JP2019187429A5 - - Google Patents
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- JP2019187429A5 JP2019187429A5 JP2019113661A JP2019113661A JP2019187429A5 JP 2019187429 A5 JP2019187429 A5 JP 2019187429A5 JP 2019113661 A JP2019113661 A JP 2019113661A JP 2019113661 A JP2019113661 A JP 2019113661A JP 2019187429 A5 JP2019187429 A5 JP 2019187429A5
- Authority
- JP
- Japan
- Prior art keywords
- disease
- ischemia
- cells
- cell
- hematopoietic stem
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 210000003958 hematopoietic stem cell Anatomy 0.000 claims 27
- 210000004027 cell Anatomy 0.000 claims 11
- 102100031573 Hematopoietic progenitor cell antigen CD34 Human genes 0.000 claims 7
- 101000777663 Homo sapiens Hematopoietic progenitor cell antigen CD34 Proteins 0.000 claims 7
- 230000000302 ischemic effect Effects 0.000 claims 7
- 239000000203 mixture Substances 0.000 claims 7
- 101150066398 CXCR4 gene Proteins 0.000 claims 4
- 206010008118 cerebral infarction Diseases 0.000 claims 4
- 230000014509 gene expression Effects 0.000 claims 4
- 208000028867 ischemia Diseases 0.000 claims 4
- 201000006474 Brain Ischemia Diseases 0.000 claims 3
- 206010008120 Cerebral ischaemia Diseases 0.000 claims 3
- 208000005764 Peripheral Arterial Disease Diseases 0.000 claims 3
- 208000030831 Peripheral arterial occlusive disease Diseases 0.000 claims 3
- 206010034576 Peripheral ischaemia Diseases 0.000 claims 3
- 208000018262 Peripheral vascular disease Diseases 0.000 claims 3
- 208000027418 Wounds and injury Diseases 0.000 claims 3
- 208000029078 coronary artery disease Diseases 0.000 claims 3
- 210000000056 organ Anatomy 0.000 claims 3
- 208000032064 Chronic Limb-Threatening Ischemia Diseases 0.000 claims 2
- 206010061218 Inflammation Diseases 0.000 claims 2
- 206010022562 Intermittent claudication Diseases 0.000 claims 2
- 206010028980 Neoplasm Diseases 0.000 claims 2
- 208000006011 Stroke Diseases 0.000 claims 2
- 206010052428 Wound Diseases 0.000 claims 2
- 206010069351 acute lung injury Diseases 0.000 claims 2
- 206010000891 acute myocardial infarction Diseases 0.000 claims 2
- 210000001185 bone marrow Anatomy 0.000 claims 2
- 201000011510 cancer Diseases 0.000 claims 2
- 208000026106 cerebrovascular disease Diseases 0.000 claims 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 2
- 210000004700 fetal blood Anatomy 0.000 claims 2
- 208000026278 immune system disease Diseases 0.000 claims 2
- 210000004263 induced pluripotent stem cell Anatomy 0.000 claims 2
- 230000004054 inflammatory process Effects 0.000 claims 2
- 201000002818 limb ischemia Diseases 0.000 claims 2
- 208000031225 myocardial ischemia Diseases 0.000 claims 2
- 208000033808 peripheral neuropathy Diseases 0.000 claims 2
- 210000002826 placenta Anatomy 0.000 claims 2
- 210000001519 tissue Anatomy 0.000 claims 2
- 208000019553 vascular disease Diseases 0.000 claims 2
- 208000004476 Acute Coronary Syndrome Diseases 0.000 claims 1
- 206010001052 Acute respiratory distress syndrome Diseases 0.000 claims 1
- 208000031104 Arterial Occlusive disease Diseases 0.000 claims 1
- 206010003210 Arteriosclerosis Diseases 0.000 claims 1
- 208000023275 Autoimmune disease Diseases 0.000 claims 1
- 208000010392 Bone Fractures Diseases 0.000 claims 1
- 208000017234 Bone cyst Diseases 0.000 claims 1
- 208000014644 Brain disease Diseases 0.000 claims 1
- 206010048962 Brain oedema Diseases 0.000 claims 1
- 206010007559 Cardiac failure congestive Diseases 0.000 claims 1
- 208000024172 Cardiovascular disease Diseases 0.000 claims 1
- 206010007710 Cartilage injury Diseases 0.000 claims 1
- 206010065384 Cerebral hypoperfusion Diseases 0.000 claims 1
- 206010061762 Chondropathy Diseases 0.000 claims 1
- 206010009900 Colitis ulcerative Diseases 0.000 claims 1
