|
US3773919A
(en)
|
1969-10-23 |
1973-11-20 |
Du Pont |
Polylactide-drug mixtures
|
|
US4816567A
(en)
|
1983-04-08 |
1989-03-28 |
Genentech, Inc. |
Recombinant immunoglobin preparations
|
|
US4595654A
(en)
|
1983-11-07 |
1986-06-17 |
Immunomedics Inc. |
Method for detecting immune complexes in serum
|
|
GB8601597D0
(en)
|
1986-01-23 |
1986-02-26 |
Wilson R H |
Nucleotide sequences
|
|
US6548640B1
(en)
|
1986-03-27 |
2003-04-15 |
Btg International Limited |
Altered antibodies
|
|
GB8823869D0
(en)
|
1988-10-12 |
1988-11-16 |
Medical Res Council |
Production of antibodies
|
|
DE3920358A1
(de)
|
1989-06-22 |
1991-01-17 |
Behringwerke Ag |
Bispezifische und oligospezifische, mono- und oligovalente antikoerperkonstrukte, ihre herstellung und verwendung
|
|
US5959177A
(en)
|
1989-10-27 |
1999-09-28 |
The Scripps Research Institute |
Transgenic plants expressing assembled secretory antibodies
|
|
EP1690935A3
(en)
|
1990-01-12 |
2008-07-30 |
Abgenix, Inc. |
Generation of xenogeneic antibodies
|
|
US6075181A
(en)
|
1990-01-12 |
2000-06-13 |
Abgenix, Inc. |
Human antibodies derived from immunized xenomice
|
|
US6150584A
(en)
|
1990-01-12 |
2000-11-21 |
Abgenix, Inc. |
Human antibodies derived from immunized xenomice
|
|
US5545806A
(en)
|
1990-08-29 |
1996-08-13 |
Genpharm International, Inc. |
Ransgenic non-human animals for producing heterologous antibodies
|
|
US5625126A
(en)
|
1990-08-29 |
1997-04-29 |
Genpharm International, Inc. |
Transgenic non-human animals for producing heterologous antibodies
|
|
US5633425A
(en)
|
1990-08-29 |
1997-05-27 |
Genpharm International, Inc. |
Transgenic non-human animals capable of producing heterologous antibodies
|
|
ES2246502T3
(es)
|
1990-08-29 |
2006-02-16 |
Genpharm International, Inc. |
Animales no humanos transgenicos capaces de producir anticuerpos heterologos.
|
|
US5661016A
(en)
|
1990-08-29 |
1997-08-26 |
Genpharm International Inc. |
Transgenic non-human animals capable of producing heterologous antibodies of various isotypes
|
|
EP0604580A1
(en)
|
1991-09-19 |
1994-07-06 |
Genentech, Inc. |
EXPRESSION IN E. COLI OF ANTIBODY FRAGMENTS HAVING AT LEAST A CYSTEINE PRESENT AS A FREE THIOL, USE FOR THE PRODUCTION OF BIFUNCTIONAL F(ab') 2? ANTIBODIES
|
|
DE69233528T2
(de)
|
1991-11-25 |
2006-03-16 |
Enzon, Inc. |
Verfahren zur Herstellung von multivalenten antigenbindenden Proteinen
|
|
WO1995005864A1
(en)
|
1993-08-27 |
1995-03-02 |
Government Of The United States Of America, Represented By The Secretary Of The Department Of Health And Human Services |
Convection-enhanced drug delivery
|
|
US5789199A
(en)
|
1994-11-03 |
1998-08-04 |
Genentech, Inc. |
Process for bacterial production of polypeptides
|
|
US5840523A
(en)
|
1995-03-01 |
1998-11-24 |
Genetech, Inc. |
Methods and compositions for secretion of heterologous polypeptides
|
|
US5641870A
