JP2019504068A5 - - Google Patents
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- Publication number
- JP2019504068A5 JP2019504068A5 JP2018535888A JP2018535888A JP2019504068A5 JP 2019504068 A5 JP2019504068 A5 JP 2019504068A5 JP 2018535888 A JP2018535888 A JP 2018535888A JP 2018535888 A JP2018535888 A JP 2018535888A JP 2019504068 A5 JP2019504068 A5 JP 2019504068A5
- Authority
- JP
- Japan
- Prior art keywords
- domperidone
- gastroparesis
- compound
- therapeutically effective
- effective amount
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 229960001253 domperidone Drugs 0.000 claims description 16
- FGXWKSZFVQUSTL-UHFFFAOYSA-N domperidone Chemical compound C12=CC=CC=C2NC(=O)N1CCCN(CC1)CCC1N1C2=CC=C(Cl)C=C2NC1=O FGXWKSZFVQUSTL-UHFFFAOYSA-N 0.000 claims description 11
- 206010021518 Impaired gastric emptying Diseases 0.000 claims description 8
- 208000001288 gastroparesis Diseases 0.000 claims description 8
- 206010028813 Nausea Diseases 0.000 claims description 5
- 206010047700 Vomiting Diseases 0.000 claims description 5
- 230000006651 lactation Effects 0.000 claims description 5
- 230000008693 nausea Effects 0.000 claims description 5
- 230000007812 deficiency Effects 0.000 claims description 3
- 150000001875 compounds Chemical class 0.000 claims 5
- 150000003839 salts Chemical class 0.000 claims 5
- 230000008673 vomiting Effects 0.000 claims 4
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 102000015554 Dopamine receptor Human genes 0.000 description 4
- 108050004812 Dopamine receptor Proteins 0.000 description 4
- VYFYYTLLBUKUHU-UHFFFAOYSA-N dopamine Chemical compound NCCC1=CC=C(O)C(O)=C1 VYFYYTLLBUKUHU-UHFFFAOYSA-N 0.000 description 2
- 229940079593 drug Drugs 0.000 description 2
- 239000003814 drug Substances 0.000 description 2
- 230000030135 gastric motility Effects 0.000 description 2
- 230000002093 peripheral effect Effects 0.000 description 2
- 208000012661 Dyskinesia Diseases 0.000 description 1
- 206010062767 Hypophysitis Diseases 0.000 description 1
- 208000018737 Parkinson disease Diseases 0.000 description 1
- 102000003946 Prolactin Human genes 0.000 description 1
- 108010057464 Prolactin Proteins 0.000 description 1
- 239000005557 antagonist Substances 0.000 description 1
- 230000003474 anti-emetic effect Effects 0.000 description 1
- 230000008499 blood brain barrier function Effects 0.000 description 1
- 210000001218 blood-brain barrier Anatomy 0.000 description 1
- 239000000969 carrier Substances 0.000 description 1
- 238000005056 compaction Methods 0.000 description 1
- 229960003638 dopamine Drugs 0.000 description 1
- 239000003210 dopamine receptor blocking agent Substances 0.000 description 1
- 238000012377 drug delivery Methods 0.000 description 1
- 210000001198 duodenum Anatomy 0.000 description 1
- 201000006549 dyspepsia Diseases 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 150000002632 lipids Chemical class 0.000 description 1
- 230000004899 motility Effects 0.000 description 1
- 210000003635 pituitary gland Anatomy 0.000 description 1
- 229940097325 prolactin Drugs 0.000 description 1
- 102000005962 receptors Human genes 0.000 description 1
- 108020003175 receptors Proteins 0.000 description 1
- 238000010992 reflux Methods 0.000 description 1
- 210000002784 stomach Anatomy 0.000 description 1
- 210000002438 upper gastrointestinal tract Anatomy 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662291198P | 2016-02-04 | 2016-02-04 | |
| US62/291,198 | 2016-02-04 | ||