- 208000034656 Contusions Diseases 0.000 claims 1
- 208000011231 Crohn disease Diseases 0.000 claims 1
- 206010051055 Deep vein thrombosis Diseases 0.000 claims 1
- 208000032131 Diabetic Neuropathies Diseases 0.000 claims 1
- 206010017076 Fracture Diseases 0.000 claims 1
- 208000001034 Frostbite Diseases 0.000 claims 1
- 208000009329 Graft vs Host Disease Diseases 0.000 claims 1
- 206010019280 Heart failures Diseases 0.000 claims 1
- 208000032843 Hemorrhage Diseases 0.000 claims 1
- 206010058490 Hyperoxia Diseases 0.000 claims 1
- 206010021143 Hypoxia Diseases 0.000 claims 1
- 208000010159 IgA glomerulonephritis Diseases 0.000 claims 1
- 206010021263 IgA nephropathy Diseases 0.000 claims 1
- 206010021519 Impaired healing Diseases 0.000 claims 1
- 208000022559 Inflammatory bowel disease Diseases 0.000 claims 1
- 206010022680 Intestinal ischaemia Diseases 0.000 claims 1
- 208000034693 Laceration Diseases 0.000 claims 1
- 208000001132 Osteoporosis Diseases 0.000 claims 1
- 208000018737 Parkinson disease Diseases 0.000 claims 1
- 208000037581 Persistent Infection Diseases 0.000 claims 1
- 208000010378 Pulmonary Embolism Diseases 0.000 claims 1
- 206010037423 Pulmonary oedema Diseases 0.000 claims 1
- 206010063897 Renal ischaemia Diseases 0.000 claims 1
- 208000027032 Renal vascular disease Diseases 0.000 claims 1
- 206010063837 Reperfusion injury Diseases 0.000 claims 1
- 208000017442 Retinal disease Diseases 0.000 claims 1
- 206010038923 Retinopathy Diseases 0.000 claims 1
- 206010039491 Sarcoma Diseases 0.000 claims 1
- 206010040047 Sepsis Diseases 0.000 claims 1
- 206010040943 Skin Ulcer Diseases 0.000 claims 1
- 208000007536 Thrombosis Diseases 0.000 claims 1
- 208000030886 Traumatic Brain injury Diseases 0.000 claims 1
- 206010067584 Type 1 diabetes mellitus Diseases 0.000 claims 1
- 208000025865 Ulcer Diseases 0.000 claims 1
- 201000006704 Ulcerative Colitis Diseases 0.000 claims 1
- 206010047249 Venous thrombosis Diseases 0.000 claims 1
- 208000011775 arteriosclerosis disease Diseases 0.000 claims 1
- 230000003143 atherosclerotic effect Effects 0.000 claims 1
- 230000000740 bleeding effect Effects 0.000 claims 1
- 210000004556 brain Anatomy 0.000 claims 1
- 208000006752 brain edema Diseases 0.000 claims 1
- 210000000481 breast Anatomy 0.000 claims 1
- 238000002659 cell therapy Methods 0.000 claims 1
- 230000002490 cerebral effect Effects 0.000 claims 1
- 230000000973 chemotherapeutic effect Effects 0.000 claims 1
- 238000002512 chemotherapy Methods 0.000 claims 1
- 201000005483 chronic intestinal vascular insufficiency Diseases 0.000 claims 1
- 208000024980 claudication Diseases 0.000 claims 1
- 210000001072 colon Anatomy 0.000 claims 1
- 210000002808 connective tissue Anatomy 0.000 claims 1
- 230000009519 contusion Effects 0.000 claims 1
- 230000006378 damage Effects 0.000 claims 1
- 230000003111 delayed effect Effects 0.000 claims 1
- 206010012601 diabetes mellitus Diseases 0.000 claims 1
- 208000035475 disorder Diseases 0.000 claims 1
- 208000009190 disseminated intravascular coagulation Diseases 0.000 claims 1
- 230000003073 embolic effect Effects 0.000 claims 1
- 208000024908 graft versus host disease Diseases 0.000 claims 1
- 230000000222 hyperoxic effect Effects 0.000 claims 1
- 230000007954 hypoxia Effects 0.000 claims 1
- 230000004968 inflammatory condition Effects 0.000 claims 1
- 208000027866 inflammatory disease Diseases 0.000 claims 1
- 208000014674 injury Diseases 0.000 claims 1
- 208000021156 intermittent vascular claudication Diseases 0.000 claims 1
- 235000015110 jellies Nutrition 0.000 claims 1
- 239000008274 jelly Substances 0.000 claims 1
- 208000017169 kidney disease Diseases 0.000 claims 1
- 210000004185 liver Anatomy 0.000 claims 1
- 210000003141 lower extremity Anatomy 0.000 claims 1