(en)
|
1995-04-20 |
1997-06-24 |
Genentech, Inc. |
Low pH hydrophobic interaction chromatography for antibody purification
|
|
CA2219361C
(en)
|
1995-04-27 |
2012-02-28 |
Abgenix, Inc. |
Human antibodies derived from immunized xenomice
|
|
WO1996034096A1
(en)
|
1995-04-28 |
1996-10-31 |
Abgenix, Inc. |
Human antibodies derived from immunized xenomice
|
|
US6717031B2
(en)
|
1995-06-07 |
2004-04-06 |
Kate Dora Games |
Method for selecting a transgenic mouse model of alzheimer's disease
|
|
US20020058311A1
(en)
|
1995-06-13 |
2002-05-16 |
Browne Michael Jospeh |
Chimeric leptin fused to immunoglobulin domain and use
|
|
US6037454A
(en)
|
1996-11-27 |
2000-03-14 |
Genentech, Inc. |
Humanized anti-CD11a antibodies
|
|
AU731817C
(en)
|
1996-11-27 |
2001-11-01 |
Genentech Inc. |
Humanized anti-CD11a antibodies
|
|
EP1972194A1
(en)
|
1996-12-03 |
2008-09-24 |
Amgen Fremont Inc. |
Transgenic mammals having human ig loci including plural vh and vk regions and antibodies produced therefrom
|
|
US20050197285A1
(en)
|
1997-03-07 |
2005-09-08 |
Rosen Craig A. |
Human secreted proteins
|
|
US20020062010A1
(en)
|
1997-05-02 |
2002-05-23 |
Genentech, Inc. |
Method for making multispecific antibodies having heteromultimeric and common components
|
|
US6040498A
(en)
|
1998-08-11 |
2000-03-21 |
North Caroline State University |
Genetically engineered duckweed
|
|
CA2301660A1
(en)
|
1997-08-26 |
1999-03-04 |
Zymogenetics, Inc. |
Adipocyte-specific protein homologs
|
|
US5968829A
(en)
|
1997-09-05 |
1999-10-19 |
Cytotherapeutics, Inc. |
Human CNS neural stem cells
|
|
US6638501B1
(en)
|
1997-09-29 |
2003-10-28 |
Neurospheres Holdings Ltd. |
Use of multipotent neural stem cell progeny to augment non-neural tissues
|
|
WO1999029888A1
(en)
|
1997-12-05 |
1999-06-17 |
The Scripps Research Institute |
Humanization of murine antibody
|
|
US5958767A
(en)
|
1998-08-14 |
1999-09-28 |
The Children's Medical Center Corp. |
Engraftable human neural stem cells
|
|
US20030170781A1
(en)
|
1999-07-01 |
2003-09-11 |
Zymogenetics, Inc. |
Secreted protein zacrp4
|
|
US7125978B1
(en)
|
1999-10-04 |
2006-10-24 |
Medicago Inc. |
Promoter for regulating expression of foreign genes
|
|
KR100797667B1
(ko)
|
1999-10-04 |
2008-01-23 |
메디카고 인코포레이티드 |
외래 유전자의 전사를 조절하는 방법
|
|
AU2913801A
(en)
|
1999-12-23 |
2001-07-03 |
Cornell Research Foundation Inc. |
A method for isolating and purifying multipotential neural progenitor cells and multipotential neural progenitor cells
|
|
WO2002005634A2
(en)
|
2000-07-13 |
2002-01-24 |
University Of South Florida |
Transgenic animal and methods
|
|
US6872559B2
(en)
|
2000-10-26 |
2005-03-29 |
Wisconsin Alumni Research Foundation |
E. coli O157:H7 C1 esterase inhibitor-binding protein and methods of use
|
|
PL362324A1
(en)
|
2001-02-19 |
2004-10-18 |
Merck Patent Gmbh |