| PCT/US2017/016334 WO2017136617A1 (en) | 2016-02-04 | 2017-02-03 | Deuterated domperidone compositions and methods for therapy of disorders |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2019504068A JP2019504068A (ja) | 2019-02-14 |
| JP2019504068A5 true JP2019504068A5 (cg-RX-API-DMAC10.html) | 2020-03-12 |
| JP7296185B2 JP7296185B2 (ja) | 2023-06-22 |
Family
ID=59501077
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018535888A Active JP7296185B2 (ja) | 2016-02-04 | 2017-02-03 | 重水素化ドンペリドン組成物及び疾患の治療方法 |
| JP2019571517A Active JP7602324B2 (ja) | 2016-02-04 | 2018-06-28 | 重水素化ドンペリドン組成物、方法、及び調製 |
| JP2022205876A Pending JP2023052045A (ja) | 2016-02-04 | 2022-12-22 | 重水素化ドンペリドン組成物、方法、及び調製 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019571517A Active JP7602324B2 (ja) | 2016-02-04 | 2018-06-28 | 重水素化ドンペリドン組成物、方法、及び調製 |
| JP2022205876A Pending JP2023052045A (ja) | 2016-02-04 | 2022-12-22 | 重水素化ドンペリドン組成物、方法、及び調製 |
Country Status (11)
| Country | Link |
|---|---|
| US (2) | US10266516B2 (cg-RX-API-DMAC10.html) |
| EP (2) | EP3411031B1 (cg-RX-API-DMAC10.html) |
| JP (3) | JP7296185B2 (cg-RX-API-DMAC10.html) |
| KR (2) | KR102851614B1 (cg-RX-API-DMAC10.html) |
| CN (4) | CN108697700B (cg-RX-API-DMAC10.html) |
| AU (2) | AU2017213852B2 (cg-RX-API-DMAC10.html) |
| BR (2) | BR112018016032B1 (cg-RX-API-DMAC10.html) |
| CA (1) | CA3055777A1 (cg-RX-API-DMAC10.html) |
| DK (2) | DK3411031T3 (cg-RX-API-DMAC10.html) |
| EA (2) | EA035515B1 (cg-RX-API-DMAC10.html) |
| WO (2) | WO2017136617A1 (cg-RX-API-DMAC10.html) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20170042806A1 (en) | 2015-04-29 | 2017-02-16 | Dexcel Pharma Technologies Ltd. | Orally disintegrating compositions |
| CN108697700B (zh) * | 2016-02-04 | 2021-08-17 | 辛多美制药有限公司 | 氘代多潘立酮组合物和用于治疗病症的方法 |
| US11364226B2 (en) | 2017-06-30 | 2022-06-21 | Cinrx Pharma, Llc | Deuterated domperidone compositions, methods, and preparation |
| US10076494B2 (en) | 2016-06-16 | 2018-09-18 | Dexcel Pharma Technologies Ltd. | Stable orally disintegrating pharmaceutical compositions |
| US12478612B2 (en) | 2017-06-30 | 2025-11-25 | Cindome Pharma, Inc. | Deuterated domperidone compositions, methods, and preparation |
| US20210260055A1 (en) * | 2018-06-21 | 2021-08-26 | Dermavant Sciences GmbH | Topical formulations of dgat1 inhibitors and their methods of use |
| KR20210082480A (ko) * | 2018-10-25 | 2021-07-05 | 신돔 파마, 인크. | 돔페리돈을 함유하는 제제 |
| SG11202103284QA (en) * | 2018-10-25 | 2021-05-28 | Cindome Pharma Inc | Formulations containing deuterated domperidone |
| US20220307004A1 (en) * | 2021-03-29 | 2022-09-29 | The Government Of The United States Of America, As Represented By The Secretary Of The Navy | Multi-Enzyme Nanoparticle-Assisted Stable Isotope Incorporation Into Small Molecules by Channeling |
| US20250268884A1 (en) * | 2022-04-20 | 2025-08-28 | Cindome Pharma, Inc. | Deuterated Domperidone for Treating Gastroparesis |
| IL322534A (en) * | 2023-03-23 | 2025-10-01 | Cindome Pharma Inc | Methods for treating diabetic gastroparesis |
Family Cites Families (45)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4066772A (en) | 1975-07-21 | 1978-01-03 | Janssen Pharmaceutica N.V. | 1,3-Dihydro-1-[3-(1-piperidinyl)propyl]-2H-benzimidazol-2-ones and related compounds |
| NZ181256A (en) * | 1975-07-21 | 1978-04-28 | Janssen Pharmaceutica Nv | 1-(w-benzazol-11-ylalkyl)-piperidine derivatives and pharmaceutical compositions containing certain of these derivatives |
| TW466119B (en) * | 1994-02-28 | 2001-12-01 | Janssen Pharmaceutica Nv | Film coated tablet of paracetamol and domperidone |