- 210000004072 lung Anatomy 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- 230000001400 myeloablative effect Effects 0.000 claims 1
- 208000010125 myocardial infarction Diseases 0.000 claims 1
- 201000001119 neuropathy Diseases 0.000 claims 1
- 230000007823 neuropathy Effects 0.000 claims 1
- 201000008482 osteoarthritis Diseases 0.000 claims 1
- 201000008968 osteosarcoma Diseases 0.000 claims 1
- 230000002611 ovarian Effects 0.000 claims 1
- 210000005259 peripheral blood Anatomy 0.000 claims 1
- 239000011886 peripheral blood Substances 0.000 claims 1
- 210000002307 prostate Anatomy 0.000 claims 1
- 208000005333 pulmonary edema Diseases 0.000 claims 1
- 238000001959 radiotherapy Methods 0.000 claims 1
- 238000007634 remodeling Methods 0.000 claims 1
- 208000015670 renal artery disease Diseases 0.000 claims 1
- 208000032253 retinal ischemia Diseases 0.000 claims 1
- 210000003491 skin Anatomy 0.000 claims 1
- 231100000019 skin ulcer Toxicity 0.000 claims 1
- 239000007787 solid Substances 0.000 claims 1
- 208000020431 spinal cord injury Diseases 0.000 claims 1
- 210000000130 stem cell Anatomy 0.000 claims 1
- 230000009885 systemic effect Effects 0.000 claims 1
- 210000002435 tendon Anatomy 0.000 claims 1
- 230000001225 therapeutic effect Effects 0.000 claims 1
- 230000001732 thrombotic effect Effects 0.000 claims 1
- 230000000451 tissue damage Effects 0.000 claims 1
- 231100000827 tissue damage Toxicity 0.000 claims 1
- 230000001052 transient effect Effects 0.000 claims 1
- 230000009529 traumatic brain injury Effects 0.000 claims 1
- 208000001072 type 2 diabetes mellitus Diseases 0.000 claims 1
- 231100000397 ulcer Toxicity 0.000 claims 1
- 230000002792 vascular Effects 0.000 claims 1
- 230000024883 vasodilation Effects 0.000 claims 1
- 208000006542 von Hippel-Lindau disease Diseases 0.000 claims 1
- 230000029663 wound healing Effects 0.000 claims 1
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2021156680A JP2021191311A (ja) | 2011-12-02 | 2021-09-27 | 増強された幹細胞組成物 |
| JP2023017468A JP2023053019A (ja) | 2011-12-02 | 2023-02-08 | 増強された幹細胞組成物 |
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161566492P | 2011-12-02 | 2011-12-02 | |
| US61/566,492 | 2011-12-02 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018244311A Division JP6775568B2 (ja) | 2011-12-02 | 2018-12-27 | 増強された幹細胞組成物 |
Related Child Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020202687A Division JP2021036918A (ja) | 2011-12-02 | 2020-12-07 | 増強された幹細胞組成物 |
| JP2021156680A Division JP2021191311A (ja) | 2011-12-02 | 2021-09-27 | 増強された幹細胞組成物 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2019187429A JP2019187429A (ja) | 2019-10-31 |
| JP2019187429A5 true JP2019187429A5 (enExample) | 2020-01-09 |
Family
ID=48536037
Family Applications (7)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014544868A Active JP6220791B2 (ja) | 2011-12-02 | 2012-11-29 | 増強された幹細胞組成物 |
| JP2017098749A Active JP6483187B2 (ja) | 2011-12-02 | 2017-05-18 | 増強された幹細胞組成物 |
| JP2018244311A Active JP6775568B2 (ja) | 2011-12-02 | 2018-12-27 | 増強された幹細胞組成物 |
| JP2019113661A Withdrawn JP2019187429A (ja) | 2011-12-02 | 2019-06-19 | 増強された幹細胞組成物 |
| JP2020202687A Pending JP2021036918A (ja) | 2011-12-02 | 2020-12-07 | 増強された幹細胞組成物 |
| JP2021156680A Pending JP2021191311A (ja) | 2011-12-02 | 2021-09-27 | 増強された幹細胞組成物 |
| JP2023017468A Pending JP2023053019A (ja) | 2011-12-02 | 2023-02-08 | 増強された幹細胞組成物 |
Family Applications Before (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014544868A Active JP6220791B2 (ja) | 2011-12-02 | 2012-11-29 | 増強された幹細胞組成物 |
| JP2017098749A Active JP6483187B2 (ja) | 2011-12-02 | 2017-05-18 | 増強された幹細胞組成物 |
| JP2018244311A Active JP6775568B2 (ja) | 2011-12-02 | 2018-12-27 | 増強された幹細胞組成物 |
