommodative lenses, lenses having aberration corrections, diffractive lenses, lenses for variably absorbing electromagnetic radiation, lenses having variable focus having adjustable focus; power activated variable focus means, e.g. mechanically or electrically by the ciliary muscle or from the outside
- A61F2/1629—Intraocular lenses having special lens configurations, e.g. multipart lenses; having particular optical properties, e.g. pseudo-accommodative lenses, lenses having aberration corrections, diffractive lenses, lenses for variably absorbing electromagnetic radiation, lenses having variable focus having adjustable focus; power activated variable focus means, e.g. mechanically or electrically by the ciliary muscle or from the outside for changing longitudinal position, i.e. along the visual axis when implanted
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/14—Eye parts, e.g. lenses, corneal implants; Implanting instruments specially adapted therefor; Artificial eyes
- A61F2/16—Intraocular lenses
- A61F2002/1681—Intraocular lenses having supporting structure for lens, e.g. haptics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/14—Eye parts, e.g. lenses, corneal implants; Implanting instruments specially adapted therefor; Artificial eyes
- A61F2/16—Intraocular lenses
- A61F2002/1681—Intraocular lenses having supporting structure for lens, e.g. haptics
- A61F2002/1682—Intraocular lenses having supporting structure for lens, e.g. haptics having mechanical force transfer mechanism to the lens, e.g. for accommodating lenses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/14—Eye parts, e.g. lenses, corneal implants; Implanting instruments specially adapted therefor; Artificial eyes
- A61F2/16—Intraocular lenses
- A61F2002/1681—Intraocular lenses having supporting structure for lens, e.g. haptics
- A61F2002/1689—Intraocular lenses having supporting structure for lens, e.g. haptics having plate-haptics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2210/00—Particular material properties of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2220/00—Fixations or connections for prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
- A61F2220/0025—Connections or couplings between prosthetic parts, e.g. between modular parts; Connecting elements
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2230/00—Geometry of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
- A61F2230/0002—Two-dimensional shapes, e.g. cross-sections
- A61F2230/0017—Angular shapes
- A61F2230/0019—Angular shapes rectangular
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2250/00—Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
- A61F2250/0058—Additional features; Implant or prostheses properties not otherwise provided for
- A61F2250/0091—Additional features; Implant or prostheses properties not otherwise provided for transparent or translucent
Landscapes
- Health & Medical Sciences (AREA)
- Ophthalmology & Optometry (AREA)
- Cardiology (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Transplantation (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Vascular Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Prostheses (AREA)
- Materials For Medical Uses (AREA)
Abstract
Description
光学本体(1)、支持部(2)及びシリコン連結部品(3)を備える可変多焦点眼内レンズであり、前記シリコン連結部品(3)は、前記光学本体(1)と前記支持部(2)との間に位置し、凹条及び凸条を介した嵌合によって光学本体(1)と支持部(2)とを結合している。
本発明に使用されるシリコン連結部品は、比較的柔軟で弾性の優れた材料であり、眼内の筋肉が緩んだり圧縮されたりする際に、眼内の光学ゾーンを効果的に前後に移動させることができる。
図1〜7を参照すると、可変3焦点眼内レンズは、組立式眼内レンズであり、3つの焦点はそれぞれ13.5D、20D及び23.5Dである。製造方法は以下の通りである。
図1〜7を参照すると、可変3焦点眼内レンズは組立式眼内レンズであり、3つの焦点はそれぞれ10D、20D及び30Dである。製造方法は以下の通りである。
図8を参照すると、可変3焦点眼内レンズは組立式眼内レンズであり、3つの焦点はそれぞれ10D、20D及び30Dである。製造方法は以下の通りである。
3 シリコン連結部品
4 凹条
5 凹条
6 凸条
7 凸条
8 凸条
9 凸条
10 凹条
Claims (8)
- 光学本体(1)、支持部(2)及びシリコン連結部品(3)を含み、前記シリコン連結部品(3)は、前記光学本体(1)と前記支持部(2)との間に位置し、凹条及び凸条を介した嵌合によって前記光学本体(1)と前記支持部(2)とを結合しており、
前記光学本体(1)の両端には凹条(4)が設けられ、前記支持部(2)の前記光学本体(1)と結合された側には凹条(5)が設けられ、
前記光学本体(1)の光学ゾーンは、2焦点、3焦点、焦点深度拡張帯または累進多焦点を有する光学ゾーンであり、
前記シリコン連結部品(3)の幅方向の両端には、それぞれ凸条(6)及び凸条(7)という凸条が設けられていることを特徴とする可変多焦点眼内レンズ。 - 前記凹条及び前記凸条は長方形又は燕尾形であることを特徴とする請求項1に記載の可変多焦点眼内レンズ。