| FR2725986B1 (fr) * | 1994-10-21 | 1996-11-29 | Adir | Nouveaux derives de piperidine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
| US5773031A (en) | 1996-02-27 | 1998-06-30 | L. Perrigo Company | Acetaminophen sustained-release formulation |
| US20140271788A1 (en) | 2013-03-15 | 2014-09-18 | Monosol Rx, Llc | Sublingual and buccal film compositions |
| US20140070440A1 (en) | 2001-10-12 | 2014-03-13 | Monosol Rx, Llc | Films and Drug Delivery Systems Made Therefrom |
| US20140163060A1 (en) | 2001-10-12 | 2014-06-12 | Monosol Rx, Llc | Films and Drug Delivery Systems Made Therefrom |
| US20130220526A1 (en) | 2001-10-12 | 2013-08-29 | Monosol Rx, Llc | Films and Drug Delivery Systems Made Therefrom |
| US20160206639A9 (en) | 2001-10-12 | 2016-07-21 | Monosol Rx, Llc | Films and Drug Delivery Systems Made Therefrom |
| ITMI20020514A1 (it) | 2002-03-12 | 2003-09-12 | Jagotec Ag | Sistema terapeutico per il rilascio controllato di uno o piu' principi attivi |
| US9101540B2 (en) | 2002-04-12 | 2015-08-11 | Alkermes Pharma Ireland Limited | Nanoparticulate megestrol formulations |
| CN1688294A (zh) | 2002-10-01 | 2005-10-26 | 旗帜药物胶囊公司 | 用于制备软胶囊壁的肠溶组合物 |
| US7387793B2 (en) | 2003-11-14 | 2008-06-17 | Eurand, Inc. | Modified release dosage forms of skeletal muscle relaxants |
| CA2858733C (en) | 2004-12-31 | 2017-12-19 | Iceutica Pty Ltd | Nanoparticle compositions and methods for synthesis thereof |
| ITMI20050477A1 (it) | 2005-03-23 | 2006-09-24 | Bouty S P A | Cerotto transdermico |
| CN100435795C (zh) * | 2006-02-27 | 2008-11-26 | 南京长澳医药科技有限公司 | 一种微粉化马来酸多潘立酮药物组合物及其制备方法 |
| CN100386323C (zh) * | 2006-02-27 | 2008-05-07 | 南京长澳医药科技有限公司 | 马来酸多潘立酮的合成方法 |
| US8846100B2 (en) | 2006-05-12 | 2014-09-30 | Shire Llc | Controlled dose drug delivery system |
| NZ573823A (en) | 2006-06-30 | 2012-05-25 | Iceutica Pty Ltd | Methods for the preparation of biologically active compounds in nanoparticulate form |
| CA2685362A1 (en) | 2007-04-26 | 2008-11-06 | Craig A. Aronchick | Compositions and methods for transmucosal delivery of domperidone |
| MX2010001789A (es) | 2007-08-15 | 2010-03-10 | Mcneil Ppc Inc | Regimen de dosificacion de ibuprofeno de liberacion inmediata y liberacion sostenida. |
| US20090131485A1 (en) | 2007-09-10 | 2009-05-21 | Concert Pharmaceuticals, Inc. | Deuterated pirfenidone |
| US20090076010A1 (en) | 2007-09-13 | 2009-03-19 | Protia, Llc | Deuterium-enriched lamotrigine |
| US20110160253A1 (en) | 2008-05-28 | 2011-06-30 | Harbeson Scott L | Deuterated tizanidine |
| US20100113405A1 (en) * | 2008-11-06 | 2010-05-06 | Auspex Pharmaceuticals, Inc. | Methylindazole modulators of 5-ht3 receptors |
| US20100120733A1 (en) * | 2008-11-07 | 2010-05-13 | Auspex Pharmaceuticals, Inc. | Steroid modulators of glucocorticoid receptor |
| NZ595985A (en) | 2009-04-24 | 2014-07-25 | Iceutica Pty Ltd | A novel formulation of naproxen |
| NZ710384A (en) | 2009-04-24 | 2017-03-31 | Iceutica Pty Ltd | A novel formulation of indomethacin |
| CA2759109A1 (en) | 2009-04-24 | 2010-10-28 | Iceutica Pty Ltd | A solid dosage form of ciprofloxacin having small particle size and improved powder handling characteristics |
| CA2759123C (en) | 2009-04-24 | 2019-01-15 | Iceutica Pty Ltd | Compositions of diclofenac acid with improved dissolution |
| MX360019B (es) | 2009-04-24 | 2018-10-15 | Iceutica Pty Ltd | Una formulación novedosa de metaxalona. |
