JP2019201631A - 治療用微小胞と幹細胞の合成 - Google Patents

治療用微小胞と幹細胞の合成 Download PDF

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JP2019201631A
JP2019201631A JP2019011767A JP2019011767A JP2019201631A JP 2019201631 A JP2019201631 A JP 2019201631A JP 2019011767 A JP2019011767 A JP 2019011767A JP 2019011767 A JP2019011767 A JP 2019011767A JP 2019201631 A JP2019201631 A JP 2019201631A
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isoxazole
pyrrolo
carboxylic acid
dione
cells
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アシュラフ,ムハンマド
Ashraf Muhammad
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JP2019011767A 2018-01-26 2019-01-28 治療用微小胞と幹細胞の合成 Pending JP2019201631A (ja)

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Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2022080455A1 (ja) * 2020-10-14 2022-04-21 ダ・ヴィンチ ユニバーサル株式会社 心筋幹/前駆細胞の作製方法及び心筋線維化抑制方法
WO2023079655A1 (ja) * 2021-11-04 2023-05-11 株式会社リバティソリューション エクソソーム抽出方法
KR20230140140A (ko) * 2022-03-29 2023-10-06 박동선 Tsg101 단백질을 암호화하는 폴리뉴클레오티드가 도입된 줄기세포 및 이의 용도
JP2023145686A (ja) * 2018-01-26 2023-10-11 アシュラフ,ムハンマド 治療用途のための微小胞および幹細胞組成物
JP2023550453A (ja) * 2020-11-18 2023-12-01 富士フイルム株式会社 セクレトーム含有組成物の生成、並びにその使用及び分析方法
US12584906B2 (en) 2020-02-10 2026-03-24 Public University Corporation Nagoya City University Coating agent for inducing differentiation of pluripotent stem cells into brain microvascular endothelium-like cells and use thereof

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2014197421A1 (en) 2013-06-05 2014-12-11 Biotime, Inc. Compositions and methods for induced tissue regeneration in mammalian species
CA3202332A1 (en) 2015-12-07 2017-06-15 Agex Therapeutics, Inc. Methods for the re-derivation of diverse pluripotent stem cell-derived brown fat cells
KR20180057546A (ko) * 2016-11-21 2018-05-30 성균관대학교산학협력단 지방줄기세포유래 엑소좀을 유효성분으로 포함하는 간 섬유증 예방 또는 치료용 조성물
CN112334190B (zh) * 2018-04-30 2024-09-20 儿童医学中心公司 间充质基质细胞外排体及其用途
CN109266603A (zh) * 2018-08-29 2019-01-25 浙江大学 一种提高心梗疗效的外泌体及应用
US12508325B2 (en) 2018-12-20 2025-12-30 Ohio State Innovation Foundation Compositions and methods for reprogramming diseased musculoskeletal cells
WO2020132161A1 (en) * 2018-12-21 2020-06-25 The Regents Of The University Of California Compositions and methods for treating hearing loss
CN114207110A (zh) * 2019-03-28 2022-03-18 Agex治疗公司 使用细胞外囊泡诱导的组织再生
KR20220039647A (ko) * 2019-04-03 2022-03-29 더 존스 홉킨스 유니버시티 골격근 줄기세포 생성 및 질환 치료를 위한 방법, 조성물 및 키트
US20220233604A1 (en) * 2019-05-15 2022-07-28 The Board Of Trustees Of The Leland Stanford Junior University Methods and compositions for treating cardiomyocytes
CN110257333A (zh) * 2019-05-27 2019-09-20 江苏大学 一种神经干细胞微囊泡及其应用
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WO2021114164A1 (zh) * 2019-12-12 2021-06-17 中国科学院深圳先进技术研究院 一种外泌体及其制备方法及应用
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CN112608972B (zh) * 2020-12-21 2021-09-10 广东源心再生医学有限公司 Myog基因作为靶点在制备治疗心肌细胞凋亡相关的心血管疾病的药物中的应用
CN114645021A (zh) * 2020-12-21 2022-06-21 未来智人再生医学研究院(广州)有限公司 一种表达靶向cd47抑制因子的多能干细胞及其衍生物与应用
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CN113322226A (zh) * 2021-06-28 2021-08-31 华南理工大学 三维培养胚胎干细胞来源的外泌体及在制备治疗肝纤维化药物的应用
WO2023136313A1 (ja) * 2022-01-14 2023-07-20 国立大学法人大阪大学 肝機能障害を処置するための組成物
WO2023154466A1 (en) * 2022-02-11 2023-08-17 The University Of North Carolina At Chapel Hill Arylbenzoisoxazole compounds as ip6k and ipmk inhibitors and methods of use thereof
PL443827A1 (pl) * 2023-02-18 2024-08-19 Uniwersytet Jagielloński Sposób otrzymywania pęcherzyków zewnątrzkomórkowych (EVs) pochodzących z indukowanych pluripotencjalnych komórek macierzystych (iPSC) oraz ich zastosowanie
WO2025117472A1 (en) * 2023-11-30 2025-06-05 Immorta Bio, Inc. Treatment of heart failure using pluripotent stem cell derived cardiomyocytes and derivatives thereof
WO2025160404A1 (en) * 2024-01-26 2025-07-31 FUJIFILM Cellular Dynamics, Inc. Generation of secretome-containing compositions, and methods of using and analyzing the same
WO2025247999A1 (en) * 2024-05-30 2025-12-04 Conveyxo Method for the production of extracellular vesicles loaded with a molecule of interest and composition comprising such extracellular vesicles
EP4656187A1 (en) * 2024-05-30 2025-12-03 ConvEyXo Method for the production of extracellular vesicles loaded with a molecule of interest and composition comprising such extracellular vesicles
CN120131648B (zh) * 2025-03-06 2025-11-25 上海市重大传染病和生物安全研究院 一种hiv-1潜伏感染激活剂、药物及用途
CN120437124A (zh) * 2025-06-10 2025-08-08 南方医科大学 小分子isx-9在促进间充质干细胞成骨分化和骨损伤再生修复中的应用