- 前記眼内レンズの直径は11.5〜13.5mmであることを特徴とする請求項1に記載の可変多焦点眼内レンズ。
- 前記光学本体(1)は、屈折率が1.48〜1.56の疎水性ポリアクリル酸エステル光学透明材料で作製され、前記光学本体(1)の有効光学ゾーンの直径は5.5〜6.5mmであることを特徴とする請求項1に記載の可変多焦点眼内レンズ。
- 前記支持部(2)は、疎水性ポリアクリル酸エステル材料又はシリコン強化材料で作製され、前記支持部(2)の厚さは0.18〜0.65mmであり、前記シリコン連結部品(3)の最も厚い部分の厚さは0.18〜0.65mmであることを特徴とする請求項1に記載の可変多焦点眼内レンズ。
- 前記凹条(4)、(5)の深さはいずれも0.1〜0.15mmであり、前記凸条(6)、(7)の高さはいずれも0.1〜0.15mmであり、前記凹条(4)、(5)の深さと前記凸条(6)、(7)の高さとが一致していることを特徴とする請求項1に記載の可変多焦点眼内レンズ。
- 前記凸条(6)、(7)の幅と凹条(4)、(5)の幅とが一致していることを特徴とする請求項1に記載の可変多焦点眼内レンズ。
- 光学本体(1)、支持部(2)及びシリコン連結部品(3)を含み、前記シリコン連結部品(3)は、前記光学本体(1)と前記支持部(2)との間に位置し、凹条及び凸条を介した嵌合によって前記光学本体(1)と前記前記支持部(2)とを結合しており、
前記光学本体(1)の両端の厚さ方向の断面には凸条(8)が設けられ、前記支持部(2)の前記光学本体(1)と結合された側の厚さ方向の断面には凸条(9)が設けられ、
前記シリコン連結部品(3)の幅方向の両端の厚さ方向の断面には、凹条(10)が設けられていることを特徴とする可変多焦点眼内レンズ。
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201611008446.4A CN106667623A (zh) | 2016-11-16 | 2016-11-16 | 一种可变多焦点人工晶状体 |
CN201611008446.4 | 2016-11-16 | ||
PCT/CN2017/109292 WO2018090841A1 (zh) | 2016-11-16 | 2017-11-03 | 一种可变多焦点人工晶状体 |
Publications (2)
Publication Number | Publication Date |
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JP2019504718A true JP2019504718A (ja) | 2019-02-21 |
JP6588169B2 JP6588169B2 (ja) | 2019-10-09 |
Family
ID=58839616
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
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JP2018542743A Active JP6588169B2 (ja) | 2016-11-16 | 2017-11-03 | 可変多焦点眼内レンズ |
Country Status (6)
Country | Link |
---|---|
US (1) | US20180344452A1 (ja) |
EP (1) | EP3400905B1 (ja) |
JP (1) | JP6588169B2 (ja) |
CN (1) | CN106667623A (ja) |
ES (1) | ES2811399T3 (ja) |
WO (1) | WO2018090841A1 (ja) |
Families Citing this family (6)
Publication number | Priority date | Publication date | Assignee | Title |
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CN106667623A (zh) * | 2016-11-16 | 2017-05-17 | 无锡蕾明视康科技有限公司 | 一种可变多焦点人工晶状体 |
CN107212949B (zh) * | 2017-07-12 | 2019-05-14 | 无锡蕾明视康科技有限公司 | 一种多焦点人工晶状体 |
US10663763B2 (en) | 2017-07-12 | 2020-05-26 | Vision Pro (Wuxi) Ltd | Multifocal intraocular lens |
CN108524060A (zh) * | 2018-04-16 | 2018-09-14 | 温州医科大学 | 一种组合式可拆卸可更换光学部的人工晶体系统 |
CN110151358A (zh) * | 2019-06-19 | 2019-08-23 | 沈阳眼产业技术研究院有限公司 | 一种双光学部人工晶体套件及其应用 |
JP2023529241A (ja) | 2020-06-01 | 2023-07-07 | アイケアーズ メディカス インコーポレイテッド | 両面非球面回折多焦点レンズ、その製造、および使用 |
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CN1849103A (zh) * | 2003-08-13 | 2006-10-18 | 卡尔霍恩影像公司 | 可光调节的多焦点透镜 |
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KR20110075018A (ko) * | 2008-10-15 | 2011-07-05 | 알콘, 인코퍼레이티드 | 조절성 안구내 렌즈 |
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CN201888856U (zh) * | 2010-05-17 | 2011-07-06 | 解江冰 | 软性人工晶体装置 |
CN205672112U (zh) * | 2016-04-29 | 2016-11-09 | 河南宇宙人工晶状体研制有限公司 | 一种多焦点人工晶状体 |
CN106667623A (zh) * | 2016-11-16 | 2017-05-17 | 无锡蕾明视康科技有限公司 | 一种可变多焦点人工晶状体 |
CN206621454U (zh) * | 2016-11-16 | 2017-11-10 | 无锡蕾明视康科技有限公司 | 一种可变多焦点人工晶状体 |
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2016
- 2016-11-16 CN CN201611008446.4A patent/CN106667623A/zh active Pending
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2017
- 2017-11-03 WO PCT/CN2017/109292 patent/WO2018090841A1/zh active Application Filing
- 2017-11-03 JP JP2018542743A patent/JP6588169B2/ja active Active
- 2017-11-03 ES ES17870698T patent/ES2811399T3/es active Active
- 2017-11-03 EP EP17870698.2A patent/EP3400905B1/en active Active
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2018
- 2018-07-30 US US16/048,354 patent/US20180344452A1/en not_active Abandoned
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US20040111152A1 (en) * | 2002-12-10 | 2004-06-10 | Kelman Charles David | Accommodating multifocal intraocular lens |
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CN106667623A (zh) | 2017-05-17 |
EP3400905B1 (en) | 2020-06-17 |
EP3400905A4 (en) | 2019-04-10 |
ES2811399T3 (es) | 2021-03-11 |
JP6588169B2 (ja) | 2019-10-09 |
WO2018090841A1 (zh) | 2018-05-24 |
US20180344452A1 (en) | 2018-12-06 |
EP3400905A1 (en) | 2018-11-14 |
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