Artificial fusion proteins with reduced immunogenicity
|
|
WO2003052377A2
(en)
|
2001-11-07 |
2003-06-26 |
Human Genome Sciences, Inc. |
41 human secreted proteins
|
|
US20040248156A1
(en)
|
2001-12-03 |
2004-12-09 |
Tianhua Hu |
Methods and materials relating to novel C1q domain-containing polypeptides and polynucleotides
|
|
US20050214786A1
(en)
|
2002-02-22 |
2005-09-29 |
Human Genome Sciences, Inc. |
26 human secreted proteins
|
|
WO2004042072A2
(en)
|
2002-11-01 |
2004-05-21 |
The Regents Of The University Of Colorado, A Body Corporate |
Quantitative analysis of protein isoforms using matrix-assisted laser desorption/ionization time of flight mass spectrometry
|
|
EP2266606B1
(en)
|
2003-05-15 |
2014-09-10 |
Genentech, Inc. |
Methods and compositions for the prevention and treatment of sepsis
|
|
WO2005002513A2
(en)
|
2003-06-16 |
2005-01-13 |
The Brigham And Women's Hospital, Inc. |
C1q complement inhibitors and methods of use thereof
|
|
WO2005002512A2
(en)
|
2003-06-19 |
2005-01-13 |
University Of Rochester |
Immunotherapeutic vaccine strategy
|
|
US8501705B2
(en)
|
2003-09-11 |
2013-08-06 |
The Board Of Regents Of The University Of Texas System |
Methods and materials for treating autoimmune and/or complement mediated diseases and conditions
|
|
PT1718677E
(pt)
|
2003-12-19 |
2012-07-18 |
Genentech Inc |
Fragmentos de anticorpo monovalentes úteis como agentes terapêuticos
|
|
CN101001872A
(zh)
*
|
2004-04-16 |
2007-07-18 |
宏观基因有限公司 |
FcγRIIB－特异性抗体及其使用方法
|
|
US7544855B2
(en)
|
2004-04-23 |
2009-06-09 |
Buck Institute |
Transgenic mouse whose genome comprises an APP having a mutation at amino acid 664
|
|
US20080008719A1
(en)
|
2004-07-10 |
2008-01-10 |
Bowdish Katherine S |
Methods and compositions for the treatment of prostate cancer
|
|
US8420783B2
(en)
|
2004-12-08 |
2013-04-16 |
Immunomedics, Inc. |
Method and compositions for immunotherapy of inflammatory and immune-dysregulatory diseases
|
|
BRPI0518994A2
(pt)
|
2004-12-31 |
2008-12-02 |
Biogen Idec Inc |
anticorpos ou polipeptÍdeos que se ligam a br3, seus usos e formulaÇÕes lÍquidas
|
|
AU2005227420B2
(en)
|
2005-10-14 |
2013-05-09 |
Alltech, Inc. |
Method and compositions for altering cell function
|
|
US8148330B2
(en)
|
2005-12-09 |
2012-04-03 |
The Board Of Trustees Of The Leland Stanford Junior University |
Modulation of synaptic maintenance
|
|
US9480658B2
(en)
*
|
2005-12-09 |
2016-11-01 |
The Board Of Trustees Of The Leland Stanford Junior University |
Modulation of synaptic maintenance
|
|
MY169492A
(en)
|
2006-03-23 |
2019-04-15 |
Bioarctic Neuroscience Ab |
Improved protofibril selective antibodies and the use thereof
|
|
US7919079B2
(en)
*
|
2006-03-31 |
2011-04-05 |
Biosante Pharmaceuticals, Inc. |
Cancer immunotherapy compositions and methods of use
|
|
WO2008030505A2
(en)
|
2006-09-05 |
2008-03-13 |
Alexion Pharmaceuticals, Inc. |