Family Applications After (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020202687A Pending JP2021036918A (ja) | 2011-12-02 | 2020-12-07 | 増強された幹細胞組成物 |
| JP2021156680A Pending JP2021191311A (ja) | 2011-12-02 | 2021-09-27 | 増強された幹細胞組成物 |
| JP2023017468A Pending JP2023053019A (ja) | 2011-12-02 | 2023-02-08 | 増強された幹細胞組成物 |
Country Status (9)
| Country | Link |
|---|---|
| US (4) | US9452186B2 (enExample) |
| EP (2) | EP3785767A1 (enExample) |
| JP (7) | JP6220791B2 (enExample) |
| CN (3) | CN112375734A (enExample) |
| AU (1) | AU2012321088B8 (enExample) |
| CA (1) | CA2857640C (enExample) |
| ES (1) | ES2836976T3 (enExample) |
| PT (1) | PT2785834T (enExample) |
| WO (1) | WO2013082243A1 (enExample) |
Families Citing this family (28)
| Publication number | Priority date | Publication date | Assignee | Title |
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| WO2013082243A1 (en) * | 2011-12-02 | 2013-06-06 | Fate Therapeutics, Inc. | Enhanced stem cell composition |
| JP6106688B2 (ja) | 2011-12-02 | 2017-04-05 | フェイト セラピューティクス，インコーポレイテッド | 虚血を処置する改善された方法 |
| EP3295940A1 (en) | 2012-04-16 | 2018-03-21 | Case Western Reserve University | Compositions and methods of modulating 15-pgdh activity |
| US9801863B2 (en) | 2012-04-16 | 2017-10-31 | Case Western Reserve University | Inhibitors of short-chain dehydrogenase activity for modulating hematopoietic stem cells and hematopoiesis |
| US9943545B2 (en) | 2013-03-15 | 2018-04-17 | Fate Therapeutics, Inc. | Stem cell culture media and methods of enhancing cell survival |
| US10851412B2 (en) | 2013-03-15 | 2020-12-01 | Fate Therapeutics, Inc. | Cell potency assay for therapeutic potential |
| US9789116B2 (en) | 2013-10-15 | 2017-10-17 | Case Western Reserve University | Compositions and methods of modulating short-chain dehydrogenase activity |
| CA2939512C (en) * | 2014-02-12 | 2023-02-28 | 7 Hills Interests, Llc | Compositions and methods to improve the homing and grafting of hematopoetic stem cells |
| US10626372B1 (en) | 2015-01-26 | 2020-04-21 | Fate Therapeutics, Inc. | Methods and compositions for inducing hematopoietic cell differentiation |
| JP2018504122A (ja) * | 2015-01-26 | 2018-02-15 | フェイト セラピューティクス，インコーポレイテッド | 免疫調節特性が増加した細胞ならびにその使用および製造のための方法 |
| CN107921025A (zh) | 2015-03-08 | 2018-04-17 | 卡斯西部储备大学 | 用于治疗纤维症的短链脱氢酶活性的抑制剂 |
| BR112018001232A2 (pt) | 2015-07-21 | 2018-09-25 | The Children's Medical Center Corporation | pd-l1 que expressa células-tronco hematopoéticas e usos |
| US20170095593A1 (en) * | 2015-10-02 | 2017-04-06 | Sharon Patricia McQuillan | Adipose-derived stem cell product |
| KR20250141836A (ko) | 2015-11-04 | 2025-09-29 | 페이트 세러퓨틱스, 인코포레이티드 | 만능 세포의 유전자 조작 |
| CN108473961B (zh) | 2015-11-04 | 2022-11-29 | 菲特治疗公司 | 用于诱导造血细胞分化的方法和组合物 |
| CA3035660A1 (en) | 2016-09-06 | 2018-03-15 | The Children's Medical Center Corporation | Immune cells derived from induced pluripotent stem cell |
| US11191746B2 (en) * | 2016-10-14 | 2021-12-07 | Jeju National University Industry-Academic Cooperation Foundation | Composition for inhibiting a growth of cancer stem cells comprising ciclesonide |
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| JP2020514323A (ja) | 2017-02-06 | 2020-05-21 | ケース ウエスタン リザーブ ユニバーシティ | 短鎖デヒドロゲナーゼ活性を調節する組成物と方法 |
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| EP3823645B1 (en) | 2018-07-22 | 2024-07-03 | Minovia Therapeutics Ltd. | Mitochondrial augmentation therapy of renal diseases |
| US12239672B2 (en) | 2018-07-22 | 2025-03-04 | Minovia Therapeutics Ltd. | Mitochondrial augmentation therapy of ocular diseases |
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| CN113069460B (zh) * | 2021-03-24 | 2022-02-08 | 兰州大学 | 哈西奈德及其衍生物用于制备治疗和/或预防脑血管疾病药物中的应用 |
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