| US20140017299A1 (en) | 2011-08-18 | 2014-01-16 | Monosol Rx, Llc | Steroid hormone delivery systems and methods of preparing the same |
| JP5093545B1 (ja) | 2012-02-28 | 2012-12-12 | ニチバン株式会社 | 貼付剤 |
| EP3450434B1 (en) | 2012-06-15 | 2021-02-24 | CoNCERT Pharmaceuticals, Inc. | Deuterated derivatives of ruxolitinib |
| ES2822375T3 (es) * | 2012-06-19 | 2021-04-30 | Intercept Pharmaceuticals Inc | Preparación de la forma no cristalina del ácido obeticólico |
| US20140019395A1 (en) | 2012-07-12 | 2014-01-16 | Craig Charles Bauer | Method and application of Fear, Love and Methodology as protocols within and of a programming group, as a means of creating an artificial individual, software system or other independent entity capable of independent self directive creation of choice and/or self directive creation of purpose within a virtual and/or any environment |
| AU2014236597A1 (en) | 2013-03-14 | 2015-09-24 | Deuterx, Llc | 3-(substituted-4-oxo-quinazolin-3(4H)-yl)-3-deutero-piperidine-2,6-dione derivatives |
| US20140271787A1 (en) | 2013-03-15 | 2014-09-18 | Monosol Rx, Llc | Continuous single layer film structure including discrete domains |
| TWI686212B (zh) | 2013-03-15 | 2020-03-01 | 阿聯商太陽法瑪全球有限公司 | 醋酸阿比特龍配方 |
| US20140272220A1 (en) | 2013-03-15 | 2014-09-18 | Monosol Rx, Llc | Reduction in stress cracking of films |
| CN108697700B (zh) | 2016-02-04 | 2021-08-17 | 辛多美制药有限公司 | 氘代多潘立酮组合物和用于治疗病症的方法 |
| US11364226B2 (en) * | 2017-06-30 | 2022-06-21 | Cinrx Pharma, Llc | Deuterated domperidone compositions, methods, and preparation |
| SG11202103284QA (en) * | 2018-10-25 | 2021-05-28 | Cindome Pharma Inc | Formulations containing deuterated domperidone |
| US20250268884A1 (en) * | 2022-04-20 | 2025-08-28 | Cindome Pharma, Inc. | Deuterated Domperidone for Treating Gastroparesis |
-
2017
- 2017-02-03 CN CN201780008640.9A patent/CN108697700B/zh active Active
- 2017-02-03 EP EP17748198.3A patent/EP3411031B1/en active Active
- 2017-02-03 EA EA201891727A patent/EA035515B1/ru not_active IP Right Cessation
- 2017-02-03 WO PCT/US2017/016334 patent/WO2017136617A1/en not_active Ceased
- 2017-02-03 DK DK17748198.3T patent/DK3411031T3/da active
- 2017-02-03 JP JP2018535888A patent/JP7296185B2/ja active Active
- 2017-02-03 AU AU2017213852A patent/AU2017213852B2/en active Active
- 2017-02-03 CN CN202111078948.5A patent/CN113995755A/zh active Pending
- 2017-02-03 KR KR1020187023566A patent/KR102851614B1/ko active Active
- 2017-02-03 BR BR112018016032-6A patent/BR112018016032B1/pt active IP Right Grant
- 2017-06-30 US US15/639,431 patent/US10266516B2/en active Active
-
2018
- 2018-06-28 BR BR112019028185A patent/BR112019028185A8/pt not_active Application Discontinuation
- 2018-06-28 CA CA3055777A patent/CA3055777A1/en active Pending
- 2018-06-28 JP JP2019571517A patent/JP7602324B2/ja active Active
- 2018-06-28 CN CN201880043378.6A patent/CN111093653B/zh active Active
- 2018-06-28 WO PCT/US2018/039928 patent/WO2019006078A1/en not_active Ceased
- 2018-06-28 AU AU2018290905A patent/AU2018290905B2/en active Active
- 2018-06-28 DK DK18743261.2T patent/DK3644995T3/da active
- 2018-06-28 EP EP18743261.2A patent/EP3644995B1/en active Active
- 2018-06-28 KR KR1020207002879A patent/KR102695402B1/ko active Active
- 2018-06-28 EA EA202090183A patent/EA202090183A1/ru unknown
- 2018-06-28 CN CN202310648870.9A patent/CN116712432A/zh active Pending
-
2019
- 2019-04-16 US US16/385,599 patent/US10590110B2/en active Active
-
2022
- 2022-12-22 JP JP2022205876A patent/JP2023052045A/ja active Pending
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