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2017513482A (ja) * 2014-04-17 2017-06-01 アシュラフ, ムハンマドASHRAF, Muhammad 安全な治療のための化学的人工多能性幹細胞

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10443044B2 (en) 2014-04-17 2019-10-15 Ips Heart Generating cardiac progenitor cells from pluripotent stem cells using isoxazole or isoxazole like compounds
US20180273906A1 (en) 2014-04-17 2018-09-27 Muhammad Ashraf Microvesicle and stem cell compositions for therapeutic applications
WO2016108288A1 (ja) 2014-12-29 2016-07-07 国立大学法人京都大学 骨格筋前駆細胞の製造方法
WO2017196175A1 (en) 2016-05-12 2017-11-16 Erasmus University Medical Center Rotterdam A method for culturing myogenic cells, cultures obtained therefrom, screening methods, and cell culture medium.

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2017513482A (ja) * 2014-04-17 2017-06-01 アシュラフ, ムハンマドASHRAF, Muhammad 安全な治療のための化学的人工多能性幹細胞

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
STEM CELLS INTERNATIONAL, vol. Vol.2017, Article ID 5785436, JPN7023000709, 15 October 2017 (2017-10-15), pages 1 - 14, ISSN: 0005168820 *

Cited By (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2023145686A (ja) * 2018-01-26 2023-10-11 アシュラフ,ムハンマド 治療用途のための微小胞および幹細胞組成物
JP7837302B2 (ja) 2018-01-26 2026-03-30 アシュラフ,ムハンマド 治療用途のための微小胞および幹細胞組成物
US12584906B2 (en) 2020-02-10 2026-03-24 Public University Corporation Nagoya City University Coating agent for inducing differentiation of pluripotent stem cells into brain microvascular endothelium-like cells and use thereof
WO2022080455A1 (ja) * 2020-10-14 2022-04-21 ダ・ヴィンチ ユニバーサル株式会社 心筋幹/前駆細胞の作製方法及び心筋線維化抑制方法
JP2025106562A (ja) * 2020-10-14 2025-07-15 ダ・ヴィンチ ユニバーサル株式会社 心筋幹/前駆細胞の作製方法及び心筋線維化抑制方法
JP2023550453A (ja) * 2020-11-18 2023-12-01 富士フイルム株式会社 セクレトーム含有組成物の生成、並びにその使用及び分析方法
WO2023079655A1 (ja) * 2021-11-04 2023-05-11 株式会社リバティソリューション エクソソーム抽出方法
KR20230140140A (ko) * 2022-03-29 2023-10-06 박동선 Tsg101 단백질을 암호화하는 폴리뉴클레오티드가 도입된 줄기세포 및 이의 용도
KR102816689B1 (ko) 2022-03-29 2025-06-02 박동선 Tsg101 단백질을 암호화하는 폴리뉴클레오티드가 도입된 줄기세포 및 이의 용도

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