JP2019199434A5 - - Google Patents
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- JP2019199434A5 JP2019199434A5 JP2018094498A JP2018094498A JP2019199434A5 JP 2019199434 A5 JP2019199434 A5 JP 2019199434A5 JP 2018094498 A JP2018094498 A JP 2018094498A JP 2018094498 A JP2018094498 A JP 2018094498A JP 2019199434 A5 JP2019199434 A5 JP 2019199434A5
- Authority
- JP
- Japan
- Prior art keywords
- hair
- hair follicle
- adult
- papilla
- follicle
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 210000004209 Hair Anatomy 0.000 claims 33
- 210000003780 Hair Follicle Anatomy 0.000 claims 31
- 230000001058 adult Effects 0.000 claims 12
- 210000004027 cells Anatomy 0.000 claims 10
- 239000011159 matrix material Substances 0.000 claims 10
- 230000002500 effect on skin Effects 0.000 claims 4
- 239000002994 raw material Substances 0.000 claims 4
- 210000000130 stem cell Anatomy 0.000 claims 3
- 238000004519 manufacturing process Methods 0.000 claims 2
- 230000003659 hair regrowth Effects 0.000 claims 1
- 230000001172 regenerating Effects 0.000 claims 1
Claims (6)
分散された毛乳頭細胞と、分散された前記原料細胞とを混合して培養することにより、毛包原基を製造すること、及び
前記毛包原基を非ヒト動物に移植して前記毛包原基から毛を生やすこと、
を含み、
前記成体毛包組織に含まれる毛乳頭及び毛母以外の部分を含む非恒常部の重量割合を変えることにより、前記毛包原基から生える毛の色を変える、再生毛の色制御方法。 Using source cells, including epithelial stem cells, obtained from adult hair follicle tissue containing the bulge region of the constituency,
The hair follicle primordium is produced by mixing and culturing the dispersed hair papilla cells and the dispersed raw material cells, and the hair follicle primordium is transplanted to a non-human animal to obtain the hair follicle. Growing hair from the primordium,
Including
A method for controlling the color of regenerated hair, which changes the color of hair growing from the hair follicle primordia by changing the weight ratio of a non-constant part including a portion other than the dermal papilla and the hair matrix contained in the adult hair follicle tissue.
分散された毛乳頭細胞と、分散された前記原料細胞とを混合して培養することにより、毛包原基を製造すること、及び
前記毛包原基を非ヒト動物に移植して前記毛包原基から毛を生やすこと、
を含み、
毛乳頭及び毛母以外の部分を含む非恒常部をさらに含む前記成体毛包組織を使用することにより、前記毛包原基から、前記毛乳頭及び毛母以外の部分を含む非恒常部を含まない成体毛包組織を使用する場合に比べて色が濃い毛を生やす、毛の再生方法。 Using source cells, including epithelial stem cells, obtained from adult hair follicle tissue containing the bulge region of the constituency,
The hair follicle primordium is produced by mixing and culturing the dispersed hair papilla cells and the dispersed raw material cells, and the hair follicle primordium is transplanted to a non-human animal to obtain the hair follicle. Growing hair from the primordium,
Including
By using the adult hair follicle tissue further including a non-constant part including a portion other than the hair papilla and the hair matrix, the non-constant part including the hair papilla and a portion other than the hair matrix is included from the hair follicle primordia. A method of hair regrowth that grows darker hair than when using no adult hair follicle tissue.
