JP2019201631A - 治療用微小胞と幹細胞の合成 - Google Patents
治療用微小胞と幹細胞の合成 Download PDFInfo
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- JP2019201631A JP2019201631A JP2019011767A JP2019011767A JP2019201631A JP 2019201631 A JP2019201631 A JP 2019201631A JP 2019011767 A JP2019011767 A JP 2019011767A JP 2019011767 A JP2019011767 A JP 2019011767A JP 2019201631 A JP2019201631 A JP 2019201631A
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- isoxazole
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- carboxylic acid
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- C12N5/06—Animal cells or tissues; Human cells or tissues
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/42—Oxazoles
- A61K31/422—Oxazoles not condensed and containing further heterocyclic rings
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- A61K31/58—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
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- A61K31/7088—Compounds having three or more nucleosides or nucleotides
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- A61K31/713—Double-stranded nucleic acids or oligonucleotides
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- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
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- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/48—Reproductive organs
- A61K35/54—Ovaries; Ova; Ovules; Embryos; Foetal cells; Germ cells
- A61K35/545—Embryonic stem cells; Pluripotent stem cells; Induced pluripotent stem cells; Uncharacterised stem cells
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
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- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
- C12N5/0657—Cardiomyocytes; Heart cells
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- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
- C12N5/0658—Skeletal muscle cells, e.g. myocytes, myotubes, myoblasts
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- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
- C12N5/0661—Smooth muscle cells
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- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
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- C12N5/069—Vascular Endothelial cells
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- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/70—Enzymes
- C12N2501/72—Transferases [EC 2.]
- C12N2501/727—Kinases (EC 2.7.)
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- C12N2502/00—Coculture with; Conditioned medium produced by
- C12N2502/13—Coculture with; Conditioned medium produced by connective tissue cells; generic mesenchyme cells, e.g. so-called "embryonic fibroblasts"
- C12N2502/1329—Cardiomyocytes
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- C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
- C12N2506/45—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from artificially induced pluripotent stem cells
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- Animal Behavior & Ethology (AREA)
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- Transplantation (AREA)
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- Cardiology (AREA)
- Gynecology & Obstetrics (AREA)
- Emergency Medicine (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2023126654A JP7837302B2 (ja) | 2018-01-26 | 2023-08-03 | 治療用途のための微小胞および幹細胞組成物 |
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US15/881,693 US20180273906A1 (en) | 2014-04-17 | 2018-01-26 | Microvesicle and stem cell compositions for therapeutic applications |
| US15/881,693 | 2018-01-26 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023126654A Division JP7837302B2 (ja) | 2018-01-26 | 2023-08-03 | 治療用途のための微小胞および幹細胞組成物 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2019201631A true JP2019201631A (ja) | 2019-11-28 |