Methods and compositions for the treatment of antibody mediated neuropathies
|
|
CN101657097A
(zh)
|
2007-03-01 |
2010-02-24 |
先进视觉疗法公司 |
以炎症为特征的疾病的治疗
|
|
CA2707859A1
(en)
|
2007-12-11 |
2009-06-18 |
Glaxo Group Limited |
Antigen binding proteins specific against beta amyloid
|
|
CR20170001A
(es)
*
|
2008-04-28 |
2017-08-10 |
Genentech Inc |
Anticuerpos anti factor d humanizados
|
|
AU2009322607B2
(en)
|
2008-12-01 |
2015-05-14 |
The Board Of Trustees Of The Leland Stanford Junior University |
Methods and compositions for detection of complement fixing antibodies
|
|
EP2426916A4
(en)
|
2009-04-28 |
2017-09-06 |
Panasonic Corporation |
Receiver
|
|
WO2012067267A1
(en)
|
2010-11-18 |
2012-05-24 |
Takahiro Ochi |
TESTING METHOD USING ANTI-C1q MONOCLONAL ANTIBODY
|
|
EP2714737A1
(en)
|
2011-05-27 |
2014-04-09 |
Glaxo Group Limited |
Bcma (cd269/tnfrsf17) -binding proteins
|
|
JPWO2012176765A1
(ja)
|
2011-06-24 |
2015-02-23 |
株式会社ペルセウスプロテオミクス |
抗ヒトｐ−カドへリン（ｃｄｈ３）遺伝子組み換え抗体
|
|
US9527927B2
(en)
|
2011-12-20 |
2016-12-27 |
Medimmune, Llc |
Modified polypeptides for bispecific antibody scaffolds
|
|
EP2847224A4
(en)
|
2012-05-10 |
2016-04-27 |
Zymeworks Inc |
SINGLE ARM MONOVALENT ANTIBODY CONSTRUCTS AND USES THEREOF
|
|
PT2861246T
(pt)
|
2012-06-18 |
2021-04-05 |
Univ Leicester |
Composições e métodos para inibir masp-1 e/ou masp-2 e/ou masp-3 para o tratamento de várias doenças e perturbações
|
|
WO2014066744A2
(en)
|
2012-10-25 |
2014-05-01 |
True North Therapeutics, Inc. |
Anti-complement c1s antibodies and uses thereof
|
|
ES2912396T3
(es)
|
2012-11-02 |
2022-05-25 |
Bioverativ Usa Inc |
Anticuerpos anti-C1s del complemento y uso de los mismos
|
|
WO2014161570A1
(en)
|
2013-04-03 |
2014-10-09 |
Roche Glycart Ag |
Antibodies against human il17 and uses thereof
|
|
US20160053023A1
(en)
|
2013-04-09 |
2016-02-25 |
Annexon, Inc. |
Methods of treatment for neuromyelitis optica
|
|
EP2997045A4
(en)
|
2013-05-15 |
2016-11-23 |
Annexon Inc |
ANTI-FACTOR C1S ANTIBODIES OF THE COMPLEMENT AND USES THEREOF
|
|
SG11201510316UA
(en)
|
2013-07-09 |
2016-01-28 |
Annexon Inc |
Anti-complement factor c1q antibodies and uses thereof
|
|
PL3215527T3
(pl)
*
|
2014-11-05 |
2025-04-28 |
Annexon, Inc. |
Humanizowane przeciwciała przeciwko czynnikowi dopełniacza C1Q i ich zastosowanie
|
|
FI3380518T3
(fi)
|
2015-11-24 |
2026-05-29 |
Annexon Inc |
Antikomplementtitekijä-C1Q:n Fab-fragmentteja ja niiden käyttöjä
|
|
US20190161535A1
(en)
*
|
2016-05-09 |
2019-05-30 |
Annexon, Inc. |
Compositions and methods for treating spinal muscular atrophy
|
|
EP3487531A4
(en)
*
|
2016-07-19 |
2020-03-25 |
Annexon, Inc. |
TREATMENT OF FRONTO-TEMPORAL DEMENTIA
|
|
TWI915400B
(zh)
|
2020-08-14 |
2026-02-21 |
日商中外製藥股份有限公司 |
單臂抗原結合分子及其用途
|
|
CN116782940A
(zh)
|
2020-12-04 |
2023-09-19 |
安尼艾克松股份有限公司 |
用于治疗眼部疾病的组合物和方法
|