前記毛乳頭及び毛母以外の部分を含む非恒常部を前記第一の重量割合より大きい第二の重量割合で含む第二の成体毛包組織を使用して製造された第二の細胞凝集塊を前記動物に移植して、前記第二の毛包原基から前記第一の色より濃い第二の色の毛を生やすこと、
を含む、請求項３に記載の毛の再生方法。 The first hair follicles primordia produced using the first adult hair follicles tissue containing the non-constant portion including the hair papilla and the non-hair matrix portion in the first weight ratio was transplanted into the animal. , To grow hair of the first color from the first hair follicles, and to make the non-constant part including the part other than the hair papilla and the hair matrix by a second weight ratio larger than the first weight ratio. A second cell aggregate produced using the containing second adult hair follicle tissue is transplanted into the animal and has a second color darker than the first color from the second hair follicle primordia. To grow hair,
3. The method for regenerating hair according to claim 3.
分散された毛乳頭細胞と、分散された前記原料細胞とを混合して培養することにより、動物に移植されることで毛を生やす毛包原基を製造すること、
を含み、
毛乳頭及び毛母以外の部分を含む非恒常部をさらに含む前記成体毛包組織を使用することにより、前記毛乳頭及び毛母以外の部分を含む非恒常部を含まない成体毛包組織を使用する場合に比べて色が濃い毛を生やす前記毛包原基を製造する、毛包原基の製造方法。 Using raw material cells containing epithelial stem cells obtained from adult hair follicle tissue containing the bulge region of the constituency, and mixing and culturing dispersed hair papilla cells and the dispersed raw material cells. To produce a hair follicle primordium that grows hair by being transplanted into an animal.
Including
By using the formed hair follicle tissue, further comprising a non-constitutive portion including a portion other than the dermal papilla and hair matrix, using the adult hair follicle tissue that does not contain a non-constant part containing a portion other than the dermal papilla and hair matrix A method for producing a hair follicle primordia, which comprises producing the hair follicle primordia that grows darker hair than in the case of.
前記毛乳頭及び毛母以外の部分を含む非恒常部を前記第一の重量割合より大きい第二の重量割合で含む前記成体毛包組織を使用することにより、前記動物に移植されることで前記第一の色より濃い第二の色の毛を生やす第二の毛包原基を製造すること、
を含む、請求項５に記載の毛包原基の製造方法。 By using the adult hair follicles tissue containing a non-constant part including a portion other than the hair papilla and the hair matrix in a first weight ratio, the hair of the first color is grown by being transplanted to the animal. To produce one hair follicles and use the adult hair follicles tissue containing a non-constant portion containing a portion other than the hair papilla and the hair matrix in a second weight ratio greater than the first weight ratio. Thereby, by transplanting to the animal, a second hair follicles primordia that grows hair of a second color darker than the first color can be produced.
The method for producing a hair follicle primordium according to claim 5 , which comprises.
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2018094498A JP7158676B2 (en) | 2018-05-16 | 2018-05-16 | Method for controlling color of regenerated hair, method for regenerating hair, and method for producing hair follicle primordium |
| PCT/JP2019/020185 WO2019221307A1 (en) | 2018-05-16 | 2019-05-15 | Color control method for regenerated hair, regeneration method for hair, and method for producing hair follicle primordia |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2018094498A JP7158676B2 (en) | 2018-05-16 | 2018-05-16 | Method for controlling color of regenerated hair, method for regenerating hair, and method for producing hair follicle primordium |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2019199434A JP2019199434A (en) | 2019-11-21 |
| JP2019199434A5 true JP2019199434A5 (en) | 2021-04-30 |
| JP7158676B2 JP7158676B2 (en) | 2022-10-24 |
Family
ID=68540265
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018094498A Active JP7158676B2 (en) | 2018-05-16 | 2018-05-16 | Method for controlling color of regenerated hair, method for regenerating hair, and method for producing hair follicle primordium |
Country Status (2)
| Country | Link |
|---|---|
| JP (1) | JP7158676B2 (en) |
| WO (1) | WO2019221307A1 (en) |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2679674B1 (en) | 2011-02-24 | 2019-04-24 | Organ Technologies, Inc. | Method of preparing regenerated hair follicle germ for transplantation in which hair color is controlled |
| JP6362588B2 (en) | 2013-05-02 | 2018-07-25 | 正典 佐伯 | Cell preparation for hair regeneration |
-
2018
- 2018-05-16 JP JP2018094498A patent/JP7158676B2/en active Active
-
2019
- 2019-05-15 WO PCT/JP2019/020185 patent/WO2019221307A1/en active Application Filing
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