| JP2019201631A5 JP2019201631A5 (https=) | 2022-03-08 |
Family
ID=68725220
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019011767A Pending JP2019201631A (ja) | 2018-01-26 | 2019-01-28 | 治療用微小胞と幹細胞の合成 |
| JP2023126654A Active JP7837302B2 (ja) | 2018-01-26 | 2023-08-03 | 治療用途のための微小胞および幹細胞組成物 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023126654A Active JP7837302B2 (ja) | 2018-01-26 | 2023-08-03 | 治療用途のための微小胞および幹細胞組成物 |
Country Status (2)
| Country | Link |
|---|---|
| US (2) | US20180273906A1 (https=) |
| JP (2) | JP2019201631A (https=) |
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2022080455A1 (ja) * | 2020-10-14 | 2022-04-21 | ダ・ヴィンチ ユニバーサル株式会社 | 心筋幹/前駆細胞の作製方法及び心筋線維化抑制方法 |
| WO2023079655A1 (ja) * | 2021-11-04 | 2023-05-11 | 株式会社リバティソリューション | エクソソーム抽出方法 |
| KR20230140140A (ko) * | 2022-03-29 | 2023-10-06 | 박동선 | Tsg101 단백질을 암호화하는 폴리뉴클레오티드가 도입된 줄기세포 및 이의 용도 |
| JP2023145686A (ja) * | 2018-01-26 | 2023-10-11 | アシュラフ,ムハンマド | 治療用途のための微小胞および幹細胞組成物 |
| JP2023550453A (ja) * | 2020-11-18 | 2023-12-01 | 富士フイルム株式会社 | セクレトーム含有組成物の生成、並びにその使用及び分析方法 |
| US12584906B2 (en) | 2020-02-10 | 2026-03-24 | Public University Corporation Nagoya City University | Coating agent for inducing differentiation of pluripotent stem cells into brain microvascular endothelium-like cells and use thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2014197421A1 (en) | 2013-06-05 | 2014-12-11 | Biotime, Inc. | Compositions and methods for induced tissue regeneration in mammalian species |
| CA3202332A1 (en) | 2015-12-07 | 2017-06-15 | Agex Therapeutics, Inc. | Methods for the re-derivation of diverse pluripotent stem cell-derived brown fat cells |
| KR20180057546A (ko) * | 2016-11-21 | 2018-05-30 | 성균관대학교산학협력단 | 지방줄기세포유래 엑소좀을 유효성분으로 포함하는 간 섬유증 예방 또는 치료용 조성물 |
| CN112334190B (zh) * | 2018-04-30 | 2024-09-20 | 儿童医学中心公司 | 间充质基质细胞外排体及其用途 |
| CN109266603A (zh) * | 2018-08-29 | 2019-01-25 | 浙江大学 | 一种提高心梗疗效的外泌体及应用 |
| US12508325B2 (en) | 2018-12-20 | 2025-12-30 | Ohio State Innovation Foundation | Compositions and methods for reprogramming diseased musculoskeletal cells |
| WO2020132161A1 (en) * | 2018-12-21 | 2020-06-25 | The Regents Of The University Of California | Compositions and methods for treating hearing loss |
| CN114207110A (zh) * | 2019-03-28 | 2022-03-18 | Agex治疗公司 | 使用细胞外囊泡诱导的组织再生 |
| KR20220039647A (ko) * | 2019-04-03 | 2022-03-29 | 더 존스 홉킨스 유니버시티 | 골격근 줄기세포 생성 및 질환 치료를 위한 방법, 조성물 및 키트 |
| US20220233604A1 (en) * | 2019-05-15 | 2022-07-28 | The Board Of Trustees Of The Leland Stanford Junior University | Methods and compositions for treating cardiomyocytes |
| CN110257333A (zh) * | 2019-05-27 | 2019-09-20 | 江苏大学 | 一种神经干细胞微囊泡及其应用 |
| CN110724665A (zh) * | 2019-11-21 | 2020-01-24 | 西安外事学院 | 一种iPS细胞培养上清液及其制备方法和应用 |
| WO2021114164A1 (zh) * | 2019-12-12 | 2021-06-17 | 中国科学院深圳先进技术研究院 | 一种外泌体及其制备方法及应用 |
| CN111961645A (zh) * | 2020-09-01 | 2020-11-20 | 杭州优渡生物科技有限公司 | 一种高效扩增人表皮成纤维细胞的培养基 |
| CN112608972B (zh) * | 2020-12-21 | 2021-09-10 | 广东源心再生医学有限公司 | Myog基因作为靶点在制备治疗心肌细胞凋亡相关的心血管疾病的药物中的应用 |
| CN114645021A (zh) * | 2020-12-21 | 2022-06-21 | 未来智人再生医学研究院(广州)有限公司 | 一种表达靶向cd47抑制因子的多能干细胞及其衍生物与应用 |
| CN114657130A (zh) * | 2020-12-22 | 2022-06-24 | 未来智人再生医学研究院(广州)有限公司 | 一种表达vegf-a靶向抑制因子的多能干细胞及其衍生物与应用 |
| CN113209135B (zh) * | 2021-04-23 | 2023-06-13 | 奥启(深圳)生物科技有限公司 | 一种用于延缓皮肤衰老的间充质干细胞外泌体制剂 |
| CN113322226A (zh) * | 2021-06-28 | 2021-08-31 | 华南理工大学 | 三维培养胚胎干细胞来源的外泌体及在制备治疗肝纤维化药物的应用 |
| WO2023136313A1 (ja) * | 2022-01-14 | 2023-07-20 | 国立大学法人大阪大学 | 肝機能障害を処置するための組成物 |
| WO2023154466A1 (en) * | 2022-02-11 | 2023-08-17 | The University Of North Carolina At Chapel Hill | Arylbenzoisoxazole compounds as ip6k and ipmk inhibitors and methods of use thereof |
| PL443827A1 (pl) * | 2023-02-18 | 2024-08-19 | Uniwersytet Jagielloński | Sposób otrzymywania pęcherzyków zewnątrzkomórkowych (EVs) pochodzących z indukowanych pluripotencjalnych komórek macierzystych (iPSC) oraz ich zastosowanie |
| WO2025117472A1 (en) * | 2023-11-30 | 2025-06-05 | Immorta Bio, Inc. | Treatment of heart failure using pluripotent stem cell derived cardiomyocytes and derivatives thereof |
| WO2025160404A1 (en) * | 2024-01-26 | 2025-07-31 | FUJIFILM Cellular Dynamics, Inc. | Generation of secretome-containing compositions, and methods of using and analyzing the same |
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| CN120131648B (zh) * | 2025-03-06 | 2025-11-25 | 上海市重大传染病和生物安全研究院 | 一种hiv-1潜伏感染激活剂、药物及用途 |
| CN120437124A (zh) * | 2025-06-10 | 2025-08-08 | 南方医科大学 | 小分子isx-9在促进间充质干细胞成骨分化和骨损伤再生修复中的应用 |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2017513482A (ja) * | 2014-04-17 | 2017-06-01 | アシュラフ, ムハンマドASHRAF, Muhammad | 安全な治療のための化学的人工多能性幹細胞 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10443044B2 (en) | 2014-04-17 | 2019-10-15 | Ips Heart | Generating cardiac progenitor cells from pluripotent stem cells using isoxazole or isoxazole like compounds |
| US20180273906A1 (en) | 2014-04-17 | 2018-09-27 | Muhammad Ashraf | Microvesicle and stem cell compositions for therapeutic applications |
| WO2016108288A1 (ja) | 2014-12-29 | 2016-07-07 | 国立大学法人京都大学 | 骨格筋前駆細胞の製造方法 |
| WO2017196175A1 (en) | 2016-05-12 | 2017-11-16 | Erasmus University Medical Center Rotterdam | A method for culturing myogenic cells, cultures obtained therefrom, screening methods, and cell culture medium. |
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2018
- 2018-01-26 US US15/881,693 patent/US20180273906A1/en active Pending
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2019
- 2019-01-28 JP JP2019011767A patent/JP2019201631A/ja active Pending
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2020
- 2020-02-19 US US16/795,217 patent/US20210054344A1/en not_active Abandoned
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2023
- 2023-08-03 JP JP2023126654A patent/JP7837302B2/ja active Active
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2017513482A (ja) * | 2014-04-17 | 2017-06-01 | アシュラフ, ムハンマドASHRAF, Muhammad | 安全な治療のための化学的人工多能性幹細胞 |
Non-Patent Citations (1)
| Title |
|---|
| STEM CELLS INTERNATIONAL, vol. Vol.2017, Article ID 5785436, JPN7023000709, 15 October 2017 (2017-10-15), pages 1 - 14, ISSN: 0005168820 * |
Cited By (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2023145686A (ja) * | 2018-01-26 | 2023-10-11 | アシュラフ,ムハンマド | 治療用途のための微小胞および幹細胞組成物 |
| JP7837302B2 (ja) | 2018-01-26 | 2026-03-30 | アシュラフ,ムハンマド | 治療用途のための微小胞および幹細胞組成物 |
| US12584906B2 (en) | 2020-02-10 | 2026-03-24 | Public University Corporation Nagoya City University | Coating agent for inducing differentiation of pluripotent stem cells into brain microvascular endothelium-like cells and use thereof |
| WO2022080455A1 (ja) * | 2020-10-14 | 2022-04-21 | ダ・ヴィンチ ユニバーサル株式会社 | 心筋幹/前駆細胞の作製方法及び心筋線維化抑制方法 |
| JP2025106562A (ja) * | 2020-10-14 | 2025-07-15 | ダ・ヴィンチ ユニバーサル株式会社 | 心筋幹/前駆細胞の作製方法及び心筋線維化抑制方法 |
| JP2023550453A (ja) * | 2020-11-18 | 2023-12-01 | 富士フイルム株式会社 | セクレトーム含有組成物の生成、並びにその使用及び分析方法 |
| WO2023079655A1 (ja) * | 2021-11-04 | 2023-05-11 | 株式会社リバティソリューション | エクソソーム抽出方法 |
| KR20230140140A (ko) * | 2022-03-29 | 2023-10-06 | 박동선 | Tsg101 단백질을 암호화하는 폴리뉴클레오티드가 도입된 줄기세포 및 이의 용도 |
| KR102816689B1 (ko) | 2022-03-29 | 2025-06-02 | 박동선 | Tsg101 단백질을 암호화하는 폴리뉴클레오티드가 도입된 줄기세포 및 이의 용도 |
Also Published As
| Publication number | Publication date |
|---|---|
| US20180273906A1 (en) | 2018-09-27 |
| JP2023145686A (ja) | 2023-10-11 |
| JP7837302B2 (ja) | 2026-03-30 |
| US20210054344A1 (en) | 2021-02-25 |
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